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TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

 TGFR1_BOVIN             Reviewed;         499 AA.
O46680;
31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
01-JUN-1998, sequence version 1.
26-FEB-2020, entry version 152.
RecName: Full=TGF-beta receptor type-1;
Short=TGFR-1;
EC=2.7.11.30;
AltName: Full=TGF-beta type I receptor;
AltName: Full=Transforming growth factor-beta receptor type I;
Short=TGF-beta receptor type I;
Short=TbetaR-I;
Flags: Precursor;
Name=TGFBR1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Placenta;
PubMed=9406190;
DOI=10.1002/(sici)1098-2795(199801)49:1<1::aid-mrd1>3.0.co;2-u;
Roelen B.A.J., Van Eijk M.J.T., Van Rooijen M.A., Bevers M.M., Larson J.H.,
Lewin H.A., Mummery C.L.;
"Molecular cloning, genetic mapping, and developmental expression of a
bovine transforming growth factor beta (TGF-beta) type I receptor.";
Mol. Reprod. Dev. 49:1-9(1998).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-
beta type II serine/threonine kinase receptor, TGFBR2, the non-
promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to
the cytoplasm and is thus regulating a plethora of physiological and
pathological processes including cell cycle arrest in epithelial and
hematopoietic cells, control of mesenchymal cell proliferation and
differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor
complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound
to the cytokine dimer results in the phosphorylation and the activation
of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and interacts
with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the
nucleus where it modulates the transcription of the TGF-beta-regulated
genes. This constitutes the canonical SMAD-dependent TGF-beta signaling
cascade. Also involved in non-canonical, SMAD-independent TGF-beta
signaling pathways. For instance, TGFBR1 induces TRAF6
autoubiquitination which in turn results in MAP3K7 ubiquitination and
activation to trigger apoptosis. Also regulates epithelial to
mesenchymal transition through a SMAD-independent signaling pathway
through PARD6A phosphorylation and activation (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-
phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-
COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Kept in an inactive conformation by FKBP1A
preventing receptor activation in absence of ligand. CD109 is another
inhibitor of the receptor (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- SUBUNIT: Homodimer; in the endoplasmic reticulum but also at the cell
membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands
assemble a functional receptor composed of two TGFBR1 and TGFBR2
heterodimers to form a ligand-receptor heterohexamer. The respective
affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics
of assembly of the receptor and may explain the different biological
activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits
TGF-beta receptor activation in keratinocytes. Interacts with RBPMS.
Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1
phosphorylation by TGFBR2 and stabilizes it in the inactive
conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits
SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and
MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A;
involved in TGF-beta induced epithelial to mesenchymal transition.
Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L,
SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts
with USP15 and VPS39. Interacts with SDCBP (via C-terminus). Interacts
with CAV1 and this interaction is impaired in the presence of SDCBP (By
similarity). Interacts with APPL1; interaction is TGF beta dependent;
mediates trafficking of the TGFBR1 from the endosomes to the nucleus
via microtubules in a TRAF6-dependent manner (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36897};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P36897}.
Cell junction, tight junction {ECO:0000250|UniProtKB:P36897}. Membrane
raft {ECO:0000250|UniProtKB:P36897}. Cell surface
{ECO:0000250|UniProtKB:P36897}.
-!- PTM: Phosphorylated at basal levels in the absence of ligand. Activated
upon phosphorylation by TGFBR2, mainly in the GS domain.
Phosphorylation in the GS domain abrogates FKBP1A-binding (By
similarity). {ECO:0000250|UniProtKB:P36897}.
-!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P36897}.
-!- PTM: Ubiquitinated; undergoes ubiquitination catalyzed by several E3
ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the
proteasomal and/or lysosomal degradation of the receptor thereby
negatively regulating its activity. Deubiquitinated by USP15, leading
to stabilization of the protein and enhanced TGF-beta signal. Its
ubiquitination and proteasome-mediated degradation is negatively
regulated by SDCBP (By similarity). {ECO:0000250|UniProtKB:P36897}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; U97485; AAC02717.1; -; mRNA.
RefSeq; NP_777046.1; NM_174621.2.
STRING; 9913.ENSBTAP00000024010; -.
PaxDb; O46680; -.
PRIDE; O46680; -.
Ensembl; ENSBTAT00000024010; ENSBTAP00000024010; ENSBTAG00000018035.
GeneID; 282382; -.
KEGG; bta:282382; -.
CTD; 7046; -.
VGNC; VGNC:35804; TGFBR1.
eggNOG; KOG2052; Eukaryota.
eggNOG; ENOG410XQT0; LUCA.
GeneTree; ENSGT00940000156394; -.
HOGENOM; CLU_000288_8_1_1; -.
InParanoid; O46680; -.
KO; K04674; -.
OMA; LMIYICH; -.
OrthoDB; 776697at2759; -.
TreeFam; TF314724; -.
Reactome; R-BTA-2173788; Downregulation of TGF-beta receptor signaling.
Reactome; R-BTA-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-BTA-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
Reactome; R-BTA-5689880; Ub-specific processing proteases.
Proteomes; UP000009136; Chromosome 8.
Bgee; ENSBTAG00000018035; Expressed in spleen and 9 other tissues.
ExpressionAtlas; O46680; baseline and differential.
GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
GO; GO:0005623; C:cell; ISS:AgBase.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0016020; C:membrane; ISS:AgBase.
GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0016361; F:activin receptor activity, type I; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0070411; F:I-SMAD binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
GO; GO:0050431; F:transforming growth factor beta binding; ISS:AgBase.
GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; ISS:AgBase.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0000186; P:activation of MAPKK activity; IEA:Ensembl.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:AgBase.
GO; GO:0060978; P:angiogenesis involved in coronary vascular morphogenesis; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0001824; P:blastocyst development; IEA:Ensembl.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IDA:BHF-UCL.
GO; GO:0030199; P:collagen fibril organization; IEA:Ensembl.
GO; GO:0060982; P:coronary artery morphogenesis; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IEA:Ensembl.
GO; GO:0042118; P:endothelial cell activation; ISS:AgBase.
GO; GO:0043542; P:endothelial cell migration; IEA:Ensembl.
GO; GO:1905223; P:epicardium morphogenesis; IEA:Ensembl.
GO; GO:0008354; P:germ cell migration; IEA:Ensembl.
GO; GO:0007507; P:heart development; ISS:AgBase.
GO; GO:0035556; P:intracellular signal transduction; ISS:AgBase.
GO; GO:0001822; P:kidney development; IEA:Ensembl.
GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:AgBase.
GO; GO:0032331; P:negative regulation of chondrocyte differentiation; IEA:Ensembl.
GO; GO:0001937; P:negative regulation of endothelial cell proliferation; IEA:Ensembl.
GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; IEA:Ensembl.
GO; GO:0060037; P:pharyngeal system development; IEA:Ensembl.
GO; GO:2001235; P:positive regulation of apoptotic signaling pathway; IEA:Ensembl.
GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:AgBase.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0060391; P:positive regulation of SMAD protein signal transduction; IEA:Ensembl.
GO; GO:0051496; P:positive regulation of stress fiber assembly; IEA:Ensembl.
GO; GO:1905075; P:positive regulation of tight junction disassembly; IEA:Ensembl.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
GO; GO:0060043; P:regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISS:AgBase.
GO; GO:0043393; P:regulation of protein binding; IEA:Ensembl.
GO; GO:0031396; P:regulation of protein ubiquitination; IEA:Ensembl.
GO; GO:0070723; P:response to cholesterol; IEA:Ensembl.
GO; GO:0060021; P:roof of mouth development; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:AgBase.
GO; GO:0003223; P:ventricular compact myocardium morphogenesis; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
InterPro; IPR000472; Activin_recp.
InterPro; IPR003605; GS_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF08515; TGF_beta_GS; 1.
SMART; SM00467; GS; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51256; GS; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Apoptosis; ATP-binding; Cell junction; Cell membrane; Differentiation;
Disulfide bond; Glycoprotein; Growth regulation; Isopeptide bond; Kinase;
Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Receptor; Reference proteome;
Serine/threonine-protein kinase; Signal; Tight junction; Transferase;
Transmembrane; Transmembrane helix; Ubl conjugation.
SIGNAL 1..29
/evidence="ECO:0000250"
CHAIN 30..499
/note="TGF-beta receptor type-1"
/id="PRO_0000254657"
TOPO_DOM 30..122
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 123..143
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 144..499
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 171..200
/note="GS"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00585"
DOMAIN 201..491
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 207..215
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 189..190
/note="FKBP1A-binding"
ACT_SITE 329
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 228
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 161
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 181
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 182
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 183
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 185
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 187
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
CARBOHYD 41
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 32..50
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 34..37
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 44..67
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 82..96
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 97..102
/evidence="ECO:0000250|UniProtKB:P36897"
CROSSLNK 387
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO)"
/evidence="ECO:0000250"
SEQUENCE 499 AA; 55814 MW; 7FA311693CA938CD CRC64;
MEAAAATPRP RLFLLMLAAA ATLVPEATPL QCFCHLCTKD NFTCVTDGLC FVSVTETTDK
VIHNSMCIAE IDLIPRDRPF VCAPSSKTGS ITTTYCCNQD HCNKIELPTV GKPSSGLGPV
ELAAVIAGPV CFVCISLMLM VYICHNRTVI HHRVPNEEDP SLDRPFISEG TTLKDLIYDM
TTSGSGSGLP LLVQRTIART IVLQESIGKG RFGEVWRGKW RGEEVAVKIF SSREERSWFR
EAEIYQTVML RHENILGFIA ADNKDNGTWT QLWLVSDYHE HGSLFDYLNR YTVTVEGMIK
LALSTASGLA HLHMEIVGTQ GKPAIAHRDL KSKNILVKKN GTCCIADLGL AVRHDSATDT
IDIAPNHRVG TKRYMAPEVL DDSINMKHFE SFKRADIYAM GLVFWEVARR CSIGGIHEDY
QLPYYDLVPS DPSVEEMRKV VCEQKLRPNI PNRWQSCEAL RVMAKIMREC WYANGAARLT
ALRIKKTLSQ LSQQEGIKM


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WP362: TGF-beta Receptor Signaling Pathway
WP566: canonical wnt - zebrafish
WP1045: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP1367: TGF-beta Receptor Signaling Pathway
WP809: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP474: Endochondral Ossification
WP1345: T Cell Receptor Signaling Pathway
WP1918: Signaling by Robo receptor
WP505: TGF Beta Signaling Pathway
WP871: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1004: Kit Receptor Signaling Pathway

Related Genes :
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Lefty1 Ebaf Lefty Stra3 Tgfb4] Left-right determination factor 1 (Protein lefty-1) (Lefty protein) (Stimulated by retinoic acid gene 3 protein) (Transforming growth factor beta-4) (TGF-beta-4)
[EIF3I EIF3S2 TRIP1] Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)
[Tgfbrap1] Transforming growth factor-beta receptor-associated protein 1 (TGF-beta receptor-associated protein 1) (TRAP-1) (TRAP1)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[TGFB2] Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

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