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Tau-theraphotoxin-Pc1b (Tau-TRTX-Pc1b) (Vanillotoxin-2) (VaTx2)

 TX2_PSACA               Reviewed;          35 AA.
P0C245;
28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
28-NOV-2006, sequence version 1.
08-MAY-2019, entry version 41.
RecName: Full=Tau-theraphotoxin-Pc1b;
Short=Tau-TRTX-Pc1b;
AltName: Full=Vanillotoxin-2 {ECO:0000303|PubMed:17093448};
Short=VaTx2 {ECO:0000303|PubMed:17093448};
Psalmopoeus cambridgei (Trinidad chevron tarantula).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Araneae; Mygalomorphae; Theraphosidae; Psalmopoeus.
NCBI_TaxID=179874;
[1]
PROTEIN SEQUENCE, FUNCTION, TOXIN TARGET, MASS SPECTROMETRY,
SUBCELLULAR LOCATION, AND AMIDATION AT PHE-35.
TISSUE=Venom;
PubMed=17093448; DOI=10.1038/nature05285;
Siemens J., Zhou S., Piskorowski R., Nikai T., Lumpkin E.A.,
Basbaum A.I., King D., Julius D.;
"Spider toxins activate the capsaicin receptor to produce inflammatory
pain.";
Nature 444:208-212(2006).
-!- FUNCTION: Selectively activates the mammalian capsaicin receptor
TRPV1, a non-selective cation channel expressed by sensory neurons
of the pain pathway. Is more potent than VaTx1, but less potent
than VaTx3. Interacts with distinct regions of the channel than
capsaicin, since it only acts on the extracellular face of the
channel, and capsaicin binds to the cytosolic side. Also activates
avian TRPV1, which is insensitive to capsaicin. Produce weak
inhibition on potassium channels Kv2.1/KCNB1.
{ECO:0000269|PubMed:17093448}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17093448}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000305|PubMed:17093448}.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin.
{ECO:0000250|UniProtKB:P60992}.
-!- MASS SPECTROMETRY: Mass=3842.0; Method=Unknown; Range=1-35;
Evidence={ECO:0000269|PubMed:17093448};
-!- MISCELLANEOUS: This toxin does not have effect on TRPV2, TRPV3,
TRPV4, TRPA1, TRPM8, Kv1.2/KCNA2 or Kv4.2/KCND2.
{ECO:0000269|PubMed:17093448}.
-!- SIMILARITY: Belongs to the neurotoxin 10 (Hwtx-1) family. 62
(Vatx) subfamily. {ECO:0000305}.
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SMR; P0C245; -.
ArachnoServer; AS000252; tau-theraphotoxin-Pc1b.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
InterPro; IPR011696; Huwentoxin-1.
Pfam; PF07740; Toxin_12; 1.
1: Evidence at protein level;
Amidation; Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Knottin; Neurotoxin;
Potassium channel impairing toxin; Secreted; Toxin;
Voltage-gated potassium channel impairing toxin.
CHAIN 1 35 Tau-theraphotoxin-Pc1b.
{ECO:0000269|PubMed:17093448}.
/FTId=PRO_0000262452.
MOD_RES 35 35 Phenylalanine amide.
{ECO:0000269|PubMed:17093448}.
DISULFID 3 17 {ECO:0000250|UniProtKB:P60992}.
DISULFID 10 22 {ECO:0000250|UniProtKB:P60992}.
DISULFID 16 29 {ECO:0000250|UniProtKB:P60992}.
SEQUENCE 35 AA; 3852 MW; B70E717ED06107D1 CRC64;
GACRWFLGGC KSTSDCCEHL SCKMGLDYCA WDGTF


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Pathways :
No related Items

Related Genes :
[] Tau-theraphotoxin-Pc1b (Tau-TRTX-Pc1b) (Vanillotoxin-2) (VaTx2)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[] Tau-theraphotoxin-Pc1c (Tau-TRTX-Pc1c) (Vanillotoxin-3) (VaTx3)
[] Huwentoxin-IV (HwTx-IV) (Huwentoxin-4) (Huwentoxin-IVa) (HWTX-IVa) (Huwentoxin-IVb) (HWTX-IVb) (Huwentoxin-IVc) (HWTX-IVc) (Mu-theraphotoxin-Hs2a) (Mu-TRTX-Hs2a)
[] Omega-theraphotoxin-Hs2a (Omega-TRTX-Hs2a) (Huwentoxin-5) (Huwentoxin-V) (HwTx-V) [Cleaved into: Omega-theraphotoxin-Hs2b (Omega-TRTX-Hs2b) (Mutant of huwentoxin-5) (Mutant of huwentoxin-V) (mHWTX-V)]
[] Mu-theraphotoxin-Hhn1b 2 (Mu-TRTX-Hhn1b) (Hainantoxin-4.2) (Hainantoxin-IV.2) (HnTx-IV.2) (Peptide F8-18.88)
[] Beta/omega-theraphotoxin-Tp2a (Beta/omega-TRTX-Tp2a) (Protoxin-2) (ProTx-2) (ProTx2) (Protoxin-II) (PT-II) (ProTx-II)
[] Beta/kappa-theraphotoxin-Cg2a (Beta/kappa-TRTX-Cg2a) (Beta-theraphotoxin-Cj2a) (Jingzhaotoxin-5) (Jingzhaotoxin-V) (JZTX-V) (Peptide F8-15.73)
[MAPT MAPTL MTBT1 TAU] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[] Mu-theraphotoxin-Hhn1b 3 (Mu-TRTX-Hhn1b) (Hainantoxin-4.3) (Hainantoxin-IV.3) (HnTx-IV.3) (Peptide F8-18.88)
[] Beta-theraphotoxin-Cm1a (Beta-TRTX-Cm1a) (CcoTx-I) (Ceratotoxin-1) (CcoTx1)
[Mapt Mtapt Tau] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[MAPT TAU] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[TTBK1 BDTK KIAA1855] Tau-tubulin kinase 1 (EC 2.7.11.1) (Brain-derived tau kinase)
[] Kappa-theraphotoxin-Scg1a (Kappa-TRTX-Scg1a) (SGTx1) (SGTx) (SgTx-I)
[Mapt Mtapt Tau] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[] Mu-theraphotoxin-Hhn1b 1 (Mu-TRTX-Hhn1b) (Hainantoxin-4) (Hainantoxin-IV) (HnTx-IV) (Peptide F8-18.88)
[MAPT TAU] Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
[] Mu-theraphotoxin-Hhn2b 2 (Mu-TRTX-Hhn2b) (Hainantoxin-1.2) (Hainantoxin-I.2) (HnTx-I.2) (Peptide F5-19.03)
[] Mu-theraphotoxin-Hhn2b 3 (Mu-TRTX-Hhn2b) (Hainantoxin-1.3) (Hainantoxin-I.3) (HnTx-I.3) (Peptide F5-19.03)
[Prkaa1 Ampk1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[PRKAA1 AMPK1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[Prkaa1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
[PRKAA1 AMPK1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (AMPK 63 kDa subunit) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) (Fragments)
[PRKAA1] 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26) (Fragment)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[Csnk1d Hckid] Casein kinase I isoform delta (CKI-delta) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[Csnk1d Hckid] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)
[CSNK1D HCKID] Casein kinase I isoform delta (CKI-delta) (CKId) (EC 2.7.11.1) (Tau-protein kinase CSNK1D) (EC 2.7.11.26)

Bibliography :
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