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Thrombin-like enzyme elegaxobin-1 (SVTLE) (EC 3.4.21.-) (Elegaxobin I) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)

 VSP1_PROEL              Reviewed;         233 AA.
P84788;
07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
07-MAR-2006, sequence version 1.
07-APR-2021, entry version 48.
RecName: Full=Thrombin-like enzyme elegaxobin-1;
Short=SVTLE;
EC=3.4.21.-;
AltName: Full=Elegaxobin I;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Protobothrops elegans (Elegant pitviper) (Trimeresurus elegans).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
NCBI_TaxID=88086;
[1] {ECO:0000305}
PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Venom {ECO:0000269|PubMed:12076650};
PubMed=12076650; DOI=10.1016/s0041-0101(02)00092-2;
Oyama E., Takahashi H.;
"Amino acid sequence of a thrombin like enzyme, elegaxobin, from the venom
of Trimeresurus elegans (Sakishima-habu).";
Toxicon 40:959-970(2002).
[2] {ECO:0000305}
PROTEIN SEQUENCE OF 1-10, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
TISSUE=Venom {ECO:0000269|PubMed:10708800};
PubMed=10708800; DOI=10.1016/s0041-0101(99)00220-2;
Oyama E., Takahashi H.;
"Purification and characterization of a thrombin-like enzyme, elegaxobin,
from the venom of Trimeresurus elegans (Sakishima-habu).";
Toxicon 38:1087-1100(2000).
-!- FUNCTION: Thrombin-like snake venom serine protease that clots rabbit
fibrinogen. Only the beta chain of fibrinogen (FGB) is cleaved,
releasing fibrinopeptide B. Incubation with human fibrinogen alpha and
beta resulted in cleavage of both fibrinogen chains but generated
neither fibrinopeptide A nor fibrinopeptide B. Promotes clotting of
rabbit fibrinogen, but not bovine or human fibrinogen.
{ECO:0000269|PubMed:10708800}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10708800,
ECO:0000269|PubMed:12076650}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000269|PubMed:10708800, ECO:0000269|PubMed:12076650}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
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SMR; P84788; -.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO; GO:0090729; F:toxin activity; IDA:UniProtKB.
GO; GO:0044485; P:envenomation resulting in fibrinogenolysis in other organism; IDA:UniProtKB.
GO; GO:0044470; P:envenomation resulting in negative regulation of blood coagulation in other organism; IDA:UniProtKB.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Hemostasis impairing toxin; Hydrolase; Protease; Secreted;
Serine protease; Toxin.
CHAIN 1..233
/note="Thrombin-like enzyme elegaxobin-1"
/id="PRO_0000227535"
DOMAIN 1..224
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 40
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P12544"
ACT_SITE 85
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P12544"
ACT_SITE 179
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P12544"
DISULFID 7..138
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 25..41
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 73..231
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 117..185
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 149..164
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 175..200
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
SEQUENCE 233 AA; 25440 MW; B93AC18E5E027E17 CRC64;
VIGGDECNIN EHPFLVLVYY DDYQCGGTLI NEEWVLTAAH CNGKNMEIYL GVHSKKVPNK
DVQRRVPKEK FFCDSSKTYT KWNKDIMLIR LDRPVRKSAH IAPLSLPSSP PSVGSVCRVM
GWGTITSPQE TYPDVPHCAK INLLDYSECR AAYPGLPPKS RTLCAGVLEG GKDTCGGDSG
GPLICNGQFQ GIVSWGGDPC AQPHEPGSYT NVFDHLDWIK GIIAGNTDAT CPL


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Related Genes :
[] Thrombin-like enzyme elegaxobin-1 (SVTLE) (EC 3.4.21.-) (Elegaxobin I) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme cerastocytin (SVTLE) (EC 3.4.21.-) (C.cerastes platelet proaggregant protein) (CC-PPP) (Factor VIII activator) (Fibrinogen-clotting enzyme) (Proaggregant serine proteinase) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BJ-48 (SVTLE BJ-48) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpirSP27 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme bhalternin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Gyroxin analog) (Snake venom serine protease) (SVSP) (Venombin A) (Fragment)
[] Thrombin-like enzyme BpirSP41 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme ancrod (SVTLE) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Venombin A)
[] Thrombin-like enzyme BpSP-1 (SVTLE BpSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme BpSP-I) (SVTLE BpSP-I) (Fragment)
[] Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme Cdc SII (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme gyroxin B1.4 (SVTLE gyroxin B1.4) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.3 (SVTLE gyroxin B1.3) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.7 (SVTLE gyroxin B1.7) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Factor V activator (FVA) (VLFVA) (EC 3.4.21.95) (Lebetina viper venom FV activator) (LVV-V) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme halystase (SVTLE) (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B2.1 (SVTLE gyroxin B2.1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Venom plasminogen activator LV-PA (EC 3.4.21.-) (LMUT0402S) (Plasminogen activating proteinase) (Snake venom serine protease) (SVSP)
[] Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[] Venom plasminogen activator TSV-PA (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Snake venom serine protease 2 (SP2) (SVSP) (EC 3.4.21.-) (Jerdonobin-II)
[] Protein C activator (EC 3.4.21.-) (ACC-C) (Snake venom serine protease) (SVSP)
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[] Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[] Snake venom serine protease LmrSP-4 (SVSP) (EC 3.4.21.-) (Fragment)
[ADAM17 CSVP TACE] Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
[] Beta-fibrinogenase mucrofibrase-5 (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Tm-5) (Tm-IIG)

Bibliography :