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Sugar efflux transporter

 SOTB_ECOLI              Reviewed;         396 AA.
P31122; P76883; P77353;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 2.
10-APR-2019, entry version 141.
RecName: Full=Sugar efflux transporter;
Name=sotB; Synonyms=ydeA; OrderedLocusNames=b1528, JW1521;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=9097039; DOI=10.1093/dnares/3.6.363;
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M.,
Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K.,
Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N.,
Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J.,
Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.;
"A 570-kb DNA sequence of the Escherichia coli K-12 genome
corresponding to the 28.0-40.1 min region on the linkage map.";
DNA Res. 3:363-377(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 217-396.
PubMed=8383113; DOI=10.1128/jb.175.5.1484-1492.1993;
Cohen S.P., Haechler H., Levy S.B.;
"Genetic and functional analysis of the multiple antibiotic resistance
(mar) locus in Escherichia coli.";
J. Bacteriol. 175:1484-1492(1993).
[5]
CHARACTERIZATION.
STRAIN=SB0;
PubMed=10094697;
Bost S., Silva F., Belin D.;
"Transcriptional activation of ydeA, which encodes a member of the
major facilitator superfamily, interferes with arabinose accumulation
and induction of the Escherichia coli arabinose PBAD promoter.";
J. Bacteriol. 181:2185-2191(1999).
[6]
CHARACTERIZATION.
STRAIN=JS219;
PubMed=10438792;
Carole S., Pichoff S., Bouche J.-P.;
"Escherichia coli gene ydeA encodes a major facilitator pump which
exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside.";
J. Bacteriol. 181:5123-5125(1999).
[7]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
-!- FUNCTION: Involved in the efflux of sugars. The physiological role
may be the reduction of the intracellular concentration of toxic
sugars or sugar metabolites. Transports L-arabinose and to a
lesser extent IPTG. Seems to contribute to the control of the
arabinose regulon.
-!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
protein.
-!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
2.A.1.2) family. {ECO:0000305}.
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EMBL; U00096; AAC74601.1; -; Genomic_DNA.
EMBL; AP009048; BAA15210.1; -; Genomic_DNA.
EMBL; M96235; -; NOT_ANNOTATED_CDS; Genomic_DNA.
PIR; C64907; C64907.
RefSeq; NP_416045.1; NC_000913.3.
RefSeq; WP_000210799.1; NZ_LN832404.1.
ProteinModelPortal; P31122; -.
BioGrid; 4259471; 243.
STRING; 511145.b1528; -.
TCDB; 2.A.1.2.15; the major facilitator superfamily (mfs).
PaxDb; P31122; -.
PRIDE; P31122; -.
EnsemblBacteria; AAC74601; AAC74601; b1528.
EnsemblBacteria; BAA15210; BAA15210; BAA15210.
GeneID; 947218; -.
KEGG; ecj:JW1521; -.
KEGG; eco:b1528; -.
PATRIC; fig|1411691.4.peg.738; -.
EchoBASE; EB1592; -.
EcoGene; EG11636; sotB.
eggNOG; ENOG4105F27; Bacteria.
eggNOG; COG2814; LUCA.
HOGENOM; HOG000268498; -.
InParanoid; P31122; -.
KO; K08159; -.
PhylomeDB; P31122; -.
BioCyc; EcoCyc:YDEA-MONOMER; -.
BioCyc; ECOL316407:JW1521-MONOMER; -.
BioCyc; MetaCyc:YDEA-MONOMER; -.
PRO; PR:P31122; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
CDD; cd06174; MFS; 1.
HAMAP; MF_00517; MFS_SotB; 1.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
InterPro; IPR036259; MFS_trans_sf.
InterPro; IPR023495; Sugar_effux_transptr_put.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
PROSITE; PS50850; MFS; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Complete proteome; Membrane;
Reference proteome; Sugar transport; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 396 Sugar efflux transporter.
/FTId=PRO_0000209323.
TOPO_DOM 1 14 Cytoplasmic. {ECO:0000255}.
TRANSMEM 15 35 Helical. {ECO:0000255}.
TOPO_DOM 36 49 Periplasmic. {ECO:0000255}.
TRANSMEM 50 70 Helical. {ECO:0000255}.
TOPO_DOM 71 80 Cytoplasmic. {ECO:0000255}.
TRANSMEM 81 101 Helical. {ECO:0000255}.
TOPO_DOM 102 102 Periplasmic. {ECO:0000255}.
TRANSMEM 103 123 Helical. {ECO:0000255}.
TOPO_DOM 124 135 Cytoplasmic. {ECO:0000255}.
TRANSMEM 136 156 Helical. {ECO:0000255}.
TOPO_DOM 157 169 Periplasmic. {ECO:0000255}.
TRANSMEM 170 190 Helical. {ECO:0000255}.
TOPO_DOM 191 208 Cytoplasmic. {ECO:0000255}.
TRANSMEM 209 229 Helical. {ECO:0000255}.
TOPO_DOM 230 245 Periplasmic. {ECO:0000255}.
TRANSMEM 246 266 Helical. {ECO:0000255}.
TOPO_DOM 267 274 Cytoplasmic. {ECO:0000255}.
TRANSMEM 275 295 Helical. {ECO:0000255}.
TOPO_DOM 296 298 Periplasmic. {ECO:0000255}.
TRANSMEM 299 319 Helical. {ECO:0000255}.
TOPO_DOM 320 332 Cytoplasmic. {ECO:0000255}.
TRANSMEM 333 353 Helical. {ECO:0000255}.
TOPO_DOM 354 363 Periplasmic. {ECO:0000255}.
TRANSMEM 364 384 Helical. {ECO:0000255}.
TOPO_DOM 385 396 Cytoplasmic. {ECO:0000255}.
SEQUENCE 396 AA; 42538 MW; CB6A34CA4EE6D4F0 CRC64;
MTTNTVSRKV AWLRVVTLAV AAFIFNTTEF VPVGLLSDIA QSFHMQTAQV GIMLTIYAWV
VALMSLPFML MTSQVERRKL LICLFVVFIA SHVLSFLSWS FTVLVISRIG VAFAHAIFWS
ITASLAIRMA PAGKRAQALS LIATGTALAM VLGLPLGRIV GQYFGWRMTF FAIGIGALIT
LLCLIKLLPL LPSEHSGSLK SLPLLFRRPA LMSIYLLTVV VVTAHYTAYS YIEPFVQNIA
GFSANFATAL LLLLGGAGII GSVIFGKLGN QYASALVSTA IALLLVCLAL LLPAANSEIH
LGVLSIFWGI AMMIIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA LVGNQVSLHW
SMSMIGYVGA VPAFAALIWS IIIFRRWPVT LEEQTQ


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Pathways :
WP1616: ABC transporters
WP1455: Serotonin Transporter Activity
WP1493: Carbon assimilation C4 pathway
WP1567: Glycolysis and Gluconeogenesis
WP1619: Amino sugar and nucleotide sugar metabolism
WP1653: Galactose metabolism
WP1680: Oxidative phosphorylation
WP1688: Polyketide sugar unit biosynthesis
WP1689: Porphyrin and chlorophyll metabolism
WP1701: Starch and sucrose metabolism
WP1703: Streptomycin biosynthesis
WP1713: Two-component system
WP2028: Sugar
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP2345: vitamin B7 (biotin) biosynthesis pathway
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway

Related Genes :
[ESL1 SUGTL2 At1g08920 F7G19.20] Sugar transporter ESL1 (Protein EARLY-RESPONSIVE TO DEHYDRATION 6-LIKE 1) (ERD six-like 1) (Sugar transporter ERD6-like 3) (Sugar transporter-like protein 2)
[SWEET12 MTN3 At5g23660 MQM1.8] Bidirectional sugar transporter SWEET12 (AtSWEET12) (MtN3-like protein) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 12)
[SWEET11 At3g48740 T21J18.1 T8P19.250] Bidirectional sugar transporter SWEET11 (AtSWEET11) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 11)
[SWEET15 SAG29 At5g13170 T19L5.130] Bidirectional sugar transporter SWEET15 (AtSWEET15) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 15) (Senescence-associated protein 29)
[SWEET13 At5g50800 K7B16.1] Bidirectional sugar transporter SWEET13 (AtSWEET13) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 13)
[SWEET11 Os8N3 XA13 Os08g0535200 LOC_Os08g42350 OsJ_28080 OSJNBa0033D24.17 P0702C09.32] Bidirectional sugar transporter SWEET11 (OsSWEET11) (Disease resistant allele Xa13)
[SWEET16 At3g16690 MGL6.16] Bidirectional sugar transporter SWEET16 (AtSWEET16) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 16)
[SWEET1 At1g21460 F24J8.9] Bidirectional sugar transporter SWEET1 (AtSWEET1) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 1)
[SWEET9 At2g39060 T7F6.23] Bidirectional sugar transporter SWEET9 (AtSWEET9) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 9)
[SWEET8 RPG1 At5g40260 MSN9.17 MSN9_160] Bidirectional sugar transporter SWEET8 (AtSWEET8) (Protein RUPTURED POLLEN GRAIN 1) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 8)
[CDR1 CAALFM_C305220WA CaO19.13421 CaO19.6000] Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Pleiotropic drug resistance protein CDR1)
[ABCA1 ABC1 CERP] ATP-binding cassette sub-family A member 1 (ATP-binding cassette transporter 1) (ABC-1) (ATP-binding cassette 1) (Cholesterol efflux regulatory protein)
[setA yabM b0070 JW0069] Sugar efflux transporter A
[URGT4 NST-KT1 At4g39390 F23K16.20] UDP-rhamnose/UDP-galactose transporter 4 (UDP-Rha/UDP-Gal transporter 4) (Bi-functional UDP-rhamnose/UDP-galactose transporter) (Nucleotide sugar transporter-KT 1) (AtNST-KT1)
[CDR1 CAGL0M01760g] Pleiotropic ABC efflux transporter of multiple drugs CDR1 (Pleiotropic drug resistance protein CDR1)
[PLT5 At3g18830 MVE11.10 MVE11.22] Polyol transporter 5 (Protein POLYOL TRANSPORTER 5) (AtPLT5) (Sugar-proton symporter PLT5)
[SLC22A18 BWR1A BWSCR1A HET IMPT1 ITM ORCTL2 SLC22A1L TSSC5] Solute carrier family 22 member 18 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein) (Efflux transporter-like protein) (Imprinted multi-membrane-spanning polyspecific transporter-related protein 1) (Organic cation transporter-like protein 2) (ORCTL-2) (Solute carrier family 22 member 1-like) (Tumor-suppressing STF cDNA 5 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein) (p45-Beckwith-Wiedemann region 1 A) (p45-BWR1A)
[PDR5 LEM1 STS1 YDR1 YOR153W] Pleiotropic ABC efflux transporter of multiple drugs (Pleiotropic drug resistance protein 5) (Suppressor of toxicity of sporidesmin)
[mdtK norE norM ydhE b1663 JW1655] Multidrug resistance protein MdtK (Multidrug-efflux transporter)
[emrE eb mvrC b0543 JW0531] Multidrug transporter EmrE (Efflux-multidrug resistance protein EmrE) (Ethidium resistance protein) (Methyl viologen resistance protein C)
[setB yeiO b2170 JW2157] Sugar efflux transporter B
[acrB acrE b0462 JW0451] Multidrug efflux pump subunit AcrB (AcrAB-TolC multidrug efflux pump subunit AcrB) (Acridine resistance protein B)
[SWEET17 At4g15920 dl4000c FCAALL.237] Bidirectional sugar transporter SWEET17 (AtSWEET17) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 17)
[PIN2 AGR AGR1 EIR1 WAV6 At5g57090 MUL3.3] Auxin efflux carrier component 2 (AtPIN2) (Auxin efflux carrier AGR) (Ethylene-insensitive root 1) (AtEIR1) (Polar-auxin-transport efflux component AGR1) (Protein AGRAVITROPIC 1) (AtAGR1) (Protein WAVY 6)
[frc UST74C CG3874] UDP-sugar transporter UST74c (Protein fringe connection)
[SLC50A1 RAG1AP1 SCP] Sugar transporter SWEET1 (HsSWEET1) (RAG1-activating protein 1) (Solute carrier family 50 member 1) (Stromal cell protein)
[sqv-7 C52E12.3] UDP-sugar transporter sqv-7 (Squashed vulva protein 7)
[GONST1 At2g13650 T10F5.19] GDP-mannose transporter GONST1 (Protein GOLGI NUCLEOTIDE SUGAR TRANSPORTER 1)
[SWEET14 At4g25010 F13M23.150] Bidirectional sugar transporter SWEET14 (AtSWEET14) (Protein SUGARS WILL EVENTUALLY BE EXPORTED TRANSPORTERS 14)
[acrA lir mtcA b0463 JW0452] Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)

Bibliography :
[30988034] Guanidine-riboswitch-regulated efflux transporters protect bacteria against ionic liquid toxicity.
[30905604] Source-Sink Regulation Is Mediated by Interaction of an FT Homolog with a SWEET Protein in Potato.
[30696401] Genome-wide characterization and expression profiling of SWEET genes in cabbage (Brassica oleracea var. capitata L.) reveal their roles in chilling and clubroot disease responses.
[30686879] Transporters through the looking glass. An insight into the mechanisms of ion-coupled transport and methods that help reveal them.
[30587136] The transcriptome of zinc deficient maize roots and its relationship to DNA methylation loss.
[30264400] Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model.
[30201376] Selective peroxisome proliferator-activated receptor-╬▒ modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
[30044900] Natural genetic variation for expression of a SWEET transporter among wild species of Solanum lycopersicum (tomato) determines the hexose composition of ripening tomato fruit.
[29774038] Altered Expression of the Malate-Permeable Anion Channel OsALMT4 Reduces the Growth of Rice Under Low Radiance.
[29746551] A multi-chamber microfluidic intestinal barrier model using Caco-2 cells for drug transport studies.