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TNF receptor-associated factor 3 (EC 2 3 2 27) (CD40 receptor-associated factor 1) (CRAF1) (RING-type E3 ubiquitin transferase TRAF3) (TRAFAMN)

 TRAF3_MOUSE             Reviewed;         567 AA.
Q60803; B2RPW3; Q62380;
30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
17-JUN-2020, entry version 186.
RecName: Full=TNF receptor-associated factor 3;
EC=2.3.2.27;
AltName: Full=CD40 receptor-associated factor 1;
Short=CRAF1;
AltName: Full=RING-type E3 ubiquitin transferase TRAF3 {ECO:0000305};
AltName: Full=TRAFAMN;
Name=Traf3; Synonyms=Craf1, Trafamn;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH TNFRSF5.
PubMed=7533327; DOI=10.1126/science.7533327;
Cheng G., Cleary A.M., Ye Z.S., Hong D.I., Lederman S., Baltimore D.;
"Involvement of CRAF1, a relative of TRAF, in CD40 signaling.";
Science 267:1494-1498(1995).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=8660894; DOI=10.1006/dbio.1996.0162;
Wang X., Bornslaeger E.A., Haub O., Tomihara-Newberger C., Lonberg N.,
Dinulos M.B., Disteche C.M., Copeland N.G., Gilbert D.J., Jenkins N.A.,
Lacy E.;
"A candidate gene for the amnionless gastrulation stage mouse mutation
encodes a TRAF-related protein.";
Dev. Biol. 177:274-290(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=8934568; DOI=10.1016/s1074-7613(00)80497-5;
Xu Y., Cheng G., Baltimore D.;
"Targeted disruption of TRAF3 leads to postnatal lethality and defective T-
dependent immune responses.";
Immunity 5:407-415(1996).
[6]
DISRUPTION PHENOTYPE, AND FUNCTION.
PubMed=17015635; DOI=10.1084/jem.20061166;
He J.Q., Zarnegar B., Oganesyan G., Saha S.K., Yamazaki S., Doyle S.E.,
Dempsey P.W., Cheng G.;
"Rescue of TRAF3-null mice by p100 NF-kappa B deficiency.";
J. Exp. Med. 203:2413-2418(2006).
[7]
FUNCTION, INTERACTION WITH MYD88, AND IDENTIFICATION IN A COMPLEX WITH
TRAF6.
PubMed=16306937; DOI=10.1038/nature04369;
Hacker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L.C., Wang G.G.,
Kamps M.P., Raz E., Wagner H., Hacker G., Mann M., Karin M.;
"Specificity in Toll-like receptor signalling through distinct effector
functions of TRAF3 and TRAF6.";
Nature 439:204-207(2006).
[8]
INTERACTION WITH TICAM1, AND FUNCTION.
PubMed=16306936; DOI=10.1038/nature04374;
Oganesyan G., Saha S.K., Guo B., He J.Q., Shahangian A., Zarnegar B.,
Perry A., Cheng G.;
"Critical role of TRAF3 in the Toll-like receptor-dependent and
-independent antiviral response.";
Nature 439:208-211(2006).
[9]
FUNCTION, DOMAIN, INTERACTION WITH MAP3K14, AND MUTAGENESIS OF CYS-52;
CYS-55; CYS-67 AND HIS-69.
PubMed=17158868; DOI=10.1074/jbc.m610271200;
He J.Q., Saha S.K., Kang J.R., Zarnegar B., Cheng G.;
"Specificity of TRAF3 in its negative regulation of the noncanonical NF-
kappa B pathway.";
J. Biol. Chem. 282:3688-3694(2007).
[10]
FUNCTION.
PubMed=18313334; DOI=10.1016/j.immuni.2008.01.009;
Gardam S., Sierro F., Basten A., Mackay F., Brink R.;
"TRAF2 and TRAF3 signal adapters act cooperatively to control the
maturation and survival signals delivered to B cells by the BAFF
receptor.";
Immunity 28:391-401(2008).
[11]
INTERACTION WITH TRAFD1.
PubMed=18849341; DOI=10.1074/jbc.m806923200;
Sanada T., Takaesu G., Mashima R., Yoshida R., Kobayashi T., Yoshimura A.;
"FLN29 deficiency reveals its negative regulatory role in the Toll-like
receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase
signaling pathway.";
J. Biol. Chem. 283:33858-33864(2008).
[12]
FUNCTION, DISRUPTION PHENOTYPE, IDENTIFICATION IN A COMPLEX WITH TRAF2;
BIRC3 AND MAP3K14, UBIQUITINATION, AND TISSUE SPECIFICITY.
PubMed=18997792; DOI=10.1038/ni.1678;
Vallabhapurapu S., Matsuzawa A., Zhang W., Tseng P.H., Keats J.J., Wang H.,
Vignali D.A., Bergsagel P.L., Karin M.;
"Nonredundant and complementary functions of TRAF2 and TRAF3 in a
ubiquitination cascade that activates NIK-dependent alternative NF-kappaB
signaling.";
Nat. Immunol. 9:1364-1370(2008).
[13]
FUNCTION, AND INTERACTION WITH MAP3K14.
PubMed=18997794; DOI=10.1038/ni.1676;
Zarnegar B.J., Wang Y., Mahoney D.J., Dempsey P.W., Cheung H.H., He J.,
Shiba T., Yang X., Yeh W.C., Mak T.W., Korneluk R.G., Cheng G.;
"Noncanonical NF-kappaB activation requires coordinated assembly of a
regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the
kinase NIK.";
Nat. Immunol. 9:1371-1378(2008).
[14]
FUNCTION.
PubMed=19228877; DOI=10.1093/intimm/dxp013;
Jabara H.H., Weng Y., Sannikova T., Geha R.S.;
"TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.";
Int. Immunol. 21:477-488(2009).
[15]
FUNCTION, E3 PROTEIN-UBIQUITIN LIGASE ACTIVITY, MUTAGENESIS OF CYS-67 AND
HIS-69, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TLR4,
IDENTIFICATION IN A COMPLEX WITH TLR4; TRAF6; MAP3K7; MYD88; IKBKG; TICAM1;
BIRC2; BIRC3 AND UBE2N, UBIQUITINATION, AND TISSUE SPECIFICITY.
PubMed=19898473; DOI=10.1038/ni.1819;
Tseng P.H., Matsuzawa A., Zhang W., Mino T., Vignali D.A., Karin M.;
"Different modes of ubiquitination of the adaptor TRAF3 selectively
activate the expression of type I interferons and proinflammatory
cytokines.";
Nat. Immunol. 11:70-75(2010).
[16]
INTERACTION WITH PTPN22.
PubMed=23871208; DOI=10.1016/j.immuni.2013.06.013;
Wang Y., Shaked I., Stanford S.M., Zhou W., Curtsinger J.M., Mikulski Z.,
Shaheen Z.R., Cheng G., Sawatzke K., Campbell A.M., Auger J.L., Bilgic H.,
Shoyama F.M., Schmeling D.O., Balfour H.H. Jr., Hasegawa K., Chan A.C.,
Corbett J.A., Binstadt B.A., Mescher M.F., Ley K., Bottini N.,
Peterson E.J.;
"The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-
driven, type 1 interferon-dependent immunity.";
Immunity 39:111-122(2013).
[17]
UBIQUITINATION, AND DEUBIQUITINATION BY OTUD7B.
PubMed=23334419; DOI=10.1038/nature11831;
Hu H., Brittain G.C., Chang J.H., Puebla-Osorio N., Jin J., Zal A.,
Xiao Y., Cheng X., Chang M., Fu Y.X., Zal T., Zhu C., Sun S.C.;
"OTUD7B controls non-canonical NF-kappaB activation through
deubiquitination of TRAF3.";
Nature 494:371-374(2013).
-!- FUNCTION: Regulates pathways leading to the activation of NF-kappa-B
and MAP kinases, and plays a central role in the regulation of B-cell
survival. Part of signaling pathways leading to the production of
cytokines and interferon. Required for normal antibody isotype
switching from IgM to IgG. Plays a role T-cell dependent immune
responses. Plays a role in the regulation of antiviral responses. Is an
essential constituent of several E3 ubiquitin-protein ligase complexes.
May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-
linked ubiquitination of target proteins. Inhibits activation of NF-
kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated
activation of NF-kappa-B. Down-regulates proteolytic processing of
NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B.
Promotes ubiquitination and proteasomal degradation of MAP3K14.
{ECO:0000269|PubMed:16306936, ECO:0000269|PubMed:16306937,
ECO:0000269|PubMed:17015635, ECO:0000269|PubMed:17158868,
ECO:0000269|PubMed:18313334, ECO:0000269|PubMed:18997792,
ECO:0000269|PubMed:18997794, ECO:0000269|PubMed:19228877,
ECO:0000269|PubMed:19898473, ECO:0000269|PubMed:8934568}.
-!- CATALYTIC ACTIVITY:
Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
[acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
EC=2.3.2.27;
-!- SUBUNIT: Homotrimer. Heterotrimer with TRAF2 and TRAF5. Interacts with
LTBR/TNFRSF3, TNFRSF4, TNFRSF5/CD40, TNFRSF8/CD30, TNFRSF13C
TNFRSF17/BCMA, TLR4 and EDAR. Interacts with MAP3K5, MAP3K14,
TRAIP/TRIP, TDP2/TTRAP, TANK/ITRAF and TRAF3IP1. Interaction with
TNFRSF5/CD40 is modulated by TANK/ITRAF, which competes for the same
binding site. Interacts with TICAM1. Interacts with TRAFD1. Interacts
with OTUB1, OTUB2 and OTUD5. Interacts with RNF216, OPTN and TBK1 (By
similarity). Identified in a complex with TRAF2, MAP3K14 and BIRC3.
Upon exposure to bacterial lipopolysaccharide (LPS), recruited to a
transient complex containing TLR4, TRAF3, TRAF6, IKBKG, MAP3K7, MYD88,
TICAM1, BIRC2, BIRC3 and UBE2N. Interacts (via RING-type zinc finger
domain) with SRC. Interacts with CARD14 (By similarity). Interacts (via
MATH domain) with PTPN22; the interaction promotes TRAF3
polyubiquitination (PubMed:23871208). Interacts with MAVS (By
similarity). Directly interacts with DDX3X; this interaction stimulates
TRAF3 'Lys-63' ubiquitination (By similarity). Interacts with IRF3 (By
similarity). Interacts with IKBKE in the course of viral infection (By
similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q13114,
ECO:0000269|PubMed:23871208}.
-!- INTERACTION:
Q60803; Q8VCF0: Mavs; NbExp=4; IntAct=EBI-520135, EBI-3862816;
Q60803; P22366: Myd88; NbExp=5; IntAct=EBI-520135, EBI-525108;
Q60803; Q80UF7: Ticam1; NbExp=2; IntAct=EBI-520135, EBI-3649271;
Q60803; O35305: Tnfrsf11a; NbExp=3; IntAct=EBI-520135, EBI-647362;
Q60803; P39429: Traf2; NbExp=2; IntAct=EBI-520135, EBI-520016;
Q60803; P62991: Ubc; NbExp=2; IntAct=EBI-520135, EBI-413074;
Q60803; Q9Y2R2: PTPN22; Xeno; NbExp=5; IntAct=EBI-520135, EBI-1211241;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19898473}. Endosome
{ECO:0000269|PubMed:19898473}. Note=Undergoes endocytosis together with
TLR4 upon LPS signaling. {ECO:0000269|PubMed:19898473}.
-!- TISSUE SPECIFICITY: Detected in bone marrow macrophages and spleen B-
cells (at protein level). In adult, highest in brain. Also found in
kidney, heart, thymus, spleen, lung, muscle, testis and ovary. Not
found in liver. {ECO:0000269|PubMed:18997792,
ECO:0000269|PubMed:19898473, ECO:0000269|PubMed:8660894}.
-!- DEVELOPMENTAL STAGE: In the embryo, expressed from 6.5 dpc with highest
levels found between 11.5 dpc and 13.5 dpc. At late stages of
gestation, from 14.5 dpc, only low levels are detected.
-!- DOMAIN: The MATH/TRAF domain binds to receptor cytoplasmic domains.
{ECO:0000269|PubMed:17158868}.
-!- DOMAIN: The Ring-type zinc finger domain is required for its function
in down-regulation of NFKB2 proteolytic processing.
{ECO:0000269|PubMed:17158868}.
-!- PTM: Undergoes 'Lys-48'-linked polyubiquitination, leading to its
proteasomal degradation in response to signaling by TNFSF13B, TLR4 or
through CD40. 'Lys-48'-linked polyubiquitinated form is deubiquitinated
by OTUD7B, preventing TRAF3 proteolysis and over-activation of non-
canonical NF-kappa-B. Undergoes 'Lys-63'-linked ubiquitination during
early stages of virus infection, and 'Lys-48'-linked ubiquitination
during later stages. Undergoes both 'Lys-48'-linked and 'Lys-63'-linked
ubiquitination in response to TLR3 and TLR4 signaling. Deubiquitinated
by OTUB1, OTUB2 and OTUD5. {ECO:0000269|PubMed:18997792,
ECO:0000269|PubMed:19898473, ECO:0000269|PubMed:23334419}.
-!- DISRUPTION PHENOTYPE: Newborns appear normal, but do not thrive. Their
blood glucose levels and leukocyte levels decrease steadily, the spleen
size is dramatically reduced, and they become progressively runted.
They die about ten days after birth. Mice exhibit abnormally high
MAP3K14 protein levels and constitutive proteolytic processing of
NFKB2/p100, leading to constitutive activation of NF-kappa-B.
{ECO:0000269|PubMed:17015635, ECO:0000269|PubMed:18997792,
ECO:0000269|PubMed:8934568}.
-!- SIMILARITY: Belongs to the TNF receptor-associated factor family. A
subfamily. {ECO:0000305}.
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EMBL; U21050; AAC52175.1; -; mRNA.
EMBL; U33840; AAC52710.1; -; mRNA.
EMBL; CH466549; EDL18642.1; -; Genomic_DNA.
EMBL; BC137634; AAI37635.1; -; mRNA.
EMBL; BC137635; AAI37636.1; -; mRNA.
CCDS; CCDS26175.1; -.
PIR; I49272; I49272.
RefSeq; NP_035762.2; NM_011632.3.
RefSeq; XP_006515861.1; XM_006515798.2.
RefSeq; XP_006515862.1; XM_006515799.1.
RefSeq; XP_006515863.1; XM_006515800.2.
RefSeq; XP_006515864.1; XM_006515801.2.
PDB; 4GHU; X-ray; 2.20 A; A=376-567.
PDBsum; 4GHU; -.
SMR; Q60803; -.
BioGRID; 204304; 27.
DIP; DIP-34050N; -.
IntAct; Q60803; 21.
MINT; Q60803; -.
STRING; 10090.ENSMUSP00000021706; -.
iPTMnet; Q60803; -.
PhosphoSitePlus; Q60803; -.
SwissPalm; Q60803; -.
EPD; Q60803; -.
MaxQB; Q60803; -.
PaxDb; Q60803; -.
PeptideAtlas; Q60803; -.
PRIDE; Q60803; -.
Antibodypedia; 129; 510 antibodies.
Ensembl; ENSMUST00000021706; ENSMUSP00000021706; ENSMUSG00000021277.
GeneID; 22031; -.
KEGG; mmu:22031; -.
UCSC; uc007pcl.2; mouse.
CTD; 7187; -.
MGI; MGI:108041; Traf3.
eggNOG; ENOG410ISDV; Eukaryota.
eggNOG; ENOG410YQ97; LUCA.
GeneTree; ENSGT00940000160538; -.
InParanoid; Q60803; -.
KO; K03174; -.
OMA; MVTLQKH; -.
OrthoDB; 918518at2759; -.
TreeFam; TF321154; -.
Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway.
Reactome; R-MMU-5689896; Ovarian tumor domain proteases.
Reactome; R-MMU-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
BioGRID-ORCS; 22031; 5 hits in 15 CRISPR screens.
ChiTaRS; Traf3; mouse.
PRO; PR:Q60803; -.
Proteomes; UP000000589; Chromosome 12.
RNAct; Q60803; protein.
Bgee; ENSMUSG00000021277; Expressed in telencephalon and 289 other tissues.
ExpressionAtlas; Q60803; baseline and differential.
Genevisible; Q60803; MM.
GO; GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; IDA:BHF-UCL.
GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0019903; F:protein phosphatase binding; ISO:MGI.
GO; GO:0031996; F:thioesterase binding; ISO:MGI.
GO; GO:0005164; F:tumor necrosis factor receptor binding; ISO:MGI.
GO; GO:0031625; F:ubiquitin protein ligase binding; ISO:MGI.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0045087; P:innate immune response; IEA:InterPro.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
GO; GO:0046330; P:positive regulation of JNK cascade; IBA:GO_Central.
GO; GO:0070534; P:protein K63-linked ubiquitination; IBA:GO_Central.
GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
GO; GO:0001817; P:regulation of cytokine production; IMP:UniProtKB.
GO; GO:0050688; P:regulation of defense response to virus; IMP:UniProtKB.
GO; GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0032648; P:regulation of interferon-beta production; IMP:UniProtKB.
GO; GO:0030162; P:regulation of proteolysis; IDA:UniProtKB.
GO; GO:0008063; P:Toll signaling pathway; IEA:InterPro.
GO; GO:0002224; P:toll-like receptor signaling pathway; IMP:UniProtKB.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IMP:UniProtKB.
CDD; cd03777; MATH_TRAF3; 1.
Gene3D; 2.60.210.10; -; 1.
Gene3D; 3.30.40.10; -; 2.
InterPro; IPR002083; MATH/TRAF_dom.
InterPro; IPR043211; TNF_rcpt-assoc_TRAF.
InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
InterPro; IPR008974; TRAF-like.
InterPro; IPR027128; TRAF3.
InterPro; IPR037304; TRAF3_MATH.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR017907; Znf_RING_CS.
InterPro; IPR001293; Znf_TRAF.
PANTHER; PTHR10131; PTHR10131; 1.
PANTHER; PTHR10131:SF76; PTHR10131:SF76; 1.
Pfam; PF02176; zf-TRAF; 1.
PIRSF; PIRSF015614; TRAF; 1.
SMART; SM00061; MATH; 1.
SUPFAM; SSF49599; SSF49599; 3.
PROSITE; PS50144; MATH; 1.
PROSITE; PS00518; ZF_RING_1; 1.
PROSITE; PS50089; ZF_RING_2; 1.
PROSITE; PS50145; ZF_TRAF; 2.
1: Evidence at protein level;
3D-structure; Apoptosis; Coiled coil; Cytoplasm; Endosome; Immunity;
Isopeptide bond; Metal-binding; Reference proteome; Repeat; Transferase;
Ubl conjugation; Ubl conjugation pathway; Zinc; Zinc-finger.
CHAIN 1..567
/note="TNF receptor-associated factor 3"
/id="PRO_0000056402"
DOMAIN 414..559
/note="MATH"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00129"
ZN_FING 67..76
/note="RING-type"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
ZN_FING 134..189
/note="TRAF-type 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
ZN_FING 190..248
/note="TRAF-type 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
COILED 266..337
/evidence="ECO:0000255"
CROSSLNK 106
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000305"
CROSSLNK 155
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000305"
MUTAGEN 52
/note="C->A: Abolishes inhibition of NFKB2 processing; when
associated with A-55."
/evidence="ECO:0000269|PubMed:17158868"
MUTAGEN 55
/note="C->A: Abolishes inhibition of NFKB2 processing; when
associated with A-52."
/evidence="ECO:0000269|PubMed:17158868"
MUTAGEN 67
/note="C->A: Strongly reduces 'Lys-63'-linked
ubiquitination; when associated with A-69. Abolishes
inhibition of NFKB2 processing; when associated with A-69."
/evidence="ECO:0000269|PubMed:17158868,
ECO:0000269|PubMed:19898473"
MUTAGEN 69
/note="H->A: Strongly reduces 'Lys-63'-linked
ubiquitination; when associated with A-69. Abolishes
inhibition of NFKB2 processing; when associated with A-67."
/evidence="ECO:0000269|PubMed:17158868,
ECO:0000269|PubMed:19898473"
MUTAGEN 106
/note="K->R: Reduces 'Lys-48'-linked polyubiquitination;
when associated with R-155."
MUTAGEN 155
/note="K->R: Reduces 'Lys-48'-linked polyubiquitination;
when associated with R-106."
CONFLICT 72..73
/note="CE -> WQ (in Ref. 2; AAC52710)"
/evidence="ECO:0000305"
CONFLICT 390
/note="M -> T (in Ref. 1; AAC52175)"
/evidence="ECO:0000305"
HELIX 377..409
/evidence="ECO:0000244|PDB:4GHU"
STRAND 413..421
/evidence="ECO:0000244|PDB:4GHU"
HELIX 424..432
/evidence="ECO:0000244|PDB:4GHU"
STRAND 444..447
/evidence="ECO:0000244|PDB:4GHU"
STRAND 452..458
/evidence="ECO:0000244|PDB:4GHU"
HELIX 463..465
/evidence="ECO:0000244|PDB:4GHU"
TURN 466..468
/evidence="ECO:0000244|PDB:4GHU"
STRAND 469..477
/evidence="ECO:0000244|PDB:4GHU"
HELIX 482..484
/evidence="ECO:0000244|PDB:4GHU"
STRAND 493..497
/evidence="ECO:0000244|PDB:4GHU"
STRAND 507..511
/evidence="ECO:0000244|PDB:4GHU"
HELIX 518..520
/evidence="ECO:0000244|PDB:4GHU"
STRAND 524..527
/evidence="ECO:0000244|PDB:4GHU"
STRAND 531..538
/evidence="ECO:0000244|PDB:4GHU"
HELIX 539..544
/evidence="ECO:0000244|PDB:4GHU"
STRAND 552..559
/evidence="ECO:0000244|PDB:4GHU"
SEQUENCE 567 AA; 64294 MW; EC282EFFF84E5A3F CRC64;
MESSKKMDAA GTLQPNPPLK LQPDRGAGSV LVPEQGGYKE KFVKTVEDKY KCEKCRLVLC
NPKQTECGHR FCESCMAALL SSSSPKCTAC QESIIKDKVF KDNCCKREIL ALQVYCRNEG
RGCAEQLTLG HLLVHLKNEC QFEELPCLRA DCKEKVLRKD LRDHVEKACK YREATCSHCK
SQVPMIKLQK HEDTDCPCVV VSCPHKCSVQ TLLRSELSAH LSECVNAPST CSFKRYGCVF
QGTNQQIKAH EASSAVQHVN LLKEWSNSLE KKVSLLQNES VEKNKSIQSL HNQICSFEIE
IERQKEMLRN NESKILHLQR VIDSQAEKLK ELDKEIRPFR QNWEEADSMK SSVESLQNRV
TELESVDKSA GQAARNTGLL ESQLSRHDQM LSVHDIRLAD MDLRFQVLET ASYNGVLIWK
IRDYKRRKQE AVMGKTLSLY SQPFYTGYFG YKMCARVYLN GDGMGKGTHL SLFFVIMRGE
YDALLPWPFK QKVTLMLMDQ GSSRRHLGDA FKPDPNSSSF KKPTGEMNIA SGCPVFVAQT
VLENGTYIKD DTIFIKVIVD TSDLPDP


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EIAAB43355 B-cell surface antigen CD40,Bp50,Cd40,CD40L receptor,Mouse,Mus musculus,Tnfrsf5,Tumor necrosis factor receptor superfamily member 5
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Pathways :
WP1271: Toll-like receptor signaling pathway
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1449: Regulation of toll-like receptor signaling pathway
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1309: Toll-like receptor signaling pathway
WP1067: Toll-like receptor signaling pathway
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1384: Toll-like receptor signaling pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP949: Toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP75: Toll-like receptor signaling pathway
WP1183: Toll-like receptor signaling pathway
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP2272: Pathogenic Escherichia coli infection
WP2328: Allograft rejection
WP88: Toll Like Receptor signaling
WP2292: Chemokine signaling pathway
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP474: Endochondral Ossification

Related Genes :
[Traf3 Craf1 Trafamn] TNF receptor-associated factor 3 (EC 2.3.2.27) (CD40 receptor-associated factor 1) (CRAF1) (RING-type E3 ubiquitin transferase TRAF3) (TRAFAMN)
[TRAF3 CAP1 CRAF1] TNF receptor-associated factor 3 (EC 2.3.2.27) (CAP-1) (CD40 receptor-associated factor 1) (CRAF1) (CD40-binding protein) (CD40BP) (LMP1-associated protein 1) (LAP1) (RING-type E3 ubiquitin transferase TRAF3)
[Traf2] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2)
[TRAF2 TRAP3] TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
[TRAF6 RNF85] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
[Traf6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[TRAF6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[Traf6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[TRAF6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[TRAF6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[TRAF6] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[CD40 TNFRSF5] Tumor necrosis factor receptor superfamily member 5 (B-cell surface antigen CD40) (Bp50) (CD40L receptor) (CDw40) (CD antigen CD40)
[traf6 si:dkey-56p7.3 zgc:63704] TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (RING-type E3 ubiquitin transferase TRAF6)
[TRAF7 RFWD1 RNF119] E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
[AMFR RNF45] E3 ubiquitin-protein ligase AMFR (EC 2.3.2.27) (Autocrine motility factor receptor) (AMF receptor) (RING finger protein 45) (RING-type E3 ubiquitin transferase AMFR) (gp78)
[Amfr] E3 ubiquitin-protein ligase AMFR (EC 2.3.2.27) (Autocrine motility factor receptor) (AMF receptor) (RING-type E3 ubiquitin transferase AMFR)
[Traf7] E3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
[BIRC2 API1 MIHB RNF48] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
[RCHY1 ARNIP CHIMP PIRH2 RNF199 ZNF363] RING finger and CHY zinc finger domain-containing protein 1 (EC 2.3.2.27) (Androgen receptor N-terminal-interacting protein) (CH-rich-interacting match with PLAG1) (E3 ubiquitin-protein ligase Pirh2) (RING finger protein 199) (RING-type E3 ubiquitin transferase RCHY1) (Zinc finger protein 363) (p53-induced RING-H2 protein) (hPirh2)
[RNF31 ZIBRA] E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31) (Zinc in-between-RING-finger ubiquitin-associated domain protein)
[RNF4 SNURF RES4-26] E3 ubiquitin-protein ligase RNF4 (EC 2.3.2.27) (RING finger protein 4) (RING-type E3 ubiquitin transferase RNF4) (Small nuclear ring finger protein) (Protein SNURF)
[TRIM24 RNF82 TIF1 TIF1A] Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
[Birc2] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (Inhibitor of apoptosis protein 2) (mIAP2) (RING-type E3 ubiquitin transferase BIRC2)
[LNX1 LNX PDZRN2 UNQ574/PRO1136] E3 ubiquitin-protein ligase LNX (EC 2.3.2.27) (Ligand of Numb-protein X 1) (Numb-binding protein 1) (PDZ domain-containing RING finger protein 2) (RING-type E3 ubiquitin transferase LNX)
[RBCK1 C20orf18 RNF54 UBCE7IP3 XAP3 XAP4] RanBP-type and C3HC4-type zinc finger-containing protein 1 (EC 2.3.2.31) (HBV-associated factor 4) (Heme-oxidized IRP2 ubiquitin ligase 1) (HOIL-1) (Hepatitis B virus X-associated protein 4) (RING finger protein 54) (RING-type E3 ubiquitin transferase HOIL-1) (Ubiquitin-conjugating enzyme 7-interacting protein 3)
[Rnf31 Paul] E3 ubiquitin-protein ligase RNF31 (EC 2.3.2.31) (HOIL-1-interacting protein) (HOIP) (Putative Ariadne-like ubiquitin ligase) (PAUL) (RING finger protein 31) (RING-type E3 ubiquitin transferase RNF31)
[Trim24 Tif1 Tif1a] Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase Trim24) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
[Hltf Smarca3 Snf2l3 Zbu1] Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (P113) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) (TNF-response element-binding protein)
[Pias2 Miz1 Piasx] E3 SUMO-protein ligase PIAS2 (EC 2.3.2.27) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (Msx-interacting zinc finger protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2) (RING-type E3 ubiquitin transferase PIAS2)
[HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1] Helicase-like transcription factor (EC 2.3.2.27) (EC 3.6.4.-) (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (RING-type E3 ubiquitin transferase HLTF) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3)

Bibliography :