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T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)

 CD3D_BOVIN              Reviewed;         168 AA.
Q28072; Q3SZH3;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 2.
13-FEB-2019, entry version 118.
RecName: Full=T-cell surface glycoprotein CD3 delta chain;
AltName: Full=T-cell receptor T3 delta chain;
AltName: CD_antigen=CD3d;
Flags: Precursor;
Name=CD3D;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-62.
PubMed=1971793; DOI=10.1002/eji.1830200415;
Clevers H., Machugh N.D., Bensaid A., Dunlap S., Baldwin C.L.,
Kaushal A., Iams K., Howard C.J., Morrison W.I.;
"Identification of a bovine surface antigen uniquely expressed on CD4-
CD8-T cell receptor gamma/delta+ T lymphocytes.";
Eur. J. Immunol. 20:809-817(1990).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition of this role of signal
transduction in T-cell activation, CD3D plays an essential role in
thymocyte differentiation. Indeed, participates in correct
intracellular TCR-CD3 complex assembly and surface expression. In
absence of a functional TCR-CD3 complex, thymocytes are unable to
differentiate properly. Interacts with CD4 and CD8 and thus serves
to establish a functional link between the TCR and coreceptors CD4
and CD8, which is needed for activation and positive selection of
CD4 or CD8 T-cells. {ECO:0000250|UniProtKB:P04234}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Interacts with coreceptors CD4 and CD8.
{ECO:0000250|UniProtKB:P04234}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P04234}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P04234}.
-!- TISSUE SPECIFICITY: CD3D is mostly present on T-lymphocytes with
its TCR-CD3 partners. Present also in fetal NK-cells.
{ECO:0000250|UniProtKB:P04234}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; BC102857; AAI02858.1; -; mRNA.
EMBL; X53269; CAA37367.1; -; mRNA.
PIR; B60232; B60232.
RefSeq; NP_001029205.1; NM_001034033.2.
UniGene; Bt.88072; -.
ProteinModelPortal; Q28072; -.
SMR; Q28072; -.
STRING; 9913.ENSBTAP00000008462; -.
PaxDb; Q28072; -.
PRIDE; Q28072; -.
Ensembl; ENSBTAT00000008462; ENSBTAP00000008462; ENSBTAG00000006452.
GeneID; 281053; -.
KEGG; bta:281053; -.
CTD; 915; -.
VGNC; VGNC:27028; CD3D.
eggNOG; ENOG410IWAX; Eukaryota.
eggNOG; ENOG410Y2TD; LUCA.
GeneTree; ENSGT00940000153312; -.
HOGENOM; HOG000015287; -.
HOVERGEN; HBG005278; -.
InParanoid; Q28072; -.
KO; K06450; -.
OMA; GENWPRK; -.
OrthoDB; 1466902at2759; -.
TreeFam; TF335892; -.
Reactome; R-BTA-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
Reactome; R-BTA-202427; Phosphorylation of CD3 and TCR zeta chains.
Reactome; R-BTA-202430; Translocation of ZAP-70 to Immunological synapse.
Reactome; R-BTA-202433; Generation of second messenger molecules.
Reactome; R-BTA-389948; PD-1 signaling.
Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-BTA-8856828; Clathrin-mediated endocytosis.
Proteomes; UP000009136; Chromosome 15.
Bgee; ENSBTAG00000006452; Expressed in 9 organ(s), highest expression level in spleen.
ExpressionAtlas; Q28072; baseline and differential.
GO; GO:0042105; C:alpha-beta T cell receptor complex; IBA:GO_Central.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:0045059; P:positive thymic T cell selection; IBA:GO_Central.
GO; GO:0051260; P:protein homooligomerization; IEA:Ensembl.
GO; GO:0030217; P:T cell differentiation; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR015485; CD3D.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
PANTHER; PTHR10570:SF5; PTHR10570:SF5; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Membrane; Phosphoprotein; Receptor;
Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1 21 {ECO:0000250}.
CHAIN 22 168 T-cell surface glycoprotein CD3 delta
chain.
/FTId=PRO_0000016486.
TOPO_DOM 22 102 Extracellular. {ECO:0000255}.
TRANSMEM 103 123 Helical. {ECO:0000255}.
TOPO_DOM 124 168 Cytoplasmic. {ECO:0000255}.
DOMAIN 135 163 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOD_RES 146 146 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04234,
ECO:0000255|PROSITE-ProRule:PRU00379}.
MOD_RES 157 157 Phosphotyrosine.
{ECO:0000250|UniProtKB:P04234,
ECO:0000255|PROSITE-ProRule:PRU00379}.
CARBOHYD 38 38 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 56 56 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 37 74 {ECO:0000250}.
CONFLICT 58 60 Missing (in Ref. 2; CAA37367).
{ECO:0000305}.
SEQUENCE 168 AA; 18931 MW; 2A9DE1D04186632D CRC64;
MEHSRFLSCL ILAALLSQVN PRILKVLEPE DKVMLECNSS ITLLQGTEGQ EVSGNNKTRD
LGKRIQDPRG MYRCGENTQQ LILQVYYRMC QNCVELDTAT LAGMIITDII ATVLLALGVY
CFAGHETGRF SRAADTQALM GNDQLYQPLR ERNDAQYSRL GDKWARNK


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Pathways :
WP1011: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP2328: Allograft rejection
WP352: T Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1144: B Cell Receptor Signaling Pathway
WP1354: B Cell Receptor Signaling Pathway
WP1794: Cell surface interactions at the vascular wall
WP1833: Integrin cell surface interactions
WP1869: Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP23: B Cell Receptor Signaling Pathway
WP274: B Cell Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway
WP794: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1002: Electron Transport Chain
WP1043: Calcium Regulation in the Cardiac Cell
WP1064: Delta-Notch Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP1078: G1 to S cell cycle control
WP1083: Cell cycle

Related Genes :
[CD3D T3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD3G T3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[Cd3g] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Cd247 Cd3z Tcrz] T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[Cd3g] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) (Fragment)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[B3GALNT1 B3GALT3 UNQ531/PRO1074] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)
[env gp160] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (W3/25 antigen) (CD antigen CD4)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD8A MAL] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
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[Cd8a Lyt-2 Lyt2] T-cell surface glycoprotein CD8 alpha chain (T-cell surface glycoprotein Lyt-2) (CD antigen CD8a)
[for DG2 PGK2 Pkg24A CG10033] cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (cGK) (EC 2.7.11.12) (Foraging protein)

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