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Thioredoxin reductase (EC 1.8.1.9)

 J0NK13_HELPX            Unreviewed;       311 AA.
J0NK13;
03-OCT-2012, integrated into UniProtKB/TrEMBL.
03-OCT-2012, sequence version 1.
16-JAN-2019, entry version 39.
RecName: Full=Thioredoxin reductase {ECO:0000256|RuleBase:RU003881};
EC=1.8.1.9 {ECO:0000256|RuleBase:RU003881};
Name=trxB {ECO:0000313|EMBL:EJB86805.1};
ORFNames=HPHPH11_1049 {ECO:0000313|EMBL:EJB86805.1};
Helicobacter pylori Hp H-11.
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
Helicobacteraceae; Helicobacter.
NCBI_TaxID=992064 {ECO:0000313|EMBL:EJB86805.1, ECO:0000313|Proteomes:UP000004974};
[1] {ECO:0000313|EMBL:EJB86805.1, ECO:0000313|Proteomes:UP000004974}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Hp H-11 {ECO:0000313|EMBL:EJB86805.1,
ECO:0000313|Proteomes:UP000004974};
PubMed=23661595; DOI=10.1111/2049-632X.12045;
Blanchard T.G., Czinn S.J., Correa P., Nakazawa T., Keelan M.,
Morningstar L., Santana-Cruz I., Maroo A., McCracken C., Shefchek K.,
Daugherty S., Song Y., Fraser C.M., Fricke W.F.;
"Genome sequences of 65 Helicobacter pylori strains isolated from
asymptomatic individuals and patients with gastric cancer, peptic
ulcer disease, or gastritis.";
Pathog. Dis. 68:39-43(2013).
-!- CATALYTIC ACTIVITY:
Reaction=[thioredoxin]-dithiol + NADP(+) = [thioredoxin]-disulfide
+ H(+) + NADPH; Xref=Rhea:RHEA:20345, Rhea:RHEA-COMP:10698,
Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950,
ChEBI:CHEBI:50058, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
EC=1.8.1.9; Evidence={ECO:0000256|RuleBase:RU003881};
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Evidence={ECO:0000256|RuleBase:RU003881};
Note=Binds 1 FAD per subunit. {ECO:0000256|RuleBase:RU003881};
-!- SIMILARITY: Belongs to the class-II pyridine nucleotide-disulfide
oxidoreductase family. {ECO:0000256|RuleBase:RU003880}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:EJB86805.1}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AKPC01000004; EJB86805.1; -; Genomic_DNA.
RefSeq; WP_000564430.1; NZ_AKPC01000004.1.
ProteinModelPortal; J0NK13; -.
EnsemblBacteria; EJB86805; EJB86805; HPHPH11_1049.
PATRIC; fig|992064.3.peg.1031; -.
Proteomes; UP000004974; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:UniProtKB-EC.
GO; GO:0019430; P:removal of superoxide radicals; IEA:InterPro.
Gene3D; 3.50.50.60; -; 2.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR023753; FAD/NAD-binding_dom.
InterPro; IPR008255; Pyr_nucl-diS_OxRdtase_2_AS.
InterPro; IPR000103; Pyridine_nuc-diS_OxRdtase_2.
InterPro; IPR005982; Thioredox_Rdtase.
Pfam; PF07992; Pyr_redox_2; 1.
PRINTS; PR00469; PNDRDTASEII.
SUPFAM; SSF51905; SSF51905; 1.
TIGRFAMs; TIGR01292; TRX_reduct; 1.
PROSITE; PS00573; PYRIDINE_REDOX_2; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000004974};
FAD {ECO:0000256|RuleBase:RU003880};
Flavoprotein {ECO:0000256|RuleBase:RU003880};
NADP {ECO:0000256|RuleBase:RU003881};
Oxidoreductase {ECO:0000256|RuleBase:RU003880,
ECO:0000256|SAAS:SAAS00270604, ECO:0000313|EMBL:EJB86805.1};
Redox-active center {ECO:0000256|RuleBase:RU003880}.
DOMAIN 3 297 Pyr_redox_2. {ECO:0000259|Pfam:PF07992}.
SEQUENCE 311 AA; 33511 MW; F9E900FA4B3A51F7 CRC64;
MIDCAIIGGG PAGLSAGLYA TRGGVKNAVL FEKGMPGGQI TGSSEIENYP GVKEVVSGLD
FMQPWQEQCF RFGLKHEMTA VQRVSKKDSH FVILAEDGKT FEAKSVIIAT GGSPKRTGIK
GESEYWGKGV STCATCDGFF YKNKEVAVLG GGDTAVEEAI YLANICKKVY LIHRRDGFRC
APITLEHAKN NDKIEFLTPY VVEEIKGDAS GVSSLSIKNT ATNETRELVV PGFFIFVGYD
VNNAVLKQED NSMLCKCDEY GSIVVDFSMK TNVQGLFAAG DIRIFAPKQV VCAASDGATA
ALSVISYLEH H


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Pathways :
WP1006: metapathway biotransformation
WP1124: metapathway biotransformation
WP1212: metapathway biotransformation
WP1251: metapathway biotransformation
WP1286: metapathway biotransformation
WP1403: AMPK signaling
WP1461: Photosynthetic Carbon Reduction
WP1566: Citrate cycle (TCA cycle)
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1680: Oxidative phosphorylation
WP1681: Pantothenate and CoA biosynthesis
WP2199: Seed Development
WP2230: Chlorophyll b degradation
WP2248: anthocyanin biosynthesis
WP2368: HMG-CoA reductase pathway
WP237: Glucocorticoid & Mineralcorticoid Metabolism
WP2409: New Pathway
WP305: Glucocorticoid Metabolism
WP495: Glucocorticoid & Mineralcorticoid Metabolism
WP668: Octadecanoid Pathway
WP702: metapathway biotransformation
WP889: metapathway biotransformation

Related Genes :
[hchA A8C65_13880 A9R57_25255 AKG99_20940 AMK83_16550 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BMT53_00170 BUE81_10670 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 CDL37_00765 CG691_19145 CG705_13560 CG706_14580 CIJ94_05515 COD46_23180 CRD98_26150 D3I61_11545 DL800_09215 DNQ41_14245 DQE83_22775 DTL43_21780 DTL84_23375 DTM25_06080 EC95NR1_00961 ERS085379_01273 ERS085386_05041 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13462_05714 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PU06_24500 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 SAMEA3753106_00003 SAMEA3753391_00513 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.-) (EC 3.5.1.124) (Maillard deglycase)
[TXNRD1 GRIM12 KDRF] Thioredoxin reductase 1, cytoplasmic (TR) (EC 1.8.1.9) (Gene associated with retinoic and interferon-induced mortality 12 protein) (GRIM-12) (Gene associated with retinoic and IFN-induced mortality 12 protein) (KM-102-derived reductase-like factor) (Thioredoxin reductase TR1)
[dim-5 29E8.110 NCU04402] Histone-lysine N-methyltransferase, H3 lysine-9 specific dim-5 (EC 2.1.1.43) (Histone H3-K9 methyltransferase dim-5) (H3-K9-HMTase dim-5) (HKMT)
[TXNRD2 KIAA1652 TRXR2] Thioredoxin reductase 2, mitochondrial (EC 1.8.1.9) (Selenoprotein Z) (SelZ) (TR-beta) (Thioredoxin reductase TR3)
[APR1 PRH19 At4g04610 F4H6.13] 5'-adenylylsulfate reductase 1, chloroplastic (EC 1.8.4.9) (3'-phosphoadenosine-5'-phosphosulfate reductase homolog 19) (PAPS reductase homolog 19) (Prh-19) (Adenosine 5'-phosphosulfate 5'-adenylylsulfate sulfotransferase 1) (APS sulfotransferase 1) (Thioredoxin-independent APS reductase 1)
[pyrG A6592_02570 A8M42_16405 A9R57_06965 AC067_22330 AC789_1c31020 ACN002_2797 ACN77_07080 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AKG99_03555 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWP75_20610 AZZ83_003241 B1K96_20050 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BB545_13920 BE963_03670 BEN53_16995 BET08_07180 BH694_13410 BHF46_05050 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BK400_05820 BMT49_17330 BMT53_21250 BMT91_11105 BN17_26661 BTQ04_11510 BTQ06_23845 BUE81_06975 BVL39_12970 BW690_04975 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C1I57_04860 C2M16_17770 C2U48_20025 C3K24_08940 C4J69_11655 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P43_15935 C5P44_09340 C6669_14670 C6986_17750 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C9E25_03325 CA593_12975 CCZ14_04445 CCZ17_10850 CDL37_13440 CG691_07365 CG692_07005 CG705_05530 CG706_07860 CIJ94_12220 COD30_01795 COD46_07095 CR538_05495 CR539_18815 CRE06_03485 CRM83_26360 CSB64_15850 CT143_09630 CT146_00680 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 CXB56_08765 D0X26_06660 D1900_12730 D2183_19100 D2F89_14380 D3I61_16000 DD762_13665 DIV22_29760 DIV25_29790 DL545_05995 DL800_20505 DNQ41_18960 DNR41_08670 DQE83_04685 DS732_20695 DS966_06010 DTL43_09355 DTL84_00105 DTL90_02675 DTM10_03745 DTM25_22630 DTM27_13675 DTM45_13530 EC1094V2_904 EC3234A_48c00890 EC95NR1_02021 ECONIH1_15890 ECs3640 EL75_0914 EL79_0915 EL80_0918 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 FORC28_1110 GJ11_18025 HMPREF3040_01161 HW43_18180 JD73_16335 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12950_01251 NCTC13125_04353 NCTC13127_01436 NCTC13462_04807 NCTC13846_01212 NCTC7152_00995 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9010_01168 NCTC9036_01135 NCTC9037_01243 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9706_03296 NCTC9775_04845 NCTC9777_02704 NCTC9969_01292 PU06_02080 RG28_07675 RK56_023165 SAMEA3472033_01264 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472067_02540 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484433_01660 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3485113_02257 SAMEA3752372_03639 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753106_03183 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SAMEA3753391_02580 SAMEA3753397_04005 SK85_03024 SY51_15605 UC41_20365 UN91_03645 WM48_14990 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[APR2 APSR PRH43 At1g62180 F19K23.11] 5'-adenylylsulfate reductase 2, chloroplastic (EC 1.8.4.9) (3'-phosphoadenosine-5'-phosphosulfate reductase homolog 43) (PAPS reductase homolog 43) (Prh-43) (Adenosine 5'-phosphosulfate 5'-adenylylsulfate sulfotransferase 2) (APS sulfotransferase 2) (Thioredoxin-independent APS reductase 2)
[APR3 PRH26 At4g21990 F1N20.90] 5'-adenylylsulfate reductase 3, chloroplastic (EC 1.8.4.9) (3'-phosphoadenosine-5'-phosphosulfate reductase homolog 26) (PAPS reductase homolog 26) (Prh-26) (Adenosine 5'-phosphosulfate 5'-adenylylsulfate sulfotransferase 3) (APS sulfotransferase 3) (Thioredoxin-independent APS reductase 3)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[al-3 B8P8.010 NCU01427] Geranylgeranyl pyrophosphate synthase (GGPP synthase) (GGPPSase) (EC 2.5.1.-) ((2E,6E)-farnesyl diphosphate synthase) (Albino-3 protein) (Dimethylallyltranstransferase) (EC 2.5.1.1) (Farnesyl diphosphate synthase) (Farnesyltranstransferase) (EC 2.5.1.29) (Geranylgeranyl diphosphate synthase) (Geranyltranstransferase) (EC 2.5.1.10)
[hmpA hmp A8C65_03855 A9R57_17040 ACN002_2592 ACN77_09545 ACN81_26320 ACU57_10360 ACU90_01485 AM270_07210 AM464_04560 AML07_10430 APZ14_05505 AUQ13_13215 AUS26_21665 AW106_11070 BB545_05760 BHS81_15570 BHS87_14445 BJJ90_06510 BK292_20760 BMT53_22940 BMT91_09730 BN17_18391 BUE81_08005 BVL39_14050 BW690_11150 BZL31_13550 C2U48_21325 C4J69_10505 C5N07_10115 C5P01_05560 C5P43_25010 C6986_16510 C7235_06805 C9E25_16695 CG691_06165 CG705_05290 CG706_03875 COD30_01045 COD46_11500 CRM83_27495 CWS33_10010 CXB56_09850 D3I61_14815 DIV22_11300 DIV25_09890 DL545_07245 DL800_19195 DNQ41_17925 DTL43_01910 DTL84_06405 EC1094V2_1116 EC3234A_44c01590 EC95NR1_01777 ERS085365_01518 ERS085374_00038 ERS085416_03760 ERS139211_00868 ERS150873_01392 ERS150876_00857 FORC28_1400 HW43_17160 NCTC11022_02631 NCTC11181_03552 NCTC13148_02382 NCTC8500_01411 NCTC8960_04037 NCTC8985_06124 NCTC9010_01386 NCTC9036_01390 NCTC9037_01459 NCTC9058_00631 NCTC9062_01812 NCTC9073_04581 NCTC9706_04593 NCTC9962_00729 PU06_05410 RG28_09110 RK56_022045 SAMEA3472044_03009 SAMEA3472067_01827 SAMEA3472070_00042 SAMEA3472080_01630 SAMEA3484427_00463 SAMEA3484429_00572 SAMEA3484433_03169 SAMEA3752557_00946 SAMEA3753097_02775 SAMEA3753106_01160 SAMEA3753391_02738 SAMEA3753397_00885 SK85_02808 WQ89_05840] Flavohemoprotein (Flavohemoglobin) (Hemoglobin-like protein) (Nitric oxide dioxygenase) (NO oxygenase) (NOD) (EC 1.14.12.17)
[iscS iscS_1 A6581_02145 A6592_14885 A8C65_03965 A8G17_10685 A8M42_18685 A9819_14635 A9R57_16930 AC067_03015 AC789_1c28660 ACN77_09430 ACN81_26435 ACU57_06285 ACU90_01375 AJ318_26005 AKG99_22280 AM270_07100 AM446_08145 AM464_04450 AM465_11700 AMK83_11225 AML07_10540 AML35_21525 APT94_12335 APU18_00295 APZ14_05615 ARC77_08945 AU473_09315 AUQ13_13105 AUS26_21555 AW059_05940 AW106_10960 AWP75_00135 AZZ83_002723 B1K96_17760 B7C53_13290 B9M99_15840 B9N33_21250 B9T59_21105 BE963_28425 BEN53_15845 BER14_02655 BET08_22520 BH694_10200 BHF46_00575 BHS81_15460 BHS87_14335 BIQ87_14690 BIU72_16435 BIZ41_13705 BJJ90_06620 BK248_16700 BK292_20650 BK334_04895 BK373_05915 BK375_00880 BK383_22845 BK400_09035 BMR23_12730 BMT49_16180 BMT53_23050 BMT91_09840 BTQ04_10030 BTQ06_16545 BUE81_08125 BVL39_14165 BW690_04500 BWP17_17035 BZL31_13665 BZL69_10285 C1I57_24205 C2M16_05920 C2U48_21435 C3K24_07520 C4J69_10615 C4K41_12560 C4M78_10890 C5N07_10225 C5P01_05670 C5P43_04165 C5P44_15165 C6669_16070 C6986_16375 C6B13_21190 C7235_06915 C7B02_18515 C7B06_11270 C7B07_12285 C7B08_05430 CA593_14170 CCZ14_18705 CCZ17_22060 CDL37_24785 CG691_06060 CG692_02695 CG705_05185 CG706_03765 CIJ94_05825 COD30_00935 COD46_11390 CR539_17655 CRD98_15000 CRE06_08785 CRM83_27605 CSB64_12500 CT143_05820 CT146_18385 CV83915_03587 CVH05_18115 CWM24_13125 CWS33_10120 CXB56_09960 D0X26_11620 D1900_21335 D2183_14465 D2F89_15600 D3I61_14705 DD762_08545 DIV22_32035 DIV25_09780 DL545_07355 DL800_19085 DNQ41_17815 DNR41_15780 DQE83_18635 DS732_18775 DS966_02860 DTL43_01800 DTL84_06515 DTL90_08325 DTM10_01260 DTM25_14855 DTM27_14340 DTM45_09080 EC1094V2_1138 EC3234A_44c01370 EC95NR1_01752 ECONIH1_14765 EL75_1117 EL79_1128 EL80_1131 ERS085365_01538 ERS085366_02045 ERS085374_00061 ERS085379_00921 ERS085383_02049 ERS085386_03188 ERS085404_01057 ERS085406_03472 ERS085411_02202 ERS085416_01266 ERS139211_00888 ERS150873_01415 ERS150876_00833 FORC28_1424 HW43_17050 JD73_17725 MJ49_18275 MS6198_28580 MS8345_02723 NCTC10090_04376 NCTC10766_01180 NCTC10767_02594 NCTC11181_03575 NCTC11341_00889 NCTC12950_01537 NCTC13125_04632 NCTC13462_05052 NCTC13846_01437 NCTC7152_01285 NCTC7922_00893 NCTC7927_01500 NCTC7928_01371 NCTC8009_03115 NCTC8179_04409 NCTC8450_04290 NCTC8500_01442 NCTC8621_01401 NCTC8959_02462 NCTC8960_04060 NCTC8985_06161 NCTC9007_03642 NCTC9010_01409 NCTC9036_01412 NCTC9037_01482 NCTC9045_01545 NCTC9050_04644 NCTC9055_03293 NCTC9058_00608 NCTC9062_01792 NCTC9073_04547 NCTC9075_01973 NCTC9111_01941 NCTC9119_01524 NCTC9434_01284 NCTC9701_01429 NCTC9703_01091 NCTC9706_04616 NCTC9775_05141 NCTC9777_02572 NCTC9962_00698 NCTC9969_01533 PU06_05300 RG28_09220 RK56_021935 RX35_01423 SAMEA3472033_00658 SAMEA3472044_02985 SAMEA3472047_01032 SAMEA3472055_00937 SAMEA3472056_00874 SAMEA3472070_00065 SAMEA3472080_01607 SAMEA3472090_01244 SAMEA3472108_03497 SAMEA3472110_00486 SAMEA3472112_00780 SAMEA3472114_03249 SAMEA3472147_00165 SAMEA3484427_00440 SAMEA3484429_00549 SAMEA3484433_03192 SAMEA3484434_00296 SAMEA3485101_04492 SAMEA3485113_03372 SAMEA3752372_01122 SAMEA3752557_00969 SAMEA3752559_00692 SAMEA3752620_00062 SAMEA3753064_03100 SAMEA3753097_02751 SAMEA3753106_01137 SAMEA3753164_00628 SAMEA3753290_03552 SAMEA3753300_01026 SAMEA3753391_02715 SAMEA3753397_00908 SK85_02782 SY51_14535 UC41_13245 UN91_26515 WM48_13555 WQ89_05730 WR15_01190 YDC107_1108] Cysteine desulfurase IscS (EC 2.8.1.7)
[lon lon_1 lon_2 A6581_06540 A8C65_09155 A8G17_09470 A8M42_12205 A9819_02150 A9R57_08730 AC067_13940 AC789_1c04390 ACN77_08400 ACN81_24745 ACU57_11790 ACU90_20700 AJ318_07395 AM270_02090 AM446_21265 AM464_19190 AM465_24425 AMK83_09080 AML07_05605 AML35_17195 APT94_11405 APU18_24755 APZ14_19130 AUQ13_18305 AUS26_08525 AW059_13755 AW106_10030 AWP75_24635 AZZ83_000203 B1K96_09680 B7C53_07945 B9M99_03985 B9N33_08900 B9T59_05700 BB545_15795 BE963_16350 BER14_14325 BET08_18215 BH694_02335 BHF46_21220 BHS81_02650 BIQ87_02425 BIU72_03070 BIZ41_19875 BJJ90_20055 BK248_01840 BK292_14395 BK334_05695 BK373_01080 BK375_01675 BK383_14710 BK400_22925 BMR23_09445 BMT49_03495 BMT53_08160 BMT91_05050 BN17_02431 BTQ06_01040 BUE81_06550 BVL39_00620 BW690_06825 BXT93_14065 BZL31_10455 BZL69_16545 C1I57_02830 C2M16_02950 C4J69_09250 C4M78_17970 C5715_07650 C5N07_12995 C5P01_16055 C5P43_02540 C6669_02490 C6986_02640 C6B13_10210 C7235_18620 C7B06_13115 C7B07_14925 C7B08_06455 C9E25_04330 CA593_00935 CCZ14_02195 CCZ17_03875 CDL37_08925 CG692_04795 CG705_03025 CG706_02860 CIJ94_10835 COD30_15795 COD46_04600 CR538_19245 CR539_06435 CRD98_01930 CSB64_03555 CT143_00390 CT146_15985 CWM24_20160 CWS33_13550 CXB56_21765 D0X26_07675 D1900_17610 D2183_00880 D2F89_19370 D3I61_03100 DD762_17560 DIV22_26545 DIV25_28050 DL545_18880 DL800_04145 DNQ41_06120 DNQ45_04780 DQE83_14690 DS732_07170 DS966_18225 DTL43_07145 DTL84_16480 DTM10_06325 DTM25_22445 DTM45_11225 EC1094V2_3409 EC3234A_4c01080 EC95NR1_04662 ECONIH1_02385 ERS085365_02395 ERS085374_02327 ERS085379_01165 ERS085383_00971 ERS085406_02176 ERS085416_01921 ERS139211_01924 ERS150876_00617 FORC28_4645 GJ11_02625 HMPREF3040_03444 HW43_05825 MJ49_04235 MS6198_04430 MS8345_00443 NCTC10082_01029 NCTC10090_01830 NCTC10418_05598 NCTC10764_05303 NCTC10766_05771 NCTC11022_05186 NCTC11181_01095 NCTC13462_01885 NCTC13846_03631 NCTC7152_03832 NCTC7922_06176 NCTC7927_04214 NCTC7928_04997 NCTC8179_01705 NCTC8959_05066 NCTC8960_01264 NCTC9007_00214 NCTC9010_03874 NCTC9036_03791 NCTC9037_03909 NCTC9050_01704 NCTC9055_00655 NCTC9058_03169 NCTC9062_04515 NCTC9111_03927 NCTC9117_04741 NCTC9434_02860 NCTC9703_03170 NCTC9706_01065 NCTC9777_00122 NCTC9969_03979 PU06_02695 RG28_02630 RK56_026450 RX35_02110 SAMEA3472033_03457 SAMEA3472044_00416 SAMEA3472047_02150 SAMEA3472055_02113 SAMEA3472067_03237 SAMEA3472070_02234 SAMEA3472080_01763 SAMEA3472090_01765 SAMEA3472108_01909 SAMEA3472110_00680 SAMEA3472112_02916 SAMEA3484427_03496 SAMEA3484429_01936 SAMEA3484433_02327 SAMEA3485113_01252 SAMEA3752372_02700 SAMEA3752557_00263 SAMEA3752559_02850 SAMEA3752620_00833 SAMEA3753097_00463 SAMEA3753106_00484 SAMEA3753164_00266 SAMEA3753300_00505 SAMEA3753391_04072 SAMEA3753397_02130 SK85_00464 SY51_02300 UC41_11885 UN86_09160 UN91_18465 WM48_02515 WR15_04115 YDC107_3709] Lon protease (EC 3.4.21.53) (ATP-dependent protease La)
[agaY agaY_1 agaY_2 kbaY kbaY_1 kbaY_2 A6581_06135 A6592_14490 A8C65_02445 A8G17_24215 A9819_18030 A9R57_12875 AC789_1c35070 ACN002_3231 ACN81_18735 ACU57_14720 ACU90_11840 AKG99_18810 AM270_10360 AM446_04575 AM464_08310 AMK83_06615 AML07_27945 AML35_14160 APT94_22945 APU18_16660 APZ14_04020 ARC77_12125 AU473_06025 AUQ13_02800 AUS26_18535 AW059_15450 AZZ83_001415 B1K96_05960 B7C53_19450 BB545_10055 BEN53_19445 BHF46_07040 BHS81_18925 BIZ41_14335 BJJ90_03045 BK248_21775 BK292_10495 BK334_09815 BK383_15710 BK400_20325 BMT49_25850 BMT53_18450 BN17_30821 BTQ04_16760 BTQ06_20745 BVL39_10420 BW690_01005 BWP17_07060 BXT93_18380 BZL31_25275 BZL69_07435 C2U48_17840 C3K24_11445 C4J69_18785 C4K41_03525 C5715_12280 C5N07_16465 C5P01_19110 C5P43_02160 C6669_12295 C6986_20200 C6B13_15150 C7235_03500 C7B02_08945 C7B06_16525 C7B07_10875 C7B08_03310 C9E25_21030 CA593_10600 CG691_12975 CG692_22965 CG705_12120 CG706_23220 COD30_05970 COD46_22025 CR538_03350 CR539_20970 CRD98_04990 CRE06_06550 CRM83_23775 CSB64_06340 CT143_11135 CT146_02800 CVH05_07665 CWS33_08100 CXB56_06685 D0X26_08835 D1900_24065 D2183_08305 D2F89_23160 D3I61_18805 DIV22_09280 DIV25_06765 DL545_03915 DL800_22990 DNQ41_21475 DNR41_10930 DQE83_16800 DTL43_04020 DTL84_11155 DTL90_07295 DTM27_04405 DTM45_14255 EC1094V2_507 EC3234A_53c00160 EC95NR1_02516 ECONIH1_18600 ECs4017 EL75_0549 EL79_0572 EL80_0564 ERS085365_00596 ERS085366_00607 ERS085374_01873 ERS085379_00428 ERS085383_00753 ERS085386_00541 ERS085404_02243 ERS085406_03651 ERS085416_00299 ERS139211_00539 ERS150873_01748 ERS150876_00972 FORC28_0668 HMPREF3040_01995 HW43_20655 JD73_01650 MS6198_36220 MS8345_03490 NCTC10082_03001 NCTC10764_04039 NCTC10767_01694 NCTC10865_00851 NCTC11022_03300 NCTC11341_01695 NCTC12950_00651 NCTC13125_03918 NCTC13148_03216 NCTC13462_04280 NCTC13846_00667 NCTC7152_00616 NCTC8009_01738 NCTC8622_00268 NCTC8960_03245 NCTC8985_05190 NCTC9036_00713 NCTC9037_00830 NCTC9045_00750 NCTC9050_03774 NCTC9055_02547 NCTC9062_02519 NCTC9111_01031 NCTC9117_00956 NCTC9119_00687 NCTC9434_00595 NCTC9701_00743 NCTC9703_05134 NCTC9706_02907 NCTC9969_00822 PU06_20125 RG28_20800 RK56_014885 RX35_04224 SAMEA3472033_00859 SAMEA3472044_03367 SAMEA3472047_01838 SAMEA3472055_00433 SAMEA3472056_03039 SAMEA3472067_02761 SAMEA3472070_01205 SAMEA3472080_00912 SAMEA3472108_00133 SAMEA3472110_01572 SAMEA3472112_01556 SAMEA3472114_00516 SAMEA3472147_03318 SAMEA3484427_00641 SAMEA3484429_00701 SAMEA3484433_01239 SAMEA3484434_03283 SAMEA3485101_01677 SAMEA3752372_01750 SAMEA3752557_01908 SAMEA3752559_03865 SAMEA3753064_02903 SAMEA3753097_03267 SAMEA3753106_03728 SAMEA3753290_00181 SAMEA3753300_02165 SAMEA3753391_02230 SAMEA3753397_00141 SK85_03447 UC41_11540 UN86_15655 WM48_17485 WQ89_06915 WR15_24715 YDC107_1814] D-tagatose-1,6-bisphosphate aldolase subunit KbaY (TBPA) (TagBP aldolase) (EC 4.1.2.40) (D-tagatose-bisphosphate aldolase class II) (Ketose 1,6-bisphosphate aldolase class II) (Tagatose-bisphosphate aldolase)
[Selenot Selt] Thioredoxin reductase-like selenoprotein T (SelT) (EC 1.8.1.9)
[ahpC b0605 JW0598] Alkyl hydroperoxide reductase C (EC 1.11.1.15) (Alkyl hydroperoxide reductase protein C22) (Peroxiredoxin) (SCRP-23) (Sulfate starvation-induced protein 8) (SSI8) (Thioredoxin peroxidase)
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[HSD17B8 FABGL HKE6 RING2 SDR30C1] Estradiol 17-beta-dehydrogenase 8 (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase 8) (17-beta-HSD 8) (3-ketoacyl-[acyl-carrier-protein] reductase alpha subunit) (KAR alpha subunit) (3-oxoacyl-[acyl-carrier-protein] reductase) (EC 1.1.1.-) (Protein Ke6) (Ke-6) (Really interesting new gene 2 protein) (Short chain dehydrogenase/reductase family 30C member 1) (Testosterone 17-beta-dehydrogenase 8) (EC 1.1.1.239)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (p28); Non-structural protein 2 (nsp2) (p65); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL1-PRO/PL2-PRO) (PL1/PL2) (Papain-like proteinases 1/2) (p210); Non-structural protein 4 (nsp4) (Peptide HD2) (p44); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p27); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p10); Non-structural protein 8 (nsp8) (p22); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p15); Non-structural protein 11 (nsp11)]
[CITRX PAP10 TRX P TRX Z At3g06730 F3E22.13] Thioredoxin-like protein CITRX, chloroplastic (EC 1.8.-.-) (Cf-9-interacting thioredoxin) (AtCiTrx) (PEP-associated protein 10) (Thioredoxin Trx p) (Thioredoxin Z)
[aro-1 aro-2 aro-4 aro-5 aro-9 B14H13.20 NCU016321] Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase (DHQS) (EC 4.2.3.4); 3-phosphoshikimate 1-carboxyvinyltransferase (EC 2.5.1.19) (5-enolpyruvylshikimate-3-phosphate synthase) (EPSP synthase) (EPSPS); Shikimate kinase (SK) (EC 2.7.1.71); 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10); Shikimate dehydrogenase (EC 1.1.1.25)]
[Cbr1 Cbr] Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.197) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189)
[CYP2C9 CYP2C10] Cytochrome P450 2C9 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
[yjbN dusA A6581_03815 A9819_23140 AC789_1c44580 ACN77_13265 ACN81_05795 AW059_18320 B1K96_03640 B7C53_20030 B9M99_07285 B9T59_11200 BB545_04715 BE963_11655 BHS81_24320 BIU72_20630 BN17_40231 BTQ06_28285 BUE81_22495 BVL39_04970 BWP17_09085 BXT93_20165 BZL69_05000 C2U48_12360 C4J69_17345 C4M78_06330 C5N07_20225 C5P01_10975 C5P43_26750 C6669_07250 C7235_23350 C7B02_13830 CA593_05650 CG691_24515 CG705_24980 CG706_06955 CIJ94_13445 COD46_18670 CR538_23810 CRD98_24950 CRM83_18265 CVH05_02240 CWS33_16005 CXB56_26125 D0X26_12230 D3I61_23865 DD762_09595 DL545_23295 DNQ41_01750 DQE83_12890 DS732_01940 DTL84_03985 EC3234A_77c00420 EL75_4140 EL79_4345 EL80_4252 ERS085374_01630 ERS085383_01453 ERS085404_01248 HMPREF3040_01367 NCTC10090_02700 NCTC10418_07037 NCTC10764_02883 NCTC10865_05778 NCTC11112_02403 NCTC11181_01881 NCTC11341_02874 NCTC12950_05132 NCTC7152_04647 NCTC7927_05171 NCTC8450_00470 NCTC8985_03929 NCTC9010_04826 NCTC9037_04708 NCTC9045_05465 NCTC9050_02741 NCTC9062_03523 NCTC9077_05824 NCTC9701_04921 NCTC9775_03044 NCTC9777_01046 RK56_017030 RX35_03830 SAMEA3472055_01598 SAMEA3472067_03766 SAMEA3472108_01690 SAMEA3472114_02034 SAMEA3472147_04808 SAMEA3484427_03836 SAMEA3484429_02481 SAMEA3752559_00279 SAMEA3753064_01454 SAMEA3753290_01943 SAMEA3753300_00780] tRNA-dihydrouridine(20/20a) synthase (EC 1.3.1.-) (EC 1.3.1.91) (U20-specific dihydrouridine synthase) (U20-specific Dus) (tRNA-dihydrouridine synthase A)
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (p28); Non-structural protein 2 (nsp2) (p65); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL1-PRO/PL2-PRO) (PL1/PL2) (Papain-like proteinases 1/2) (p210); Non-structural protein 4 (nsp4) (Peptide HD2) (p44); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p27); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p10); Non-structural protein 8 (nsp8) (p22); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p15); Non-structural protein 11 (nsp11)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (p28); Non-structural protein 2 (nsp2) (p65); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL1-PRO/PL2-PRO) (PL1/PL2) (Papain-like proteinases 1/2) (p210); Non-structural protein 4 (nsp4) (Peptide HD2) (p44); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (M-PRO) (nsp5) (p27); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7) (p10); Non-structural protein 8 (nsp8) (p22); Non-structural protein 9 (nsp9) (p12); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL) (p15); Non-structural protein 11 (nsp11)]
[deoB deoB_1 deoB_2 A6581_18435 A6592_04045 A8C65_14880 A8G17_11820 A8M42_06180 A9819_24940 A9R57_15275 AC067_06680 AC789_1c48570 ACN002_4658 ACN77_18800 ACN81_09725 ACU57_07730 ACU90_07335 AJ318_04080 AKG99_17840 AM270_09420 AM446_23835 AM464_16645 AMK83_27215 AML07_24190 AML35_20385 APT94_26795 APZ14_00310 ARC77_19195 AU473_26955 AUQ13_08470 AUS26_22745 AW059_08815 AW106_03365 AWP75_12435 B7C53_17230 B9M99_13045 B9T59_08560 BB545_14470 BEN53_02045 BER14_23575 BHF46_08895 BHS81_26120 BHS87_24460 BIU72_19185 BIZ41_21305 BJJ90_22330 BK248_20430 BK292_12685 BK375_05645 BK383_08060 BK400_04595 BMT53_19385 BMT91_18315 BN17_44001 BTQ04_23920 BTQ06_24930 BUE81_16730 BVL39_03170 BW690_00245 BWP17_03345 BXT93_03635 BZL31_17600 BZL69_04480 C2M16_09775 C2U48_10615 C4J69_04425 C5715_27770 C5N07_17145 C5P01_07940 C5P43_05850 C5P44_08225 C6669_05295 C6B13_05365 C7235_21210 C7B02_11850 C7B06_04870 C7B07_05275 C7B08_10705 C9E25_18285 CA593_03855 CDL37_17005 CG691_15815 CG692_08055 CG705_14960 CG706_01630 CIJ94_12725 COD30_02990 COD46_20840 CR538_21630 CR539_03895 CRD98_11765 CRE06_01180 CRM83_16065 CT143_15860 CVH05_08695 CWM24_03560 CWS33_04540 CXB56_24120 D0X26_18860 D2F89_14620 D3I61_00580 DD762_00055 DIV22_03170 DIV25_11860 DL545_21400 DL800_30195 DNQ41_03625 DNR41_14235 DQE83_11300 DS732_04780 DS966_19545 DTL43_03380 DTL84_22730 DTL90_19490 DTM25_09905 DTM27_21085 DTM45_25715 EC1094V2_3878 EC3234A_1c00160 EC95NR1_04160 ECONIH1_26270 ECs5342 EL79_3889 EL80_3834 ERS085365_02743 ERS085366_01249 ERS085374_03702 ERS085379_04468 ERS085383_01369 ERS085386_00785 ERS085404_00902 ERS085411_00244 ERS085416_03167 ERS139211_02369 ERS150873_03705 ERS150876_00253 FORC28_5223 GJ11_27480 HMPREF3040_02399 HW43_03575 JD73_14090 MS6198_51650 NCTC10082_01592 NCTC10090_02421 NCTC10766_05279 NCTC10767_03748 NCTC10865_05310 NCTC11022_04689 NCTC11181_01567 NCTC11341_03373 NCTC12950_04636 NCTC13125_02405 NCTC13127_05676 NCTC13462_02426 NCTC13846_04072 NCTC7152_04313 NCTC7922_05563 NCTC7927_04716 NCTC8959_04642 NCTC9007_00655 NCTC9010_04403 NCTC9036_04213 NCTC9045_04944 NCTC9050_02216 NCTC9055_01157 NCTC9058_02603 NCTC9077_05352 NCTC9081_01884 NCTC9111_04454 NCTC9117_05292 NCTC9119_04461 NCTC9701_04569 NCTC9703_03633 NCTC9706_01613 NCTC9777_00679 NCTC9969_04460 PU06_28325 RG28_04875 RK56_014050 RX35_04718 SAMEA3472033_01558 SAMEA3472055_02724 SAMEA3472056_01166 SAMEA3472067_01225 SAMEA3472070_02581 SAMEA3472108_04809 SAMEA3472110_00263 SAMEA3472112_00095 SAMEA3472114_04692 SAMEA3472147_03103 SAMEA3484433_03664 SAMEA3484434_03174 SAMEA3485101_00911 SAMEA3485113_03631 SAMEA3752372_00095 SAMEA3752559_04074 SAMEA3753064_04931 SAMEA3753106_03897 SAMEA3753290_04972 SAMEA3753300_03102 SAMEA3753391_04192 SAMEA3753397_03471 SK85_04732 UN86_17300 UN91_11595 WQ89_19730 WR15_19865 YDC107_3200] Phosphopentomutase (EC 5.4.2.7) (Phosphodeoxyribomutase)
[inhA Rv1484 MTCY277.05] Enoyl-[acyl-carrier-protein] reductase [NADH] (ENR) (Enoyl-ACP reductase) (EC 1.3.1.9) (FAS-II enoyl-ACP reductase) (NADH-dependent 2-trans-enoyl-ACP reductase)
[DHAR1 DHAR5 At1g19570 F14P1.9 F18O14.22] Glutathione S-transferase DHAR1, mitochondrial (EC 2.5.1.18) (Chloride intracellular channel homolog 1) (CLIC homolog 1) (Glutathione-dependent dehydroascorbate reductase 1) (AtDHAR1) (GSH-dependent dehydroascorbate reductase 1) (mtDHAR) (EC 1.8.5.1)

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