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Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)

 SOAT2_HUMAN             Reviewed;         522 AA.
O75908; F5H7W4; I6L9H9; Q4VB99; Q4VBA1; Q96TD4; Q9UNR2;
18-OCT-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
11-DEC-2019, entry version 157.
RecName: Full=Sterol O-acyltransferase 2;
EC=2.3.1.26;
AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2;
Short=ACAT-2;
AltName: Full=Cholesterol acyltransferase 2;
Name=SOAT2; Synonyms=ACACT2, ACAT2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9756920; DOI=10.1074/jbc.273.41.26765;
Oelkers P., Behari A., Cromley D., Billheimer J.T., Sturley S.L.;
"Characterization of two human genes encoding acyl coenzyme A:cholesterol
acyltransferase-related enzymes.";
J. Biol. Chem. 273:26765-26771(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT ILE-254.
TISSUE=Intestine;
PubMed=10846185; DOI=10.1074/jbc.m003927200;
Chang C.C.Y., Sakashita N., Ornvold K., Lee O., Chang E.T., Dong R.,
Lin S., Lee C.-Y.G., Strom S.C., Kashyap R., Fung J.J., Farese R.V. Jr.,
Patoiseau J.-F., Delhon A., Chang T.-Y.;
"Immunological quantitation and localization of ACAT-1 and ACAT-2 in human
liver and small intestine.";
J. Biol. Chem. 275:28083-28092(2000).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11325614; DOI=10.1016/s1388-1981(01)00106-8;
Katsuren K., Tamura T., Arashiro R., Takata K., Matsuura T., Niikawa N.,
Ohta T.;
"Structure of the human acyl-CoA:cholesterol acyltransferase-2 (ACAT-2)
gene and its relation to dyslipidemia.";
Biochim. Biophys. Acta 1531:230-240(2001).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=11401500; DOI=10.1006/bbrc.2001.4612;
Song B.L., Qi W., Yang X.Y., Chang C.C.Y., Zhu J.Q., Chang T.Y., Li B.L.;
"Organization of human ACAT-2 gene and its cell-type-specific promoter
activity.";
Biochem. Biophys. Res. Commun. 282:580-588(2001).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4), AND VARIANTS
GLY-14 AND ILE-254.
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
TISSUE SPECIFICITY, AND ALTERNATIVE SPLICING (ISOFORMS 2 AND 3).
PubMed=16331323; DOI=10.1111/j.1745-7270.2005.00118.x;
Yao X.M., Wang C.H., Song B.L., Yang X.Y., Wang Z.Z., Qi W., Lin Z.X.,
Chang C.C., Chang T.Y., Li B.L.;
"Two human ACAT2 mRNA variants produced by alternative splicing and coding
for novel isoenzymes.";
Acta Biochim. Biophys. Sin. 37:797-806(2005).
-!- FUNCTION: Plays a role in lipoprotein assembly and dietary cholesterol
absorption. In addition to its acyltransferase activity, it may act as
a ligase. May provide cholesteryl esters for lipoprotein secretion from
hepatocytes and intestinal mucosa.
-!- CATALYTIC ACTIVITY:
Reaction=an acyl-CoA + cholesterol = a cholesterol ester + CoA;
Xref=Rhea:RHEA:17729, ChEBI:CHEBI:16113, ChEBI:CHEBI:17002,
ChEBI:CHEBI:57287, ChEBI:CHEBI:58342; EC=2.3.1.26;
-!- SUBUNIT: May form homo- or heterodimers. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1; Synonyms=ACAD2a;
IsoId=O75908-1; Sequence=Displayed;
Name=2; Synonyms=ACAD2b;
IsoId=O75908-2; Sequence=VSP_057159;
Name=3; Synonyms=ACAD2c;
IsoId=O75908-3; Sequence=VSP_057158, VSP_057160;
Name=4;
IsoId=O75908-4; Sequence=VSP_057161, VSP_057162;
-!- TISSUE SPECIFICITY: Expression seems confined in hepatocytes and
enterocytes. {ECO:0000269|PubMed:16331323}.
-!- MISCELLANEOUS: [Isoform 2]: Lower enzymatic activity. {ECO:0000305}.
-!- MISCELLANEOUS: [Isoform 3]: Lower enzymatic activity. {ECO:0000305}.
-!- SIMILARITY: Belongs to the membrane-bound acyltransferase family.
Sterol o-acyltransferase subfamily. {ECO:0000305}.
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EMBL; AF059203; AAC63998.1; -; mRNA.
EMBL; AF099031; AAC78335.2; -; mRNA.
EMBL; AF331516; AAK18275.1; -; Genomic_DNA.
EMBL; AF331502; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331503; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331504; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331505; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331506; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331507; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331508; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331509; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331510; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331511; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331512; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331513; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331514; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF331515; AAK18275.1; JOINED; Genomic_DNA.
EMBL; AF332858; AAK48829.1; -; Genomic_DNA.
EMBL; AF332857; AAK48829.1; JOINED; Genomic_DNA.
EMBL; AC073573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC096090; AAH96090.1; -; mRNA.
EMBL; BC096091; AAH96091.1; -; mRNA.
EMBL; BC096092; AAH96092.1; -; mRNA.
EMBL; BC099626; AAH99626.1; -; mRNA.
CCDS; CCDS8847.1; -. [O75908-1]
RefSeq; NP_003569.1; NM_003578.3. [O75908-1]
BioGrid; 114015; 3.
IntAct; O75908; 3.
MINT; O75908; -.
STRING; 9606.ENSP00000301466; -.
BindingDB; O75908; -.
ChEMBL; CHEMBL4465; -.
DrugBank; DB01094; Hesperetin.
SwissLipids; SLP:000001262; -. [O75908-1]
iPTMnet; O75908; -.
PhosphoSitePlus; O75908; -.
SwissPalm; O75908; -.
BioMuta; SOAT2; -.
MassIVE; O75908; -.
PaxDb; O75908; -.
PeptideAtlas; O75908; -.
PRIDE; O75908; -.
ProteomicsDB; 27608; -.
ProteomicsDB; 50258; -. [O75908-1]
Ensembl; ENST00000301466; ENSP00000301466; ENSG00000167780. [O75908-1]
Ensembl; ENST00000542365; ENSP00000442234; ENSG00000167780. [O75908-4]
GeneID; 8435; -.
KEGG; hsa:8435; -.
UCSC; uc001sbv.4; human. [O75908-1]
CTD; 8435; -.
DisGeNET; 8435; -.
EuPathDB; HostDB:ENSG00000167780.11; -.
GeneCards; SOAT2; -.
HGNC; HGNC:11178; SOAT2.
MIM; 601311; gene.
neXtProt; NX_O75908; -.
OpenTargets; ENSG00000167780; -.
PharmGKB; PA36016; -.
eggNOG; KOG0380; Eukaryota.
eggNOG; COG5056; LUCA.
GeneTree; ENSGT00950000183081; -.
HOGENOM; HOG000020782; -.
InParanoid; O75908; -.
KO; K00637; -.
OMA; TMNDRHT; -.
OrthoDB; 1275897at2759; -.
PhylomeDB; O75908; -.
TreeFam; TF315226; -.
BRENDA; 2.3.1.26; 2681.
Reactome; R-HSA-8964038; LDL clearance.
SABIO-RK; O75908; -.
GeneWiki; SOAT2; -.
GenomeRNAi; 8435; -.
Pharos; O75908; Tchem.
PRO; PR:O75908; -.
Proteomes; UP000005640; Chromosome 12.
RNAct; O75908; protein.
Bgee; ENSG00000167780; Expressed in 68 organ(s), highest expression level in liver.
ExpressionAtlas; O75908; baseline and differential.
Genevisible; O75908; HS.
GO; GO:0005903; C:brush border; IDA:BHF-UCL.
GO; GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.
GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:BHF-UCL.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0015485; F:cholesterol binding; IDA:BHF-UCL.
GO; GO:0034736; F:cholesterol O-acyltransferase activity; IDA:BHF-UCL.
GO; GO:0000062; F:fatty-acyl-CoA binding; IDA:BHF-UCL.
GO; GO:0016746; F:transferase activity, transferring acyl groups; TAS:ProtInc.
GO; GO:0033344; P:cholesterol efflux; IMP:BHF-UCL.
GO; GO:0034435; P:cholesterol esterification; IDA:BHF-UCL.
GO; GO:0042632; P:cholesterol homeostasis; TAS:BHF-UCL.
GO; GO:0008203; P:cholesterol metabolic process; IDA:BHF-UCL.
GO; GO:0030299; P:intestinal cholesterol absorption; IC:BHF-UCL.
GO; GO:0034383; P:low-density lipoprotein particle clearance; TAS:Reactome.
GO; GO:0010742; P:macrophage derived foam cell differentiation; TAS:BHF-UCL.
GO; GO:0034379; P:very-low-density lipoprotein particle assembly; IMP:BHF-UCL.
InterPro; IPR004299; MBOAT_fam.
InterPro; IPR014371; Oat_ACAT_DAG_ARE.
InterPro; IPR030687; Sterol_acyltranf_meta.
PANTHER; PTHR10408; PTHR10408; 1.
Pfam; PF03062; MBOAT; 1.
PIRSF; PIRSF000439; Oat_ACAT_DAG_ARE; 1.
PIRSF; PIRSF500230; Sterol_acyltranf_ACAT; 1.
2: Evidence at transcript level;
Acyltransferase; Alternative splicing; Cholesterol metabolism;
Endoplasmic reticulum; Lipid metabolism; Membrane; Polymorphism;
Reference proteome; Steroid metabolism; Sterol metabolism; Transferase;
Transmembrane; Transmembrane helix.
CHAIN 1..522
/note="Sterol O-acyltransferase 2"
/id="PRO_0000207645"
TOPO_DOM 1..122
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 123..141
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 142..160
/note="Lumenal"
/evidence="ECO:0000255"
TRANSMEM 161..179
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 180..200
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 201..219
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 220..340
/note="Lumenal"
/evidence="ECO:0000255"
TRANSMEM 341..363
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 364..475
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 476..494
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 495..522
/note="Lumenal"
/evidence="ECO:0000255"
ACT_SITE 434
/evidence="ECO:0000255"
VAR_SEQ 93..148
/note="Missing (in isoform 3)"
/evidence="ECO:0000269|PubMed:16331323"
/id="VSP_057158"
VAR_SEQ 93..112
/note="Missing (in isoform 2)"
/evidence="ECO:0000269|PubMed:16331323"
/id="VSP_057159"
VAR_SEQ 236..261
/note="Missing (in isoform 3)"
/evidence="ECO:0000269|PubMed:16331323"
/id="VSP_057160"
VAR_SEQ 289..310
/note="TPYVRWNYVAKNFAQALGCVLY -> PWDVCSMPASSWAASVFLSLPT (in
isoform 4)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_057161"
VAR_SEQ 311..522
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_057162"
VARIANT 14
/note="E -> G (in dbSNP:rs9658625)"
/evidence="ECO:0000269|PubMed:15489334"
/id="VAR_020373"
VARIANT 254
/note="T -> I (in dbSNP:rs2272296)"
/evidence="ECO:0000269|PubMed:10846185,
ECO:0000269|PubMed:15489334"
/id="VAR_020374"
CONFLICT 22
/note="R -> P (in Ref. 4; AAK48829)"
/evidence="ECO:0000305"
SEQUENCE 522 AA; 59896 MW; EEAC2DB569FFE729 CRC64;
MEPGGARLRL QRTEGLGGER ERQPCGDGNT ETHRAPDLVQ WTRHMEAVKA QLLEQAQGQL
RELLDRAMRE AIQSYPSQDK PLPPPPPGSL SRTQEPSLGK QKVFIIRKSL LDELMEVQHF
RTIYHMFIAG LCVFIISTLA IDFIDEGRLL LEFDLLIFSF GQLPLALVTW VPMFLSTLLA
PYQALRLWAR GTWTQATGLG CALLAAHAVV LCALPVHVAV EHQLPPASRC VLVFEQVRFL
MKSYSFLREA VPGTLRARRG EGIQAPSFSS YLYFLFCPTL IYRETYPRTP YVRWNYVAKN
FAQALGCVLY ACFILGRLCV PVFANMSREP FSTRALVLSI LHATLPGIFM LLLIFFAFLH
CWLNAFAEML RFGDRMFYRD WWNSTSFSNY YRTWNVVVHD WLYSYVYQDG LRLLGARARG
VAMLGVFLVS AVAHEYIFCF VLGFFYPVML ILFLVIGGML NFMMHDQRTG PAWNVLMWTM
LFLGQGIQVS LYCQEWYARR HCPLPQATFW GLVTPRSWSC HT


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Related Genes :
[SOAT2 ACACT2 ACAT2] Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
[SOAT1 ACACT ACACT1 ACAT ACAT1 SOAT STAT] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[Soat1 Acact] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[Soat2 Acact-2 Acat2] Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
[Soat1 Acact Acat] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[Soat2 Acat2] Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
[CES1 CES2 SES1] Liver carboxylesterase 1 (Acyl-coenzyme A:cholesterol acyltransferase) (ACAT) (Brain carboxylesterase hBr1) (Carboxylesterase 1) (CE-1) (hCE-1) (EC 3.1.1.1) (Cocaine carboxylesterase) (Egasyn) (HMSE) (Methylumbelliferyl-acetate deacetylase 1) (EC 3.1.1.56) (Monocyte/macrophage serine esterase) (Retinyl ester hydrolase) (REH) (Serine esterase 1) (Triacylglycerol hydrolase) (TGH)
[DGAT1 AGRP1 DGAT] Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (ACAT-related gene product 1) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)
[LCAT] Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)
[SOAT1 ACAT1] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[PSAT LCAT2 PSAT1 At1g04010 F21M11.5] Phospholipid--sterol O-acyltransferase (EC 2.3.1.-) (Lecithin-cholesterol acyltransferase-like 2)
[SOAT1 ACAT ACAT1] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[Lcat] Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)
[Lcat] Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)
[SOAT2 ACAT2] Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2)
[SOAT1 ACAT ACAT1] Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
[Mboat2 Lpcat4 Oact2] Lysophospholipid acyltransferase 2 (LPLAT 2) (EC 2.3.1.-) (1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (Lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Lysophosphatidylcholine acyltransferase 4) (Lyso-PC acyltransferase 4) (mLPCAT4) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 2) (O-acyltransferase domain-containing protein 2)
[mboa-6 R155.1] Lysophospholipid acyltransferase 5 (LPLAT 5) (EC 2.3.1.-) (Probable 1-acylglycerophosphocholine O-acyltransferase) (EC 2.3.1.23) (Probable 1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (Probable 1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Probable lysophosphatidylcholine acyltransferase) (LPCAT) (Lyso-PC acyltransferase) (Probable lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Probable lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase)
[Gpat4 Agpat6 Tsarg7] Glycerol-3-phosphate acyltransferase 4 (GPAT4) (EC 2.3.1.15) (1-acylglycerol-3-phosphate O-acyltransferase 6) (1-AGP acyltransferase 6) (1-AGPAT 6) (Acyl-CoA:glycerol-3-phosphate acyltransferase 4) (Lysophosphatidic acid acyltransferase zeta) (LPAAT-zeta) (Testis spermatogenesis apoptosis-related protein 7)
[Agpat5 D8Ertd319e] 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 5) (1-AGP acyltransferase 5) (1-AGPAT 5) (Lysophosphatidic acid acyltransferase epsilon) (LPAAT-epsilon)
[mboa-7 lpiat tag-289 F14F3.3] Lysophospholipid acyltransferase 7 (LPLAT 7) (EC 2.3.1.-) (1-acylglycerophosphatidylinositol O-acyltransferase) (EC 2.3.1.n4) (Lysophosphatidylinositol acyltransferase) (LPIAT) (Lyso-PI acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 7)
[Lpcat1 Aytl2] Lysophosphatidylcholine acyltransferase 1 (LPC acyltransferase 1) (LPCAT-1) (LysoPC acyltransferase 1) (mLPCAT1) (EC 2.3.1.23) (1-acylglycerophosphocholine O-acyltransferase) (1-alkylglycerophosphocholine O-acetyltransferase) (EC 2.3.1.67) (Acetyl-CoA:lyso-platelet-activating factor acetyltransferase) (Acetyl-CoA:lyso-PAF acetyltransferase) (Lyso-PAF acetyltransferase) (LysoPAFAT) (Acyltransferase-like 2)
[Dgat1 Dgat] Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)
[tgs1 Rv3130c MTCY03A2.28 MTCY164.41c] Probable diacyglycerol O-acyltransferase tgs1 (TGS1) (EC 2.3.1.20) (Probable triacylglycerol synthase tgs1)
[Dgat1 Dgat] Diacylglycerol O-acyltransferase 1 (EC 2.3.1.20) (Acyl-CoA retinol O-fatty-acyltransferase) (ARAT) (Retinol O-fatty-acyltransferase) (EC 2.3.1.76) (Diglyceride acyltransferase)
[Cyp1a2 Cyp1a-2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P450-P2) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[Gpat3 Agpat9] Glycerol-3-phosphate acyltransferase 3 (GPAT-3) (EC 2.3.1.15) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 10) (AGPAT 10) (1-acyl-sn-glycerol-3-phosphate O-acyltransferase 9) (1-AGP acyltransferase 9) (1-AGPAT 9) (EC 2.3.1.51) (Acyl-CoA:glycerol-3-phosphate acyltransferase 3) (mGPAT3) (Lysophosphatidic acid acyltransferase theta) (LPAAT-theta)
[Plaat3 H-rev107 Hrasls3 Hrev107 Pla2g16] Phospholipase A and acyltransferase 3 (EC 2.3.1.-) (EC 3.1.1.32) (EC 3.1.1.4) (Adipose-specific phospholipase A2) (AdPLA) (Group XVI phospholipase A2) (H-rev 107 protein homolog) (HRAS-like suppressor 3) (HRSL3)
[LCAT] Phosphatidylcholine-sterol acyltransferase (EC 2.3.1.43) (Lecithin-cholesterol acyltransferase) (Phospholipid-cholesterol acyltransferase)
[Mboat1 Lpeat1 Oact1] Lysophospholipid acyltransferase 1 (LPLAT 1) (EC 2.3.1.-) (1-acylglycerophosphoethanolamine O-acyltransferase) (EC 2.3.1.n7) (1-acylglycerophosphoserine O-acyltransferase) (EC 2.3.1.n6) (Lysophosphatidylethanolamine acyltransferase) (LPEAT) (Lyso-PE acyltransferase) (Lysophosphatidylserine acyltransferase) (LPSAT) (Lyso-PS acyltransferase) (Membrane-bound O-acyltransferase domain-containing protein 1) (O-acyltransferase domain-containing protein 1)

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[23124952] Using self-organizing map (SOM) and support vector machine (SVM) for classification of selectivity of ACAT inhibitors.
[21232182] Regulation of acyl-coenzyme A: cholesterol acyltransferase 2 expression by saturated fatty acids.
[19495703] A novel technical approach for the measurement of individual ACAT-1 and ACAT-2 enzymatic activity in the testis.
[16820149] A selective ACAT-1 inhibitor, K-604, suppresses fatty streak lesions in fat-fed hamsters without affecting plasma cholesterol levels.
[16042405] Acyl-coenzyme A binding protein expression alters liver fatty acyl-coenzyme A metabolism.
[15458444] HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.
[15262831] Acyl-coenzyme A:cholesterol acyltransferase inhibition ameliorates proteinuria, hyperlipidemia, lecithin-cholesterol acyltransferase, SRB-1, and low-denisty lipoprotein receptor deficiencies in nephrotic syndrome.
[15242859] Acyl-coenzyme A:cholesterol acyltransferase-2 (ACAT-2) is responsible for elevated intestinal ACAT activity in diabetic rats.
[12621162] Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia.