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Suppressor of cytokine signaling 1

 M3Z8K3_MUSPF            Unreviewed;       216 AA.
01-MAY-2013, integrated into UniProtKB/TrEMBL.
01-MAY-2013, sequence version 1.
17-JUN-2020, entry version 55.
SubName: Full=Suppressor of cytokine signaling 1 {ECO:0000313|Ensembl:ENSMPUP00000019917};
Name=SOCS1 {ECO:0000313|Ensembl:ENSMPUP00000019917};
Mustela putorius furo (European domestic ferret) (Mustela furo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
NCBI_TaxID=9669 {ECO:0000313|Ensembl:ENSMPUP00000019917, ECO:0000313|Proteomes:UP000000715};
[1] {ECO:0000313|Ensembl:ENSMPUP00000019917, ECO:0000313|Proteomes:UP000000715}
STRAIN=ID#1420 {ECO:0000313|Ensembl:ENSMPUP00000019917,
Di Palma F., Alfoldi J., Johnson J., Jaffe D., Berlin A., Gnerre S.,
Grabherr M., Hall G., Lara M., MacCallum I., Mauceli E., Przyblyski D.,
Ribeiro F., Russell P., Sharpe T., Turner-Maier J., Walker B.J., Young S.,
Birren B., Lindblad-Toh K.;
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|Ensembl:ENSMPUP00000019917}
Submitted (MAR-2013) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AEYP01027547; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_004750430.1; XM_004750373.2.
STRING; 9668.ENSMPUP00000019917; -.
Ensembl; ENSMPUT00000020201; ENSMPUP00000019917; ENSMPUG00000020049.
GeneID; 101691205; -.
CTD; 8651; -.
eggNOG; KOG4566; Eukaryota.
eggNOG; ENOG4111V4J; LUCA.
GeneTree; ENSGT00940000161164; -.
HOGENOM; CLU_079452_2_1_1; -.
InParanoid; M3Z8K3; -.
UniPathway; UPA00143; -.
Proteomes; UP000000715; Unassembled WGS sequence.
GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005159; F:insulin-like growth factor receptor binding; IEA:Ensembl.
GO; GO:0019210; F:kinase inhibitor activity; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0071230; P:cellular response to amino acid stimulus; IEA:Ensembl.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:Ensembl.
GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0043377; P:negative regulation of CD8-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Ensembl.
GO; GO:0042532; P:negative regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0043372; P:positive regulation of CD4-positive, alpha-beta T cell differentiation; IEA:Ensembl.
GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
GO; GO:0010533; P:regulation of activation of Janus kinase activity; IEA:Ensembl.
GO; GO:0050707; P:regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; IEA:InterPro.
CDD; cd10382; SH2_SOCS1; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR028411; SOCS1.
InterPro; IPR035861; SOCS1_SH2.
InterPro; IPR001496; SOCS_box.
InterPro; IPR036036; SOCS_box-like_dom_sf.
PANTHER; PTHR10155:SF4; PTHR10155:SF4; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF07525; SOCS_box; 1.
SMART; SM00252; SH2; 1.
SMART; SM00253; SOCS; 1.
SMART; SM00969; SOCS_box; 1.
SUPFAM; SSF158235; SSF158235; 1.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50225; SOCS; 1.
4: Predicted;
Reference proteome {ECO:0000313|Proteomes:UP000000715};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
DOMAIN 84..179
DOMAIN 166..215
/note="SOCS box"
REGION 1..59
SEQUENCE 216 AA; 23945 MW; F2C17BD10113D283 CRC64;

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Pathways :
WP1313: Insulin Signaling
WP1349: Wnt Signaling Pathway
WP785: Wnt Signaling Pathway
WP428: Wnt Signaling Pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP1016: Wnt Signaling Pathway
WP1135: Wnt Signaling Pathway
WP1350: Type II interferon signaling (IFNG)
WP899: Wnt Signaling Pathway
WP1323: EGFR1 Signaling Pathway
WP1315: IL-5 Signaling Pathway
WP265: Delta-Notch Signaling Pathway
WP403: Wnt Signaling Pathway
WP17: daf-2 or insulin signaling pathway
WP1354: B Cell Receptor Signaling Pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1359: IL-3 Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP1337: MAPK signaling pathway
WP2292: Chemokine signaling pathway
WP564: Wnt Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1371: G Protein Signaling Pathways
WP211: BMP signaling pathway
WP492: Hedgehog Signaling Pathway

Related Genes :

Bibliography :
[32632113] Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation.
[32615164] LLGL1 regulates gemcitabine resistance by modulating ERK-SP1-OSMR pathway in pancreatic ductal adenocarcinoma.
[32589469] High Expression Levels of the Gene Are Associated with Acute Myocardial Infarction.
[32586165] Loss of death-associated protein kinase 1 in human bone marrow mesenchymal stem cells decreases immunosuppression of CD4+ T cells.
[32581043] CD200 promotes immunosuppression in the pancreatic tumor microenvironment.
[32574254] The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis.
[32567373] Clinical Management and Therapeutic Strategies for the Thyroid-Associated Ophthalmopathy: Current and Future Perspectives.
[32548823] Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches.
[32542768] Fibroblast growth factor inducible 14 signaling facilitates anti-dsDNA IgG penetration into mesangial cells.
[32534026] Duck Tembusu virus promotes the expression of suppressor of cytokine signaling 1 by downregulating miR-148a-5p to facilitate virus replication.