GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Thrombin-like enzyme kangshuanmei (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)

 VSP1_GLOBR              Reviewed;         236 AA.
P85109;
03-APR-2007, integrated into UniProtKB/Swiss-Prot.
03-APR-2007, sequence version 1.
02-DEC-2020, entry version 52.
RecName: Full=Thrombin-like enzyme kangshuanmei;
Short=SVTLE;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Gloydius brevicaudus (Korean slamosa snake) (Agkistrodon halys
brevicaudus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
NCBI_TaxID=259325;
[1] {ECO:0000305}
PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
SPECTROMETRY, AND GLYCOSYLATION AT ASN-81; ASN-99; ASN-148 AND ASN-229.
TISSUE=Venom {ECO:0000269|PubMed:16908038};
PubMed=16908038; DOI=10.1016/j.toxicon.2006.06.001;
Sakai J., Zhang S., Chen H., Atsumi F., Matsui T., Shiono H., Sanada S.,
Okada T.;
"Primary structure of a thrombin-like serine protease, kangshuanmei, from
the venom of Agkistrodon halys brevicaudus stejneger.";
Toxicon 48:313-322(2006).
[2] {ECO:0000305}
PROTEIN SEQUENCE OF 1-50, FUNCTION, ACTIVITY REGULATION, SUBUNIT,
SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
TISSUE=Venom {ECO:0000269|PubMed:11491462};
PubMed=11491462;
Zhang S., Ma B., Sakai J., Shiono H., Matsui T., Sugie I., Okada T.;
"Characterization of a thrombin-like serine protease, Kangshuanmei,
isolated from the venom of a Chinese snake, Agkistrodon halys brevicaudus
stejneger.";
J. Nat. Toxins 10:221-238(2001).
-!- FUNCTION: Thrombin-like snake venom serine protease. Cleaves bonds
after Arg and Lys, converts fibrinogen (FGA and FGB) to fibrin and
releases both fibrinopeptides A and B, and fibrinogen peptide Bbeta1-
42. Has a blood clotting activity. {ECO:0000269|PubMed:11491462,
ECO:0000269|PubMed:16908038}.
-!- ACTIVITY REGULATION: Inhibited by 4-(2-aminoethyl)-benzensulfonyl
fluoride. Not inhibited by antithrombin-III.
{ECO:0000269|PubMed:11491462}.
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:11491462}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11491462,
ECO:0000269|PubMed:16908038}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000269|PubMed:11491462, ECO:0000269|PubMed:16908038}.
-!- PTM: N-glycosylated by units composed of Fuc, Man, GlcNAc, Gal and
NeuAC residues. {ECO:0000269|PubMed:16908038}.
-!- MASS SPECTROMETRY: Mass=26476; Method=MALDI; Note=For the
deglycosylated protein.; Evidence={ECO:0000269|PubMed:16908038};
-!- MASS SPECTROMETRY: Mass=32278; Method=MALDI; Note=For the glycosylated
protein.; Evidence={ECO:0000269|PubMed:16908038};
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
SMR; P85109; -.
MEROPS; S01.524; -.
iPTMnet; P85109; -.
PRIDE; P85109; -.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0004252; F:serine-type endopeptidase activity; IDA:UniProtKB.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0030194; P:positive regulation of blood coagulation; IDA:UniProtKB.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Toxin.
CHAIN 1..236
/note="Thrombin-like enzyme kangshuanmei"
/id="PRO_0000283728"
DOMAIN 1..227
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 43
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P33589"
ACT_SITE 88
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P33589"
ACT_SITE 182
/note="Charge relay system"
/evidence="ECO:0000250|UniProtKB:P33589"
CARBOHYD 81
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16908038"
CARBOHYD 99
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16908038"
CARBOHYD 148
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16908038"
CARBOHYD 229
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16908038"
DISULFID 7..141
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 28..44
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 78..234
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 120..188
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 152..167
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 178..203
/evidence="ECO:0000250|UniProtKB:Q9PSN3,
ECO:0000255|PROSITE-ProRule:PRU00274"
SEQUENCE 236 AA; 26432 MW; B1579E328A6522E5 CRC64;
VIGGDECNIN EHRFLVALYH SRSRTFLCGG TLINQEWVLT AAHCDRFFMY IRLGMHNKNV
NFDDEQRRSP KEKYFFRCSN NFTKWDKDIM LIRLDSPVNN SAHIAPLSLP SNPPSVGSVC
RVMGWGQTTS PQEDLSDVPR CANINLFNFT VCRAAYPWLP ATSRVLCAGD MEGGIDTCNR
DSGGPLICNG QFQGIVSKGQ NLCAQPRKPA LYTKVFDHLD WIQSIIAGNK TVTCPP


Related products :

Catalog number Product name Quantity
18-661-15015 ADAM 17 - EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
E1319h ELISA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
U1319h CLIA ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
E1319h ELISA kit ADAM 17,ADAM17,CSVP,Disintegrin and metalloproteinase domain-containing protein 17,Homo sapiens,Human,Snake venom-like protease,TACE,TNF-alpha convertase,TNF-alpha-converting enzyme 96T
EIAAB08673 Atrial natriuretic peptide-converting enzyme,Corin,CORIN,CRN,Heart-specific serine proteinase ATC2,Homo sapiens,Human,Pro-ANP-converting enzyme,TMPRSS10,Transmembrane protease serine 10
18-272-195437 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195436 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-195435 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.05 mg
18-272-197022 TACE - Rabbit polyclonal to TACE; EC 3.4.24.86; A disintegrin and metalloproteinase domain 17; TNF-alpha-converting enzyme; TNF-alpha convertase; Snake venom-like protease; CD156b antigen Polyclonal 0.1 mg
Y050525 Anti-cSVP(snake venom-like protease) Antibody 100ug
gen16977 ADA17_HUMAN Snake venom-like protease ELISA tesk kit 1
U1812m CLIA Asp 1,ASP1,Aspartyl protease 1,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Memapsin-1,Membrane-associated aspartic protease 1,Mous 96T
U1812h CLIA kit AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,CD 96T
E1812h ELISA kit AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,C 96T
E0718m ELISA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 96T
E0718r ELISA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 96T
U0718r CLIA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 96T
U0718m CLIA Asp 2,ASP2,Aspartyl protease 2,Bace,Bace1,Beta-secretase 1,Beta-site amyloid precursor protein cleaving enzyme 1,Beta-site APP cleaving enzyme 1,Memapsin-2,Membrane-associated aspartic protease 2 96T
U1812h CLIA AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,CDA13,D 96T
E1812h ELISA AEPLC,ALP56,Asp 1,ASP1,ASP21,Aspartic-like protease 56 kDa,Aspartyl protease 1,BACE2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,CDA13, 96T
U1812m CLIA kit Asp 1,ASP1,Aspartyl protease 1,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Memapsin-1,Membrane-associated aspartic protease 1 96T
E1812m ELISA kit Asp 1,ASP1,Aspartyl protease 1,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Memapsin-1,Membrane-associated aspartic protease 96T
E1812m ELISA Asp 1,ASP1,Aspartyl protease 1,Bace2,Beta-secretase 2,Beta-site amyloid precursor protein cleaving enzyme 2,Beta-site APP cleaving enzyme 2,Memapsin-1,Membrane-associated aspartic protease 1,Mou 96T
U1910m CLIA kit Kallikrein-7,Klk7,Mouse,Mus musculus,Prss6,Scce,Serine protease 6,Stratum corneum chymotryptic enzyme,Thymopsin 96T
U1910m CLIA Kallikrein-7,Klk7,Mouse,Mus musculus,Prss6,Scce,Serine protease 6,Stratum corneum chymotryptic enzyme,Thymopsin 96T
Pathways :
WP626: Abscisic Acid Biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP2349: vitamin B3 (niacin), NAD and NADP biosynthesis pathway
WP1493: Carbon assimilation C4 pathway
WP2199: Seed Development
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP272: Blood Clotting Cascade
WP142: mRNA processing
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1122: Blood Clotting Cascade
WP459: Serine Biosynthesis
WP1659: Glycine, serine and threonine metabolism
WP218: Serine and Glycine biosynthesis
WP390: Serine-isocitrate lyase pathway
WP470: Proteasome Degradation
WP1929: Thrombin signalling through proteinase activated receptors (PARs)
WP887: Blood Clotting Cascade
WP460: Blood Clotting Cascade
WP1818: Formation of Fibrin Clot (Clotting Cascade)
WP775: Blood Clotting Cascade
WP2185: Purine metabolism
WP255: Blood Clotting Cascade

Related Genes :
[] Thrombin-like enzyme cerastocytin (SVTLE) (EC 3.4.21.-) (C.cerastes platelet proaggregant protein) (CC-PPP) (Factor VIII activator) (Fibrinogen-clotting enzyme) (Proaggregant serine proteinase) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BJ-48 (SVTLE BJ-48) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpirSP27 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme bhalternin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Gyroxin analog) (Snake venom serine protease) (SVSP) (Venombin A) (Fragment)
[] Thrombin-like enzyme BpirSP41 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme ancrod (SVTLE) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Venombin A)
[] Thrombin-like enzyme elegaxobin-1 (SVTLE) (EC 3.4.21.-) (Elegaxobin I) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpSP-1 (SVTLE BpSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme BpSP-I) (SVTLE BpSP-I) (Fragment)
[] Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme Cdc SII (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme gyroxin B1.4 (SVTLE gyroxin B1.4) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.3 (SVTLE gyroxin B1.3) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.7 (SVTLE gyroxin B1.7) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Factor V activator (FVA) (VLFVA) (EC 3.4.21.95) (Lebetina viper venom FV activator) (LVV-V) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme halystase (SVTLE) (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B2.1 (SVTLE gyroxin B2.1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Venom plasminogen activator LV-PA (EC 3.4.21.-) (LMUT0402S) (Plasminogen activating proteinase) (Snake venom serine protease) (SVSP)
[] Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[] Venom plasminogen activator TSV-PA (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Snake venom serine protease 2 (SP2) (SVSP) (EC 3.4.21.-) (Jerdonobin-II)
[] Protein C activator (EC 3.4.21.-) (ACC-C) (Snake venom serine protease) (SVSP)
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[] Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Snake venom serine protease LmrSP-4 (SVSP) (EC 3.4.21.-) (Fragment)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[ADAM17 CSVP TACE] Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
[] Beta-fibrinogenase mucrofibrase-5 (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Tm-5) (Tm-IIG)

Bibliography :
No related Items