GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Suppressor of cytokine signaling 1

 A0A337SQG2_FELCA        Unreviewed;       203 AA.
A0A337SQG2;
10-OCT-2018, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 2.
26-FEB-2020, entry version 9.
SubName: Full=Suppressor of cytokine signaling 1 {ECO:0000313|Ensembl:ENSFCAP00000047835};
Name=SOCS1 {ECO:0000313|Ensembl:ENSFCAP00000047835};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000047835, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000047835, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047835,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000047835, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047835,
ECO:0000313|Proteomes:UP000011712};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000047835}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000047835};
Ensembl;
Submitted (JUL-2018) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000256|SAAS:SAAS00966769}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AANG04001668; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSFCAT00000063984; ENSFCAP00000047835; ENSFCAG00000041934.
GeneTree; ENSGT00940000161164; -.
UniPathway; UPA00143; -.
Proteomes; UP000011712; Chromosome E3.
GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0019210; F:kinase inhibitor activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0043377; P:negative regulation of CD8-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0010533; P:regulation of activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0050707; P:regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IEA:InterPro.
CDD; cd10382; SH2_SOCS1; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR028411; SOCS1.
InterPro; IPR035861; SOCS1_SH2.
InterPro; IPR001496; SOCS_box.
InterPro; IPR036036; SOCS_box-like_dom_sf.
PANTHER; PTHR10155:SF4; PTHR10155:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07525; SOCS_box; 1.
SMART; SM00252; SH2; 1.
SMART; SM00253; SOCS; 1.
SMART; SM00969; SOCS_box; 1.
SUPFAM; SSF158235; SSF158235; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50225; SOCS; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000011712};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
DOMAIN 71..166
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 153..202
/note="SOCS box"
/evidence="ECO:0000259|PROSITE:PS50225"
REGION 1..53
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 12..53
/note="Pro-rich"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 203 AA; 21794 MW; 03DB18318D564940 CRC64;
RTAGCQAGRP AAPAPAPAPA PAPAPAPAPA PAPAPAPAPA PAPAPAPAPA PAPAPYRRIT
RASALLDACG FYWGPLSVHG AHERLRAEPV GTFLVRDSRQ RNCFFALSVK MASGPTSIRV
HFQAGRFHLD GSRESFDCLF ELLEHYVAAP RRMLGAPLRQ RRVRPLQELC RQRIVATVGR
ENLARIPLNP VLRDYLSSFP FQI


Related products :

Catalog number Product name Quantity
EIAAB39202 CIS4,CIS-4,Cytokine-inducible SH2 protein 4,Homo sapiens,Human,SOCS4,SOCS-4,SOCS6,SOCS-6,Suppressor of cytokine signaling 4,Suppressor of cytokine signaling 6
EIAAB39203 Cis4,CIS-4,Cish4,Cytokine-inducible SH2 protein 4,Mouse,Mus musculus,Socs4,SOCS-4,Socs6,SOCS-6,Suppressor of cytokine signaling 4,Suppressor of cytokine signaling 6
EIAAB39198 Homo sapiens,Human,SOCS4,SOCS-4,SOCS7,SOCS-7,Suppressor of cytokine signaling 4,Suppressor of cytokine signaling 7
EIAAB39196 Mouse,Mus musculus,Socs4,SOCS-4,Socs7,SOCS-7,Suppressor of cytokine signaling 4,Suppressor of cytokine signaling 7
EIAAB07443 CIS,CIS-1,Cish,Cytokine-inducible SH2-containing protein,Rat,Rattus norvegicus,SOCS,Suppressor of cytokine signaling
EIAAB07442 CIS,Cis,CIS-1,Cish,Cytokine-inducible SH2-containing protein,Mouse,Mus musculus,SOCS,Suppressor of cytokine signaling
EIAAB39191 Cish2,Cytokine-inducible SH2 protein 2,Rat,Rattus norvegicus,Socs2,SOCS-2,Suppressor of cytokine signaling 2
EIAAB39200 Cish5,Cytokine-inducible SH2-containing protein 5,Mouse,Mus musculus,Socs5,SOCS-5,Suppressor of cytokine signaling 5
U1684r CLIA Cish3,Cytokine-inducible SH2 protein 3,Rat,Rattus norvegicus,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
EIAAB39193 Cis2,CIS-2,Cish2,Cytokine-inducible SH2 protein 2,Mouse,Mus musculus,Socs2,SOCS-2,Suppressor of cytokine signaling 2
E1684r ELISA kit Cish3,Cytokine-inducible SH2 protein 3,Rat,Rattus norvegicus,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
E1684r ELISA Cish3,Cytokine-inducible SH2 protein 3,Rat,Rattus norvegicus,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
EIAAB39201 CIS6,CIS-6,CISH5,CISH6,Cytokine-inducible SH2 protein 6,Cytokine-inducible SH2-containing protein 5,Homo sapiens,Human,KIAA0671,SOCS5,SOCS-5,Suppressor of cytokine signaling 5
29-704 SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine sig 0.1 mg
EIAAB07441 CIS,CIS-1,CISH,Cytokine-inducible SH2-containing protein,G18,Homo sapiens,Human,Protein G18,SOCS,Suppressor of cytokine signaling
EIAAB07444 Chicken,CIS,CIS,CIS-1,CISH,Cytokine-inducible SH2-containing protein,Gallus gallus,SOCS,Suppressor of cytokine signaling
E1684m ELISA Cis3,CIS-3,Cish3,Cytokine-inducible SH2 protein 3,Mouse,Mus musculus,Protein EF-10,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
U1684m CLIA Cis3,CIS-3,Cish3,Cytokine-inducible SH2 protein 3,Mouse,Mus musculus,Protein EF-10,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
E1684m ELISA kit Cis3,CIS-3,Cish3,Cytokine-inducible SH2 protein 3,Mouse,Mus musculus,Protein EF-10,Socs3,SOCS-3,Suppressor of cytokine signaling 3 96T
FP-0095 Suppressor of cytokine signaling 7 10 ug
FP-0094 Suppressor of cytokine signaling 6 10 ug
FP-0092 Suppressor of cytokine signaling 4 10 ug
FP-0091 Suppressor of cytokine signaling 3 10 ug
FP-0090 Suppressor of cytokine signaling 2 10 ug
FP-0089 Suppressor of cytokine signaling 1 10 ug
Pathways :
WP1349: Wnt Signaling Pathway
WP785: Wnt Signaling Pathway
WP1313: Insulin Signaling
WP428: Wnt Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1016: Wnt Signaling Pathway
WP1135: Wnt Signaling Pathway
WP1350: Type II interferon signaling (IFNG)
WP899: Wnt Signaling Pathway
WP1323: EGFR1 Signaling Pathway
WP1315: IL-5 Signaling Pathway
WP265: Delta-Notch Signaling Pathway
WP403: Wnt Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1359: IL-3 Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP1337: MAPK signaling pathway
WP2292: Chemokine signaling pathway
WP564: Wnt Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1371: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP744: IL-5 Signaling Pathway

Related Genes :

Bibliography :
[32615164] LLGL1 regulates gemcitabine resistance by modulating ERK-SP1-OSMR pathway in pancreatic ductal adenocarcinoma.
[32589469] High Expression Levels of the Gene Are Associated with Acute Myocardial Infarction.
[32586165] Loss of death-associated protein kinase 1 in human bone marrow mesenchymal stem cells decreases immunosuppression of CD4+ T cells.
[32581043] CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
[32574254] The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis.
[32567373] Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives.
[32548823] Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches.
[32542768] Fibroblast growth factor inducible 14 signaling facilitates anti-dsDNA IgG penetration into mesangial cells.
[32534026] Duck Tembusu virus promotes the expression of suppressor of cytokine signaling 1 by downregulating miR-148a-5p to facilitate virus replication.
[32532301] Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1.