GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)

 TGFR1_PIG               Reviewed;         503 AA.
Q5CD18; Q5CD19;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
12-APR-2005, sequence version 1.
22-APR-2020, entry version 111.
RecName: Full=TGF-beta receptor type-1;
Short=TGFR-1;
EC=2.7.11.30;
AltName: Full=TGF-beta type I receptor;
AltName: Full=Transforming growth factor-beta receptor type I;
Short=TGF-beta receptor type I;
Short=TbetaR-I;
Flags: Precursor;
Name=TGFBR1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANTS SER-8 AND
VAL-417.
TISSUE=Testis;
PubMed=16341765; DOI=10.1007/s10528-005-8165-0;
Shimanuki S., Mikawa A., Miyake Y., Hamasima N., Mikawa S., Awata T.;
"Structure and polymorphism analysis of transforming growth factor beta
receptor 1 (TGFBR1) in pigs.";
Biochem. Genet. 43:491-500(2005).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-
beta type II serine/threonine kinase receptor, TGFBR2, the non-
promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to
the cytoplasm and is thus regulating a plethora of physiological and
pathological processes including cell cycle arrest in epithelial and
hematopoietic cells, control of mesenchymal cell proliferation and
differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor
complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound
to the cytokine dimer results in the phosphorylation and the activation
of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and interacts
with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the
nucleus where it modulates the transcription of the TGF-beta-regulated
genes. This constitutes the canonical SMAD-dependent TGF-beta signaling
cascade. Also involved in non-canonical, SMAD-independent TGF-beta
signaling pathways. For instance, TGFBR1 induces TRAF6
autoubiquitination which in turn results in MAP3K7 ubiquitination and
activation to trigger apoptosis. Also regulates epithelial to
mesenchymal transition through a SMAD-independent signaling pathway
through PARD6A phosphorylation and activation (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-
phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-
COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Kept in an inactive conformation by FKBP1A
preventing receptor activation in absence of ligand. CD109 is another
inhibitor of the receptor (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- SUBUNIT: Homodimer; in the endoplasmic reticulum but also at the cell
membrane. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands
assemble a functional receptor composed of two TGFBR1 and TGFBR2
heterodimers to form a ligand-receptor heterohexamer. The respective
affinity of TGBRB1 and TGFBR2 for the ligands may modulate the kinetics
of assembly of the receptor and may explain the different biological
activities of TGFB1, TGFB2 and TGFB3. Interacts with CD109; inhibits
TGF-beta receptor activation in keratinocytes. Interacts with RBPMS.
Interacts (unphosphorylated) with FKBP1A; prevents TGFBR1
phosphorylation by TGFBR2 and stabilizes it in the inactive
conformation. Interacts with SMAD2, SMAD3 and ZFYVE9; ZFYVE9 recruits
SMAD2 and SMAD3 to the TGF-beta receptor. Interacts with TRAF6 and
MAP3K7; induces MAP3K7 activation by TRAF6. Interacts with PARD6A;
involved in TGF-beta induced epithelial to mesenchymal transition.
Interacts with SMAD7, NEDD4L, SMURF1 and SMURF2; SMAD7 recruits NEDD4L,
SMURF1 and SMURF2 to the TGF-beta receptor (By similarity). Interacts
with USP15 and VPS39. Interacts with SDCBP (via C-terminus). Interacts
with CAV1 and this interaction is impaired in the presence of SDCBP (By
similarity). Interacts with APPL1; interaction is TGF beta dependent;
mediates trafficking of the TGFBR1 from the endosomes to the nucleus
via microtubules in a TRAF6-dependent manner (By similarity).
{ECO:0000250|UniProtKB:P36897}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36897};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P36897}.
Cell junction, tight junction {ECO:0000250|UniProtKB:P36897}. Membrane
raft {ECO:0000250|UniProtKB:P36897}. Cell surface
{ECO:0000250|UniProtKB:P36897}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q5CD18-1; Sequence=Displayed;
Name=2;
IsoId=Q5CD18-2; Sequence=VSP_021594;
-!- PTM: Phosphorylated at basal levels in the absence of ligand. Activated
upon phosphorylation by TGFBR2, mainly in the GS domain.
Phosphorylation in the GS domain abrogates FKBP1A-binding (By
similarity). {ECO:0000250|UniProtKB:P36897}.
-!- PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P36897}.
-!- PTM: Ubiquitinated; undergoes ubiquitination catalyzed by several E3
ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the
proteasomal and/or lysosomal degradation of the receptor thereby
negatively regulating its activity. Deubiquitinated by USP15, leading
to stabilization of the protein and enhanced TGF-beta signal. Its
ubiquitination and proteasome-mediated degradation is negatively
regulated by SDCBP (By similarity). {ECO:0000250|UniProtKB:P36897}.
-!- MISCELLANEOUS: [Isoform 2]: May be due to a competing donor splice
site. {ECO:0000305}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AB182259; BAD91022.1; -; mRNA.
EMBL; AB182260; BAD91023.1; -; mRNA.
RefSeq; NP_001033728.1; NM_001038639.1. [Q5CD18-1]
SMR; Q5CD18; -.
STRING; 9823.ENSSSCP00000029422; -.
PaxDb; Q5CD18; -.
GeneID; 396665; -.
KEGG; ssc:396665; -.
CTD; 7046; -.
eggNOG; KOG2052; Eukaryota.
eggNOG; ENOG410XQT0; LUCA.
InParanoid; Q5CD18; -.
KO; K04674; -.
Proteomes; UP000008227; Unplaced.
GO; GO:0048179; C:activin receptor complex; IBA:GO_Central.
GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
GO; GO:0005623; C:cell; ISS:AgBase.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0005768; C:endosome; ISS:UniProtKB.
GO; GO:0016020; C:membrane; ISS:AgBase.
GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0016361; F:activin receptor activity, type I; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
GO; GO:0050431; F:transforming growth factor beta binding; ISS:AgBase.
GO; GO:0005025; F:transforming growth factor beta receptor activity, type I; ISS:AgBase.
GO; GO:0032924; P:activin receptor signaling pathway; ISS:AgBase.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0042118; P:endothelial cell activation; ISS:AgBase.
GO; GO:0007507; P:heart development; ISS:AgBase.
GO; GO:0035556; P:intracellular signal transduction; ISS:AgBase.
GO; GO:0048762; P:mesenchymal cell differentiation; ISS:AgBase.
GO; GO:0007399; P:nervous system development; IBA:GO_Central.
GO; GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; ISS:AgBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:AgBase.
GO; GO:0006468; P:protein phosphorylation; IBA:GO_Central.
GO; GO:0010717; P:regulation of epithelial to mesenchymal transition; ISS:AgBase.
GO; GO:0010468; P:regulation of gene expression; ISS:AgBase.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:AgBase.
InterPro; IPR000472; Activin_recp.
InterPro; IPR003605; GS_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF01064; Activin_recp; 1.
Pfam; PF00069; Pkinase; 1.
Pfam; PF08515; TGF_beta_GS; 1.
SMART; SM00467; GS; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51256; GS; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
Alternative splicing; Apoptosis; ATP-binding; Cell junction; Cell membrane;
Differentiation; Disulfide bond; Glycoprotein; Growth regulation;
Isopeptide bond; Kinase; Magnesium; Manganese; Membrane; Metal-binding;
Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor;
Reference proteome; Serine/threonine-protein kinase; Signal;
Tight junction; Transferase; Transmembrane; Transmembrane helix;
Ubl conjugation.
SIGNAL 1..29
/evidence="ECO:0000250"
CHAIN 30..503
/note="TGF-beta receptor type-1"
/id="PRO_0000260305"
TOPO_DOM 30..126
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 127..147
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 148..503
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 175..204
/note="GS"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00585"
DOMAIN 205..495
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 211..219
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOTIF 193..194
/note="FKBP1A-binding"
ACT_SITE 333
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 232
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 165
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 185
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 186
/note="Phosphothreonine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 187
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 189
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
MOD_RES 191
/note="Phosphoserine; by TGFBR2"
/evidence="ECO:0000250|UniProtKB:P36897"
CARBOHYD 41
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 32..50
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 34..37
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 44..67
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 82..96
/evidence="ECO:0000250|UniProtKB:P36897"
DISULFID 97..102
/evidence="ECO:0000250|UniProtKB:P36897"
CROSSLNK 391
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO)"
/evidence="ECO:0000250"
VAR_SEQ 111..114
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:16341765"
/id="VSP_021594"
VARIANT 8
/note="P -> S"
/evidence="ECO:0000269|PubMed:16341765"
VARIANT 417
/note="I -> V"
/evidence="ECO:0000269|PubMed:16341765"
SEQUENCE 503 AA; 56174 MW; CFA1EEC793401A4A CRC64;
MEVAAGAPRS RLLLFVLAAT ATLAPEATAF QCFCHLCTKD NFTCVTDGLC FVSVTETTDK
VIHNSMCIAE IDLIPRDRPF VCAPSSKTGS VTTTYCCNQD HCNKIELPTV GPFPGKPPSG
LGPVELAAVI AGPVCFVCIS LMLMVYICHN RTVIHHRVPN EEDPSLDRPF ISEGTTLKDL
IYDMTTSGSG SGLPLLVQRT IARTIVLQES IGKGRFGEVW RGKWRGEEVA VKIFSSREER
SWFREAEIYQ TVMLRHENIL GFIAADNKDN GTWTQLWLVS DYHEHGSLFD YLNRYTVTVE
GMIKLALSTA SGLAHLHMEI VGTQGKPAIA HRDLKSKNIL VKKNGTCCIA DLGLAVRHDS
ATDTIDIAPN HRVGTKRYMA PEVLDDSINM KHFESFKRAD IYAMGLVFWE IARRCSIGGI
HEDYQLPYYD LVPSDPSVEE MRKVVCEQKL RPNIPNRWQS CEALRVMAKI MRECWYANGA
ARLTALRIKK TLSQLSQQEG IKM


Related products :

Catalog number Product name Quantity
EIAAB42158 Rat,Rattus norvegicus,Serine_threonine-protein kinase receptor R4,SKR4,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,Tgfbr1,TGFR-1,Transforming growth factor-beta
EIAAB42165 Homo sapiens,Human,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42157 Bos taurus,Bovine,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42164 Mouse,Mus musculus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42163 Rat,Rattus norvegicus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42156 Pig,Sus scrofa,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42162 Pig,Sus scrofa,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42159 ESK2,Mouse,Mus musculus,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,Tgfbr1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42161 Chicken,Gallus gallus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
101-M96 TGFR-1 (ALK-5) Anti-Human Host: Mouse transforming growth factor, beta receptor 1; AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4;TGF-beta receptor type-1 tbetaR-I; TGF-beta receptor typ 100
18-272-195253 TGFBR2 - Goat polyclonal to TGFBR2; EC 2.7.11.30; TGF-beta receptor type II; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TbetaR-II Polyclonal 0.05 mg
EIAAB42139 Betaglycan,Homo sapiens,Human,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42137 Betaglycan,Mouse,Mus musculus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42140 Betaglycan,Rat,Rattus norvegicus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42138 Betaglycan,Pig,Sus scrofa,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
101-M96 TGFR-1 (ALK-5), Host: Mouse, Species: Anti-Human, Synonyms: transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; LDS1A; LDS2A; TGFR-1; TGF-beta receptor type-1 100 ug
U0066h CLIA CD121 antigen-like family member B,CDw121b,Homo sapiens,Human,IL1R2,IL-1R-2,IL1RB,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type 96T
U0066r CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norve 96T
E0066r ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norv 96T
E0066m ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscu 96T
U0066m CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscul 96T
E0066r ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus 96T
E0066m ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus 96T
H7658 Transforming growth factor beta receptor type 3 (TGFBR3), Pig, ELISA Kit 96T
CSB-EL023453RA Rat Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit 96T