GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Thrombin-like enzyme BjussuSP-1 (SVTLE BjussuSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Jararacussin-I) (Snake venom serine protease 1) (SVSP) (Thrombin-like enzyme BjussuSP-I) (SVTLE BjussuSP-I)

 VSP1_BOTJR              Reviewed;         232 AA.
Q2PQJ3;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
24-JAN-2006, sequence version 1.
02-JUN-2021, entry version 57.
RecName: Full=Thrombin-like enzyme BjussuSP-1;
Short=SVTLE BjussuSP-1;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Jararacussin-I;
AltName: Full=Snake venom serine protease 1;
Short=SVSP;
AltName: Full=Thrombin-like enzyme BjussuSP-I;
Short=SVTLE BjussuSP-I;
Bothrops jararacussu (Jararacussu).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
NCBI_TaxID=8726;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ACTIVITY REGULATION, AND
GLYCOSYLATION.
TISSUE=Venom gland;
PubMed=17996740; DOI=10.1016/j.biochi.2007.10.005;
Sant'Ana C.D., Bernardes C.P., Izidoro L.F., Mazzi M.V., Soares S.G.,
Fuly A.L., Zingali R.B., Magro A.J., Braz A.S., Fontes M.R., Stabeli R.G.,
Sampaio S.V., Soares A.M.;
"Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with
procoagulant and kallikrein-like activity isolated from Bothrops
jararacussu snake venom.";
Biochimie 90:500-507(2008).
[2]
PROTEIN SEQUENCE OF 1-20, FUNCTION, SUBUNIT, ACTIVITY REGULATION,
GLYCOSYLATION, AND SIALIC ACID.
TISSUE=Venom;
PubMed=17466550; DOI=10.1016/j.cbpa.2007.02.036;
Sant'Ana C.D., Ticli F.K., Oliveira L.L., Giglio J.R., Rechia C.G.,
Fuly A.L., Selistre de Araujo H.S., Franco J.J., Stabeli R.G., Soares A.M.,
Sampaio S.V.;
"BjussuSP-I: a new thrombin-like enzyme isolated from Bothrops jararacussu
snake venom.";
Comp. Biochem. Physiol. 151:443-454(2008).
[3]
FUNCTION.
TISSUE=Venom;
PubMed=17292935; DOI=10.1016/j.toxicon.2006.12.011;
Perez A.V., Saravia P., Rucavado A., Sant'Ana C.D., Soares A.M.,
Gutierrez J.M.;
"Local and systemic pathophysiological alterations induced by a serine
proteinase from the venom of the snake Bothrops jararacussu.";
Toxicon 49:1063-1069(2007).
[4]
X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS), AND DISULFIDE BONDS.
TISSUE=Venom;
PubMed=23139169; DOI=10.1002/pro.2189;
Ullah A., Souza T.A., Zanphorlin L.M., Mariutti R.B., Santana V.S.,
Murakami M.T., Arni R.K.;
"Crystal structure of jararacussin-I: the highly negatively charged
catalytic interface contributes to macromolecular selectivity in snake
venom thrombin-like enzymes.";
Protein Sci. 22:128-132(2013).
-!- FUNCTION: Thrombin-like enzyme that shows clotting activity upon human
plasma. Shows specific fibrinogenolytic activity for Aalpha chain
(FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic
artificial substrates of the blood coagulation cascasde: S-27654 for
factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa
(F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous
injection into mice induces a mild edema. Intravenous and intramuscular
injection reduce plasma fibrinogen concentration and increase the
levels of fibrin(ogen) degradation products. Intramuscular injection
also promotes an increase in the expression of proMMP-9, but is unable
to activate it. {ECO:0000269|PubMed:17292935,
ECO:0000269|PubMed:17466550, ECO:0000269|PubMed:17996740}.
-!- ACTIVITY REGULATION: Inhibited by leupeptin, heparin, and 1.10-
phenantroline. {ECO:0000269|PubMed:17466550,
ECO:0000269|PubMed:17996740}.
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17466550}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- PTM: N-glycosylated. Contains sialic acid residues. Deglycosylation
reduces in 50% the formation of fibrin clot.
{ECO:0000269|PubMed:17466550, ECO:0000269|PubMed:17996740}.
-!- MISCELLANEOUS: Does not show hemorrhagic and myotoxic activities
(PubMed:17466550), as well as activity on platelet aggregation and
plasmin (represented by the chromogenic substrate S-2251)
(PubMed:17996740). {ECO:0000305|PubMed:17466550,
ECO:0000305|PubMed:17996740}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; DQ307451; ABC24687.1; -; mRNA.
PDB; 4GSO; X-ray; 2.60 A; A=1-232.
PDBsum; 4GSO; -.
SMR; Q2PQJ3; -.
MEROPS; S01.023; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
3D-structure; Blood coagulation cascade activating toxin;
Direct protein sequencing; Disulfide bond; Fibrinolytic toxin;
Glycoprotein; Hemostasis impairing toxin; Hydrolase; Protease; Secreted;
Serine protease; Sialic acid; Toxin.
CHAIN 1..232
/note="Thrombin-like enzyme BjussuSP-1"
/id="PRO_0000296362"
DOMAIN 1..223
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 40
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 85
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 178
/note="Charge relay system"
/evidence="ECO:0000250"
CARBOHYD 77
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 129
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 7..138
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
DISULFID 25..41
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
DISULFID 73..230
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
DISULFID 117..184
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
DISULFID 149..163
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
DISULFID 174..199
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274,
ECO:0000269|PubMed:23139169"
TURN 9..11
/evidence="ECO:0007829|PDB:4GSO"
STRAND 15..29
/evidence="ECO:0007829|PDB:4GSO"
STRAND 31..37
/evidence="ECO:0007829|PDB:4GSO"
HELIX 39..41
/evidence="ECO:0007829|PDB:4GSO"
STRAND 47..51
/evidence="ECO:0007829|PDB:4GSO"
STRAND 63..65
/evidence="ECO:0007829|PDB:4GSO"
STRAND 67..72
/evidence="ECO:0007829|PDB:4GSO"
STRAND 87..93
/evidence="ECO:0007829|PDB:4GSO"
STRAND 116..123
/evidence="ECO:0007829|PDB:4GSO"
STRAND 126..129
/evidence="ECO:0007829|PDB:4GSO"
STRAND 137..143
/evidence="ECO:0007829|PDB:4GSO"
HELIX 147..150
/evidence="ECO:0007829|PDB:4GSO"
STRAND 161..165
/evidence="ECO:0007829|PDB:4GSO"
STRAND 181..184
/evidence="ECO:0007829|PDB:4GSO"
STRAND 187..194
/evidence="ECO:0007829|PDB:4GSO"
STRAND 206..210
/evidence="ECO:0007829|PDB:4GSO"
HELIX 211..214
/evidence="ECO:0007829|PDB:4GSO"
HELIX 215..223
/evidence="ECO:0007829|PDB:4GSO"
SEQUENCE 232 AA; 25163 MW; 14C6B2DE6A97064D CRC64;
VLGGDECDIN EHPFLAFLYS HGYFCGLTLI NQEWVVTAAH CDSTNFQMQL GVHSKKVLNE
DEQTRNPKEK FICPNKNMSE VLDKDIMLIK LDKPISNSKH IAPLSLPSNP PSVGSVCRIM
GWGSITIPNE TYPDVPYCAN INLVDYEVCQ GAYNGLPAKT TLCAGVLEGG KDTCVGDSGG
PLICNGQFQG IVSYGAHSCG QGPKPGIYTN VFDYTDWIQR NIAGNTDATC PP


Related products :

Catalog number Product name Quantity
18-661-15015 ADAM 17 - EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
EIAAB08673 Atrial natriuretic peptide-converting enzyme,Corin,CORIN,CRN,Heart-specific serine proteinase ATC2,Homo sapiens,Human,Pro-ANP-converting enzyme,TMPRSS10,Transmembrane protease serine 10
E1319h ELISA kit ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
E1319h ELISA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
U1319h CLIA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
18-272-195437 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195435 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195436 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-197022 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
abx109217 Polyclonal Rabbit Thrombin-like enzyme crotalase Antibody (HRP) 100 μg
25-068 PCBD1 is pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerizat 0.05 mg
25-402 PCBD1 is pterin-4 alpha-carbinolamine dehydratase, an enzyme involved in phenylalanine hydroxylation. A deficiency of this enzyme leads to hyperphenylalaninemia. The enzyme regulates the homodimerizat 0.05 mg
abx107799 Polyclonal Rabbit Thrombin-like enzyme crotalase Antibody (FITC) 100 μg
abx106387 Polyclonal Rabbit Thrombin-like enzyme crotalase Antibody (Biotin) 100 μg
EIAAB44848 Homo sapiens,Human,ThiFP1,UBA5,UBE1DC1,Ubiquitin-activating enzyme 5,Ubiquitin-activating enzyme E1 domain-containing protein 1,Ubiquitin-like modifier-activating enzyme 5,UFM1-activating enzyme
26-292 ACAA1 is an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome.Acetyl-Coenzyme A acyltransferase (ACAA1) is an enzyme operat 0.05 mg
EIAAB44847 Mouse,Mus musculus,Uba5,Ube1dc1,Ubiquitin-activating enzyme 5,Ubiquitin-activating enzyme E1 domain-containing protein 1,Ubiquitin-like modifier-activating enzyme 5,UFM1-activating enzyme
EIAAB44846 Bos taurus,Bovine,UBA5,UBE1DC1,Ubiquitin-activating enzyme 5,Ubiquitin-activating enzyme E1 domain-containing protein 1,Ubiquitin-like modifier-activating enzyme 5,UFM1-activating enzyme
EIAAB44849 Rat,Rattus norvegicus,Uba5,Ube1dc1,Ubiquitin-activating enzyme 5,Ubiquitin-activating enzyme E1 domain-containing protein 1,Ubiquitin-like modifier-activating enzyme 5,UFM1-activating enzyme
E1812h ELISA kit AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,C 96T
E0718m ELISA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 96T
U1812m CLIA Asp 1,ASP1,Aspartyl protease 1,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Memapsin-1,Membrane-associated aspartic protease 1,Mous 96T
U0718m CLIA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 96T
E0718r ELISA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 96T
U1812h CLIA kit AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,CD 96T
Pathways :
WP626: Abscisic Acid Biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1493: Carbon assimilation C4 pathway
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP272: Blood Clotting Cascade
WP142: mRNA processing
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP2199: Seed Development
WP1122: Blood Clotting Cascade
WP459: Serine Biosynthesis
WP1659: Glycine, serine and threonine metabolism
WP218: Serine and Glycine biosynthesis
WP390: Serine-isocitrate lyase pathway
WP470: Proteasome Degradation
WP887: Blood Clotting Cascade
WP460: Blood Clotting Cascade
WP775: Blood Clotting Cascade
WP1818: Formation of Fibrin Clot (Clotting Cascade)
WP2185: Purine metabolism
WP255: Blood Clotting Cascade

Related Genes :
[] Thrombin-like enzyme cerastocytin (SVTLE) (EC 3.4.21.-) (C.cerastes platelet proaggregant protein) (CC-PPP) (Factor VIII activator) (Fibrinogen-clotting enzyme) (Proaggregant serine proteinase) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BJ-48 (SVTLE BJ-48) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpirSP27 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Gyroxin analog) (Snake venom serine protease) (SVSP) (Venombin A) (Fragment)
[] Thrombin-like enzyme bhalternin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpirSP41 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme elegaxobin-1 (SVTLE) (EC 3.4.21.-) (Elegaxobin I) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme ancrod (SVTLE) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Venombin A)
[] Thrombin-like enzyme BpSP-1 (SVTLE BpSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme BpSP-I) (SVTLE BpSP-I) (Fragment)
[] Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme Cdc SII (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme gyroxin B1.4 (SVTLE gyroxin B1.4) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.3 (SVTLE gyroxin B1.3) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.7 (SVTLE gyroxin B1.7) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme halystase (SVTLE) (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B2.1 (SVTLE gyroxin B2.1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Factor V activator (FVA) (VLFVA) (EC 3.4.21.95) (Lebetina viper venom FV activator) (LVV-V) (Snake venom serine protease) (SVSP)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Venom plasminogen activator LV-PA (EC 3.4.21.-) (LMUT0402S) (Plasminogen activating proteinase) (Snake venom serine protease) (SVSP)
[] Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[] Snake venom serine protease 2 (SP2) (SVSP) (EC 3.4.21.-) (Jerdonobin-II)
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Uridylate-specific endoribonuclease nsp11 (EC 4.6.1.-) (Non-structural protein 11) (Nsp11); Non-structural protein 12 (Nsp12)]
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[] Venom plasminogen activator TSV-PA (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Genome polyprotein [Cleaved into: Core protein precursor (Capsid protein C) (p23); Mature core protein (p21); Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); Viroporin p7; Protease NS2 (p23) (EC 3.4.22.-) (Non-structural protein 2) (NS2); Serine protease/helicase NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3 helicase) (NS3 protease) (NS3P) (Viroporin p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56/58); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]

Bibliography :