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TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

 TGFR1_RAT               Reviewed;         501 AA.
P80204;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
26-FEB-2020, entry version 178.
RecName: Full=TGF-beta receptor type-1;
Short=TGFR-1;
EC=2.7.11.30;
AltName: Full=Serine/threonine-protein kinase receptor R4;
Short=SKR4;
AltName: Full=TGF-beta type I receptor;
AltName: Full=Transforming growth factor-beta receptor type I;
Short=TGF-beta receptor type I;
Short=TbetaR-I;
Flags: Precursor;
Name=Tgfbr1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Urogenital ridge;
PubMed=8395914; DOI=10.1002/aja.1001960207;
He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.;
"Developmental expression of four novel serine/threonine kinase receptors
homologous to the activin/transforming growth factor-beta type II receptor
family.";
Dev. Dyn. 196:133-142(1993).
[2]
INTERACTION WITH FKBP1A, AND ACTIVITY REGULATION.
PubMed=8756725; DOI=10.1016/s0092-8674(00)80116-6;
Wang T., Li B.Y., Danielson P.D., Shah P.C., Rockwell S., Lechleider R.J.,
Martin J., Manganaro T., Donahoe P.K.;
"The immunophilin FKBP12 functions as a common inhibitor of the TGF beta
family type I receptors.";
Cell 86:435-444(1996).
[3]
SUMOYLATION AT LYS-389.
PubMed=18469808; DOI=10.1038/ncb1728;
Kang J.S., Saunier E.F., Akhurst R.J., Derynck R.;
"The type I TGF-beta receptor is covalently modified and regulated by
sumoylation.";
Nat. Cell Biol. 10:654-664(2008).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-
beta type II serine/threonine kinase receptor, TGFBR2, the non-
promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to
the cytoplasm and is thus regulating a plethora of physiological and
pathological processes including cell cycle arrest in epithelial and
hematopoietic cells, control of mesenchymal cell proliferation and
differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor
complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound
to the cytokine dimer results in the phosphorylation and the activation
of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and interacts
with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the
nucleus where it modulates the transcription of the TGF-beta-regulated
genes. This constitutes the canonical SMAD-dependent TGF-beta signaling
cascade. Also involved in non-canonical, SMAD-independent TGF-beta
signaling pathways. For instance, TGFBR1 induces TRAF6
autoubiquitination which in turn results in MAP3K7 ubiquitination and
activation to trigger apoptosis. Also regulates epithelial to
mesenchymal transition through a SMAD-independent signaling pathway
through PARD6A phosphorylation and activation (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-
phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-
COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Kept in an inactive conformation by FKBP1A
preventing receptor activation in absence of ligand. CD109 is another
inhibitor of the receptor. {ECO:0000269|PubMed:8756725}.
-!- SUBUNIT: Homodimer; in the endoplasmic reticulum but also at the cell
membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands
assemble a functional receptor composed of two TGFBR1 and TGFBR2
heterodimers to form a ligand-receptor heterohexamer. The respective
affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics
of assembly of the receptor and may explain the different biological
activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits
TGF-beta receptor activation in keratinocytes. Interacts with RBPMS.
Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3
to the TGF-beta receptor. Interacts with TRAF6 and MAP3K7; induces
MAP3K7 activation by TRAF6. Interacts with PARD6A; involved in TGF-beta
induced epithelial to mesenchymal transition. Interacts with SMAD7,
NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1 and SMURF2 to
the TGF-beta receptor (By similarity). Interacts with USP15 and VPS39
(By similarity). Interacts (unphosphorylated) with FKBP1A; prevents
TGFBR1 phosphorylation by TGFBR2 and stabilizes it in the inactive
conformation. Interacts with SDCBP (via C-terminus). Interacts with
CAV1 and this interaction is impaired in the presence of SDCBP (By
similarity). Interacts with APPL1; interaction is TGF beta dependent;
mediates trafficking of the TGFBR1 from the endosomes to the nucleus
via microtubules in a TRAF6-dependent manner (By similarity).
{ECO:0000250|UniProtKB:P36897, ECO:0000269|PubMed:8756725}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36897};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P36897}.
Cell junction, tight junction {ECO:0000250|UniProtKB:P36897}. Membrane
raft {ECO:0000250|UniProtKB:P36897}. Cell surface
{ECO:0000250|UniProtKB:P36897}.
-!- TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and lungs.
-!- PTM: Phosphorylated at basal levels in the absence of ligand. Activated
upon phosphorylation by TGFBR2, mainly in the GS domain.
Phosphorylation in the GS domain abrogates FKBP1A-binding (By
similarity). {ECO:0000250|UniProtKB:P36897}.
-!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P36897}.
-!- PTM: Ubiquitinated; undergoes ubiquitination catalyzed by several E3
ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the
proteasomal and/or lysosomal degradation of the receptor thereby
negatively regulating its activity. Deubiquitinated by USP15, leading
to stabilization of the protein and enhanced TGF-beta signal. Its
ubiquitination and proteasome-mediated degradation is negatively
regulated by SDCBP (By similarity). {ECO:0000250|UniProtKB:P36897}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; L26110; AAA83216.1; -; mRNA.
RefSeq; XP_006238092.2; XM_006238030.3.
BioGrid; 248223; 2.
CORUM; P80204; -.
IntAct; P80204; 4.
MINT; P80204; -.
STRING; 10116.ENSRNOP00000009452; -.
PhosphoSitePlus; P80204; -.
PaxDb; P80204; -.
PRIDE; P80204; -.
GeneID; 29591; -.
UCSC; RGD:3852; rat.
CTD; 7046; -.
RGD; 3852; Tgfbr1.
eggNOG; KOG2052; Eukaryota.
eggNOG; ENOG410XQT0; LUCA.
HOGENOM; CLU_000288_8_1_1; -.
InParanoid; P80204; -.
OrthoDB; 776697at2759; -.
PhylomeDB; P80204; -.
TreeFam; TF314724; -.
BRENDA; 2.7.10.2; 5301.
BRENDA; 2.7.11.30; 5301.
Reactome; R-RNO-2173788; Downregulation of TGF-beta receptor signaling.
Reactome; R-RNO-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-RNO-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
Reactome; R-RNO-5689880; Ub-specific processing proteases.
PRO; PR:P80204; -.
Proteomes; UP000002494; Unplaced.
Genevisible; P80204; RN.
GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
GO; GO:0005923; C:bicellular tight junction; ISO:RGD.
GO; GO:0005901; C:caveola; IDA:MGI.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0045121; C:membrane raft; IDA:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0043235; C:receptor complex; ISO:RGD.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0016361; F:activin receptor activity, type I; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IMP:RGD.
GO; GO:0070411; F:I-SMAD binding; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; ISO:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IMP:RGD.
GO; GO:0044877; F:protein-containing complex binding; IMP:RGD.
GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
GO; GO:0046332; F:SMAD binding; ISO:RGD.
GO; GO:0050431; F:transforming growth factor beta binding; IDA:RGD.
GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; IMP:RGD.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; ISO:RGD.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISO:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
GO; GO:0000186; P:activation of MAPKK activity; ISO:RGD.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:AgBase.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0001525; P:angiogenesis; ISO:RGD.
GO; GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; ISO:RGD.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:0009952; P:anterior/posterior pattern specification; ISO:RGD.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0048844; P:artery morphogenesis; ISO:RGD.
GO; GO:0001824; P:blastocyst development; ISO:RGD.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0048870; P:cell motility; ISO:RGD.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:RGD.
GO; GO:0030199; P:collagen fibril organization; ISO:RGD.
GO; GO:0060982; P:coronary artery morphogenesis; ISO:RGD.
GO; GO:0048565; P:digestive tract development; IEP:RGD.
GO; GO:0007566; P:embryo implantation; IEP:RGD.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; ISO:RGD.
GO; GO:0042118; P:endothelial cell activation; ISS:AgBase.
GO; GO:0043542; P:endothelial cell migration; ISO:RGD.
GO; GO:1905223; P:epicardium morphogenesis; ISO:RGD.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISO:RGD.
GO; GO:0008354; P:germ cell migration; ISO:RGD.
GO; GO:0007507; P:heart development; ISS:AgBase.
GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
GO; GO:0035556; P:intracellular signal transduction; ISS:AgBase.
GO; GO:0001822; P:kidney development; ISO:RGD.
GO; GO:0002088; P:lens development in camera-type eye; ISO:RGD.
GO; GO:0030324; P:lung development; IEP:RGD.
GO; GO:0008584; P:male gonad development; ISO:RGD.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:AgBase.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; ISO:RGD.
GO; GO:0045602; P:negative regulation of endothelial cell differentiation; IMP:RGD.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISO:RGD.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; ISO:RGD.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0048663; P:neuron fate commitment; ISO:RGD.
GO; GO:0060017; P:parathyroid gland development; ISO:RGD.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:RGD.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; ISO:RGD.
GO; GO:0060037; P:pharyngeal system development; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:RGD.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; ISO:RGD.
GO; GO:0030307; P:positive regulation of cell growth; ISO:RGD.
GO; GO:0030335; P:positive regulation of cell migration; ISO:RGD.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
GO; GO:0051272; P:positive regulation of cellular component movement; ISO:RGD.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:AgBase.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:RGD.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; ISO:RGD.
GO; GO:0051491; P:positive regulation of filopodium assembly; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; ISO:RGD.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:RGD.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; ISO:RGD.
GO; GO:0051496; P:positive regulation of stress fiber assembly; ISO:RGD.
GO; GO:1905075; P:positive regulation of tight junction disassembly; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0009791; P:post-embryonic development; ISO:RGD.
GO; GO:0046777; P:protein autophosphorylation; IMP:RGD.
GO; GO:0006468; P:protein phosphorylation; IMP:RGD.
GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; ISO:RGD.
GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISS:AgBase.
GO; GO:0043393; P:regulation of protein binding; ISO:RGD.
GO; GO:0031396; P:regulation of protein ubiquitination; ISO:RGD.
GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0070723; P:response to cholesterol; ISO:RGD.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO; GO:0043627; P:response to estrogen; IDA:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0034695; P:response to prostaglandin E; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
GO; GO:0060021; P:roof of mouth development; ISO:RGD.
GO; GO:0007165; P:signal transduction; ISO:RGD.
GO; GO:0001501; P:skeletal system development; ISO:RGD.
GO; GO:0048705; P:skeletal system morphogenesis; ISO:RGD.
GO; GO:0048538; P:thymus development; ISO:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:RGD.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; ISO:RGD.
GO; GO:0060412; P:ventricular septum morphogenesis; ISO:RGD.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; ISO:RGD.
InterPro; IPR000472; Activin_recp.
InterPro; IPR003605; GS_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF08515; TGF_beta_GS; 1.
SMART; SM00467; GS; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51256; GS; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Apoptosis; ATP-binding; Cell junction; Cell membrane; Differentiation;
Disulfide bond; Glycoprotein; Growth regulation; Isopeptide bond; Kinase;
Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Receptor; Reference proteome;
Serine/threonine-protein kinase; Signal; Tight junction; Transferase;
Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1..29
/evidence="ECO:0000250"
CHAIN 30..501
/note="TGF-beta receptor type-1"
/id="PRO_0000024425"
TOPO_DOM 30..124
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 125..145
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 146..501
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 173..202
/note="GS"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00585"
DOMAIN 203..493
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 209..217
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 191..192
/note="FKBP1A-binding"
ACT_SITE 331
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 230
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 163
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 183
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 184
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 185
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 187
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 189
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
CARBOHYD 41
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 32..50
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 34..37
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 44..67
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 82..94
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 95..100
/evidence="ECO:0000250|UniProtKB:P36897"
CROSSLNK 389
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO)"
SEQUENCE 501 AA; 56000 MW; EAD7F8D37E456102 CRC64;
MEAASAALRR CLLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC FVSVTETTDK
VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTYCCNQDHC NKIELPTTGP FSEKQSAGLG
PVELAAVIAG PVCFVCIALM LMVYICHNRT VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY
DMTTSGSGSG LPLLVQRTIA RTIVLQESIG KGRFGEVWRG KWRGEEVAVK IFSSREERSW
FREAEIYQTV MLRHENILGF IAADNKDNGT WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM
IKLALSTASG LAHLHMEIVG TQGKPAIAHR DLKSKNILVK KNGTCCIADL GLAVRHDSAT
DTIDIAPNHR VGTKRYMAPE VLDDSINMKH FESFKRADIY AMGLVFWEIA RRCSIGGIHE
DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP NIPNRWQSCE ALRVMAKIMR ECWYANGAAR
LTALRIKKTL SQLSQQEGIK M


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EIAAB42161 Chicken,Gallus gallus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
101-M96 TGFR-1 (ALK-5), Host: Mouse, Species: Anti-Human, Synonyms: transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; LDS1A; LDS2A; TGFR-1; TGF-beta receptor type-1 100 ug
EIAAB42139 Betaglycan,Homo sapiens,Human,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
18-272-195253 TGFBR2 - Goat polyclonal to TGFBR2; EC 2.7.11.30; TGF-beta receptor type II; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TbetaR-II Polyclonal 0.05 mg
EIAAB42137 Betaglycan,Mouse,Mus musculus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42140 Betaglycan,Rat,Rattus norvegicus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42138 Betaglycan,Pig,Sus scrofa,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42160 Activin A receptor type II-like protein kinase of 53kD,Activin receptor-like kinase 5,ALK5,ALK5,ALK-5,Homo sapiens,Human,Serine_threonine-protein kinase receptor R4,SKR4,SKR4,TbetaR-I,TGF-beta recepto
U0066h CLIA CD121 antigen-like family member B,CDw121b,Homo sapiens,Human,IL1R2,IL-1R-2,IL1RB,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type 96T
E0066m ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscu 96T
E0066r ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norv 96T
U0066r CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norve 96T
U0066m CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscul 96T
E0066m ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus 96T
E0066r ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus 96T
EIAAB42145 Homo sapiens,Human,TGF-beta receptor-associated protein 1,TGFBRAP1,Transforming growth factor-beta receptor-associated protein 1,TRAP1,TRAP-1
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP809: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP566: canonical wnt - zebrafish
WP926: TGF-beta Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP2292: Chemokine signaling pathway
WP474: Endochondral Ossification
WP304: Kit receptor signaling pathway
WP1004: Kit Receptor Signaling Pathway
WP147: Kit Receptor Signaling Pathway
WP783: Androgen Receptor Signaling Pathway

Related Genes :
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Acvr1b Acvrlk4 Alk4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[ACVR1B ACVRLK4 ALK4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Acvr1b Alk4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[STK16 MPSK1 PKL12 TSF1] Serine/threonine-protein kinase 16 (EC 2.7.11.1) (Myristoylated and palmitoylated serine/threonine-protein kinase) (MPSK) (Protein kinase PKL12) (TGF-beta-stimulated factor 1) (TSF-1) (Tyrosine-protein kinase STK16) (EC 2.7.10.2) (hPSK)
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]

Bibliography :