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T-cell surface glycoprotein CD8 alpha chain (CD antigen CD8a)

 CD8A_FELCA              Reviewed;         239 AA.
P41688;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
16-JAN-2019, entry version 109.
RecName: Full=T-cell surface glycoprotein CD8 alpha chain;
AltName: CD_antigen=CD8a;
Flags: Precursor;
Name=CD8A;
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
PubMed=8132208;
Pecoraro M., Kawaguchi Y., Miyazawa T., Norimine J., Maeda K.,
Toyosaki T., Tohya Y., Kai C., Mikami T.;
"Isolation, sequence and expression of a cDNA encoding the alpha-chain
of the feline CD8.";
Immunology 81:127-131(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Thymus;
Miyazawa T.;
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Integral membrane glycoprotein that plays an essential
role in the immune response and serves multiple functions in
responses against both external and internal offenses. In T-cells,
functions primarily as a coreceptor for MHC class I
molecule:peptide complex. The antigens presented by class I
peptides are derived from cytosolic proteins while class II
derived from extracellular proteins. Interacts simultaneously with
the T-cell receptor (TCR) and the MHC class I proteins presented
by antigen presenting cells (APCs). In turn, recruits the Src
kinase LCK to the vicinity of the TCR-CD3 complex. LCK then
initiates different intracellular signaling pathways by
phosphorylating various substrates ultimately leading to
lymphokine production, motility, adhesion and activation of
cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to
recognize and eliminate infected cells and tumor cells. In NK-
cells, the presence of CD8A homodimers at the cell surface
provides a survival mechanism allowing conjugation and lysis of
multiple target cells. CD8A homodimer molecules also promote the
survival and differentiation of activated lymphocytes into memory
CD8 T-cells. {ECO:0000250|UniProtKB:P01732}.
-!- SUBUNIT: Forms disulfide-linked heterodimers with CD8B at the cell
surface. Forms also homodimers in several cell types including NK-
cells or peripheral blood T-lymphocytes. Interacts with the MHC
class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent
manner. {ECO:0000250|UniProtKB:P01732}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P01732}. Note=CD8A localizes to
lipid rafts only when associated with its partner CD8B.
{ECO:0000250|UniProtKB:P01732}.
-!- PTM: Palmitoylated, but association with CD8B seems to be more
important for the enrichment of CD8A in lipid rafts.
{ECO:0000250|UniProtKB:P01732}.
-!- PTM: O-glycosylated. {ECO:0000250|UniProtKB:P01732}.
-!- PTM: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following
activation. {ECO:0000250|UniProtKB:P01732}.
-----------------------------------------------------------------------
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EMBL; D16536; BAA03973.1; -; mRNA.
EMBL; AB000485; BAA19126.1; -; mRNA.
PIR; I46082; I46082.
RefSeq; NP_001009843.1; NM_001009843.2.
ProteinModelPortal; P41688; -.
SMR; P41688; -.
STRING; 9685.ENSFCAP00000013754; -.
GeneID; 493799; -.
KEGG; fca:493799; -.
CTD; 925; -.
eggNOG; ENOG410IWN3; Eukaryota.
eggNOG; ENOG410Z6EI; LUCA.
HOGENOM; HOG000004794; -.
HOVERGEN; HBG008488; -.
InParanoid; P41688; -.
KO; K06458; -.
OrthoDB; 1448152at2759; -.
TreeFam; TF336070; -.
Proteomes; UP000011712; Unplaced.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
GO; GO:0045065; P:cytotoxic T cell differentiation; IBA:GO_Central.
GO; GO:0002456; P:T cell mediated immunity; IBA:GO_Central.
Gene3D; 2.60.40.10; -; 1.
InterPro; IPR015468; CD8_asu.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
PANTHER; PTHR10441; PTHR10441; 1.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 1.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 1.
PROSITE; PS50835; IG_LIKE; 1.
2: Evidence at transcript level;
Adaptive immunity; Cell membrane; Complete proteome; Disulfide bond;
Glycoprotein; Immunity; Immunoglobulin domain; Lipoprotein; Membrane;
Palmitate; Reference proteome; Signal; Transmembrane;
Transmembrane helix.
SIGNAL 1 21 {ECO:0000255}.
CHAIN 22 239 T-cell surface glycoprotein CD8 alpha
chain.
/FTId=PRO_0000014637.
TOPO_DOM 22 188 Extracellular. {ECO:0000255}.
TRANSMEM 189 210 Helical. {ECO:0000255}.
TOPO_DOM 211 239 Cytoplasmic. {ECO:0000255}.
DOMAIN 25 139 Ig-like V-type.
LIPID 210 210 S-palmitoyl cysteine.
{ECO:0000250|UniProtKB:P01732}.
DISULFID 46 119 {ECO:0000255|PROSITE-ProRule:PRU00114}.
SEQUENCE 239 AA; 26120 MW; F9A171820E8FF1BC CRC64;
MASPVTAQLL PLALLLHAAA AAGPSPFRLS PVRVEGRLGQ RVELQCEVLL SSAAPGCTWL
FQKNEPAARP IFLAYLSRSR TKLAEELDPK QISGQRIQDT LYSLTLHRFR KEEEGYYFCS
VVSNSVLYFS AFVPVFLPVK PTTTPAPRPP TQAPITTSQR VSLRPGTCQP SAGSTVEASG
LDLSCDIYIW APLAGTCAFL LLSLVITVIC NHRNRRRVCK CPRPVVRAGG KPSPSERYV


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Pathways :
WP1011: T Cell Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway
WP1614: 1- and 2-Methylnaphthalene degradation
WP1794: Cell surface interactions at the vascular wall
WP1833: Integrin cell surface interactions
WP2328: Allograft rejection
WP352: T Cell Receptor Signaling Pathway
WP480: T Cell Receptor Signaling Pathway
WP780: T Cell Receptor Signaling Pathway
WP894: T Cell Receptor Signaling Pathway
WP1002: Electron Transport Chain
WP1003: Ovarian Infertility Genes
WP1025: B Cell Receptor Signaling Pathway
WP1043: Calcium Regulation in the Cardiac Cell
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1069: Integrin-mediated cell adhesion
WP1078: G1 to S cell cycle control
WP1083: Cell cycle
WP111: Electron Transport Chain
WP1119: Electron Transport Chain
WP1120: Ovarian Infertility Genes
WP1144: B Cell Receptor Signaling Pathway
WP1159: Calcium Regulation in the Cardiac Cell
WP1163: TNF-alpha NF-kB Signaling Pathway

Related Genes :
[CD8A MAL] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
[Cd8a Lyt-2 Lyt2] T-cell surface glycoprotein CD8 alpha chain (T-cell surface glycoprotein Lyt-2) (CD antigen CD8a)
[Cd8a] T-cell surface glycoprotein CD8 alpha chain (CD8 antigen 32 kDa chain) (OX-8 membrane antigen) (CD antigen CD8a)
[CD8A] T-cell surface glycoprotein CD8 alpha chain (CD antigen CD8a)
[CD8A] T-cell surface glycoprotein CD8 alpha chain (CD antigen CD8a)
[CD8A] T-cell surface glycoprotein CD8 alpha chain (CD antigen CD8a)
[CD8A] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[CD8B CD8B1] T-cell surface glycoprotein CD8 beta chain (CD antigen CD8b)
[Cd4] T-cell surface glycoprotein CD4 (T-cell differentiation antigen L3T4) (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[CD3E T3E] T-cell surface glycoprotein CD3 epsilon chain (T-cell surface antigen T3/Leu-4 epsilon chain) (CD antigen CD3e)
[CD3D T3D] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[CD3G T3G] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[CD4] T-cell surface glycoprotein CD4 (T-cell surface antigen T4/Leu-3) (CD antigen CD4)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Lck Lsk-t] Proto-oncogene tyrosine-protein kinase LCK (EC 2.7.10.2) (Leukocyte C-terminal Src kinase) (LSK) (Lymphocyte cell-specific protein-tyrosine kinase) (p56-LCK)
[Cd247 Cd3z Tcrz] T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
[Cd3g] T-cell surface glycoprotein CD3 gamma chain (T-cell receptor T3 gamma chain) (CD antigen CD3g)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[Cd160 By55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[Ly9 Ly-9] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[LY9 CDABP0070] T-lymphocyte surface antigen Ly-9 (Cell surface molecule Ly-9) (Lymphocyte antigen 9) (SLAM family member 3) (SLAMF3) (Signaling lymphocytic activation molecule 3) (CD antigen CD229)
[CD160 BY55] CD160 antigen (Natural killer cell receptor BY55) (CD antigen CD160) [Cleaved into: CD160 antigen, soluble form]
[HAVCR2 TIM3 TIMD3] Hepatitis A virus cellular receptor 2 (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[HLA-E HLA-6.2 HLAE] HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
[CD53 MOX44 TSPAN25] Leukocyte surface antigen CD53 (Cell surface glycoprotein CD53) (Tetraspanin-25) (Tspan-25) (CD antigen CD53)
[PTPRC CD45] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (T200) (CD antigen CD45)
[Cd3d T3d] T-cell surface glycoprotein CD3 delta chain (T-cell receptor T3 delta chain) (CD antigen CD3d)
[Havcr2 Tim3 Timd3] Hepatitis A virus cellular receptor 2 homolog (HAVcr-2) (T-cell immunoglobulin and mucin domain-containing protein 3) (TIMD-3) (T-cell immunoglobulin mucin receptor 3) (TIM-3) (T-cell membrane protein 3) (CD antigen CD366)
[CD1A] T-cell surface glycoprotein CD1a (T-cell surface antigen T6/Leu-6) (hTa1 thymocyte antigen) (CD antigen CD1a)

Bibliography :
[28419443] Loss of natural killer T cells promotes pancreatic cancer in LSL-Kras mice.
[26669617] Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma.
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