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Taste receptor type 2 member 13 (T2R13) (Taste receptor family B member 3) (TRB3)

 T2R13_HUMAN             Reviewed;         303 AA.
Q9NYV9; Q4G0I5; Q502V8; Q645X2;
11-APR-2003, integrated into UniProtKB/Swiss-Prot.
01-OCT-2000, sequence version 1.
05-JUN-2019, entry version 132.
RecName: Full=Taste receptor type 2 member 13;
AltName: Full=Taste receptor family B member 3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
PubMed=10761934; DOI=10.1016/S0092-8674(00)80705-9;
Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
Zuker C.S.;
"A novel family of mammalian taste receptors.";
Cell 100:693-702(2000).
PubMed=15496549; DOI=10.1093/molbev/msi027;
Fischer A., Gilad Y., Man O., Paeaebo S.;
"Evolution of bitter taste receptors in humans and apes.";
Mol. Biol. Evol. 22:432-436(2005).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=10761935; DOI=10.1016/S0092-8674(00)80706-0;
Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
Zuker C.S., Ryba N.J.P.;
"T2Rs function as bitter taste receptors.";
Cell 100:703-711(2000).
PubMed=12139982; DOI=10.1016/S0959-4388(02)00345-8;
Montmayeur J.-P., Matsunami H.;
"Receptors for bitter and sweet taste.";
Curr. Opin. Neurobiol. 12:366-371(2002).
PubMed=11696554; DOI=10.1074/jbc.R100054200;
Margolskee R.F.;
"Molecular mechanisms of bitter and sweet taste transduction.";
J. Biol. Chem. 277:1-4(2002).
PubMed=12581520; DOI=10.1016/S0092-8674(03)00071-0;
Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
Zuker C.S., Ryba N.J.;
"Coding of sweet, bitter, and umami tastes: different receptor cells
sharing similar signaling pathways.";
Cell 112:293-301(2003).
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
Vogelstein B., Kinzler K.W., Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal
Science 314:268-274(2006).
-!- FUNCTION: Receptor that may play a role in the perception of
bitterness and is gustducin-linked. May play a role in sensing the
chemical composition of the gastrointestinal content. The activity
of this receptor may stimulate alpha gustducin, mediate PLC-beta-2
activation and lead to the gating of TRPM5.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells
of the tongue and palate epithelium and exclusively in gustducin-
positive cells.
-!- MISCELLANEOUS: Most taste cells may be activated by a limited
number of bitter compounds; individual taste cells can
discriminate among bitter stimuli.
-!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF227137; AAF43910.1; -; Genomic_DNA.
EMBL; AY724945; AAU21147.1; -; Genomic_DNA.
EMBL; BC069376; AAH69376.1; -; mRNA.
EMBL; BC095518; AAH95518.1; -; mRNA.
CCDS; CCDS8635.1; -.
RefSeq; NP_076409.1; NM_023920.2.
BioGrid; 119148; 2.
STRING; 9606.ENSP00000375095; -.
iPTMnet; Q9NYV9; -.
PhosphoSitePlus; Q9NYV9; -.
BioMuta; TAS2R13; -.
DMDM; 29839659; -.
PaxDb; Q9NYV9; -.
ProteomicsDB; 83285; -.
DNASU; 50838; -.
Ensembl; ENST00000390677; ENSP00000375095; ENSG00000212128.
Ensembl; ENST00000574870; ENSP00000461365; ENSG00000273457.
Ensembl; ENST00000613662; ENSP00000478277; ENSG00000277254.
GeneID; 50838; -.
KEGG; hsa:50838; -.
UCSC; uc001qzg.1; human.
CTD; 50838; -.
DisGeNET; 50838; -.
GeneCards; TAS2R13; -.
HGNC; HGNC:14919; TAS2R13.
MIM; 604792; gene.
neXtProt; NX_Q9NYV9; -.
OpenTargets; ENSG00000212128; -.
PharmGKB; PA37929; -.
eggNOG; ENOG410J9F7; Eukaryota.
GeneTree; ENSGT00960000186648; -.
HOGENOM; HOG000234595; -.
InParanoid; Q9NYV9; -.
KO; K08474; -.
OrthoDB; 1061430at2759; -.
PhylomeDB; Q9NYV9; -.
TreeFam; TF335891; -.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
GeneWiki; TAS2R13; -.
GenomeRNAi; 50838; -.
PRO; PR:Q9NYV9; -.
Proteomes; UP000005640; Chromosome 12.
Bgee; ENSG00000212128; Expressed in 13 organ(s), highest expression level in corpus callosum.
Genevisible; Q9NYV9; HS.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0033038; F:bitter taste receptor activity; IDA:UniProtKB.
GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.
GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0032467; P:positive regulation of cytokinesis; IMP:UniProtKB.
InterPro; IPR007960; T2R.
Pfam; PF05296; TAS2R; 1.
1: Evidence at protein level;
Complete proteome; G-protein coupled receptor; Glycoprotein; Membrane;
Polymorphism; Receptor; Reference proteome; Sensory transduction;
Taste; Transducer; Transmembrane; Transmembrane helix.
CHAIN 1 303 Taste receptor type 2 member 13.
TOPO_DOM 1 7 Extracellular. {ECO:0000255}.
TRANSMEM 8 28 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 29 55 Cytoplasmic. {ECO:0000255}.
TRANSMEM 56 76 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 77 85 Extracellular. {ECO:0000255}.
TRANSMEM 86 106 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 107 128 Cytoplasmic. {ECO:0000255}.
TRANSMEM 129 149 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 150 184 Extracellular. {ECO:0000255}.
TRANSMEM 185 205 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 206 232 Cytoplasmic. {ECO:0000255}.
TRANSMEM 233 253 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 254 261 Extracellular. {ECO:0000255}.
TRANSMEM 262 282 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 283 303 Cytoplasmic. {ECO:0000255}.
CARBOHYD 162 162 N-linked (GlcNAc...) asparagine.
CARBOHYD 166 166 N-linked (GlcNAc...) asparagine.
VARIANT 149 149 N -> S (in a breast cancer sample;
somatic mutation).
VARIANT 259 259 N -> S (in dbSNP:rs1015443).
SEQUENCE 303 AA; 35118 MW; 756BF5382E36BFB5 CRC64;

Related products :

Catalog number Product name Quantity
EIAAB41111 Homo sapiens,Human,T2R13,TAS2R13,Taste receptor family B member 3,Taste receptor type 2 member 13,TRB3
EIAAB43724 Mouse,mT2r64,mTRB3,mTRB5,Mus musculus,T2R13,T2R140,T2R40,T2r64,T2R8,Tas2r13,Tas2r137,Tas2r140,Tas2r40,Tas2r8,Taste receptor family B member 3,Taste receptor type 2 member 140,Taste receptor type 2 mem
EIAAB41112 Mouse,mT2R48,Mus musculus,T2R121,T2R13,Tas2r121,Tas2r13,Taste receptor type 2 member 121,Taste receptor type 2 member 13
EIAAB43674 Mouse,Mus musculus,T2R10,T2R103,Tas2r10,Tas2r103,Taste receptor family B member 2,Taste receptor type 2 member 10,Taste receptor type 2 member 103,TRB2
EIAAB41110 Rat,Rattus norvegicus,T2R13,T2R7,Tas2r13,Tas2r7,Taste receptor type 2 member 13,Taste receptor type 2 member 7
EIAAB43709 Rat,Rattus norvegicus,T2R123,T2R2,T2R23,Tas2r123,Tas2r14,Tas2r2,Tas2r23,Taste receptor type 2 member 123,Taste receptor type 2 member 2,Taste receptor type 2 member 23
EIAAB41120 Homo sapiens,Human,T2R31,T2R44,T2R53,TAS2R31,TAS2R44,Taste receptor type 2 member 31,Taste receptor type 2 member 44,Taste receptor type 2 member 53
EIAAB43678 Mouse,Mus musculus,T2R105,T2R5,T2R9,Tas2r105,Tas2r5,Tas2r9,Taste receptor type 2 member 105,Taste receptor type 2 member 5,Taste receptor type 2 member 9
EIAAB43704 Rat,Rattus norvegicus,T2R1,T2R119,T2R19,Tas2r1,Tas2r119,Tas2r19,Taste receptor type 2 member 1,Taste receptor type 2 member 119,Taste receptor type 2 member 19
EIAAB41118 Homo sapiens,Human,T2R49,T2R56,TAS2R20,TAS2R49,Taste receptor type 2 member 20,Taste receptor type 2 member 49,Taste receptor type 2 member 56
EIAAB41117 Homo sapiens,Human,T2R48,TAS2R19,TAS2R23,TAS2R48,Taste receptor type 2 member 19,Taste receptor type 2 member 23,Taste receptor type 2 member 48
EIAAB41122 Homo sapiens,Human,PTC,PTC bitter taste receptor,T2R38,T2R61,TAS2R38,Taste receptor type 2 member 38,Taste receptor type 2 member 61
EIAAB41113 Homo sapiens,Human,T2R14,TAS2R14,Taste receptor family B member 1,Taste receptor type 2 member 14,TRB1
EIAAB41186 Homo sapiens,Human,T2R7,TAS2R7,Taste receptor family B member 4,Taste receptor type 2 member 7,TRB4
EIAAB41188 Homo sapiens,Human,T2R9,TAS2R9,Taste receptor family B member 6,Taste receptor type 2 member 9,TRB6
EIAAB41108 Homo sapiens,Human,T2R10,TAS2R10,Taste receptor family B member 2,Taste receptor type 2 member 10,TRB2
EIAAB41187 Homo sapiens,Human,T2R8,TAS2R8,Taste receptor family B member 5,Taste receptor type 2 member 8,TRB5
EIAAB41176 Homo sapiens,Human,T2R1,TAS2R1,Taste receptor family B member 7,Taste receptor type 2 member 1,TRB7
EIAAB41127 GPR60,G-protein coupled receptor 60,Homo sapiens,Human,T2R40,T2R58,TAS2R40,Taste receptor type 2 member 40,Taste receptor type 2 member 58
EIAAB43708 Mouse,mT2R55,Mus musculus,STC9-2,T2R123,T2R23,T2r55,Tas2r123,Tas2r23,Taste receptor type 2 member 123,Taste receptor type 2 member 23
EIAAB43727 Mouse,mT2R36,Mus musculus,T2R143,T2r36,T2R43,Tas2r143,Tas2r43,Taste receptor type 2 member 143,Taste receptor type 2 member 43
EIAAB43716 Rat,Rattus norvegicus,T2R134,T2R23,T2R34,Tas2r134,Tas2r23,Tas2r34,Taste receptor type 2 member 134,Taste receptor type 2 member 23
EIAAB43718 Mouse,mT2r38,Mus musculus,T2R135,T2R35,T2r38,Tas2r135,Tas2r35,Taste receptor type 2 member 135,Taste receptor type 2 member 35
EIAAB43721 Mouse,mT2r52,Mus musculus,T2R136,T2R36,T2r52,Tas2r136,Tas2r36,Taste receptor type 2 member 136,Taste receptor type 2 member 36
EIAAB41181 Mouse,Mus musculus,T2R4,T2R8,Tas2r108,Tas2r4,Tas2r8,Taste receptor type 2 member 4,Taste receptor type 2 member 8
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1249: EPO Receptor Signaling
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP768: EPO Receptor Signaling
WP147: Kit Receptor Signaling Pathway
WP362: TGF-beta Receptor Signaling Pathway
WP926: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP474: Endochondral Ossification
WP949: Toll-like receptor signaling pathway
WP1284: EPO Receptor Signaling
WP783: Androgen Receptor Signaling Pathway
WP1336: EPO Receptor Signaling
WP2328: Allograft rejection
WP809: TGF-beta Receptor Signaling Pathway
WP1121: Kit Receptor Signaling Pathway
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP57: Signal Transduction of S1P Receptor
WP1913: Signaling by Insulin receptor
WP590: Cardiovascular Signaling
WP1348: Androgen Receptor Signaling Pathway
WP258: TGF-beta Receptor Signaling Pathway
WP878: EPO Receptor Signaling
WP1367: TGF-beta Receptor Signaling Pathway
WP285: B Cell Receptor Signaling Pathway

Related Genes :
[Tas1r3 Sac T1r3 Tr3] Taste receptor type 1 member 3 (Saccharin preference protein) (Sweet taste receptor T1R3)
[TAS1R3 T1R3 TR3] Taste receptor type 1 member 3 (Sweet taste receptor T1R3)
[TRIB3 C20orf97 NIPK SKIP3 TRB3] Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
[Trib3 Nipk Trb3] Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase)
[Tas1r1 Gpr70 T1r1 Tr1] Taste receptor type 1 member 1 (G-protein coupled receptor 70)
[TRB3 TBP2 At3g49850 T16K5.200] Telomere repeat-binding factor 3 (AtTRB3) (MYB transcription factor) (Telomere-binding protein 2) (AtTBP2)
[Tas1r3 T1r3 Tr3] Taste receptor type 1 member 3 (Sweet taste receptor T1R3)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[odr-7 T18D3.2] Nuclear hormone receptor family member odr-7 (Odorant response abnormal protein 7)
[CLEC1B CLEC2 UNQ721/PRO1384] C-type lectin domain family 1 member B (C-type lectin-like receptor 2) (CLEC-2)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[Esrrb Err-2 Err2 Nr3b2] Steroid hormone receptor ERR2 (Estrogen receptor-like 2) (Estrogen-related receptor beta) (ERR-beta) (Nuclear receptor subfamily 3 group B member 2)
[PLA2R1 CLEC13C] Secretory phospholipase A2 receptor (PLA2-R) (PLA2R) (180 kDa secretory phospholipase A2 receptor) (C-type lectin domain family 13 member C) (M-type receptor) [Cleaved into: Soluble secretory phospholipase A2 receptor (Soluble PLA2-R) (Soluble PLA2R)]
[Lilrb3 Pirb] Leukocyte immunoglobulin-like receptor subfamily B member 3 (LIR-3) (Leukocyte immunoglobulin-like receptor 3) (Cell-surface glycoprotein p91) (Paired immunoglobulin-like receptor B) (PIR-B)
[nhr-6 cnr-8 nr4a5 C48D5.1] Nuclear hormone receptor family member nhr-6 (Nuclear receptor subfamily 4 group A member 5) (Steroid hormone receptor family member cnr8)
[TNFRSF13B TACI] Tumor necrosis factor receptor superfamily member 13B (Transmembrane activator and CAML interactor) (CD antigen CD267)
[Nr1h2 Lxrb] Oxysterols receptor LXR-beta (Liver X receptor beta) (Nuclear receptor subfamily 1 group H member 2) (Orphan nuclear receptor OR-1) (Ubiquitously-expressed nuclear receptor) (UR)
[CLEC2A KACL UNQ5792/PRO19597] C-type lectin domain family 2 member A (Keratinocyte-associated C-type lectin) (KACL) (Proliferation-induced lymphocyte-associated receptor) (PILAR)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[CLEC7A BGR CLECSF12 DECTIN1 UNQ539/PRO1082] C-type lectin domain family 7 member A (Beta-glucan receptor) (C-type lectin superfamily member 12) (Dendritic cell-associated C-type lectin 1) (DC-associated C-type lectin 1) (Dectin-1) (CD antigen CD369)
[MRC1 CLEC13D CLEC13DL MRC1L1] Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[Gr66a CG7189] Gustatory receptor for bitter taste 66a
[PDGFRB PDGFR PDGFR1] Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
[LILRA3 ILT6 LIR4] Leukocyte immunoglobulin-like receptor subfamily A member 3 (CD85 antigen-like family member E) (Immunoglobulin-like transcript 6) (ILT-6) (Leukocyte immunoglobulin-like receptor 4) (LIR-4) (Monocyte inhibitory receptor HM43/HM31) (CD antigen CD85e)
[SLC52A1 GPR172B PAR2 RFT1] Solute carrier family 52, riboflavin transporter, member 1 (Porcine endogenous retrovirus A receptor 2) (PERV-A receptor 2) (Protein GPR172B) (Riboflavin transporter 1) (hRFT1)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[Rxrb Nr2b2] Retinoic acid receptor RXR-beta (MHC class I regulatory element-binding protein H-2RIIBP) (Nuclear receptor subfamily 2 group B member 2) (Retinoid X receptor beta)
[CLEC4D CLECSF8 MCL] C-type lectin domain family 4 member D (C-type lectin superfamily member 8) (C-type lectin-like receptor 6) (CLEC-6) (CD antigen CD368)

Bibliography :