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Thiamine metabolism regulatory protein THI3 (EC 4.1.1.72) (Keto isocaproate decarboxylase 1) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)

 THI3_YEAST              Reviewed;         609 AA.
Q07471; D6VRR9; P89098;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
03-JUL-2019, entry version 157.
RecName: Full=Thiamine metabolism regulatory protein THI3;
EC=4.1.1.72 {ECO:0000269|PubMed:10753893, ECO:0000269|PubMed:9341119};
AltName: Full=Keto isocaproate decarboxylase 1;
AltName: Full=Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase;
Short=2ODC;
Name=THI3; Synonyms=KID1; OrderedLocusNames=YDL080C;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=S288c / GRF88;
Nishimura H., Nosaka K., Kaneko Y., Watanabe K., Iwashima A.;
"Sequencing and expression of THI3 gene coding a positive regulatory
factor with thiamin pyrophosphate-binding motif for thiamin metabolism
in Saccharomyces cerevisiae.";
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169867;
Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N.,
Paulin L., Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M.,
Prydz H., Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L.,
Rieger M., Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M.,
Scharfe M., Schmidt E.R., Schneider C., Scholler P., Schwarz S.,
Soler-Mira A., Urrestarazu L.A., Verhasselt P., Vissers S., Voet M.,
Volckaert G., Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S.,
Harris D.E., Bowman S., Brown D., Churcher C.M., Connor R., Dedman K.,
Gentles S., Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D.,
Niblett D., Odell C., Oliver K., Rajandream M.A., Richards C.,
Shore L., Walsh S.V., Barrell B.G., Dietrich F.S., Mulligan J.T.,
Allen E., Araujo R., Aviles E., Berno A., Carpenter J., Chen E.,
Cherry J.M., Chung E., Duncan M., Hunicke-Smith S., Hyman R.W.,
Komp C., Lashkari D., Lew H., Lin D., Mosedale D., Nakahara K.,
Namath A., Oefner P., Oh C., Petel F.X., Roberts D., Schramm S.,
Schroeder M., Shogren T., Shroff N., Winant A., Yelton M.A.,
Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S.,
Greco T., Hallsworth K., Hawkins J., Hillier L.W., Jier M.,
Johnson D., Johnston L., Kirsten J., Kucaba T., Langston Y.,
Latreille P., Le T., Mardis E., Menezes S., Miller N., Nhan M.,
Pauley A., Peluso D., Rifkin L., Riles L., Taich A., Trevaskis E.,
Vignati D., Wilcox L., Wohldman P., Vaudin M., Wilson R.,
Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
Mewes H.-W., Zollner A., Zaccaria P.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
Nature 387:75-78(1997).
[3]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[4]
FUNCTION, AND REGULATION OF THIAMINE METABOLISM.
PubMed=1624458; DOI=10.1128/jb.174.14.4701-4706.1992;
Nishimura H., Kawasaki Y., Kaneko Y., Nosaka K., Iwashima A.;
"A positive regulatory gene, THI3, is required for thiamine metabolism
in Saccharomyces cerevisiae.";
J. Bacteriol. 174:4701-4706(1992).
[5]
ROLE IN LEUCINE CATABOLISM.
PubMed=9341119; DOI=10.1074/jbc.272.43.26871;
Dickinson J.R., Lanterman M.M., Danner D.J., Pearson B.M., Sanz P.,
Harrison S.J., Hewlins M.J.;
"A 13C nuclear magnetic resonance investigation of the metabolism of
leucine to isoamyl alcohol in Saccharomyces cerevisiae.";
J. Biol. Chem. 272:26871-26878(1997).
[6]
ROLE IN VALINE CATABOLISM.
PubMed=9748245; DOI=10.1074/jbc.273.40.25751;
Dickinson J.R., Harrison S.J., Hewlins M.J.;
"An investigation of the metabolism of valine to isobutyl alcohol in
Saccharomyces cerevisiae.";
J. Biol. Chem. 273:25751-25756(1998).
[7]
ROLE IN ISOLEUCINE CATABOLISM.
PubMed=10753893; DOI=10.1074/jbc.275.15.10937;
Dickinson J.R., Harrison S.J., Dickinson J.A., Hewlins M.J.;
"An investigation of the metabolism of isoleucine to active Amyl
alcohol in Saccharomyces cerevisiae.";
J. Biol. Chem. 275:10937-10942(2000).
[8]
ROLE IN PHENYLALANINE; TRYPTOPHAN AND LEUCINE CATABOLISM.
PubMed=12499363; DOI=10.1074/jbc.M211914200;
Dickinson J.R., Salgado L.E., Hewlins M.J.;
"The catabolism of amino acids to long chain and complex alcohols in
Saccharomyces cerevisiae.";
J. Biol. Chem. 278:8028-8034(2003).
[9]
FUNCTION, AND AROMATIC AMINO ACIDS AS NITROGEN SOURCE.
PubMed=12902239; DOI=10.1128/AEM.69.8.4534-4541.2003;
Vuralhan Z., Morais M.A., Tai S.L., Piper M.D., Pronk J.T.;
"Identification and characterization of phenylpyruvate decarboxylase
genes in Saccharomyces cerevisiae.";
Appl. Environ. Microbiol. 69:4534-4541(2003).
[10]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[11]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[12]
LACK OF DECARBOXYLATION ACTIVITY.
PubMed=22904058; DOI=10.1128/AEM.01675-12;
Romagnoli G., Luttik M.A., Koetter P., Pronk J.T., Daran J.M.;
"Substrate specificity of thiamine pyrophosphate-dependent 2-oxo-acid
decarboxylases in Saccharomyces cerevisiae.";
Appl. Environ. Microbiol. 78:7538-7548(2012).
-!- FUNCTION: One of five 2-oxo acid decarboxylases (PDC1, PDC5, PDC6,
ARO10, and THI3) involved in amino acid catabolism. The enzyme
catalyzes the decarboxylation of amino acids, which, in a first
step, have been transaminated to the corresponding 2-oxo acids
(alpha-keto-acids). In a third step, the resulting aldehydes are
reduced to alcohols, collectively referred to as fusel oils or
alcohols. Its preferred substrates are the transaminated amino
acids derived from leucine (4-methyl-2-oxopentanoate, also alpha-
keto-isocaproate) and isoleucine ((3S)-3-methyl-2-oxopentanoate,
also alpha-keto-beta-methylvalerate), whereas transaminated
valine, transaminated aromatic amino acids, and pyruvate are no
substrates. In analogy to the pyruvate decarboxylases the enzyme
may in a side-reaction catalyze condensation (or carboligation)
reactions leading to the formation of 2-hydroxy ketone,
collectively called acyloins. The enzyme is also positively
regulating the thiamine metabolism by a molecular mechanism that
may involve thiamine concentration sensing and signal
transmission. {ECO:0000269|PubMed:10753893,
ECO:0000269|PubMed:12499363, ECO:0000269|PubMed:12902239,
ECO:0000269|PubMed:1624458, ECO:0000269|PubMed:9341119,
ECO:0000269|PubMed:9748245}.
-!- CATALYTIC ACTIVITY:
Reaction=4-methyl-2-oxopentanoate + H(+) = 3-methylbutanal + CO2;
Xref=Rhea:RHEA:54360, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
ChEBI:CHEBI:16638, ChEBI:CHEBI:17865; EC=4.1.1.72;
Evidence={ECO:0000269|PubMed:9341119};
-!- CATALYTIC ACTIVITY:
Reaction=(S)-3-methyl-2-oxopentanoate + H(+) = 2-methylbutanal +
CO2; Xref=Rhea:RHEA:21108, ChEBI:CHEBI:15378, ChEBI:CHEBI:16182,
ChEBI:CHEBI:16526, ChEBI:CHEBI:35146; EC=4.1.1.72;
Evidence={ECO:0000269|PubMed:10753893};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
Note=Binds 1 Mg(2+) per subunit. {ECO:0000250};
-!- COFACTOR:
Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Evidence={ECO:0000250};
Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000250};
-!- PATHWAY: Amino-acid degradation; Ehrlich pathway.
-!- INTERACTION:
P32896:PDC2; NbExp=3; IntAct=EBI-19209, EBI-13004;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14562095}.
-!- BIOTECHNOLOGY: Fusel oils are important flavor and aroma compounds
in yeast-fermented products contributing to the quality of
beverages and food. In low concentration they are generally
desirable, whereas high concentrations may spoil the product. By
adjusting growth conditions and substrate their production is
sought to be influenced.
-!- MISCELLANEOUS: Present with 2140 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the TPP enzyme family. {ECO:0000305}.
-!- CAUTION: While genetic evidence suggests this enzyme is involved
in leucine and isoleucine catabolism (PubMed:9341119,
PubMed:10753893), no decarboxylase enzymatic activity could be
detected in cell extracts of S.cerevisiae strains expressing the
individual gene (PubMed:22904058). {ECO:0000305|PubMed:10753893,
ECO:0000305|PubMed:22904058, ECO:0000305|PubMed:9341119}.
-!- SEQUENCE CAUTION:
Sequence=BAA04886.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; D21880; BAA04886.1; ALT_INIT; Genomic_DNA.
EMBL; Z74128; CAA98646.1; -; Genomic_DNA.
EMBL; BK006938; DAA11779.1; -; Genomic_DNA.
PIR; S67616; S67616.
RefSeq; NP_010203.1; NM_001180139.1.
SMR; Q07471; -.
BioGrid; 31981; 111.
DIP; DIP-6304N; -.
IntAct; Q07471; 15.
MINT; Q07471; -.
STRING; 4932.YDL080C; -.
iPTMnet; Q07471; -.
MaxQB; Q07471; -.
PaxDb; Q07471; -.
PRIDE; Q07471; -.
EnsemblFungi; YDL080C_mRNA; YDL080C_mRNA; YDL080C.
GeneID; 851479; -.
KEGG; sce:YDL080C; -.
EuPathDB; FungiDB:YDL080C; -.
SGD; S000002238; THI3.
GeneTree; ENSGT00940000176336; -.
HOGENOM; HOG000061334; -.
InParanoid; Q07471; -.
KO; K01568; -.
OMA; LRQEWVW; -.
BioCyc; MetaCyc:MONOMER3O-409; -.
BioCyc; YEAST:MONOMER3O-409; -.
UniPathway; UPA00866; -.
PRO; PR:Q07471; -.
Proteomes; UP000002311; Chromosome IV.
GO; GO:0005829; C:cytosol; IBA:GO_Central.
GO; GO:0005634; C:nucleus; IDA:SGD.
GO; GO:0047433; F:branched-chain-2-oxoacid decarboxylase activity; IBA:GO_Central.
GO; GO:0016831; F:carboxy-lyase activity; IBA:GO_Central.
GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
GO; GO:0004737; F:pyruvate decarboxylase activity; IBA:GO_Central.
GO; GO:0001102; F:RNA polymerase II activating transcription factor binding; IPI:SGD.
GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
GO; GO:0000949; P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway; IBA:GO_Central.
GO; GO:0009083; P:branched-chain amino acid catabolic process; IEA:UniProtKB-KW.
GO; GO:0006067; P:ethanol metabolic process; IBA:GO_Central.
GO; GO:0006559; P:L-phenylalanine catabolic process; IBA:GO_Central.
GO; GO:0090180; P:positive regulation of thiamine biosynthetic process; IMP:SGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:SGD.
GO; GO:0006090; P:pyruvate metabolic process; IBA:GO_Central.
GO; GO:0006569; P:tryptophan catabolic process; IBA:GO_Central.
InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
InterPro; IPR029061; THDP-binding.
InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
InterPro; IPR012110; TPP_enzyme.
InterPro; IPR011766; TPP_enzyme-bd_C.
Pfam; PF02775; TPP_enzyme_C; 1.
Pfam; PF00205; TPP_enzyme_M; 1.
Pfam; PF02776; TPP_enzyme_N; 1.
PIRSF; PIRSF036565; Pyruvt_ip_decrb; 1.
SUPFAM; SSF52467; SSF52467; 1.
SUPFAM; SSF52518; SSF52518; 2.
1: Evidence at protein level;
Branched-chain amino acid catabolism; Complete proteome;
Decarboxylase; Lyase; Magnesium; Metal-binding; Nucleus;
Reference proteome; Thiamine pyrophosphate.
CHAIN 1 609 Thiamine metabolism regulatory protein
THI3.
/FTId=PRO_0000090836.
SEQUENCE 609 AA; 68366 MW; 8EC37CC5B2BFA1AD CRC64;
MNSSYTQRYA LPKCIAISDY LFHRLNQLNI HTIFGLSGEF SMPLLDKLYN IPNLRWAGNS
NELNAAYAAD GYSRLKGLGC LITTFGVGEL SAINGVAGSY AEHVGILHIV GMPPTSAQTK
QLLLHHTLGN GDFTVFHRIA SDVACYTTLI IDSELCADEV DKCIKKAWIE QRPVYMGMPV
NQVNLPIESA RLNTPLDLQL HKNDPDVEKE VISRILSFIY KSQNPAIIVD ACTSRQNLIE
ETKELCNRLK FPVFVTPMGK GTVNETDPQF GGVFTGSISA PEVREVVDFA DFIIVIGCML
SEFSTSTFHF QYKTKNCALL YSTSVKLKNA TYPDLSIKLL LQKILANLDE SKLSYQPSEQ
PSMMVPRPYP AGNVLLRQEW VWNEISHWFQ PGDIIITETG ASAFGVNQTR FPVNTLGISQ
ALWGSVGYTM GACLGAEFAV QEINKDKFPA TKHRVILFMG DGAFQLTVQE LSTIVKWGLT
PYIFVMNNQG YSVDRFLHHR SDASYYDIQP WNYLGLLRVF GCTNYETKKI ITVGEFRSMI
SDPNFATNDK IRMIEIMLPP RDVPQALLDR WVVEKEQSKQ VQEENENSSA VNTPTPEFQP
LLKKNQVGY


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Related Genes :
[THI3 KID1 YDL080C] Thiamine metabolism regulatory protein THI3 (EC 4.1.1.72) (Keto isocaproate decarboxylase 1) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
[ARO10 YDR380W D9481.3] Transaminated amino acid decarboxylase (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (EC 4.1.1.80) (Thiamine diphosphate-dependent phenylpyruvate decarboxylase) (PPDC) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC) (Transaminated branched-chain amino acid decarboxylase)
[PDC1 YLR044C L2104] Pyruvate decarboxylase isozyme 1 (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
[PDC5 YLR134W L3133 L9606.7] Pyruvate decarboxylase isozyme 2 (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
[PDC6 YGR087C] Pyruvate decarboxylase isozyme 3 (EC 4.1.1.-) (EC 4.1.1.43) (EC 4.1.1.72) (EC 4.1.1.74) (Thiamine pyrophosphate-dependent 2-oxo-acid decarboxylase) (2ODC)
[kgd sucA MSMEG_5049 MSMEI_4922] Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]
[azin2 azi2 odc1-b odc2] Antizyme inhibitor 2 (AzI2) (Ornithine decarboxylase 2) (ODC 2) (xODC2) (Ornithine decarboxylase-like protein) (ODC-like protein) (ornithine decarboxylase paralog) (ODC-p)
[kgd Rv1248c] Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)]
[DBT BCATE2] Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (EC 2.3.1.168) (52 kDa mitochondrial autoantigen of primary biliary cirrhosis) (Branched chain 2-oxo-acid dehydrogenase complex component E2) (BCOADC-E2) (Branched-chain alpha-keto acid dehydrogenase complex component E2) (BCKAD-E2) (BCKADE2) (Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex) (Dihydrolipoamide branched chain transacylase) (Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase)
[BCKDHA] 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain) (BCKDE1A) (BCKDH E1-alpha)
[cfp pdc-1 NCU02193] Pyruvate decarboxylase (EC 4.1.1.1) (8-10 nm cytoplasmic filament-associated protein) (P59NC)
[proA] 4-hydroxy-4-methyl-2-oxoglutarate aldolase/4-carboxy-4-hydroxy-2-oxoadipate aldolase (HMG/CHA aldolase) (EC 4.1.3.16) (EC 4.1.3.17) (4-hydroxy-2-oxoglutarate aldolase) (Oxaloacetate decarboxylase) (OAA decarboxylase) (EC 4.1.1.112)
[pucL yunL BSU32450] Uric acid degradation bifunctional protein PucL [Includes: 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase (OHCU decarboxylase) (EC 4.1.1.97); Uricase (EC 1.7.3.3) (Urate oxidase)]
[SLC44A4 C6orf29 CTL4 NG22 TPPT1 UNQ441/PRO874] Choline transporter-like protein 4 (Solute carrier family 44 member 4) (Thiamine pyrophosphate transporter 1) (hTPPT1)
[MVD MPD] Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase)
[BCKDHB] 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial (EC 1.2.4.4) (Branched-chain alpha-keto acid dehydrogenase E1 component beta chain) (BCKDE1B) (BCKDH E1-beta)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[GAD2 GAD65] Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMT91_24760 BvCmsC61A_00149 BvCmsH15A_00510 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C4J69_22715 C7B08_25495 CR538_10415 D2F89_25795 D3Y67_22910 D9G42_11130 D9I97_22010 D9J11_25195 DP258_02540 E5M00_18610 EC3234A_36c00010 EC382_21100 ECTO6_01955 EFV06_13085 EPS71_23885 FORC82_1921 NCTC8500_02249 NCTC9037_02122 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[Gadl1] Acidic amino acid decarboxylase GADL1 (Aspartate 1-decarboxylase) (ADC) (EC 4.1.1.11) (Cysteine sulfinic acid decarboxylase) (CSADC) (EC 4.1.1.29) (Glutamate decarboxylase-like protein 1)
[Hsd3b4] NADPH-dependent 3-keto-steroid reductase Hsd3b4 (3 beta-hydroxysteroid dehydrogenase type 4) (3 beta-hydroxysteroid dehydrogenase type IV) (3 beta-HSD IV) (EC 1.1.1.270) (Dihydrotestosterone 3-ketoreductase) (EC 1.1.1.210)
[hpcH hpaI] 4-hydroxy-2-oxo-heptane-1,7-dioate aldolase (EC 4.1.2.52) (2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase) (HHED aldolase) (4-hydroxy-2-ketoheptane-1,7-dioate aldolase) (HKHD aldolase)
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP008_02510 BvCmsKSP015_01352 BvCmsKSP036_04668 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsKSP083_03900 BvCmsNSNP027_04914 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP039_03266 BvCmsNSP047_03567 BvCmsNSP078_03451 BvCmsSINP011_04162 BvCmsSIP006_05510 BvCmsSIP082_02402 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CIJ94_05515 COD46_23180 CQP61_17160 CRD98_26150 CY655_12940 D5618_21870 D9D20_21030 D9D43_06110 D9H68_20750 D9H70_25730 D9I87_15275 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTM25_06080 DU321_04440 E2855_02503 E2863_02392 EC95NR1_00961 ED648_25045 EFB45_10990 EPS97_16570 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 EVY21_22520 ExPECSC038_01920 EXX32_14605 EXX71_02385 EXX78_21815 EYD11_09165 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Gad2 Gad65] Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform)
[Gad2 Gad65] Glutamate decarboxylase 2 (EC 4.1.1.15) (65 kDa glutamic acid decarboxylase) (GAD-65) (Glutamate decarboxylase 65 kDa isoform)
[FDC1 YDR539W D3703.2] Ferulic acid decarboxylase 1 (EC 4.1.1.102) (Phenacrylate decarboxylase)
[PDHA1 PHE1A] Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)
[GAD1 GAD GAD67] Glutamate decarboxylase 1 (EC 4.1.1.15) (67 kDa glutamic acid decarboxylase) (GAD-67) (Glutamate decarboxylase 67 kDa isoform)
[GLDP1 GDP1 At4g33010 F26P21.130] Glycine dehydrogenase (decarboxylating) 1, mitochondrial (EC 1.4.4.2) (Glycine cleavage system P protein 1) (Glycine decarboxylase 1) (Glycine decarboxylase P-protein 1) (AtGLDP1) (Glycine dehydrogenase (aminomethyl-transferring) 1)

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