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Stress-induced-phosphoprotein 1 (CeSTI1) (STI1) (Hsc70/Hsp90-organizing protein) (CeHop) (Hop)

 STIP1_CAEEL             Reviewed;         320 AA.
O16259;
03-APR-2013, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
02-JUN-2021, entry version 140.
RecName: Full=Stress-induced-phosphoprotein 1 {ECO:0000303|PubMed:19467242, ECO:0000312|EMBL:CCD63252.1};
Short=CeSTI1 {ECO:0000303|PubMed:19467242};
Short=STI1 {ECO:0000303|PubMed:19467242};
AltName: Full=Hsc70/Hsp90-organizing protein {ECO:0000303|PubMed:19559711};
Short=CeHop {ECO:0000303|PubMed:19559711};
Short=Hop {ECO:0000303|PubMed:19559711};
Name=sti-1 {ECO:0000312|EMBL:CCD63252.1, ECO:0000312|WormBase:R09E12.3};
ORFNames=R09E12.3;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1] {ECO:0000312|EMBL:CCD63252.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|EMBL:CCD63252.1};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
IDENTIFICATION BY MASS SPECTROMETRY, FUNCTION, INTERACTION WITH HSP-1 AND
DAF-21, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
INDUCTION, AND DISRUPTION PHENOTYPE.
PubMed=19467242; DOI=10.1016/j.jmb.2009.05.035;
Song H.O., Lee W., An K., Lee H.S., Cho J.H., Park Z.Y., Ahnn J.;
"C. elegans STI-1, the homolog of Sti1/Hop, is involved in aging and stress
response.";
J. Mol. Biol. 390:604-617(2009).
[3] {ECO:0000305}
FUNCTION, INTERACTION WITH HSP-1 AND DAF-21, TISSUE SPECIFICITY, AND
DISRUPTION PHENOTYPE.
PubMed=19559711; DOI=10.1016/j.jmb.2009.06.051;
Gaiser A.M., Brandt F., Richter K.;
"The non-canonical Hop protein from Caenorhabditis elegans exerts essential
functions and forms binary complexes with either Hsc70 or Hsp90.";
J. Mol. Biol. 391:621-634(2009).
[4] {ECO:0000312|PDB:4GCN}
X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 1-124 AND 131-253.
Midwest center for structural genomics (MCSG);
Submitted (JUL-2012) to the PDB data bank.
-!- FUNCTION: Plays a role in gonad development. Up-regulates longevity and
thermotolerance. Binds daf-21/hsp90 and inhibits its ATPase activity.
{ECO:0000269|PubMed:19467242, ECO:0000269|PubMed:19559711}.
-!- SUBUNIT: Forms a complex with hsp-1/hsp70 and daf-21/hsp90. Interacts
with daf-21/hsp90 (via the C-terminal MEEVD pentapeptide).
{ECO:0000269|PubMed:19467242, ECO:0000269|PubMed:19559711}.
-!- INTERACTION:
O16259; Q18688: daf-21; NbExp=3; IntAct=EBI-6514174, EBI-313329;
O16259; P09446: hsp-1; NbExp=3; IntAct=EBI-6514174, EBI-322448;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19467242}.
Note=Detected in cytoplasm in early-stage embryos.
{ECO:0000269|PubMed:19467242}.
-!- TISSUE SPECIFICITY: Expressed ubiquitously in the whole body. Detected
predominantly in the pharyngeal muscles, vulva epithelial cells,
striated body-wall muscles, spermathecae and intestinal cell ring. Also
observed in the tail regions of hermaphrodite and in the sensory rays
and spicules of males. {ECO:0000269|PubMed:19467242,
ECO:0000269|PubMed:19559711}.
-!- DEVELOPMENTAL STAGE: Expressed at all developmental stages.
{ECO:0000269|PubMed:19467242}.
-!- INDUCTION: Up-regulated by heat stress (at protein level).
{ECO:0000269|PubMed:19467242}.
-!- DISRUPTION PHENOTYPE: Reduced brood size and decreased fertility under
heat stress. Decreased thermotolerance and shortening of life span by
68% and 77% at 20 degrees Celsius and 25 degrees Celsius respectively.
Growth of gonads is hampered resulting in shortened arms of the gonads,
abnormally shaped spermathecae, lower sperm number and endomitotic
oocyte development. {ECO:0000269|PubMed:19467242,
ECO:0000269|PubMed:19559711}.
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EMBL; FO080369; CCD63252.1; -; Genomic_DNA.
PIR; T03899; T03899.
RefSeq; NP_503322.1; NM_070921.6.
PDB; 4GCN; X-ray; 1.85 A; A/B=1-124.
PDB; 4GCO; X-ray; 1.60 A; A=131-253.
PDBsum; 4GCN; -.
PDBsum; 4GCO; -.
SMR; O16259; -.
BioGRID; 43661; 22.
ComplexPortal; CPX-4003; Hsp90-sti-1 chaperone complex.
IntAct; O16259; 22.
STRING; 6239.R09E12.3; -.
EPD; O16259; -.
PaxDb; O16259; -.
PeptideAtlas; O16259; -.
EnsemblMetazoa; R09E12.3.1; R09E12.3.1; WBGene00019983.
UCSC; R09E12.3; c. elegans.
WormBase; R09E12.3; CE12646; WBGene00019983; sti-1.
eggNOG; KOG0548; Eukaryota.
GeneTree; ENSGT00940000170181; -.
HOGENOM; CLU_000134_46_1_1; -.
InParanoid; O16259; -.
OMA; LMEFQRA; -.
OrthoDB; 933764at2759; -.
PhylomeDB; O16259; -.
Reactome; R-CEL-3371497; HSP90 chaperone cycle for steroid hormone receptors (SHR).
PRO; PR:O16259; -.
Proteomes; UP000001940; Chromosome V.
Bgee; WBGene00019983; Expressed in adult organism and 6 other tissues.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0042030; F:ATPase inhibitor activity; IDA:WormBase.
GO; GO:0030544; F:Hsp70 protein binding; IPI:WormBase.
GO; GO:0051879; F:Hsp90 protein binding; IPI:WormBase.
GO; GO:0008340; P:determination of adult lifespan; IMP:WormBase.
GO; GO:0032780; P:negative regulation of ATPase activity; IDA:WormBase.
GO; GO:0000003; P:reproduction; IMP:WormBase.
GO; GO:0009408; P:response to heat; IMP:WormBase.
Gene3D; 1.25.40.10; -; 2.
InterPro; IPR041243; STI1.
InterPro; IPR006636; STI1_HS-bd.
InterPro; IPR013026; TPR-contain_dom.
InterPro; IPR011990; TPR-like_helical_dom_sf.
InterPro; IPR019734; TPR_repeat.
Pfam; PF17830; STI1; 1.
SMART; SM00727; STI1; 1.
SMART; SM00028; TPR; 6.
SUPFAM; SSF48452; SSF48452; 2.
PROSITE; PS50005; TPR; 6.
PROSITE; PS50293; TPR_REGION; 1.
1: Evidence at protein level;
3D-structure; Cytoplasm; Developmental protein; Reference proteome; Repeat;
Stress response; TPR repeat.
CHAIN 1..320
/note="Stress-induced-phosphoprotein 1"
/id="PRO_0000422047"
REPEAT 5..38
/note="TPR 1"
/evidence="ECO:0000255"
REPEAT 40..72
/note="TPR 2"
/evidence="ECO:0000255"
REPEAT 80..113
/note="TPR 3"
/evidence="ECO:0000255"
REPEAT 140..173
/note="TPR 4"
/evidence="ECO:0000255"
REPEAT 175..207
/note="TPR 5"
/evidence="ECO:0000255"
REPEAT 208..241
/note="TPR 6"
/evidence="ECO:0000255"
DOMAIN 269..308
/note="STI1"
/evidence="ECO:0000255"
REGION 241..269
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
HELIX 1..17
/evidence="ECO:0007829|PDB:4GCN"
HELIX 21..34
/evidence="ECO:0007829|PDB:4GCN"
HELIX 39..51
/evidence="ECO:0007829|PDB:4GCN"
HELIX 55..71
/evidence="ECO:0007829|PDB:4GCN"
HELIX 76..92
/evidence="ECO:0007829|PDB:4GCN"
HELIX 96..109
/evidence="ECO:0007829|PDB:4GCN"
HELIX 113..123
/evidence="ECO:0007829|PDB:4GCN"
HELIX 137..152
/evidence="ECO:0007829|PDB:4GCO"
HELIX 156..169
/evidence="ECO:0007829|PDB:4GCO"
HELIX 174..186
/evidence="ECO:0007829|PDB:4GCO"
HELIX 190..203
/evidence="ECO:0007829|PDB:4GCO"
HELIX 208..220
/evidence="ECO:0007829|PDB:4GCO"
HELIX 224..237
/evidence="ECO:0007829|PDB:4GCO"
HELIX 242..251
/evidence="ECO:0007829|PDB:4GCO"
SEQUENCE 320 AA; 36962 MW; 9D21907275A09780 CRC64;
MTDAAIAEKD LGNAAYKQKD FEKAHVHYDK AIELDPSNIT FYNNKAAVYF EEKKFAECVQ
FCEKAVEVGR ETRADYKLIA KAMSRAGNAF QKQNDLSLAV QWFHRSLSEF RDPELVKKVK
ELEKQLKAAE RLAYINPELA QEEKNKGNEY FKKGDYPTAM RHYNEAVKRD PENAILYSNR
AACLTKLMEF QRALDDCDTC IRLDSKFIKG YIRKAACLVA MREWSKAQRA YEDALQVDPS
NEEAREGVRN CLRSNDEDPE KAKERSLADP EVQEILRDPG MRMILEQMSN DPGAVREHLK
NPEIFQKLMK LRDAGVIQMR


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Pathways :
WP2199: Seed Development
WP210: Cytoplasmic Ribosomal Proteins
WP902: FAS pathway and Stress induction of HSP regulation
WP1019: FAS pathway and Stress induction of HSP regulation
WP1678: Nucleotide excision repair
WP262: EBV LMP1 signaling
WP1613: 1,4-Dichlorobenzene degradation
WP35: G Protein Signaling Pathways
WP1625: Base excision repair
WP2119: Interferon induced apoptosis
WP1138: FAS pathway and Stress induction of HSP regulation
WP1690: Propanoate metabolism
WP1209: EBV LMP1 signaling
WP1694: Pyrimidine metabolism
WP511: FAS pathway and Stress induction of HSP regulation
WP1654: gamma-Hexachlorocyclohexane degradation
WP2203: TSLP Signaling Pathway
WP1661: Glyoxylate and dicarboxylate metabolism
WP2292: Chemokine signaling pathway
WP1438: Influenza A virus infection
WP1714: Tyrosine metabolism
WP686: Epigenetic Stress Regulation
WP1527: stress response
WP1892: Protein folding
WP758: EBV LMP1 signaling

Related Genes :
[sti-1 R09E12.3] Stress-induced-phosphoprotein 1 (CeSTI1) (STI1) (Hsc70/Hsp90-organizing protein) (CeHop) (Hop)
[HSPA8 HSC70 HSP73 HSPA10] Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8) (Lipopolysaccharide-associated protein 1) (LAP-1) (LPS-associated protein 1)
[STIP1 QtsA-11959] Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop)
[Hspa8 Hsc70 Hsc73] Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
[Hspa8 Hsc70 Hsc73] Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
[HSPA8 HSC70] Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
[STI1 YOR027W OR26.17] Heat shock protein STI1
[Hsp90aa1 Hsp86 Hsp86-1 Hspca] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Tumor-specific transplantation 86 kDa antigen) (TSTA)
[HSP90AA1 HSP90A HSPC1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86) (Lipopolysaccharide-associated protein 2) (LAP-2) (LPS-associated protein 2) (Renal carcinoma antigen NY-REN-38)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[Hsp90aa1 Hsp86 Hspca] Heat shock protein HSP 90-alpha (EC 3.6.4.10) (Heat shock 86 kDa) (HSP 86) (HSP86)
[HSP90AA1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 QtrA-10430] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP90AA1 HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSP70-4 HSC70-4 HSP70 MED37_2 MED37C At3g12580 T16H11.7 T2E22.11] Heat shock 70 kDa protein 4 (Heat shock cognate 70 kDa protein 4) (Heat shock cognate protein 70-4) (AtHsc70-4) (Heat shock protein 70-4) (AtHsp70-4)
[HSP90AA1 HSP90A HSPCA] Heat shock protein HSP 90-alpha (EC 3.6.4.10)
[HSPA8 HSC70] Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)
[HSP90AB1 HSP90B HSPC2 HSPCB] Heat shock protein HSP 90-beta (HSP 90) (Heat shock 84 kDa) (HSP 84) (HSP84)
[Hsp90ab1 Hsp84 Hsp84-1 Hspcb] Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84) (Tumor-specific transplantation 84 kDa antigen) (TSTA)
[CDC37 SMO1 YDR168W YD9489.03] Hsp90 co-chaperone Cdc37 (Cell division control protein 37) (Hsp90 chaperone protein kinase-targeting subunit)
[CHIP PUB61 At3g07370 F21O3.8] E3 ubiquitin-protein ligase CHIP (EC 2.3.2.27) (Carboxyl terminus of HSC70-interacting protein) (AtCHIP) (Plant U-box protein 61) (RING-type E3 ubiquitin transferase CHIP) (U-box domain-containing protein 61)
[Hsp90ab1 Hsp84 Hspcb] Heat shock protein HSP 90-beta (Heat shock 84 kDa) (HSP 84) (HSP84)
[HSP90AB1 QccE-21185] Heat shock protein HSP 90-beta
[HSP90AB1 HSPCB] Heat shock protein HSP 90-beta
[HSP90AB1 HSPCB] Heat shock protein HSP 90-beta
[HSP90AB1 HSPCB] Heat shock protein HSP 90-beta
[hsp90a.1 hsp90 hsp90a hsp90aa1 zgc:86652] Heat shock protein HSP 90-alpha 1
[hsp90ab1 hsp90b] Heat shock protein HSP 90-beta
[HSP90B1 GRP94 TRA1] Endoplasmin (94 kDa glucose-regulated protein) (GRP-94) (Heat shock protein 90 kDa beta member 1) (Tumor rejection antigen 1) (gp96 homolog)

Bibliography :
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