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T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)

 CD3G_BOVIN              Reviewed;         173 AA.
Q28074; Q3SZA7;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
30-MAY-2006, sequence version 2.
16-JAN-2019, entry version 109.
RecName: Full=T-cell surface glycoprotein CD3 gamma chain;
AltName: Full=T-cell receptor T3 gamma chain;
AltName: CD_antigen=CD3g;
Flags: Precursor;
Name=CD3G;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-91.
PubMed=1971793; DOI=10.1002/eji.1830200415;
Clevers H., Machugh N.D., Bensaid A., Dunlap S., Baldwin C.L.,
Kaushal A., Iams K., Howard C.J., Morrison W.I.;
"Identification of a bovine surface antigen uniquely expressed on CD4-
CD8-T cell receptor gamma/delta+ T lymphocytes.";
Eur. J. Immunol. 20:809-817(1990).
-!- FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell
surface that plays an essential role in adaptive immune response.
When antigen presenting cells (APCs) activate T-cell receptor
(TCR), TCR-mediated signals are transmitted across the cell
membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3
chains contain immunoreceptor tyrosine-based activation motifs
(ITAMs) in their cytoplasmic domain. Upon TCR engagement, these
motifs become phosphorylated by Src family protein tyrosine
kinases LCK and FYN, resulting in the activation of downstream
signaling pathways. In addition to this role of signal
transduction in T-cell activation, CD3G plays an essential role in
the dynamic regulation of TCR expression at the cell surface.
Indeed, constitutive TCR cycling is dependent on the di-leucine-
based (diL) receptor-sorting motif present in CD3G.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBUNIT: The TCR-CD3 complex is composed of a CD3D/CD3E and a
CD3G/CD3E heterodimers that preferentially associate with TCRalpha
and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and
TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with
CD3Z homodimer to form the TCR-CD3 complex. Alternatively,
TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
{ECO:0000250|UniProtKB:P09693}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P09693}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P09693}.
-!- DOMAIN: A di-leucine motif and a tyrosine-based motif are
individually sufficient to induce both endocytosis and delivery to
lysosomes. {ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8. Phosphorylated also
by PKC; leading to the TCR complex down-regulation.
{ECO:0000250|UniProtKB:P09693}.
-!- PTM: Phosphorylated on Tyr residues after T-cell receptor
triggering by LCK in association with CD4/CD8.
{ECO:0000250|UniProtKB:P04234}.
-!- SEQUENCE CAUTION:
Sequence=CAA37366.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; BC103010; AAI03011.1; -; mRNA.
EMBL; X53268; CAA37366.1; ALT_INIT; mRNA.
PIR; A60232; A60232.
UniGene; Bt.13934; -.
ProteinModelPortal; Q28074; -.
SMR; Q28074; -.
STRING; 9913.ENSBTAP00000044200; -.
PaxDb; Q28074; -.
PRIDE; Q28074; -.
eggNOG; ENOG410IWAX; Eukaryota.
eggNOG; ENOG410Y2TD; LUCA.
HOGENOM; HOG000015287; -.
HOVERGEN; HBG005278; -.
InParanoid; Q28074; -.
OrthoDB; 1466902at2759; -.
Proteomes; UP000009136; Unplaced.
GO; GO:0042105; C:alpha-beta T cell receptor complex; IBA:GO_Central.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0004888; F:transmembrane signaling receptor activity; IBA:GO_Central.
GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045059; P:positive thymic T cell selection; IBA:GO_Central.
GO; GO:0030217; P:T cell differentiation; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015484; CD3_esu/gsu/dsu.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR032052; Ig_4.
InterPro; IPR003598; Ig_sub2.
InterPro; IPR003110; Phos_immunorcpt_sig_ITAM.
PANTHER; PTHR10570; PTHR10570; 1.
Pfam; PF16680; Ig_4; 1.
Pfam; PF02189; ITAM; 1.
SMART; SM00408; IGc2; 1.
SMART; SM00077; ITAM; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS51055; ITAM_1; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Membrane;
Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 173 T-cell surface glycoprotein CD3 gamma
chain.
/FTId=PRO_0000014614.
TOPO_DOM 23 111 Extracellular. {ECO:0000255}.
TRANSMEM 112 132 Helical. {ECO:0000255}.
TOPO_DOM 133 173 Cytoplasmic. {ECO:0000255}.
DOMAIN 24 94 Ig-like.
DOMAIN 145 173 ITAM. {ECO:0000255|PROSITE-
ProRule:PRU00379}.
MOTIF 149 150 Di-leucine motif.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 141 141 Phosphoserine.
{ECO:0000250|UniProtKB:P09693}.
MOD_RES 144 144 Phosphoserine; by PKC.
{ECO:0000250|UniProtKB:P09693}.
CARBOHYD 45 45 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 88 88 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 42 83 {ECO:0000250|UniProtKB:P09693}.
SEQUENCE 173 AA; 19463 MW; 74ADF52B384AA06C CRC64;
MEQGKHLAGL ILAVFLLQGT MAHVKEVKVD DNREDGSVIL ICVTNDTTIT WLKDVEQIGS
GDTKKNTWNL GSSTKDPRGI YKCEGSNNQS KSLQIYYRMC QNCIELNPST VAGFIFTEIV
SIFLLAVGVY FIAGQEGVRQ SRASDKQTLL NNDQLYQPLK EREDDQYSHL RKN


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Related Genes :
[CD3G T3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[Cd3g] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD3D T3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[Cd3g] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[Cd247 Cd3z Tcrz] T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g) (Fragment)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[B3GALNT1 B3GALT3 UNQ531/PRO1074] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)
[env gp160] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
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Bibliography :