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TGF-beta receptor type-2 (TGFR-2) (EC 2 7 11 30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

 TGFR2_CHICK             Reviewed;         557 AA.
Q90999;
16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
26-FEB-2020, entry version 159.
RecName: Full=TGF-beta receptor type-2;
Short=TGFR-2;
EC=2.7.11.30;
AltName: Full=TGF-beta type II receptor;
AltName: Full=Transforming growth factor-beta receptor type II;
Short=TGF-beta receptor type II;
Short=TbetaR-II;
Flags: Precursor;
Name=TGFBR2;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH TGF-BETA, AND TISSUE
SPECIFICITY.
TISSUE=Embryonic brain;
PubMed=8167376; DOI=10.1002/aja.1001990103;
Barnett J.V., Moustakas A., Lin W., Wang X.-F., Lin H.Y., Galper J.B.,
Maas R.L.;
"Cloning and developmental expression of the chick type II and type III TGF
beta receptors.";
Dev. Dyn. 199:12-27(1994).
[2]
STRUCTURE BY NMR OF 36-142, AND DISULFIDE BONDS.
PubMed=12589747; DOI=10.1016/s0022-2836(03)00023-8;
Marlow M.S., Brown C.B., Barnett J.V., Krezel A.M.;
"Solution structure of the chick TGFbeta type II receptor ligand-binding
domain.";
J. Mol. Biol. 326:989-997(2003).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-
beta type I serine/threonine kinase receptor, TGFBR1, the non-
promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to
the cytoplasm and is thus regulating a plethora of physiological and
pathological processes including cell cycle arrest in epithelial and
hematopoietic cells, control of mesenchymal cell proliferation and
differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor
complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound
to the cytokine dimer results in the phosphorylation and the activation
of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and interacts
with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the
nucleus where it modulates the transcription of the TGF-beta-regulated
genes. This constitutes the canonical SMAD-dependent TGF-beta signaling
cascade. Also involved in non-canonical, SMAD-independent TGF-beta
signaling pathways (By similarity). {ECO:0000250|UniProtKB:P37173,
ECO:0000269|PubMed:8167376}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-
phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-
COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- SUBUNIT: Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands
assemble a functional receptor composed of two TGFBR1 and TGFBR2
heterodimers to form a ligand-receptor heterohexamer.
{ECO:0000250|UniProtKB:P37173}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P37173};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P37173}.
Membrane raft {ECO:0000250|UniProtKB:P37173}.
-!- TISSUE SPECIFICITY: Detected at low levels in embryonic heart, brain
and lung. Detected at high levels in hatchling heart and lung.
{ECO:0000269|PubMed:8167376}.
-!- PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; L18784; AAA49091.1; -; mRNA.
PIR; I50429; I50429.
RefSeq; NP_990759.1; NM_205428.1.
PDB; 1KS6; NMR; -; A=36-142.
PDBsum; 1KS6; -.
SMR; Q90999; -.
IntAct; Q90999; 1.
STRING; 9031.ENSGALP00000018634; -.
PaxDb; Q90999; -.
Ensembl; ENSGALT00000037691; ENSGALP00000036896; ENSGALG00000011442.
Ensembl; ENSGALT00000092202; ENSGALP00000074168; ENSGALG00000011442.
GeneID; 396399; -.
KEGG; gga:396399; -.
CTD; 7048; -.
eggNOG; KOG3653; Eukaryota.
eggNOG; ENOG410XS2Z; LUCA.
GeneTree; ENSGT00940000157527; -.
HOGENOM; CLU_000288_8_3_1; -.
InParanoid; Q90999; -.
KO; K04388; -.
OMA; HQGIQTV; -.
OrthoDB; 426838at2759; -.
PhylomeDB; Q90999; -.
TreeFam; TF314724; -.
Reactome; R-GGA-2173788; Downregulation of TGF-beta receptor signaling.
Reactome; R-GGA-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-GGA-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
EvolutionaryTrace; Q90999; -.
PRO; PR:Q90999; -.
Proteomes; UP000000539; Chromosome 2.
Bgee; ENSGALG00000011442; Expressed in spleen and 10 other tissues.
ExpressionAtlas; Q90999; baseline and differential.
GO; GO:0005901; C:caveola; ISA:AgBase.
GO; GO:0005623; C:cell; IDA:AgBase.
GO; GO:0009897; C:external side of plasma membrane; ISA:AgBase.
GO; GO:0031012; C:extracellular matrix; ISM:AgBase.
GO; GO:0016021; C:integral component of membrane; ISA:AgBase.
GO; GO:0016020; C:membrane; IDA:AgBase.
GO; GO:0045121; C:membrane raft; ISA:AgBase.
GO; GO:0005886; C:plasma membrane; ISA:AgBase.
GO; GO:0043235; C:receptor complex; ISA:AgBase.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0017002; F:activin-activated receptor activity; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005539; F:glycosaminoglycan binding; ISA:AgBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0046332; F:SMAD binding; IBA:GO_Central.
GO; GO:0050431; F:transforming growth factor beta binding; IDA:AgBase.
GO; GO:0005026; F:transforming growth factor beta receptor activity, type II; IEA:InterPro.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; ISA:AgBase.
GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; ISA:AgBase.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IDA:AgBase.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0006915; P:apoptotic process; ISA:AgBase.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; IEP:AgBase.
GO; GO:0001775; P:cell activation; IMP:AgBase.
GO; GO:0016477; P:cell migration; TAS:AgBase.
GO; GO:0045216; P:cell-cell junction organization; ISM:AgBase.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0070483; P:detection of hypoxia; ISM:AgBase.
GO; GO:0048568; P:embryonic organ development; IEP:AgBase.
GO; GO:0001654; P:eye development; IEP:AgBase.
GO; GO:0060325; P:face morphogenesis; ISM:AgBase.
GO; GO:0007507; P:heart development; IDA:AgBase.
GO; GO:0030324; P:lung development; IEP:AgBase.
GO; GO:0048762; P:mesenchymal cell differentiation; IMP:AgBase.
GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISM:AgBase.
GO; GO:0030335; P:positive regulation of cell migration; IMP:AgBase.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IMP:AgBase.
GO; GO:0010628; P:positive regulation of gene expression; TAS:AgBase.
GO; GO:0050714; P:positive regulation of protein secretion; ISM:AgBase.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISA:AgBase.
GO; GO:0051496; P:positive regulation of stress fiber assembly; ISS:AgBase.
GO; GO:1905075; P:positive regulation of tight junction disassembly; ISS:AgBase.
GO; GO:0006468; P:protein phosphorylation; ISA:AgBase.
GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
GO; GO:0070723; P:response to cholesterol; ISA:AgBase.
GO; GO:0042493; P:response to drug; ISA:AgBase.
GO; GO:0001666; P:response to hypoxia; ISM:AgBase.
GO; GO:0032570; P:response to progesterone; ISM:AgBase.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISA:AgBase.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
InterPro; IPR017194; Transform_growth_fac-b_typ-2.
InterPro; IPR015013; Transforming_GF_b_rcpt_2_ecto.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF08917; ecTbetaR2; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF037393; TGFRII; 1.
PRINTS; PR00653; ACTIVIN2R.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
3D-structure; Apoptosis; ATP-binding; Cell membrane; Differentiation;
Disulfide bond; Glycoprotein; Growth regulation; Kinase; Magnesium;
Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein;
Receptor; Reference proteome; Serine/threonine-protein kinase; Signal;
Transferase; Transmembrane; Transmembrane helix.
SIGNAL 1..23
/evidence="ECO:0000255"
CHAIN 24..557
/note="TGF-beta receptor type-2"
/id="PRO_5000142219"
TOPO_DOM 24..155
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 156..176
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 177..557
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 234..537
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 240..248
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ACT_SITE 369
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 267
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
CARBOHYD 62
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 84
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 41..74
/evidence="ECO:0000269|PubMed:12589747"
DISULFID 44..61
/evidence="ECO:0000269|PubMed:12589747"
DISULFID 51..57
/evidence="ECO:0000269|PubMed:12589747"
DISULFID 67..91
/evidence="ECO:0000269|PubMed:12589747"
DISULFID 111..126
/evidence="ECO:0000269|PubMed:12589747"
DISULFID 128..133
/evidence="ECO:0000269|PubMed:12589747"
STRAND 44..48
/evidence="ECO:0000244|PDB:1KS6"
STRAND 69..71
/evidence="ECO:0000244|PDB:1KS6"
STRAND 74..81
/evidence="ECO:0000244|PDB:1KS6"
STRAND 84..90
/evidence="ECO:0000244|PDB:1KS6"
STRAND 106..110
/evidence="ECO:0000244|PDB:1KS6"
STRAND 114..116
/evidence="ECO:0000244|PDB:1KS6"
STRAND 119..132
/evidence="ECO:0000244|PDB:1KS6"
TURN 133..135
/evidence="ECO:0000244|PDB:1KS6"
SEQUENCE 557 AA; 63308 MW; 0C578ABFAB357DF1 CRC64;
MPPRLRPLLL RVSLWVLVGS SSPALLHDRS KENGLQLPRL CKFCDVKATT CSNQDQCKSN
CNITSICEKN NEVCAAVWRR NDENVTLETI CHDPQKRLYG HMLDDSSSEQ CVMKEKKDDG
GLMFMCSCTG EECNDVLIFS AIDPHKPEEK DEISKVTIIS LVPLLVISVA VIVIFYAYRT
HKKRKLNKAW EKNVKPKKHK DCSDVCAIML DDDHSDISST CANNINHNTE LLPIELDIVV
GKGRFAEVYK AKLKQNTSEQ YETVAVKIFP YEEYASWKTE KDIFSDVNLK HENILQFLTA
EERKTDLGKQ YWLITAFHAR GNLQEYLTRH IISWEDLWKL GGSLARGIAH LHSDHTPCGR
PKTPIVHRDL KSSNILVKND LTCCLCDFGL SLRLDPSLSV DDLANSGQVG TARYMAPEVL
ESRMNLENME SFKQTDVYSM ALVLWEMTSR CNGVGEVKEY EPPFGSKVRE HPCVESMKDN
VLRDRGRPEI PSSWLNHQGI QMVCETLIEC WDHDPEARLT AQCVAERFSE FKHHDKLSGR
SCSEEKIPED GSVTTAK


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[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
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[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGFB2] Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024] Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[EIF3I EIF3S2 TRIP1] Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

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