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TIMELESS isoform 1 (Timeless circadian regulator) (Timeless homolog)

 H2R1D2_PANTR            Unreviewed;      1209 AA.
H2R1D2; A0A2J8Q1R8;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
13-FEB-2019, entry version 42.
SubName: Full=TIMELESS isoform 1 {ECO:0000313|EMBL:PNI90203.1};
SubName: Full=Timeless circadian regulator {ECO:0000313|Ensembl:ENSPTRP00000042163};
SubName: Full=Timeless homolog {ECO:0000313|EMBL:JAA03064.1};
Name=TIMELESS {ECO:0000313|EMBL:JAA03064.1,
ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|VGNC:VGNC:5623};
ORFNames=CK820_G0046623 {ECO:0000313|EMBL:PNI90203.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000042163, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000042163}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA03064.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Adipose stromal {ECO:0000313|EMBL:JAA03064.1},
Skeletal muscle {ECO:0000313|EMBL:JAA39590.1},
Skin {ECO:0000313|EMBL:JAA24061.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA14011.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI90203.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI90203.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI90203.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
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EMBL; AACZ04012964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AACZ04012965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABC01008274; JAA03064.1; -; mRNA.
EMBL; GABF01008134; JAA14011.1; -; mRNA.
EMBL; GABD01009039; JAA24061.1; -; mRNA.
EMBL; GABE01005149; JAA39590.1; -; mRNA.
EMBL; NBAG03000092; PNI90203.1; -; Genomic_DNA.
RefSeq; XP_509535.2; XM_509535.5.
STRING; 9598.ENSPTRP00000042163; -.
Ensembl; ENSPTRT00000050973; ENSPTRP00000042163; ENSPTRG00000022963.
GeneID; 452431; -.
CTD; 8914; -.
VGNC; VGNC:5623; TIMELESS.
eggNOG; KOG1974; Eukaryota.
eggNOG; ENOG410XQM6; LUCA.
GeneTree; ENSGT00390000015124; -.
OMA; DSMVPFD; -.
OrthoDB; 839367at2759; -.
TreeFam; TF312802; -.
Proteomes; UP000002277; Chromosome 12.
Bgee; ENSPTRG00000022963; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:0000790; C:nuclear chromatin; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0031298; C:replication fork protection complex; IBA:GO_Central.
GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
GO; GO:0003677; F:DNA binding; IBA:GO_Central.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Ensembl.
GO; GO:0044770; P:cell cycle phase transition; IEA:Ensembl.
GO; GO:1904976; P:cellular response to bleomycin; IEA:Ensembl.
GO; GO:0072719; P:cellular response to cisplatin; IEA:Ensembl.
GO; GO:0072711; P:cellular response to hydroxyurea; IEA:Ensembl.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0006281; P:DNA repair; IBA:GO_Central.
GO; GO:0000076; P:DNA replication checkpoint; IBA:GO_Central.
GO; GO:0030324; P:lung development; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1905168; P:positive regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
GO; GO:0042752; P:regulation of circadian rhythm; IEA:Ensembl.
GO; GO:0043111; P:replication fork arrest; IBA:GO_Central.
GO; GO:0048478; P:replication fork protection; IBA:GO_Central.
InterPro; IPR006906; Timeless.
InterPro; IPR007725; TIMELESS_C.
Pfam; PF04821; TIMELESS; 1.
Pfam; PF05029; TIMELESS_C; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Reference proteome {ECO:0000313|Proteomes:UP000002277}.
DOMAIN 24 283 TIMELESS. {ECO:0000259|Pfam:PF04821}.
DOMAIN 729 1180 TIMELESS_C. {ECO:0000259|Pfam:PF05029}.
COILED 663 688 {ECO:0000256|SAM:Coils}.
SEQUENCE 1209 AA; 138930 MW; AD0A6A6B2C48F5DD CRC64;
MDLHMMNCEL LATCSALGYL EGDTYHKEPD CLESVKDLIR YLRHEDETRD VRQQLGAAQI
LQSDLLPILT QHHQDKPLFD AVIRLMVNLT QPALLCFGNL PKEPSFRHHF LQVLTYLQAY
KEAFASEKAF GVLSETLYEL LQLGWEERQE EDNLLIERIL LLVRNILHVP ADLDQEKKID
DDASAHDQLL WAIHLSGLDD LLLFLASSSA EEQWSLHVLE IVSLMFRDQN PEQLAGVGQG
RLAQERSADF AELEVLRQRE MAEKKTRALQ RGNRHSRFGG SYIVQGLKSI GERDLIFHKG
LHNLRNYSSD LGKQPKKVPK RRQAARELSI QRRSALNVRL FLRDFCSEFL ENCYNRLMGS
VKDHLLREKA QQYDETYYMW ALAFFMAFNR AASFRPGLVS ETLSVRTFHF IEQNLTNYYE
MMLTDRKEAA SWARRMHLAL KAYQELLATV NEMDISPDEA VRESSRIIKN NIFYVMEYRE
LFLALFRKFD ERCQPRSFLR DLVETTHLFL KMLERFCRSR GNLVVQNKQK KRRKKKKKVL
DQAIVSGNVP SSPEEVEAVW PALAEQLQCC AQNSELSMDS VVPFDAASEV PVEEQRAEAM
VRIQDCLLAG QAPQALTLLR SAREVWPEGD VFGSQDIFPE EEIQLLKQIL SAPLPRQQGP
EERGAEEEEE EEEEEEEEEL QVVQVSEKEF NFLDYLKRFA CSTVVRAYVL LLRSYQQNSA
HTNHCIVKML HRLAHDLKME ALLFQLSVFC LFNRLLSDPA AGAYKELVTF AKYILGKFFA
LAAVNQKAFV ELLFWKNTAV VREMTEGYGS LDDRSSSRRA PTWSPEEEAH LRELYLANKD
VEGQDVVEAI LAHLNTVPRT RKQIIHHLVQ MGLADSVKDF QRKGTHIVLW TGDQELELQR
LFEEFRDSDD VLGHIMKNIT AKRSRARIVD KLLALGLVAE RRELYKKRRK KLASSILPNG
AESLKDFCQE DLEEEENLPE EDSEEEEEGG SEAEQVQGSL VLSNENLGQS LHQEGFSIPL
LWLQNCLIRA ADDREEDGCS QAVPLVPLTE ENEEAMENEQ FQQLLRKLGV RPPASGQETF
WRIPAKLSPT QLRRVAASLS QPEEEQKLQP ELQPKVPGEQ GSDEEHCKEH RAQALRALLL
AHKKKAGLAS PEEEDAVGKE PLKAAPKKRQ LLDSDEEQEE DEGRNRAPEL GAPGIQKKKR
YQIEDDEDD


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1059: Diurnally regulated genes with circadian orthologs
WP1175: Diurnally regulated genes with circadian orthologs
WP1268: Diurnally regulated genes with circadian orthologs
WP1306: Diurnally regulated genes with circadian orthologs
WP1379: Diurnally regulated genes with circadian orthologs
WP1689: Porphyrin and chlorophyll metabolism
WP1797: Circadian Clock
WP1973: Circadian clock tutorial_kenyano
WP2122: Circadian Clock tutorial_KuroiR
WP2123: Circadian clock tutorial_oronda
WP2125: Circadian clock tutorial_eliene
WP2128: circadian clock tutorial_Henk
WP2131: Circadian clock
WP2133: Circadian clock tutorial_Max
WP2134: Circadian Clock tutorial_yves
WP2135: Circadian clock
WP2138: Circadian clock tutorial_i6003923
WP2144: circadian clock_b.ballarin
WP2146: circadian clock_schmidtdav
WP2147: circadian clock_ballarin
WP2149: Circadian clock
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP32: Translation Factors
WP410: Diurnally regulated genes with circadian orthologs

Related Genes :
[Timeless Tim1 Timeless1] Protein timeless homolog (mTim)
[TIMELESS TIM TIM1 TIMELESS1] Protein timeless homolog (hTIM)
[Timeless] Protein timeless homolog (rTIM) (Timeless-like protein) (rTLP)
[Per1 Per Rigui] Period circadian protein homolog 1 (mPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
[tim-1 Y75B8A.22] Protein timeless homolog
[PER2 KIAA0347] Period circadian protein homolog 2 (hPER2) (Circadian clock protein PERIOD 2)
[PER1 KIAA0482 PER RIGUI] Period circadian protein homolog 1 (hPER1) (Circadian clock protein PERIOD 1) (Circadian pacemaker protein Rigui)
[Per2] Period circadian protein homolog 2 (mPER2) (Circadian clock protein PERIOD 2)
[PER3 GIG13] Period circadian protein homolog 3 (hPER3) (Cell growth-inhibiting gene 13 protein) (Circadian clock protein PERIOD 3)
[Per2] Period circadian protein homolog 2 (rPER2) (Circadian clock protein PERIOD 2)
[TIPIN] TIMELESS-interacting protein
[Per3] Period circadian protein homolog 3 (mPER3) (Circadian clock protein PERIOD 3)
[Per1] Period circadian protein homolog 1 (rPER1) (Circadian clock protein PERIOD 1)
[PER2] Period circadian protein homolog 2 (sPER2) (Circadian clock protein PERIOD 2)
[Tipin] TIMELESS-interacting protein
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[Chek1 Chk1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Checkpoint kinase-1)
[DDX11 CHL1 CHLR1 KRG2] ATP-dependent DNA helicase DDX11 (EC 3.6.4.12) (CHL1-related protein 1) (hCHLR1) (DEAD/H-box protein 11) (Keratinocyte growth factor-regulated gene 2 protein) (KRG-2)
[CRY1 PHLL1] Cryptochrome-1
[Cry1] Cryptochrome-1
[PER1] Period circadian protein homolog 1 (sPER1) (Circadian clock protein PERIOD 1)
[Clock] Circadian locomoter output cycles protein kaput (mCLOCK) (EC 2.3.1.48)
[CLOCK] Circadian locomoter output cycles protein kaput
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[Csnk1d Hckid] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[CSNK1E] Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)
[per CG2647] Period circadian protein (Protein clock-6) (CLK-6)
[Cry1] Cryptochrome-1
[CLOCK BHLHE8 KIAA0334] Circadian locomoter output cycles protein kaput (hCLOCK) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 8) (bHLHe8)
[Csnk1e] Casein kinase I isoform epsilon (CKI-epsilon) (CKIe) (EC 2.7.11.1)

Bibliography :