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TEK receptor tyrosine kinase

 U3JY02_FICAL            Unreviewed;      1128 AA.
U3JY02;
13-NOV-2013, integrated into UniProtKB/TrEMBL.
13-NOV-2013, sequence version 1.
13-FEB-2019, entry version 47.
SubName: Full=TEK receptor tyrosine kinase {ECO:0000313|Ensembl:ENSFALP00000007656};
Name=TEK {ECO:0000313|Ensembl:ENSFALP00000007656};
Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Passeriformes; Muscicapidae;
Ficedula.
NCBI_TaxID=59894 {ECO:0000313|Ensembl:ENSFALP00000007656, ECO:0000313|Proteomes:UP000016665};
[1] {ECO:0000313|Ensembl:ENSFALP00000007656}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2013) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
EC=2.7.10.1; Evidence={ECO:0000256|SAAS:SAAS01124082};
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|SAAS:SAAS00941529}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; AGTO01001270; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_005061160.1; XM_005061103.1.
Ensembl; ENSFALT00000007688; ENSFALP00000007656; ENSFALG00000007333.
GeneID; 101812140; -.
KEGG; fab:101812140; -.
CTD; 7010; -.
GeneTree; ENSGT00940000158840; -.
KO; K05121; -.
OMA; EACQPGY; -.
OrthoDB; 707342at2759; -.
Proteomes; UP000016665; Unplaced.
GO; GO:0005884; C:actin filament; IEA:Ensembl.
GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
GO; GO:0009925; C:basal plasma membrane; IEA:Ensembl.
GO; GO:0009986; C:cell surface; IEA:Ensembl.
GO; GO:0005911; C:cell-cell junction; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005815; C:microtubule organizing center; IEA:Ensembl.
GO; GO:0005902; C:microvillus; IEA:Ensembl.
GO; GO:0001725; C:stress fiber; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0010595; P:positive regulation of endothelial cell migration; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0051894; P:positive regulation of focal adhesion assembly; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0051259; P:protein complex oligomerization; IEA:Ensembl.
GO; GO:0032878; P:regulation of establishment or maintenance of cell polarity; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0048014; P:Tie signaling pathway; IEA:Ensembl.
CDD; cd00063; FN3; 2.
Gene3D; 2.60.40.10; -; 6.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR018941; Tyr_kin_Tie2_Ig-like_dom-1_N.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
Pfam; PF00041; fn3; 3.
Pfam; PF10430; Ig_Tie2_1; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PRINTS; PR00109; TYRKINASE.
SMART; SM00181; EGF; 3.
SMART; SM00060; FN3; 3.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF48726; SSF48726; 1.
SUPFAM; SSF49265; SSF49265; 2.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00022; EGF_1; 3.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS50853; FN3; 3.
PROSITE; PS50835; IG_LIKE; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|SAAS:SAAS00708816};
Complete proteome {ECO:0000313|Proteomes:UP000016665};
Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
Kinase {ECO:0000256|SAAS:SAAS00582553};
Membrane {ECO:0000256|SAAS:SAAS00602683, ECO:0000256|SAM:Phobius};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00708816};
Receptor {ECO:0000256|SAAS:SAAS00600436};
Reference proteome {ECO:0000313|Proteomes:UP000016665};
Signal {ECO:0000256|SAM:SignalP};
Transferase {ECO:0000256|SAAS:SAAS00582553};
Transmembrane {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00602683,
ECO:0000256|SAM:Phobius};
Tyrosine-protein kinase {ECO:0000256|SAAS:SAAS00582553}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 1128 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004645024.
TRANSMEM 749 773 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 216 252 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 307 341 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 350 440 Ig-like. {ECO:0000259|PROSITE:PS50835}.
DOMAIN 447 541 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 545 639 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 644 737 Fibronectin type-III.
{ECO:0000259|PROSITE:PS50853}.
DOMAIN 828 1100 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
DISULFID 242 251 {ECO:0000256|PROSITE-ProRule:PRU00076}.
DISULFID 331 340 {ECO:0000256|PROSITE-ProRule:PRU00076}.
SEQUENCE 1128 AA; 126177 MW; CAC337814DCF307E CRC64;
MDPLAHLVLY GFSLLISGKV EAALDLILIN SFPLVGNSET SLICVTSKWR SRESITIGRD
QEDVASQHRE PLEVNEDSKR AAAKTVVWKR EQASETIGAY YCEAKLKDEV TRIHTMKMPL
GASFHPMALT VTANKGEHVN ISFIRMASKE EDAVIYKNGS FIHSVPRHEV PGELEVSYPQ
VQPQDAGIYS ARYIGGNLFT SAYTRLIVRR CEAEKWGPSC SFHCPSCTNN GICHEDTGEC
ICPPGFMGKT CEKACGANTF GKTCEETCKE NYGCRNFMFC LPDPYGCSCA TGWMGLECDK
ECKPGFYGSD CKLKCNCHNR GTCDRFKGCI CSFGWHGLQC EKKGSADLSP QIVNLQDPVE
LNSGVEFKPF CIATGMPLPK SEEFKLLKQD GTVLRPDEIS TSNRSEAMFR INRILPGDTG
TWVCSVQTVA GMAEKPFQVT VKVPPVPQYA PRLTDRGHNF LIIDINAELH NGDGPVVSTK
LLYKPAKRYQ SWMSVEVKGT TKRLDNLEPK TEYQFCVQLS RQGEGGEGHP GPQASFTTAA
LGLPPPEGIT LFPKSMTSLN LSWHPLTLRT EDDIRVEVER KSVNDNGDES SVITQVPGNM
STLIIKDLEP RQQYMCRVRV NTRSQGEWSN YLYAWTFSDR IPPAPNNVRF SNTTDTSSVI
SWTAAEGHSI SSIIISYKIY GKAEHNHIDI IIKNTSITQY HLKGLEPDTV YQVQINAQNN
IGLSNPNTSF ELKTLPETKA PYESKGGKML LIAILGSAGM TCVTILLAFL IMLQLRRANF
QRRMAQAFQN VVREEPALQF NSGTLTLSRK AKNSPDPTIY PVLEWNDIKF QDVIGEGNFG
QVLKARIKKD GLRMDAAIKR MKEYASKDDH RDFAGELEVL CKLGHHPNII NLLGACEHRG
YLYLAIEYAP HGNLLDFLRK SRVLETDPAF AIANSTASTL SSQQLLHFAA DVAKGMDYLS
QKQFIHRDLA ARNILVGENY VAKIADFGLS RGQEVYVKKT MGRLPVRWMA IESLNYSVYT
TNSDVWSYGV LLWEIVSLGG TPYCGMTCAE LYEKLPQGYR LEKPLNCDDE VYDLMRQCWK
EKPYERPSFA QILVSLNRML EDRKTYVNTT LYEKFTYAGI DCSAEEAA


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Pathways :
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1067: Toll-like receptor signaling pathway
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1183: Toll-like receptor signaling pathway
WP120: Phenylalanine and Tyrosine Biosynthesis
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1249: EPO Receptor Signaling
WP1271: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP1309: Toll-like receptor signaling pathway
WP1336: EPO Receptor Signaling
WP1341: Kit Receptor Signaling Pathway
WP1345: T Cell Receptor Signaling Pathway

Related Genes :
[TEK TIE2 VMCM VMCM1] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[TEK TIE-2 TIE2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TIE-2) (CD antigen CD202b)
[Tek rCG_53516] Endothelial-specific receptor tyrosine kinase (TEK receptor tyrosine kinase)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[DDR2 NTRKR3 TKT TYRO10] Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
[NTRK1 MTC TRK TRKA] High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)
[TIE1 TIE] Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)
[Tie1 Tie Tie-1] Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)
[Ddr1 Cak Eddr1 Mpk6] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (Protein-tyrosine kinase MPK-6) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5] Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[TEK] TEK receptor tyrosine kinase
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[Ddr1 Eddr1 Ptk3] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (Protein-tyrosine kinase 3) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[tie2 tie-2] Tyrosine-protein kinase receptor Tie-2 (EC 2.7.10.1) (Tyrosine kinase with Ig and EGF homology domains-2)
[Ephb2 Epth3 Nuk Sek3] Ephrin type-B receptor 2 (EC 2.7.10.1) (Neural kinase) (Nuk receptor tyrosine kinase) (Tyrosine-protein kinase receptor EPH-3) (Tyrosine-protein kinase receptor SEK-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[Tek mCG_122568] Angiopoietin-1 receptor (Endothelial-specific receptor tyrosine kinase, isoform CRA_a)
[Ddr2 Ntrkr3 Tkt Tyro10] Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
[Flt3 Flk-2 Flt-3] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135)
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
[BMX] Cytoplasmic tyrosine-protein kinase BMX (EC 2.7.10.2) (Bone marrow tyrosine kinase gene in chromosome X protein) (Epithelial and endothelial tyrosine kinase) (ETK) (NTK38)
[EPHA1 EPH EPHT EPHT1] Ephrin type-A receptor 1 (hEpha1) (EC 2.7.10.1) (EPH tyrosine kinase) (EPH tyrosine kinase 1) (Erythropoietin-producing hepatoma receptor) (Tyrosine-protein kinase receptor EPH)
[TYRO3 BYK DTK RSE SKY TIF] Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[Ptpn11] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
[EPHA3 ETK ETK1 HEK TYRO4] Ephrin type-A receptor 3 (EC 2.7.10.1) (EPH-like kinase 4) (EK4) (hEK4) (HEK) (Human embryo kinase) (Tyrosine-protein kinase TYRO4) (Tyrosine-protein kinase receptor ETK1) (Eph-like tyrosine kinase 1)
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
[EPHB1 ELK EPHT2 HEK6 NET] Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
[PTPRJ DEP1] Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)

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