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Succinate--CoA ligase [ADP-forming] subunit beta (EC 6 2 1 5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)

 SUCC_DEIRA              Reviewed;         386 AA.
Q9RUY3;
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
02-DEC-2020, entry version 123.
RecName: Full=Succinate--CoA ligase [ADP-forming] subunit beta {ECO:0000255|HAMAP-Rule:MF_00558};
EC=6.2.1.5 {ECO:0000255|HAMAP-Rule:MF_00558};
AltName: Full=Succinyl-CoA synthetase subunit beta {ECO:0000255|HAMAP-Rule:MF_00558};
Short=SCS-beta {ECO:0000255|HAMAP-Rule:MF_00558};
Name=sucC {ECO:0000255|HAMAP-Rule:MF_00558}; OrderedLocusNames=DR_1247;
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG
4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422).
Bacteria; Deinococcus-Thermus; Deinococci; Deinococcales; Deinococcaceae;
Deinococcus.
NCBI_TaxID=243230;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB
9279 / R1 / VKM B-1422;
PubMed=10567266; DOI=10.1126/science.286.5444.1571;
White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D.,
Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L.,
Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M.,
Vamathevan J.J., Lam P., McDonald L.A., Utterback T.R., Zalewski C.,
Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D.,
Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C.,
Fraser C.M.;
"Genome sequence of the radioresistant bacterium Deinococcus radiodurans
R1.";
Science 286:1571-1577(1999).
-!- FUNCTION: Succinyl-CoA synthetase functions in the citric acid cycle
(TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of
either ATP or GTP and thus represents the only step of substrate-level
phosphorylation in the TCA. The beta subunit provides nucleotide
specificity of the enzyme and binds the substrate succinate, while the
binding sites for coenzyme A and phosphate are found in the alpha
subunit. {ECO:0000255|HAMAP-Rule:MF_00558}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + CoA + succinate = ADP + phosphate + succinyl-CoA;
Xref=Rhea:RHEA:17661, ChEBI:CHEBI:30031, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:57287, ChEBI:CHEBI:57292,
ChEBI:CHEBI:456216; EC=6.2.1.5; Evidence={ECO:0000255|HAMAP-
Rule:MF_00558};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000255|HAMAP-Rule:MF_00558};
Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_00558};
-!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; succinate
from succinyl-CoA (ligase route): step 1/1. {ECO:0000255|HAMAP-
Rule:MF_00558}.
-!- SUBUNIT: Heterotetramer of two alpha and two beta subunits.
{ECO:0000255|HAMAP-Rule:MF_00558}.
-!- SIMILARITY: Belongs to the succinate/malate CoA ligase beta subunit
family. {ECO:0000255|HAMAP-Rule:MF_00558}.
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EMBL; AE000513; AAF10816.1; -; Genomic_DNA.
PIR; E75419; E75419.
RefSeq; NP_294971.1; NC_001263.1.
RefSeq; WP_010887890.1; NZ_CP015081.1.
SMR; Q9RUY3; -.
STRING; 243230.DR_1247; -.
EnsemblBacteria; AAF10816; AAF10816; DR_1247.
KEGG; dra:DR_1247; -.
PATRIC; fig|243230.17.peg.1442; -.
eggNOG; COG0045; Bacteria.
HOGENOM; CLU_037430_0_2_0; -.
InParanoid; Q9RUY3; -.
OMA; ITACDEV; -.
OrthoDB; 316012at2; -.
UniPathway; UPA00223; UER00999.
Proteomes; UP000002524; Chromosome I.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0042709; C:succinate-CoA ligase complex; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IBA:GO_Central.
GO; GO:0006104; P:succinyl-CoA metabolic process; IBA:GO_Central.
GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
Gene3D; 3.30.1490.20; -; 1.
Gene3D; 3.40.50.261; -; 1.
HAMAP; MF_00558; Succ_CoA_beta; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR013650; ATP-grasp_succ-CoA_synth-type.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR005811; CoA_ligase.
InterPro; IPR017866; Succ-CoA_synthase_bsu_CS.
InterPro; IPR005809; Succ_CoA_synthase_bsu.
InterPro; IPR016102; Succinyl-CoA_synth-like.
PANTHER; PTHR11815; PTHR11815; 1.
Pfam; PF08442; ATP-grasp_2; 1.
Pfam; PF00549; Ligase_CoA; 1.
PIRSF; PIRSF001554; SucCS_beta; 1.
SUPFAM; SSF52210; SSF52210; 1.
TIGRFAMs; TIGR01016; sucCoAbeta; 1.
PROSITE; PS50975; ATP_GRASP; 1.
PROSITE; PS01217; SUCCINYL_COA_LIG_3; 1.
3: Inferred from homology;
ATP-binding; Ligase; Magnesium; Metal-binding; Nucleotide-binding;
Reference proteome; Tricarboxylic acid cycle.
CHAIN 1..386
/note="Succinate--CoA ligase [ADP-forming] subunit beta"
/id="PRO_0000102831"
DOMAIN 9..237
/note="ATP-grasp"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
NP_BIND 52..54
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
REGION 315..317
/note="Substrate binding; shared with subunit alpha"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
METAL 192
/note="Magnesium"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
METAL 206
/note="Magnesium"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 45
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 94
/note="ATP; via amide nitrogen"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 101
/note="ATP"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
BINDING 258
/note="Substrate; shared with subunit alpha"
/evidence="ECO:0000255|HAMAP-Rule:MF_00558"
SEQUENCE 386 AA; 41685 MW; ABDFAEDA014E8F84 CRC64;
MKLHEYQGKE VLRDFGVNVQ DGKVATTPEE VQAIYKEYGQ PVVVKAQVHV GGRGKAGGVK
YSANEDKALE NAKNILGMDI KGLTVNKVLV TKAVDIDAGT EYYVGMIVDR NVQSYTLMAS
AEGGMEIEEV AATNPEKIIR HRVDPVTGLR PYEAREVAIK AGFRGNLNKI ADMMVKMSKA
ALERDAVLVE INPLFVDADG TPIALDTKFE IDDNAMYRHK DLAHYRELSA EHPLEVEASD
YGFAYVKLDD GNVGVLGNGA GIVMTTLDVV NRAGAKPANF LDIGGGAKAD VVYNAVKLVS
KDPDVKAIFI NIFGGITRAD EVAKGVIRAL DEGILTKPVR MRIAGTAEDE AKALLNEKNS
DLIKMYPTMF EAANEAAKEA NALGGK


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WP2218: sGC
WP506: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1722: Th1/Th2
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1106: Keap1-Nrf2
WP1897: Regulation of beta-cell development
WP401: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP930: TGF Beta Signaling Pathway

Related Genes :
[sucC b0728 JW0717] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[SUCLA2] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
[sucD b0729 JW0718] Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[Suclg1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[sucC scsB] Succinate--CoA ligase [GDP-forming] subunit beta (EC 6.2.1.4) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC PA1588] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[scsA DDB_G0289325] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (p36)
[] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[Suclg1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[acdBI PF1787] Acetate--CoA ligase [ADP-forming] I subunit beta (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit beta) (ACS I subunit beta)
[Scsalpha1 Scsalpha CG1065] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (Succinyl-coenzyme A synthetase alpha subunit 1)
[] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[SUCLG1] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha) (Fragment)
[tca-9 B9J10.140 NCU08471] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta)
[SUCLA2 QflA-11886] Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (ATP-specific succinyl-CoA synthetase subunit beta) (A-SCS) (Succinyl-CoA synthetase beta-A chain) (SCS-betaA)
[sucC BSU16090] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[acdAI PF1540] Acetate--CoA ligase [ADP-forming] I subunit alpha (EC 6.2.1.13) (ADP-forming acetyl coenzyme A synthetase I subunit alpha) (ACS I subunit alpha)
[sucD PA1589] Succinate--CoA ligase [ADP-forming] subunit alpha (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[NOO_LOCUS8770] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (EC 6.2.1.5) (Succinyl-CoA synthetase beta chain) (SCS-beta); Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[odhB sucC EPO11_04555] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC sucD HWD61_08285] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[sucD sucC KL86CIT2_200018] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]
[sucC Rv0951 MTCY10D7.23c] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC2 sucC SCO6585 SC8A6.06] Succinate--CoA ligase [ADP-forming] subunit beta 2 (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta 2) (SCS-beta 2)
[] Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (EC 6.2.1.4) (EC 6.2.1.5) (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)
[sucC RB10617] Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta)
[sucC sucD CMG10_01695] Multifunctional fusion protein [Includes: Succinate--CoA ligase [ADP-forming] subunit beta (EC 6.2.1.5) (Succinyl-CoA synthetase subunit beta) (SCS-beta); Succinate--CoA ligase [ADP-forming] subunit alpha (Succinyl-CoA synthetase subunit alpha) (SCS-alpha)]

Bibliography :