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Suppressor of cytokine signaling 1

 A0A2K6JQI0_RHIBE        Unreviewed;       215 AA.
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
17-JUN-2020, entry version 18.
SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSRBIP00000001278};
Name=SOCS1 {ECO:0000313|Ensembl:ENSRBIP00000001278};
Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Colobinae; Rhinopithecus.
NCBI_TaxID=61621 {ECO:0000313|Ensembl:ENSRBIP00000001278, ECO:0000313|Proteomes:UP000233180};
[1] {ECO:0000313|Ensembl:ENSRBIP00000001278, ECO:0000313|Proteomes:UP000233180}
Wu, C.-I. and Zhang, Y.;
"Genome of Rhinopithecus bieti.";
Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSRBIP00000001278}
Submitted (FEB-2018) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
RefSeq; XP_017746184.1; XM_017890695.1.
Ensembl; ENSRBIT00000007147; ENSRBIP00000001278; ENSRBIG00000006588.
GeneID; 108541230; -.
KEGG; rbb:108541230; -.
CTD; 8651; -.
GeneTree; ENSGT00940000161164; -.
KO; K04694; -.
OrthoDB; 1135696at2759; -.
UniPathway; UPA00143; -.
Proteomes; UP000233180; Unplaced.
GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0019210; F:kinase inhibitor activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0043377; P:negative regulation of CD8-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0010533; P:regulation of activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0050707; P:regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IEA:InterPro.
CDD; cd10382; SH2_SOCS1; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR028411; SOCS1.
InterPro; IPR035861; SOCS1_SH2.
InterPro; IPR001496; SOCS_box.
InterPro; IPR036036; SOCS_box-like_dom_sf.
PANTHER; PTHR10155:SF4; PTHR10155:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07525; SOCS_box; 1.
SMART; SM00252; SH2; 1.
SMART; SM00253; SOCS; 1.
SMART; SM00969; SOCS_box; 1.
SUPFAM; SSF158235; SSF158235; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50225; SOCS; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000233180};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
DOMAIN 83..178
DOMAIN 165..214
/note="SOCS box"
REGION 1..58
SEQUENCE 215 AA; 23945 MW; 7D1296C87BD67A28 CRC64;

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Pathways :
WP1313: Insulin Signaling
WP1349: Wnt Signaling Pathway
WP785: Wnt Signaling Pathway
WP428: Wnt Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1016: Wnt Signaling Pathway
WP1135: Wnt Signaling Pathway
WP1350: Type II interferon signaling (IFNG)
WP899: Wnt Signaling Pathway
WP1323: EGFR1 Signaling Pathway
WP1315: IL-5 Signaling Pathway
WP265: Delta-Notch Signaling Pathway
WP403: Wnt Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1359: IL-3 Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP1337: MAPK signaling pathway
WP2292: Chemokine signaling pathway
WP564: Wnt Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1371: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP492: Hedgehog Signaling Pathway

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Bibliography :
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[32615164] LLGL1 regulates gemcitabine resistance by modulating ERK-SP1-OSMR pathway in pancreatic ductal adenocarcinoma.
[32589469] High Expression Levels of the Gene Are Associated with Acute Myocardial Infarction.
[32586165] Loss of death-associated protein kinase 1 in human bone marrow mesenchymal stem cells decreases immunosuppression of CD4+ T cells.
[32581043] CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
[32574254] The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis.
[32567373] Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives.
[32548823] Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches.
[32542768] Fibroblast growth factor inducible 14 signaling facilitates anti-dsDNA IgG penetration into mesangial cells.
[32534026] Duck Tembusu virus promotes the expression of suppressor of cytokine signaling 1 by downregulating miR-148a-5p to facilitate virus replication.