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TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)

 TCAM1_MOUSE             Reviewed;         732 AA.
Q80UF7; Q3UDB7; Q3UP66; Q6P6J2; Q8CIB7; Q8JZV0;
05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
02-JUN-2021, entry version 136.
RecName: Full=TIR domain-containing adapter molecule 1;
Short=TICAM-1;
AltName: Full=Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta;
Short=TIR domain-containing adapter protein inducing IFN-beta;
Name=Ticam1; Synonyms=Trif;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12539043; DOI=10.1038/ni886;
Oshiumi H., Matsumoto M., Funami K., Akazawa T., Seya T.;
"TICAM-1, an adapter molecule that participates in Toll-like receptor 3
mediated interferon-beta induction.";
Nat. Immunol. 4:161-167(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, and Spleen;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J, FVB/N, and FVB/N-3;
TISSUE=Eye, Jaw, Limb, Mammary tumor, and Salivary gland;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=12855817; DOI=10.1126/science.1087262;
Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H.,
Takeuchi O., Sugiyama M., Okabe M., Takeda K., Akira S.;
"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling
pathway.";
Science 301:640-643(2003).
[5]
FUNCTION.
PubMed=16002681; DOI=10.4049/jimmunol.175.2.839;
De Trez C., Pajak B., Brait M., Glaichenhaus N., Urbain J., Moser M.,
Lauvau G., Muraille E.;
"TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFN-beta,
but not MyD88, regulate Escherichia coli-induced dendritic cell maturation
and apoptosis in vivo.";
J. Immunol. 175:839-846(2005).
[6]
INTERACTION WITH TRAF3.
PubMed=16306936; DOI=10.1038/nature04374;
Oganesyan G., Saha S.K., Guo B., He J.Q., Shahangian A., Zarnegar B.,
Perry A., Cheng G.;
"Critical role of TRAF3 in the Toll-like receptor-dependent and
-independent antiviral response.";
Nature 439:208-211(2006).
[7]
REVIEW.
PubMed=17457343; DOI=10.1038/nri2079;
O'Neill L.A., Bowie A.G.;
"The family of five: TIR-domain-containing adaptors in Toll-like receptor
signalling.";
Nat. Rev. Immunol. 7:353-364(2007).
[8]
INTERACTION WITH TRAFD1.
PubMed=18849341; DOI=10.1074/jbc.m806923200;
Sanada T., Takaesu G., Mashima R., Yoshida R., Kobayashi T., Yoshimura A.;
"FLN29 deficiency reveals its negative regulatory role in the Toll-like
receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase
signaling pathway.";
J. Biol. Chem. 283:33858-33864(2008).
[9]
FUNCTION, INTERACTION WITH DDX21 AND DHX36, IDENTIFICATION IN A COMPLEX
WITH DDX1; DDX21 AND DHX36, IDENTIFICATION BY MASS SPECTROMETRY, AND
SUBCELLULAR LOCATION.
PubMed=21703541; DOI=10.1016/j.immuni.2011.03.027;
Zhang Z., Kim T., Bao M., Facchinetti V., Jung S.Y., Ghaffari A.A., Qin J.,
Cheng G., Liu Y.J.;
"DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule
TRIF to sense dsRNA in dendritic cells.";
Immunity 34:866-878(2011).
[10]
INTERACTION WITH WDFY1; TLR3 AND TLR4.
PubMed=25736436; DOI=10.15252/embr.201439637;
Hu Y.H., Zhang Y., Jiang L.Q., Wang S., Lei C.Q., Sun M.S., Shu H.B.,
Liu Y.;
"WDFY1 mediates TLR3/4 signaling by recruiting TRIF.";
EMBO Rep. 16:447-455(2015).
-!- FUNCTION: Involved in innate immunity against invading pathogens.
Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-
kappa-B and interferon-regulatory factor (IRF) activation, and to
induce apoptosis (PubMed:12855817, PubMed:16002681, PubMed:21703541).
Ligand binding to these receptors results in TRIF recruitment through
its TIR domain (PubMed:12855817, PubMed:16002681, PubMed:21703541).
Distinct protein-interaction motifs allow recruitment of the effector
proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation
of transcription factors IRF3 and IRF7, NF-kappa-B and FADD
respectively (PubMed:12855817, PubMed:16002681, PubMed:21703541).
Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and
subsequent activation of the transcription factor IRF3 to induce
expression of type I interferon and exert a potent immunity against
invading pathogens (By similarity). Component of a multi-helicase-
TICAM1 complex that acts as a cytoplasmic sensor of viral double-
stranded RNA (dsRNA) and plays a role in the activation of a cascade of
antiviral responses including the induction of proinflammatory
cytokines (PubMed:21703541). {ECO:0000250|UniProtKB:Q8IUC6,
ECO:0000269|PubMed:12855817, ECO:0000269|PubMed:16002681,
ECO:0000269|PubMed:21703541}.
-!- SUBUNIT: Homodimer (By similarity). Found in a multi-helicase-TICAM1
complex at least composed of DHX36, DDX1, DDX21 and TICAM1; this
complex exists in resting cells with or without poly(I:C) RNA ligand
stimulation (PubMed:21703541). Interacts (via TIR domain) with DDX21
(via C-terminus) (PubMed:21703541). Interacts (via TIR domain) with
DHX36 (via C-terminus) (PubMed:21703541). Interacts with AZI2 and IRF7
(By similarity). Interacts (when phosphorylated) with IRF3; following
activation and phosphorylation on the pLxIS motif by TBK1, recruits
IRF3 (By similarity). Interacts with TICAM2 in TLR4 recruitment (By
similarity). Interaction with PIAS4 inhibits the TICAM1-induced NF-
kappa-B, IRF and IFNB1 activation (By similarity). Interacts with IKBKB
and IKBKE (By similarity). Interaction with SARM1 blocks TICAM1-
dependent transcription factor activation (By similarity). Interacts
with TRAF3. Interacts with TRAFD1. Interacts with UBQLN1 (via UBA
domain). Interacts with TBK1, TRAF6 and RIPK1 and these interactions
are enhanced in the presence of WDFY1 (By similarity). Interacts (via
the TIR domain) with TLR3 in response to poly(I:C) and this interaction
is enhanced in the presence of WDFY1 (PubMed:25736436). Interacts with
TLR4 in response to poly(I:C) in a WDFY1-dependent manner
(PubMed:25736436). Interacts with WDFY1 in response to poly(I:C)
(PubMed:25736436). Interacts with TRIM56 (By similarity). Interacts
(via the TIR domain) with TLR5 (By similarity). Interacts with TRIM8
(By similarity). {ECO:0000250|UniProtKB:Q8IUC6,
ECO:0000269|PubMed:16306936, ECO:0000269|PubMed:18849341,
ECO:0000269|PubMed:21703541, ECO:0000269|PubMed:25736436}.
-!- INTERACTION:
Q80UF7; P35991: Btk; NbExp=2; IntAct=EBI-3649271, EBI-625119;
Q80UF7; Q3TTA7: Cblb; NbExp=2; IntAct=EBI-3649271, EBI-3649276;
Q80UF7; Q9WUN2: Tbk1; NbExp=2; IntAct=EBI-3649271, EBI-764193;
Q80UF7; Q60803: Traf3; NbExp=2; IntAct=EBI-3649271, EBI-520135;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21703541}.
Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q8IUC6}.
Mitochondrion {ECO:0000269|PubMed:21703541}. Note=Colocalizes with
UBQLN1 in the autophagosome. Colocalizes in the cytosol with DDX1,
DDX21 and DHX36 (PubMed:21703541). Colocalizes in the mitochondria with
DDX1 and poly(I:C) RNA ligand (PubMed:21703541). The multi-helicase-
TICAM1 complex may translocate to the mitochondria upon poly(I:C) RNA
ligand stimulation (PubMed:21703541). {ECO:0000250|UniProtKB:Q8IUC6,
ECO:0000269|PubMed:21703541}.
-!- DOMAIN: The pLxIS motif constitutes an IRF3-binding motif: following
phosphorylation by TBK1, the phosphorylated pLxIS motif of TICAM1
recruits IRF3. IRF3 is then phosphorylated and activated by TBK1 to
induce type-I interferons and other cytokines.
{ECO:0000250|UniProtKB:Q8IUC6}.
-!- DOMAIN: The N-terminal region is essential for activation of the IFNB
promoter activity. {ECO:0000250|UniProtKB:Q8IUC6}.
-!- DOMAIN: The N-terminal domain (TRIF-NTD) is globular and consists of
two alpha-helical subdomains connected by a 14-residue linker. It
shares structural similarity with IFIT family members N-terminal
regions. {ECO:0000250|UniProtKB:Q8IUC6}.
-!- PTM: Phosphorylated by TBK1. Following activation, phosphorylated by
TBK1 at Ser-209 in the pLxIS motif. The phosphorylated pLxIS motif
constitutes an IRF3-binding motif, leading to recruitment of the
transcription factor IRF3 to induce type-I interferons and other
cytokines. {ECO:0000250|UniProtKB:Q8IUC6}.
-!- PTM: Polyubiquitinated by TRIM38 with 'Lys-48'-linked chains, leading
to proteasomal degradation. Polyubiquitinated with 'Lys-6'- and 'Lys-
33'-linked chains in a TRIM8-dependent manner; ubiquitination disrupts
the interaction with TBK1 and subsequent interferon production.
{ECO:0000250|UniProtKB:Q8IUC6}.
-!- DISRUPTION PHENOTYPE: Mice are viable but exhibit abnormalities of the
innate immune system. {ECO:0000269|PubMed:12855817}.
-!- SEQUENCE CAUTION:
Sequence=AAH33406.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
Sequence=AAH37048.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Sequence=AAH62191.1; Type=Frameshift; Evidence={ECO:0000305};
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EMBL; AB091053; BAC55581.1; -; mRNA.
EMBL; AK143766; BAE25531.1; -; mRNA.
EMBL; AK150150; BAE29344.1; -; mRNA.
EMBL; AK155245; BAE33144.1; -; mRNA.
EMBL; BC033406; AAH33406.1; ALT_SEQ; mRNA.
EMBL; BC037048; AAH37048.1; ALT_INIT; mRNA.
EMBL; BC062191; AAH62191.1; ALT_FRAME; mRNA.
EMBL; BC094338; AAH94338.1; -; mRNA.
CCDS; CCDS28900.1; -.
RefSeq; NP_778154.1; NM_174989.4.
SMR; Q80UF7; -.
BioGRID; 223122; 9.
DIP; DIP-60033N; -.
IntAct; Q80UF7; 6.
STRING; 10090.ENSMUSP00000055104; -.
PhosphoSitePlus; Q80UF7; -.
EPD; Q80UF7; -.
PaxDb; Q80UF7; -.
PRIDE; Q80UF7; -.
ProteomicsDB; 263143; -.
Antibodypedia; 11536; 352 antibodies.
DNASU; 106759; -.
Ensembl; ENSMUST00000058136; ENSMUSP00000055104; ENSMUSG00000047123.
GeneID; 106759; -.
KEGG; mmu:106759; -.
UCSC; uc008dbm.2; mouse.
CTD; 148022; -.
MGI; MGI:2147032; Ticam1.
eggNOG; ENOG502RXF3; Eukaryota.
GeneTree; ENSGT00940000162411; -.
HOGENOM; CLU_022539_0_0_1; -.
InParanoid; Q80UF7; -.
OMA; YNFVVLH; -.
OrthoDB; 435629at2759; -.
PhylomeDB; Q80UF7; -.
TreeFam; TF336953; -.
Reactome; R-MMU-140534; Caspase activation via Death Receptors in the presence of ligand.
Reactome; R-MMU-166166; MyD88-independent TLR4 cascade.
Reactome; R-MMU-2562578; TRIF-mediated programmed cell death.
Reactome; R-MMU-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
Reactome; R-MMU-937041; IKK complex recruitment mediated by RIP1.
Reactome; R-MMU-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex.
Reactome; R-MMU-975163; IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.
BioGRID-ORCS; 106759; 3 hits in 54 CRISPR screens.
PRO; PR:Q80UF7; -.
Proteomes; UP000000589; Chromosome 17.
RNAct; Q80UF7; protein.
Bgee; ENSMUSG00000047123; Expressed in intestine and 184 other tissues.
Genevisible; Q80UF7; MM.
GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0097342; C:ripoptosome; ISO:MGI.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0097190; P:apoptotic signaling pathway; IMP:MGI.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IMP:ParkinsonsUK-UCL.
GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; IMP:ARUK-UCL.
GO; GO:0051607; P:defense response to virus; IMP:MGI.
GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IMP:MGI.
GO; GO:0002281; P:macrophage activation involved in immune response; IMP:MGI.
GO; GO:0002756; P:MyD88-independent toll-like receptor signaling pathway; IMP:MGI.
GO; GO:0010508; P:positive regulation of autophagy; IMP:ParkinsonsUK-UCL.
GO; GO:0050871; P:positive regulation of B cell activation; IMP:MGI.
GO; GO:0030890; P:positive regulation of B cell proliferation; IMP:MGI.
GO; GO:0032722; P:positive regulation of chemokine production; IMP:MGI.
GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IMP:ARUK-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IMP:ARUK-UCL.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IMP:UniProtKB.
GO; GO:0032728; P:positive regulation of interferon-beta production; IMP:MGI.
GO; GO:0032755; P:positive regulation of interleukin-6 production; IMP:MGI.
GO; GO:0002735; P:positive regulation of myeloid dendritic cell cytokine production; IMP:UniProtKB.
GO; GO:0032816; P:positive regulation of natural killer cell activation; IMP:MGI.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:MGI.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:MGI.
GO; GO:0032092; P:positive regulation of protein binding; IDA:MGI.
GO; GO:0031398; P:positive regulation of protein ubiquitination; IDA:MGI.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IDA:MGI.
GO; GO:0032481; P:positive regulation of type I interferon production; IMP:MGI.
GO; GO:0043254; P:regulation of protein-containing complex assembly; IMP:MGI.
GO; GO:0043330; P:response to exogenous dsRNA; IDA:MGI.
GO; GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; IMP:ParkinsonsUK-UCL.
Gene3D; 3.40.50.10140; -; 1.
InterPro; IPR025735; RHIM_dom.
InterPro; IPR017278; TICAM1.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
InterPro; IPR040886; TRIF_N.
PANTHER; PTHR47230; PTHR47230; 1.
Pfam; PF12721; RHIM; 1.
Pfam; PF17798; TRIF-NTD; 1.
PIRSF; PIRSF037744; TIR_Ticam; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS50104; TIR; 1.
1: Evidence at protein level;
Antiviral defense; Apoptosis; Cytoplasm; Cytoplasmic vesicle; Immunity;
Inflammatory response; Innate immunity; Mitochondrion; Phosphoprotein;
Reference proteome; Ubl conjugation.
CHAIN 1..732
/note="TIR domain-containing adapter molecule 1"
/id="PRO_0000317664"
DOMAIN 395..534
/note="TIR"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
REGION 1..153
/note="TRIF-NTD"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
REGION 144..191
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 305..389
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 514..713
/note="Sufficient to induce apoptosis"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
REGION 603..679
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 696..732
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOTIF 84..91
/note="TRAF6-binding"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
MOTIF 206..209
/note="pLxIS motif"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
MOTIF 247..254
/note="TRAF6-binding"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
MOTIF 296..306
/note="TRAF6-binding"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
COMPBIAS 157..182
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 305..351
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 361..389
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 605..659
/note="Pro residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 696..711
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 209
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8IUC6"
CONFLICT 227
/note="S -> G (in Ref. 2; BAE29344)"
/evidence="ECO:0000305"
CONFLICT 351..435
/note="Missing (in Ref. 3; AAH62191)"
/evidence="ECO:0000305"
CONFLICT 435
/note="V -> A (in Ref. 2; BAE25531)"
/evidence="ECO:0000305"
CONFLICT 513
/note="V -> A (in Ref. 2; BAE29344)"
/evidence="ECO:0000305"
CONFLICT 628..639
/note="Missing (in Ref. 3; AAH33406)"
/evidence="ECO:0000305"
SEQUENCE 732 AA; 79230 MW; 2EAC87F1936B7C83 CRC64;
MDNPGPSLRG AFGILGALER DRLTHLKHKL GSLCSGSQES KLLHAMVLLA LGQDTEARVS
LESLKMNTVA QLVAHQWADM ETTEGPEEPP DLSWTVARLY HLLAEENLCP ASTRDMAYQV
ALRDFASQGD HQLGQLQNEA WDRCSSDIKG DPSGFQPLHS HQGSLQPPSA SPAVTRSQPR
PIDTPDWSWG HTLHSTNSTA SLASHLEISQ SPTLAFLSSH HGTHGPSKLC NTPLDTQEPQ
LVPEGCQEPE EISWPPSVET SVSLGLPHEI SVPEVSPEEA SPILPDALAA PDTSVHCPIE
CTELSTNSRS PLTSTTESVG KQWPITSQRS PQVPVGDDSL QNTTSSSPPA QPPSLQASPK
LPPSPLSSAS SPSSYPAPPT STSPVLDHSE TSDQKFYNFV VIHARADEQV ALRIREKLET
LGVPDGATFC EEFQVPGRGE LHCLQDAIDH SGFTILLLTA SFDCSLSLHQ INHALMNSLT
QSGRQDCVIP LLPLECSQAQ LSPDTTRLLH SIVWLDEHSP IFARKVANTF KTQKLQAQRV
RWKKAQEART LKEQSIQLEA ERQNVAAISA AYTAYVHSYR AWQAEMNKLG VAFGKNLSLG
TPTPSWPGCP QPIPSHPQGG TPVFPYSPQP PSFPQPPCFP QPPSFPQPPS FPLPPVSSPQ
SQSFPSASSP APQTPGPQPL IIHHAQMVQL GVNNHMWGHT GAQSSDDKTE CSENPCMGPL
TDQGEPLLET PE


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Catalog number Product name Quantity
EIAAB41675 Bos taurus,Bovine,TICAM1,TICAM-1,TIR domain-containing adapter molecule 1,TIR domain-containing adapter protein inducing IFN-beta,Toll-interleukin-1 receptor domain-containing adapter protein inducing
EIAAB41674 Mouse,Mus musculus,Ticam1,TICAM-1,TIR domain-containing adapter molecule 1,TIR domain-containing adapter protein inducing IFN-beta,Toll-interleukin-1 receptor domain-containing adapter protein inducin
EIAAB41677 Mouse,Mus musculus,Ticam2,TICAM-2,TIR domain-containing adapter molecule 2,Tirp,Toll_interleukin-1 receptor domain-containing protein,Tram,TRIF-related adapter molecule
18-661-15155 Toll-interleukin 1 receptor domain-containing adapter protein - TIR domain-containing adapter protein; MyD88 adapter-like protein; Adaptor protein Wyatt Polyclonal 0.1 mg
18-661-15156 Toll-interleukin 1 receptor domain-containing adapter protein - TIR domain-containing adapter protein; MyD88 adapter-like protein; Adaptor protein Wyatt Polyclonal 0.1 mg
PC-Tram Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule , WB control 100-150ul
P-Tram Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule , Antigen blocking peptide 100ul
EIAAB41679 Homo sapiens,Human,Putative NF-kappa-B-activating protein 502,TICAM2,TICAM-2,TIR domain-containing adapter molecule 2,TIRAP3,TIRP,Toll_interleukin-1 receptor domain-containing protein,Toll-like recept
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule , Host species: Rabbit, Polyclonal antibody 200ul
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Polyclonal anbtibody Host: Rabbit Affinity purifed 200ul
Tram-101AP Polyclonal Antibody Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Immunogen: peptide Host: Rabbit 200ul
Tram-FITC Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule , FITC conjugates 200ul
Tram-Biotin Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule , Biotin conjugates 200ul
EIAAB42483 Adaptor protein Wyatt,Homo sapiens,Human,MAL,MyD88 adapter-like protein,TIR domain-containing adapter protein,TIRAP,Toll_interleukin-1 receptor domain-containing adapter protein
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Polyclonal Antibody Host Species: Rabbit Immunogen: peptide Epitope Location: 200ul
EIAAB42482 Adaptor protein Wyatt,Mal,Mouse,Mus musculus,MyD88 adapter-like protein,TIR domain-containing adapter protein,Tirap,Toll_interleukin-1 receptor domain-containing adapter protein
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule WB control: PC-Tram Host: Rabbit Affinity purifed 100-150ul
Tram-101AP PC-Tram (WB control) Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Immunogen: peptide Host: Rabbit 100-150ul
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Antigenic peptide: P-Tram Host: Rabbit Affinity purifed 100ul
EIAAB41676 Homo sapiens,Human,Proline-rich, vinculin and TIR domain-containing protein B,PRVTIRB,Putative NF-kappa-B-activating protein 502H,TICAM1,TICAM-1,TIR domain-containing adapter molecule 1,TIR domain-con
EIAAB41678 Bos taurus,Bovine,TICAM2,TICAM-2,TIR domain-containing adapter molecule 2,TRAM,TRIF-related adapter molecule
Tram-101AP P-Tram (Antigenic peptide) Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Immunogen: peptide Host: Rabbit 100ul
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Biotin Conjugates: Tram-Biotin Host: Rabbit Affinity purifed 200ul
Tram-101AP Tram-FITC (FITC-conjugates) Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule Immunogen: peptide Host: Rabbit 200ul
Tram-101AP Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF) Adapter Molecule FITC-conjugates: Tram-FITC Host: Rabbit Affinity purifed 200ul
Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1566: Citrate cycle (TCA cycle)
WP2218: sGC
WP210: Cytoplasmic Ribosomal Proteins
WP2272: Pathogenic Escherichia coli infection
WP362: TGF-beta Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1367: TGF-beta Receptor Signaling Pathway
WP1835: Interferon alpha/beta signaling
WP1045: TGF-beta Receptor Signaling Pathway
WP2292: Chemokine signaling pathway
WP809: TGF-beta Receptor Signaling Pathway
WP566: canonical wnt - zebrafish
WP237: Glucocorticoid & Mineralcorticoid Metabolism
WP448: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP988: Keap1-Nrf2
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1722: Th1/Th2
WP346: Protein Modifications
WP829: Toll-like receptor signaling pathway
WP1665: Limonene and pinene degradation
WP88: Toll Like Receptor signaling
WP615: Senescence and Autophagy

Related Genes :
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
[Ticam1 Trif] TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)
[TICAM2 TIRAP3 TIRP TRAM] TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
[Ticam2 Tirp Tram] TIR domain-containing adapter molecule 2 (TICAM-2) (TRIF-related adapter molecule) (Toll/interleukin-1 receptor domain-containing protein)
[TICAM1 TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (TIR domain-containing adapter protein inducing IFN-beta)
[TIRAP MAL] Toll/interleukin-1 receptor domain-containing adapter protein (TIR domain-containing adapter protein) (Adaptor protein Wyatt) (MyD88 adapter-like protein) (MyD88-2)
[MAVS IPS1 KIAA1271 VISA] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Putative NF-kappa-B-activating protein 031N) (Virus-induced-signaling adapter) (VISA)
[Mavs Ips1 Visa] Mitochondrial antiviral-signaling protein (MAVS) (CARD adapter inducing interferon beta) (Cardif) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
[TICAM1] TIR domain-containing adapter molecule 1 (TICAM-1)
[TRAF6 RNF85] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
[IL18 IGIF IL1F4] Interleukin-18 (IL-18) (Iboctadekin) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[TLR2 TIL4] Toll-like receptor 2 (EC 3.2.2.6) (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[SARM1 KIAA0524 SAMD2 SARM] NAD(+) hydrolase SARM1 (NADase SARM1) (hSARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and Armadillo repeat protein) (Sterile alpha and TIR motif-containing protein 1) (Sterile alpha motif domain-containing protein 2) (MyD88-5) (SAM domain-containing protein 2) (Tir-1 homolog) (HsTIR)
[Sigirr Tir8] Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[IFNAR2 IFNABR IFNARB] Interferon alpha/beta receptor 2 (IFN-R-2) (IFN-alpha binding protein) (IFN-alpha/beta receptor 2) (Interferon alpha binding protein) (Type I interferon receptor 2)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[Il18 Igif] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Tlr1] Toll-like receptor 1 (EC 3.2.2.6) (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[Tlr4 Lps] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[Mavs Ips1 Visa] Mitochondrial antiviral-signaling protein (MAVS) (Interferon beta promoter stimulator protein 1) (IPS-1) (Virus-induced-signaling adapter) (VISA)
[TLR5 TIL3] Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
[IFIH1 MDA5 RH116] Interferon-induced helicase C domain-containing protein 1 (EC 3.6.4.13) (Clinically amyopathic dermatomyositis autoantigen 140 kDa) (CADM-140 autoantigen) (Helicase with 2 CARD domains) (Helicard) (Interferon-induced with helicase C domain protein 1) (Melanoma differentiation-associated protein 5) (MDA-5) (Murabutide down-regulated protein) (RIG-I-like receptor 2) (RLR-2) (RNA helicase-DEAD box protein 116)
[RACK1 GNB2L1 HLC7 PIG21] Receptor of activated protein C kinase 1 (Cell proliferation-inducing gene 21 protein) (Guanine nucleotide-binding protein subunit beta-2-like 1) (Guanine nucleotide-binding protein subunit beta-like protein 12.3) (Human lung cancer oncogene 7 protein) (HLC-7) (Receptor for activated C kinase) (Small ribosomal subunit protein RACK1) [Cleaved into: Receptor of activated protein C kinase 1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[AP2B1 ADTB2 CLAPB1] AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
[IL18 IGIF] Interleukin-18 (IL-18) (Interferon gamma-inducing factor) (IFN-gamma-inducing factor) (Interleukin-1 gamma) (IL-1 gamma)
[Sarm1 Kiaa0524] NAD(+) hydrolase SARM1 (NADase SARM1) (EC 3.2.2.6) (NADP(+) hydrolase SARM1) (EC 3.2.2.-) (Sterile alpha and TIR motif-containing protein 1)

Bibliography :