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TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)

 TGFR2_MOUSE             Reviewed;         592 AA.
Q62312; Q63947;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
22-APR-2020, entry version 184.
RecName: Full=TGF-beta receptor type-2;
Short=TGFR-2;
EC=2.7.11.30;
AltName: Full=TGF-beta type II receptor;
AltName: Full=Transforming growth factor-beta receptor type II;
Short=TGF-beta receptor type II;
Short=TbetaR-II;
Flags: Precursor;
Name=Tgfbr2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND ALTERNATIVE SPLICING.
TISSUE=Brain;
PubMed=7957954; DOI=10.1016/0014-5793(94)01156-7;
Suzuki A., Shioda N., Maeda T., Tada M., Ueno N.;
"Cloning of an isoform of mouse TGF-beta type II receptor gene.";
FEBS Lett. 355:19-22(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8119124;
Lawler S., Candia A.F., Ebner R., Shum L., Lopez A.R., Moses H.L.,
Wright C.V., Derynck R.;
"The murine type II TGF-beta receptor has a coincident embryonic expression
and binding preference for TGF-beta 1.";
Development 120:165-175(1994).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM RII-2).
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-578, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434 AND SER-578, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Kidney, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-
beta type I serine/threonine kinase receptor, TGFBR1, the non-
promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3.
Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to
the cytoplasm and is thus regulating a plethora of physiological and
pathological processes including cell cycle arrest in epithelial and
hematopoietic cells, control of mesenchymal cell proliferation and
differentiation, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. The formation of the receptor
complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound
to the cytokine dimer results in the phosphorylation and the activation
of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1
phosphorylates SMAD2 which dissociates from the receptor and interacts
with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the
nucleus where it modulates the transcription of the TGF-beta-regulated
genes. This constitutes the canonical SMAD-dependent TGF-beta signaling
cascade. Also involved in non-canonical, SMAD-independent TGF-beta
signaling pathways (By similarity). {ECO:0000250|UniProtKB:P37173}.
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-threonine + ATP = [receptor-protein]-O-
phospho-L-threonine + ADP + H(+); Xref=Rhea:RHEA:44880, Rhea:RHEA-
COMP:11024, Rhea:RHEA-COMP:11025, ChEBI:CHEBI:15378,
ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- CATALYTIC ACTIVITY:
Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
ChEBI:CHEBI:456216; EC=2.7.11.30;
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- SUBUNIT: Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric
ligands assemble a functional receptor composed of two TGFBR1 and
TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The
respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate
the kinetics of assembly of the receptor and may explain the different
biological activities of TGFB1, TGFB2 and TGFB3. Interacts with DAXX.
Interacts with TCTEX1D4. Interacts with ZFYVE9; ZFYVE9 recruits SMAD2
and SMAD3 to the TGF-beta receptor (By similarity). Interacts with and
is activated by SCUBE3; this interaction does not affect TGFB1-binding
to TGFBR2 (By similarity). Interacts with VPS39; this interaction is
independent of the receptor kinase activity and of the presence of TGF-
beta (By similarity). Interacts with CLU (By similarity).
{ECO:0000250|UniProtKB:P37173}.
-!- INTERACTION:
Q62312; P55284: Cdh5; NbExp=4; IntAct=EBI-2899332, EBI-7087433;
Q62312; Q8TDM6: DLG5; Xeno; NbExp=3; IntAct=EBI-2899332, EBI-715138;
Q62312; P98083-1: Shc1; NbExp=2; IntAct=EBI-2899332, EBI-7533258;
Q62312; P98083-2: Shc1; NbExp=3; IntAct=EBI-2899332, EBI-1019301;
Q62312; Q64729: Tgfbr1; NbExp=3; IntAct=EBI-2899332, EBI-2899393;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P37173};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:P37173}.
Membrane raft {ECO:0000250|UniProtKB:P37173}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=RII-2;
IsoId=Q62312-1; Sequence=Displayed;
Name=RII-1;
IsoId=Q62312-2; Sequence=VSP_004955, VSP_004956;
-!- TISSUE SPECIFICITY: Widely expressed in adult. Expressed primarily in
mesenchyme and epidermis of the midgestational fetus.
-!- PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain.
{ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
protein kinase family. TGFB receptor subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; D32072; BAA06840.1; -; mRNA.
EMBL; S69114; AAB30100.2; -; mRNA.
EMBL; BC052629; -; NOT_ANNOTATED_CDS; mRNA.
CCDS; CCDS23601.1; -. [Q62312-1]
CCDS; CCDS23602.1; -. [Q62312-2]
PIR; S51371; S51371.
RefSeq; NP_033397.3; NM_009371.3. [Q62312-1]
SMR; Q62312; -.
BioGrid; 204164; 4.
ComplexPortal; CPX-823; TGF-beta-1-TGFR complex.
ComplexPortal; CPX-826; TGF-beta-3-TGFR complex.
ComplexPortal; CPX-836; TGF-beta-2-TGFR complex.
CORUM; Q62312; -.
DIP; DIP-44605N; -.
IntAct; Q62312; 9.
MINT; Q62312; -.
STRING; 10090.ENSMUSP00000062333; -.
iPTMnet; Q62312; -.
PhosphoSitePlus; Q62312; -.
SwissPalm; Q62312; -.
PaxDb; Q62312; -.
PRIDE; Q62312; -.
Antibodypedia; 11570; 783 antibodies.
Ensembl; ENSMUST00000035014; ENSMUSP00000035014; ENSMUSG00000032440. [Q62312-2]
Ensembl; ENSMUST00000061101; ENSMUSP00000062333; ENSMUSG00000032440. [Q62312-1]
GeneID; 21813; -.
KEGG; mmu:21813; -.
UCSC; uc009rys.2; mouse. [Q62312-1]
UCSC; uc009ryt.2; mouse. [Q62312-2]
CTD; 7048; -.
MGI; MGI:98729; Tgfbr2.
eggNOG; KOG3653; Eukaryota.
eggNOG; ENOG410XS2Z; LUCA.
GeneTree; ENSGT00940000157527; -.
HOGENOM; CLU_000288_8_3_1; -.
InParanoid; Q62312; -.
KO; K04388; -.
OMA; HQGIQTV; -.
PhylomeDB; Q62312; -.
TreeFam; TF314724; -.
BRENDA; 2.7.10.2; 3474.
Reactome; R-MMU-2173788; Downregulation of TGF-beta receptor signaling.
Reactome; R-MMU-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-MMU-2173791; TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition).
ChiTaRS; Tgfbr2; mouse.
PRO; PR:Q62312; -.
Proteomes; UP000000589; Chromosome 9.
RNAct; Q62312; protein.
Bgee; ENSMUSG00000032440; Expressed in uterus and 316 other tissues.
ExpressionAtlas; Q62312; baseline and differential.
Genevisible; Q62312; MM.
GO; GO:0005901; C:caveola; ISO:MGI.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
GO; GO:0016021; C:integral component of membrane; ISO:MGI.
GO; GO:0005887; C:integral component of plasma membrane; ISO:MGI.
GO; GO:0045121; C:membrane raft; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0043235; C:receptor complex; ISO:MGI.
GO; GO:0048185; F:activin binding; IBA:GO_Central.
GO; GO:0017002; F:activin-activated receptor activity; IBA:GO_Central.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0005539; F:glycosaminoglycan binding; ISO:MGI.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; ISO:MGI.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0046332; F:SMAD binding; IDA:BHF-UCL.
GO; GO:0050431; F:transforming growth factor beta binding; IPI:MGI.
GO; GO:0005026; F:transforming growth factor beta receptor activity, type II; ISO:MGI.
GO; GO:0005024; F:transforming growth factor beta-activated receptor activity; IGI:MGI.
GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; ISO:MGI.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; ISO:MGI.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISO:MGI.
GO; GO:0032147; P:activation of protein kinase activity; IDA:MGI.
GO; GO:0007568; P:aging; IEA:Ensembl.
GO; GO:0009887; P:animal organ morphogenesis; ISO:MGI.
GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; ISO:MGI.
GO; GO:0003181; P:atrioventricular valve morphogenesis; IMP:BHF-UCL.
GO; GO:0007420; P:brain development; IMP:BHF-UCL.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IMP:MGI.
GO; GO:0060433; P:bronchus development; IMP:MGI.
GO; GO:0060434; P:bronchus morphogenesis; IMP:MGI.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; IMP:BHF-UCL.
GO; GO:0051216; P:cartilage development; IMP:UniProtKB.
GO; GO:0071363; P:cellular response to growth factor stimulus; IBA:GO_Central.
GO; GO:0007182; P:common-partner SMAD protein phosphorylation; ISO:MGI.
GO; GO:0048565; P:digestive tract development; IEA:Ensembl.
GO; GO:0007566; P:embryo implantation; IEA:Ensembl.
GO; GO:0048701; P:embryonic cranial skeleton morphogenesis; IMP:BHF-UCL.
GO; GO:0035162; P:embryonic hemopoiesis; IMP:BHF-UCL.
GO; GO:0003274; P:endocardial cushion fusion; IMP:BHF-UCL.
GO; GO:0007369; P:gastrulation; IMP:MGI.
GO; GO:0003430; P:growth plate cartilage chondrocyte growth; IMP:MGI.
GO; GO:0003417; P:growth plate cartilage development; IGI:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0001947; P:heart looping; IMP:BHF-UCL.
GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
GO; GO:1905317; P:inferior endocardial cushion morphogenesis; IMP:BHF-UCL.
GO; GO:0002088; P:lens development in camera-type eye; IMP:MGI.
GO; GO:1990086; P:lens fiber cell apoptotic process; IDA:MGI.
GO; GO:0030324; P:lung development; IMP:MGI.
GO; GO:0060463; P:lung lobe morphogenesis; IMP:MGI.
GO; GO:0060425; P:lung morphogenesis; IMP:MGI.
GO; GO:0060443; P:mammary gland morphogenesis; IMP:MGI.
GO; GO:0003149; P:membranous septum morphogenesis; IMP:BHF-UCL.
GO; GO:1990428; P:miRNA transport; IMP:BHF-UCL.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI.
GO; GO:0060044; P:negative regulation of cardiac muscle cell proliferation; ISO:MGI.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
GO; GO:0007219; P:Notch signaling pathway; IDA:MGI.
GO; GO:0003151; P:outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0003148; P:outflow tract septum morphogenesis; IMP:BHF-UCL.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; ISO:MGI.
GO; GO:0018105; P:peptidyl-serine phosphorylation; ISO:MGI.
GO; GO:0018107; P:peptidyl-threonine phosphorylation; ISO:MGI.
GO; GO:0045766; P:positive regulation of angiogenesis; IGI:MGI.
GO; GO:0002663; P:positive regulation of B cell tolerance induction; IMP:MGI.
GO; GO:2000563; P:positive regulation of CD4-positive, alpha-beta T cell proliferation; ISO:MGI.
GO; GO:0010634; P:positive regulation of epithelial cell migration; IMP:MGI.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISO:MGI.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0002053; P:positive regulation of mesenchymal cell proliferation; IMP:BHF-UCL.
GO; GO:0051138; P:positive regulation of NK T cell differentiation; IMP:MGI.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; ISO:MGI.
GO; GO:0043415; P:positive regulation of skeletal muscle tissue regeneration; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; ISO:MGI.
GO; GO:0002666; P:positive regulation of T cell tolerance induction; IMP:MGI.
GO; GO:0002651; P:positive regulation of tolerance induction to self antigen; IMP:MGI.
GO; GO:0006468; P:protein phosphorylation; ISO:MGI.
GO; GO:0006898; P:receptor-mediated endocytosis; ISO:MGI.
GO; GO:0042127; P:regulation of cell population proliferation; IMP:MGI.
GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
GO; GO:0070723; P:response to cholesterol; IDA:BHF-UCL.
GO; GO:0042493; P:response to drug; ISO:MGI.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0009612; P:response to mechanical stimulus; IEA:Ensembl.
GO; GO:0007584; P:response to nutrient; IEA:Ensembl.
GO; GO:0048545; P:response to steroid hormone; IEA:Ensembl.
GO; GO:0062009; P:secondary palate development; IMP:BHF-UCL.
GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
GO; GO:0060440; P:trachea formation; IMP:MGI.
GO; GO:0060439; P:trachea morphogenesis; IMP:MGI.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI.
GO; GO:0003186; P:tricuspid valve morphogenesis; IMP:BHF-UCL.
GO; GO:0001570; P:vasculogenesis; IMP:BHF-UCL.
GO; GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL.
GO; GO:0042060; P:wound healing; IEA:Ensembl.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR000333; TGFB_receptor.
InterPro; IPR017194; Transform_growth_fac-b_typ-2.
InterPro; IPR015013; Transforming_GF_b_rcpt_2_ecto.
PANTHER; PTHR23255; PTHR23255; 1.
Pfam; PF08917; ecTbetaR2; 1.
Pfam; PF07714; Pkinase_Tyr; 1.
PIRSF; PIRSF037393; TGFRII; 1.
PRINTS; PR00653; ACTIVIN2R.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Alternative splicing; Apoptosis; ATP-binding; Cell membrane;
Differentiation; Disulfide bond; Glycoprotein; Growth regulation; Kinase;
Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding;
Phosphoprotein; Receptor; Reference proteome;
Serine/threonine-protein kinase; Signal; Transferase; Transmembrane;
Transmembrane helix.
SIGNAL 1..23
/evidence="ECO:0000255"
CHAIN 24..592
/note="TGF-beta receptor type-2"
/id="PRO_0000024427"
TOPO_DOM 24..184
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 185..214
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 215..592
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 269..569
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 275..283
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ACT_SITE 404
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 302
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 434
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 573
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P37173"
MOD_RES 578
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079"
CARBOHYD 48
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 95
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 119
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 76..109
/evidence="ECO:0000250|UniProtKB:P37173"
DISULFID 79..96
/evidence="ECO:0000250|UniProtKB:P37173"
DISULFID 86..92
/evidence="ECO:0000250|UniProtKB:P37173"
DISULFID 102..126
/evidence="ECO:0000250|UniProtKB:P37173"
DISULFID 146..161
/evidence="ECO:0000250|UniProtKB:P37173"
DISULFID 163..168
/evidence="ECO:0000250|UniProtKB:P37173"
VAR_SEQ 32..56
/note="Missing (in isoform RII-1)"
/evidence="ECO:0000305"
/id="VSP_004955"
VAR_SEQ 57
/note="F -> V (in isoform RII-1)"
/evidence="ECO:0000305"
/id="VSP_004956"
CONFLICT 8
/note="G -> A (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 117
/note="D -> N (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 354
/note="A -> R (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 440..443
/note="NSGQ -> KQRE (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 486
/note="C -> W (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 506
/note="H -> P (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
CONFLICT 569..570
/note="PE -> MD (in Ref. 2; AAB30100)"
/evidence="ECO:0000305"
SEQUENCE 592 AA; 67122 MW; 1A12D58550921F5E CRC64;
MGRGLLRGLW PLHIVLWTRI ASTIPPHVPK SDVEMEAQKD ASIHLSCNRT IHPLKHFNSD
VMASDNGGAV KLPQLCKFCD VRLSTCDNQK SCMSNCSITA ICEKPHEVCV AVWRKNDKNI
TLETVCHDPK LTYHGFTLED AASPKCVMKE KKRAGETFFM CACNMEECND YIIFSEEYTT
SSPDLLLVII QVTGVSLLPP LGIAIAVIII FYCYRVHRQQ KLSPSWESSK PRKLMDFSDN
CAIILEDDRS DISSTCANNI NHNTELLPIE LDTLVGKGRF AEVYKAKLKQ NTSEQFETVA
VKIFPYEEYS SWKTEKDIFS DINLKHENIL QFLTAEERKT ELGKQYWLIT AFHAKGNLQE
YLTRHVISWE DLRKLGSSLA RGIAHLHSDH TPCGRPKMPI VHRDLKSSNI LVKNDLTCCL
CDFGLSLRLD PTLSVDDLAN SGQVGTARYM APEVLESRMN LENVESFKQT DVYSMALVLW
EMTSRCNAVG EVKDYEPPFG SKVREHPCVE SMKDSVLRDR GRPEIPSFWL NHQGIQIVCE
TLTECWDHDP EARLTAQCVA ERFSELEHPE RLSGRSCSQE KIPEDGSLNT TK


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EIAAB42164 Mouse,Mus musculus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42163 Rat,Rattus norvegicus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,Tgfbr2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42156 Pig,Sus scrofa,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,TGF-beta type I receptor,TGFBR1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42162 Pig,Sus scrofa,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
EIAAB42159 ESK2,Mouse,Mus musculus,TbetaR-I,TGF-beta receptor type I,TGF-beta receptor type-1,Tgfbr1,TGFR-1,Transforming growth factor-beta receptor type I
EIAAB42161 Chicken,Gallus gallus,TbetaR-II,TGF-beta receptor type II,TGF-beta receptor type-2,TGF-beta type II receptor,TGFBR2,TGFR-2,Transforming growth factor-beta receptor type II
101-M96 TGFR-1 (ALK-5) Anti-Human Host: Mouse transforming growth factor, beta receptor 1; AAT5; ALK5; MSSE; SKR4; ALK-5; LDS1A; LDS2A; TGFR-1; ACVRLK4;TGF-beta receptor type-1 tbetaR-I; TGF-beta receptor typ 100
18-272-195253 TGFBR2 - Goat polyclonal to TGFBR2; EC 2.7.11.30; TGF-beta receptor type II; TGFR-2; TGF-beta type II receptor; Transforming growth factor-beta receptor type II; TbetaR-II Polyclonal 0.05 mg
EIAAB42139 Betaglycan,Homo sapiens,Human,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42137 Betaglycan,Mouse,Mus musculus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42140 Betaglycan,Rat,Rattus norvegicus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42138 Betaglycan,Pig,Sus scrofa,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
101-M96 TGFR-1 (ALK-5), Host: Mouse, Species: Anti-Human, Synonyms: transforming growth factor, beta receptor 1; AAT5; ALK5; SKR4; LDS1A; LDS2A; TGFR-1; TGF-beta receptor type-1 100 ug
U0066h CLIA CD121 antigen-like family member B,CDw121b,Homo sapiens,Human,IL1R2,IL-1R-2,IL1RB,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type 96T
U0066r CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norve 96T
E0066r ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus norv 96T
E0066m ELISA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscu 96T
U0066m CLIA CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus muscul 96T
E0066r ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Rat,Rattus 96T
E0066m ELISA kit CD121 antigen-like family member B,Il1r2,Il-1r2,IL-1R-2,Il1rb,IL-1R-beta,IL-1RT2,IL-1RT-2,Interleukin-1 receptor beta,Interleukin-1 receptor type 2,Interleukin-1 receptor type II,Mouse,Mus 96T
H7658 Transforming growth factor beta receptor type 3 (TGFBR3), Pig, ELISA Kit 96T
CSB-EL023453RA Rat Transforming growth factor beta receptor type 3(TGFBR3) ELISA kit 96T
Pathways :
WP258: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP566: canonical wnt - zebrafish
WP1045: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP809: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP474: Endochondral Ossification
WP219: Cytoplasmic tRNA Synthetases
WP39: Fatty Acid Beta Oxidation 1
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP989: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1121: Kit Receptor Signaling Pathway

Related Genes :
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[ACVR1 ACVRLK2] Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I)
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[TGFB2] Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024] Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[EIF3I EIF3S2 TRIP1] Eukaryotic translation initiation factor 3 subunit I (eIF3i) (Eukaryotic translation initiation factor 3 subunit 2) (TGF-beta receptor-interacting protein 1) (TRIP-1) (eIF-3-beta) (eIF3 p36)
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[BMPR2 PPH1] Bone morphogenetic protein receptor type-2 (BMP type-2 receptor) (BMPR-2) (EC 2.7.11.30) (Bone morphogenetic protein receptor type II) (BMP type II receptor) (BMPR-II)
[Pdgfrb Pdgfr Pdgfr1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)

Bibliography :