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TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

 TGFR1_RAT               Reviewed;         501 AA.
P80204;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
01-OCT-1993, sequence version 1.
16-OCT-2019, entry version 176.
RecName: Full=TGF-beta receptor type-1;
Short=TGFR-1;
EC=2.7.11.30;
AltName: Full=Serine/threonine-protein kinase receptor R4;
Short=SKR4;
AltName: Full=TGF-beta type I receptor;
AltName: Full=Transforming growth factor-beta receptor type I;
Short=TGF-beta receptor type I;
Short=TbetaR-I;
Flags: Precursor;
Name=Tgfbr1;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Urogenital ridge;
PubMed=8395914; DOI=10.1002/aja.1001960207;
He W.-W., Gustafson M.L., Hirobe S., Donahoe P.K.;
"Developmental expression of four novel serine/threonine kinase
receptors homologous to the activin/transforming growth factor-beta
type II receptor family.";
Dev. Dyn. 196:133-142(1993).
[2]
INTERACTION WITH FKBP1A, AND ACTIVITY REGULATION.
PubMed=8756725; DOI=10.1016/s0092-8674(00)80116-6;
Wang T., Li B.Y., Danielson P.D., Shah P.C., Rockwell S.,
Lechleider R.J., Martin J., Manganaro T., Donahoe P.K.;
"The immunophilin FKBP12 functions as a common inhibitor of the TGF
beta family type I receptors.";
Cell 86:435-444(1996).
[3]
SUMOYLATION AT LYS-389.
PubMed=18469808; DOI=10.1038/ncb1728;
Kang J.S., Saunier E.F., Akhurst R.J., Derynck R.;
"The type I TGF-beta receptor is covalently modified and regulated by
sumoylation.";
Nat. Cell Biol. 10:654-664(2008).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the
TGF-beta type II serine/threonine kinase receptor, TGFBR2, the
non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2
and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the
cell surface to the cytoplasm and is thus regulating a plethora of
physiological and pathological processes including cell cycle
arrest in epithelial and hematopoietic cells, control of
mesenchymal cell proliferation and differentiation, wound healing,
extracellular matrix production, immunosuppression and
carcinogenesis. The formation of the receptor complex composed of
2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the
cytokine dimer results in the phosphorylation and the activation
of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and
interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently
translocated to the nucleus where it modulates the transcription
of the TGF-beta-regulated genes. This constitutes the canonical
SMAD-dependent TGF-beta signaling cascade. Also involved in non-
canonical, SMAD-independent TGF-beta signaling pathways. For
instance, TGFBR1 induces TRAF6 autoubiquitination which in turn
results in MAP3K7 ubiquitination and activation to trigger
apoptosis. Also regulates epithelial to mesenchymal transition
through a SMAD-independent signaling pathway through PARD6A
phosphorylation and activation (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
protein]-O-phospho-L-threonine + ADP + H(+);
Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Kept in an inactive conformation by FKBP1A
preventing receptor activation in absence of ligand. CD109 is
another inhibitor of the receptor. {ECO:0000269|PubMed:8756725}.
-!- SUBUNIT: Homodimer; in the endoplasmic reticulum but also at the
cell membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric
ligands assemble a functional receptor composed of two TGFBR1 and
TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The
respective affinity of TGBRB1 and TGFBR2 for the ligands may
modulate the kinetics of assembly of the receptor and may explain
the different biological activities of TGFB1, TGFB2 and TGFB3.
Interacts with CD109; inhibits TGF-beta receptor activation in
keratinocytes. Interacts with RBPMS. Interacts with SMAD2, SMAD3
and ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta
receptor. Interacts with TRAF6 and MAP3K7; induces MAP3K7
activation by TRAF6. Interacts with PARD6A; involved in TGF-beta
induced epithelial to mesenchymal transition. Interacts with
SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L, SMURF1
and SMURF2 to the TGF-beta receptor (By similarity). Interacts
with USP15 and VPS39 (By similarity). Interacts (unphosphorylated)
with FKBP1A; prevents TGFBR1 phosphorylation by TGFBR2 and
stabilizes it in the inactive conformation. Interacts with SDCBP
(via C-terminus). Interacts with CAV1 and this interaction is
impaired in the presence of SDCBP (By similarity). Interacts with
APPL1; interaction is TGF beta dependent; mediates trafficking of
the TGFBR1 from the endosomes to the nucleus via microtubules in a
TRAF6-dependent manner (By similarity).
{ECO:0000250|UniProtKB:P36897, ECO:0000269|PubMed:8756725}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P36897}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P36897}. Cell junction, tight
junction {ECO:0000250|UniProtKB:P36897}. Membrane raft
{ECO:0000250|UniProtKB:P36897}. Cell surface
{ECO:0000250|UniProtKB:P36897}.
-!- TISSUE SPECIFICITY: Urogenital ridge, testis, ovary, brain and
lungs.
-!- PTM: Phosphorylated at basal levels in the absence of ligand.
Activated upon phosphorylation by TGFBR2, mainly in the GS domain.
Phosphorylation in the GS domain abrogates FKBP1A-binding (By
similarity). {ECO:0000250|UniProtKB:P36897}.
-!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P36897}.
-!- PTM: Ubiquitinated; undergoes ubiquitination catalyzed by several
E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results
in the proteasomal and/or lysosomal degradation of the receptor
thereby negatively regulating its activity. Deubiquitinated by
USP15, leading to stabilization of the protein and enhanced TGF-
beta signal. Its ubiquitination and proteasome-mediated
degradation is negatively regulated by SDCBP (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L26110; AAA83216.1; -; mRNA.
RefSeq; XP_006238092.2; XM_006238030.3.
SMR; P80204; -.
BioGrid; 248223; 2.
CORUM; P80204; -.
IntAct; P80204; 4.
MINT; P80204; -.
STRING; 10116.ENSRNOP00000009452; -.
PhosphoSitePlus; P80204; -.
PaxDb; P80204; -.
PRIDE; P80204; -.
GeneID; 29591; -.
UCSC; RGD:3852; rat.
CTD; 7046; -.
RGD; 3852; Tgfbr1.
eggNOG; KOG2052; Eukaryota.
eggNOG; ENOG410XQT0; LUCA.
HOGENOM; HOG000230587; -.
InParanoid; P80204; -.
OrthoDB; 776697at2759; -.
PhylomeDB; P80204; -.
TreeFam; TF314724; -.
BRENDA; 2.7.10.2; 5301.
BRENDA; 2.7.11.30; 5301.
Reactome; R-RNO-2173788; Downregulation of TGF-beta receptor signaling.
Reactome; R-RNO-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-RNO-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
Reactome; R-RNO-5689880; Ub-specific processing proteases.
PRO; PR:P80204; -.
Proteomes; UP000002494; Unplaced.
Genevisible; P80204; RN.
GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
GO; GO:0005901; C:caveola; IDA:MGI.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0045121; C:membrane raft; IDA:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IDA:RGD.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0016361; F:activin receptor activity, type I; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IMP:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IMP:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IMP:RGD.
GO; GO:0044877; F:protein-containing complex binding; IPI:RGD.
GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
GO; GO:0050431; F:transforming growth factor beta binding; IDA:RGD.
GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; IMP:RGD.
GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:RGD.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:AgBase.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0031100; P:animal organ regeneration; IEP:RGD.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0048565; P:digestive tract development; IEP:RGD.
GO; GO:0007566; P:embryo implantation; IEP:RGD.
GO; GO:0042118; P:endothelial cell activation; ISS:AgBase.
GO; GO:0007507; P:heart development; ISS:AgBase.
GO; GO:0035556; P:intracellular signal transduction; ISS:AgBase.
GO; GO:0030324; P:lung development; IEP:RGD.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:AgBase.
GO; GO:0045602; P:negative regulation of endothelial cell differentiation; IMP:RGD.
GO; GO:1902894; P:negative regulation of pri-miRNA transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; IMP:BHF-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0046777; P:protein autophosphorylation; IMP:RGD.
GO; GO:0006468; P:protein phosphorylation; IMP:RGD.
GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISS:AgBase.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0051602; P:response to electrical stimulus; IEP:RGD.
GO; GO:0043627; P:response to estrogen; IDA:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0034695; P:response to prostaglandin E; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:RGD.
InterPro; IPR000472; Activin_recp.
InterPro; IPR003605; GS_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF08515; TGF_beta_GS; 1.
SMART; SM00467; GS; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51256; GS; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Apoptosis; ATP-binding; Cell junction; Cell membrane;
Complete proteome; Differentiation; Disulfide bond; Glycoprotein;
Growth regulation; Isopeptide bond; Kinase; Magnesium; Manganese;
Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Receptor;
Reference proteome; Serine/threonine-protein kinase; Signal;
Tight junction; Transferase; Transmembrane; Transmembrane helix;
Ubl conjugation.
SIGNAL 1 29 {ECO:0000250}.
CHAIN 30 501 TGF-beta receptor type-1.
/FTId=PRO_0000024425.
TOPO_DOM 30 124 Extracellular. {ECO:0000255}.
TRANSMEM 125 145 Helical. {ECO:0000255}.
TOPO_DOM 146 501 Cytoplasmic. {ECO:0000255}.
DOMAIN 173 202 GS. {ECO:0000255|PROSITE-
ProRule:PRU00585}.
DOMAIN 203 493 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
NP_BIND 209 217 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOTIF 191 192 FKBP1A-binding.
ACT_SITE 331 331 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 230 230 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 163 163 Phosphoserine.
{ECO:0000250|UniProtKB:P36897}.
MOD_RES 183 183 Phosphothreonine; by TGFBR2.
{ECO:0000250|UniProtKB:P36897}.
MOD_RES 184 184 Phosphothreonine; by TGFBR2.
{ECO:0000250|UniProtKB:P36897}.
MOD_RES 185 185 Phosphoserine; by TGFBR2.
{ECO:0000250|UniProtKB:P36897}.
MOD_RES 187 187 Phosphoserine; by TGFBR2.
{ECO:0000250|UniProtKB:P36897}.
MOD_RES 189 189 Phosphoserine; by TGFBR2.
{ECO:0000250|UniProtKB:P36897}.
CARBOHYD 41 41 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 32 50 {ECO:0000250|UniProtKB:P36897}.
DISULFID 34 37 {ECO:0000250|UniProtKB:P36897}.
DISULFID 44 67 {ECO:0000250|UniProtKB:P36897}.
DISULFID 82 94 {ECO:0000250|UniProtKB:P36897}.
DISULFID 95 100 {ECO:0000250|UniProtKB:P36897}.
CROSSLNK 389 389 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO).
SEQUENCE 501 AA; 56000 MW; EAD7F8D37E456102 CRC64;
MEAASAALRR CLLLIVLVAA ATLLPGAKAL QCFCHLCTKD NFTCETDGLC FVSVTETTDK
VIHNSMCIAE IDLIPRDRPF VCAPSSKTGA VTYCCNQDHC NKIELPTTGP FSEKQSAGLG
PVELAAVIAG PVCFVCIALM LMVYICHNRT VIHHRVPNEE DPSLDRPFIS EGTTLKDLIY
DMTTSGSGSG LPLLVQRTIA RTIVLQESIG KGRFGEVWRG KWRGEEVAVK IFSSREERSW
FREAEIYQTV MLRHENILGF IAADNKDNGT WTQLWLVSDY HEHGSLFDYL NRYTVTVEGM
IKLALSTASG LAHLHMEIVG TQGKPAIAHR DLKSKNILVK KNGTCCIADL GLAVRHDSAT
DTIDIAPNHR VGTKRYMAPE VLDDSINMKH FESFKRADIY AMGLVFWEIA RRCSIGGIHE
DYQLPYYDLV PSDPSVEEMR KVVCEQKLRP NIPNRWQSCE ALRVMAKIMR ECWYANGAAR
LTALRIKKTL SQLSQQEGIK M


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WP1112: EPO Receptor Signaling

Related Genes :
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Acvr1b Acvrlk4 Alk4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[BMPR1A ACVRLK3 ALK3] Bone morphogenetic protein receptor type-1A (BMP type-1A receptor) (BMPR-1A) (EC 2.7.11.30) (Activin receptor-like kinase 3) (ALK-3) (Serine/threonine-protein kinase receptor R5) (SKR5) (CD antigen CD292)
[ACVR1B ACVRLK4 ALK4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Acvr1b Alk4] Activin receptor type-1B (EC 2.7.11.30) (Activin receptor type IB) (ACTR-IB) (Activin receptor-like kinase 4) (ALK-4) (Serine/threonine-protein kinase receptor R2) (SKR2)
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)

Bibliography :
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