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TLR8 isoform 2

 A0A2I3RDS7_PANTR        Unreviewed;      1059 AA.
A0A2I3RDS7; A0A2J8KUI2;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
08-MAY-2019, entry version 9.
SubName: Full=TLR8 isoform 2 {ECO:0000313|EMBL:PNI38658.1};
Name=TLR8 {ECO:0000313|Ensembl:ENSPTRP00000062546,
ECO:0000313|VGNC:VGNC:55731};
ORFNames=CK820_G0035803 {ECO:0000313|EMBL:PNI38658.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000062546, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000062546, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|EMBL:PNI38658.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI38658.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI38658.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSPTRP00000062546}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AACZ04014639; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; NBAG03000336; PNI38658.1; -; Genomic_DNA.
Ensembl; ENSPTRT00000102524; ENSPTRP00000062546; ENSPTRG00000021667.
VGNC; VGNC:55731; TLR8.
GeneTree; ENSGT00940000160879; -.
Proteomes; UP000002277; Chromosome X.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR47410:SF1; PTHR47410:SF1; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 15.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Immunity {ECO:0000256|SAAS:SAAS00179614};
Innate immunity {ECO:0000256|SAAS:SAAS00179614};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00179597};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
TRANSMEM 844 866 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 896 1043 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1059 AA; 121694 MW; 8D7CEFE49461CD16 CRC64;
MKESSLQNSS CSLGKETKKE NMFLQSSMLT CIFLLISGSC ELCAEENFSR SYPCDEKKQN
DSVIAECSNR RLREVPQTVG KYVTELDLSD NFITHITNES FQGLQNLTKI NLNHNPNVQH
QNGNPGIQSN GLNITDGAFL NLKNLRELLL EDNQLPQIPS GLPESLTELS LIQNNIYNIT
KEGISRLINL KNLYLAWNCY FNKVCEKTNI EDGVFETLTN LELLSLSFNS LSHVPPKLPS
SLRKLFLSNT QIKYISEEDF KGLINLTLLD LSGNCPRCFN APFPCVPCDG GASINIDRFA
FQNLTQLRYL NLSSTSLRKI NAAWFKNMPH LKVLDLEFNY LVGEIASGAF LTMLPRLEIL
DLSFNYIKGS YPQHINISKN FSKLLSLRAL HLRGYVFQEL REDDFQPLMQ LPNLSTINLG
INFIKQIDFK LFQNFSNLEI IYLSENRISP LVKDTRQSYA NSSSFQRHIL KRRSTDFEFD
PHSNFYHFTR PLIKPQCAAY GKALDLSLNS IFFIGPNQFE NLPDIACLNL SANSNAQVLS
GTEFSAIPHV KYLDLTNNRL DFDNASALTE LSDLEVLDLS YNSHYFRIAG VTHHLEFIQN
FTNLKVLNLS HNNIYTLTDK YNLESKSLVE LVFSGNRLDI LWNDDDNRYI SIFKGLKNLT
RLDLSLNRLK HIPNEAFLNL PASLTELHIN DNMLKFFNWT LLQQFPRLEL LDLRGNKLLF
LTDSLSDFTS SLRTLLLSHN RISHLPSGFL SEVSSLKHLD LSSNLLKTIN KSALETKTTT
KLSMLELHGN PFECTCDIGD FRRWMDEHLN VKIPRLVDVI CASPGDQRGK SIVSLELTTC
VSDVTAVILF FFTFFITTMV MLAALAHHLF YWDVWFIYNV CLAKVKGYRS LSTSQTFYDA
YISYDTKDAS VTDWVINELR YHLEESRDKN VLLCLEERDW DPGLAIIDNL MQSINQSKKT
VFVLTKKYAK SWNFKTAFYL ALQRLMDENM DVIIFILLEP VLQHSQYLRL RQRICKSSIL
QWPDNPKAEG LFWQTLRNVV LTENDSRYNS MYVDSIKQY


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