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Succinate--CoA ligase [ADP-forming] subunit beta (EC 6 2 1 5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)

 SUCC_AQUAE              Reviewed;         385 AA.
O67546;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
01-AUG-1998, sequence version 1.
02-DEC-2020, entry version 129.
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit beta {ECO:0000255|HAMAP-Rule:MF_00558};
EC=6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558};
AltName: Full=Succinyl-CoA synthetase subunit beta {ECO:0000255|HAMAP-Rule:MF_00558};
Short=SCS-beta {ECO:0000255|HAMAP-Rule:MF_00558};
Name=sucC {ECO:0000255|HAMAP-Rule:MF_00558}; OrderedLocusNames=aq_1620;
Aquifex aeolicus (strain VF5).
Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
NCBI_TaxID=224324;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
PubMed=9537320; DOI=10.1038/32831;
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
-!- FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle
(TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of
either ATP or GTP and thus represents the only step of substrate-level
phosphorylation in the TCA. The beta subunit provides nucleotide
specificity of the enzyme and binds the substrate succinate, while the
binding sites for coenzyme A and phosphate are found in the alpha
subunit. {ECO:0000255|HAMAP-Rule:MF_00558}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA;
Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
ChEBI:CHEBI:456216; EC=6.2.1.5; Evidence={ECO:0000255|HAMAP-
Rule:MF_00558};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_00558};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00558};
-!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate
from succinyl-CoA (ligase route): step 1/1. {ECO:0000255|HAMAP-
Rule:MF_00558}.
-!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
{ECO:0000255|HAMAP-Rule:MF_00558}.
-!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit
family. {ECO:0000255|HAMAP-Rule:MF_00558}.
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EMBL; AE000657; AAC07508.1; -; Genomic_DNA.
PIR; H70439; H70439.
RefSeq; NP_214111.1; NC_000918.1.
RefSeq; WP_010881049.1; NC_000918.1.
SMR; O67546; -.
STRING; 224324.aq_1620; -.
EnsemblBacteria; AAC07508; AAC07508; aq_1620.
KEGG; aae:aq_1620; -.
PATRIC; fig|224324.8.peg.1249; -.
eggNOG; COG0045; Bacteria.
HOGENOM; CLU_037430_0_2_0; -.
InParanoid; O67546; -.
OMA; ITACDEV; -.
OrthoDB; 316012at2; -.
BioCyc; AAEO224324:G1G15-1146-MONOMER; -.
UniPathway; UPA00223; UER00999.
Proteomes; UP000000798; Chromosome.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0042709; C:succinate-CoA ligase complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IBA:GO_Central.
GO; GO:0006104; P:succinyl-CoA metabolic process; IBA:GO_Central.
GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
Gene3D; 3.30.1490.20; -; 1.
Gene3D; 3.40.50.261; -; 1.
HAMAP; MF_00558; Succ_CoA_beta; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR005811; CoA_ligase.
InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
InterPro; IPR005809; Succ_CoA_synthase_bsu.
InterPro; IPR016102; Succinyl-CoA_synth-like.
PANTHER; PTHR11815; PTHR11815; 1.
Pfam; PF08442; ATP-grasp_2; 1.
Pfam; PF00549; Ligase_CoA; 1.
PIRSF; PIRSF001554; SucCS_beta; 1.
SUPFAM; SSF52210; SSF52210; 1.
TIGRFAMs; TIGR01016; sucCoAbeta; 1.
PROSITE; PS50975; ATP_GRASP; 1.
PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
3: Inferred from homology;
ATP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding;
Reference proteome; Tricarboxylic acid cycle.
CHAIN 1..385
/note="Succinate--CoA ligase [ADP-forming] subunit beta"
/id="PRO_0000102817"
DOMAIN 9..240
/note="ATP-grasp"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
NP_BIND 53..55
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
REGION 317..319
/note="Substrate binding; shared with subunit alpha"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
METAL 195
/note="Magnesium"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
METAL 209
/note="Magnesium"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 46
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 98
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 101
/note="ATP; via amide nitrogen"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 106
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 260
/note="Substrate; shared with subunit alpha"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
SEQUENCE 385 AA; 42186 MW; 2D8EA66C921FC85B CRC64;
MKLHEHQAKE IFAKYGIPVP EGKVAFSLKE AKEVAEELGE FPLVVKAQIH CGGRGKAGGV
KIVKDMDELE KAVESLLGKV LKTFQCPDGK PVNRVLIEKA TNIDKEYYLA ITLDRSKSKP
VIMASAAGGM EIEEIVKENP EAIIIETIDP ELGLMPYQAR ELAFKLNLPV KEFASIALKL
YQIYSDLDAS LVEINPLVLT KEGNLIALDA KLDIDDNALF RHKDLEEMED ETQLPQLEVE
AKKYGLNYIK LNGNIGCMVN GAGLAMATMD IIKLAGGEPA NFLDVGGGAN VEQIANAFRI
LMADPDVKAV FINIFGGILR VDRLAQGLIE ASKMVELRVP IVARLEGTNV EEGKRMLQES
GLNFIIAEDM WDGAKKAVEI ANKQS


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WP1722: Th1/Th2
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1106: Keap1-Nrf2
WP1897: Regulation of beta-cell development
WP401: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP930: TGF Beta Signaling Pathway

Related Genes :
[sucC b0728 JW0717] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[SUCLA2] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
[sucD b0729 JW0718] Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[Suclg1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[sucC scsB] Succinate--CoA ligase [GDP-forming] subunit beta (EC 6.2.1.4) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC PA1588] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[scsA DDB_G0289325] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (p36)
[] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[Suclg1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[acdBI PF1787] Acetate--CoA ligase [ADP-forming] I subunit beta (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit beta) (ACS I subunit beta)
[Scsalpha1 Scsalpha CG1065] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (Succinyl-coenzyme A synthetase alpha subunit 1)
[] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (Fragment)
[tca-9 B9J10.140 NCU08471] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta)
[SUCLA2 QflA-11886] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
[sucC BSU16090] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[acdAI PF1540] Acetate--CoA ligase [ADP-forming] I subunit alpha (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit alpha) (ACS I subunit alpha)
[sucD PA1589] Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[NOO_LOCUS8770] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[odhB sucC EPO11_04555] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC sucD HWD61_08285] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[sucD sucC KL86CIT2_200018] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[sucC Rv0951 MTCY10D7.23c] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC2 sucC SCO6585 SC8A6.06] Succinate--CoA ligase [ADP-forming] subunit beta 2 (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta 2) (SCS-beta 2)
[] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[sucC RB10617] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC sucD CMG10_01695] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]

Bibliography :