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Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)

 VSPST_TRIST             Reviewed;         260 AA.
Q8AY81;
24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
12-AUG-2020, entry version 75.
RecName: Full=Thrombin-like enzyme stejnobin;
Short=SVTLE;
EC=3.4.21.-;
AltName: Full=Fibrinogen-clotting enzyme;
AltName: Full=Snake venom serine protease;
Short=SVSP;
Flags: Precursor;
Trimeresurus stejnegeri (Chinese green tree viper) (Viridovipera
stejnegeri).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
Serpentes; Colubroidea; Viperidae; Crotalinae; Trimeresurus.
NCBI_TaxID=39682;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Venom gland;
Lee W.-H., Zhang Y.;
"Molecular cloning and sequence comparison of serine proteases from the
venom of Trimeresurus stejnegeri.";
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
[2]
PROTEIN SEQUENCE OF 25-34, FUNCTION, ACTIVITY REGULATION,
BIOPHYSICOCHEMICAL PROPERTIES, SUBUNIT, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND GLYCOSYLATION.
TISSUE=Venom;
PubMed=9604287; DOI=10.1016/s0041-0101(97)00050-0;
Zhang Y., Gao R., Lee W.-H., Zhu S.-W., Xiong Y.-L., Wang W.-Y.;
"Characterization of a fibrinogen-clotting enzyme from Trimeresurus
stejnegeri venom, and comparative study with other venom proteases.";
Toxicon 36:131-142(1998).
-!- FUNCTION: Thrombin-like snake venom serine protease that has
fibrinogen-clotting activity (FGA or FGB).
{ECO:0000269|PubMed:9604287}.
-!- ACTIVITY REGULATION: Its activity is inhibited by
diisopropylfluorophosphate (DFP) and PMSF, whereas EDTA has no effect
on it. {ECO:0000269|PubMed:9604287}.
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=250 uM for H-D-Phe-Pip-Arg-pNA (S-2238)
{ECO:0000269|PubMed:9604287};
KM=50 uM for H-D-Pro-Phe-Arg-pNA (S-2302)
{ECO:0000269|PubMed:9604287};
KM=125 uM for H-D-Val-Leu-Arg-pNA (S-2266)
{ECO:0000269|PubMed:9604287};
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:9604287}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9604287}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
{ECO:0000269|PubMed:9604287}.
-!- PTM: Glycosylated. {ECO:0000269|PubMed:9604287}.
-!- MISCELLANEOUS: Does not act on factor X, prothrombin and plasminogen.
{ECO:0000305|PubMed:9604287}.
-!- SIMILARITY: Belongs to the peptidase S1 family. Snake venom subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00274}.
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EMBL; AF545576; AAN52347.1; -; mRNA.
SMR; Q8AY81; -.
MEROPS; S01.181; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
Pfam; PF00089; Trypsin; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
1: Evidence at protein level;
Blood coagulation cascade activating toxin; Direct protein sequencing;
Disulfide bond; Glycoprotein; Hemostasis impairing toxin; Hydrolase;
Protease; Secreted; Serine protease; Signal; Toxin; Zymogen.
SIGNAL 1..18
/evidence="ECO:0000255"
PROPEP 19..24
/evidence="ECO:0000250"
/id="PRO_0000296309"
CHAIN 25..260
/note="Thrombin-like enzyme stejnobin"
/id="PRO_0000296310"
DOMAIN 25..251
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 67
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 112
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 206
/note="Charge relay system"
/evidence="ECO:0000250"
CARBOHYD 81
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 105
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 156
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 172
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 253
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 31..165
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 52..68
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 102..258
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 144..212
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 176..191
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
DISULFID 202..227
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
SEQUENCE 260 AA; 29328 MW; F1339FBB8F848A57 CRC64;
MMLIRVLANL LILQLSYAQK SSELVIGGDE CNINEHRFLV ALYDFWSGDF LCGGTLINQE
YVLTAAHCKT RNMYIYLGMH NKSVQFDDEQ RRYPKKKYFF RCRNNFTRWD KDIMLIRLNR
PVRNSAHIAP LSLPSSPPTV GSVCRVMGWG TITSPNETLP DVPRCANINL FNYTVCHGVF
PWLPARSRIL CAGVLQGGID TCKRDSGGPL ICNGQFQGIV SWGPKPCAQP RKPALYTKVF
DHLDWIQSII AGNTTVTCPP


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Related Genes :
[] Thrombin-like enzyme stejnobin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme cerastocytin (SVTLE) (EC 3.4.21.-) (C.cerastes platelet proaggregant protein) (CC-PPP) (Factor VIII activator) (Fibrinogen-clotting enzyme) (Proaggregant serine proteinase) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BJ-48 (SVTLE BJ-48) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme BpirSP27 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme bhalternin (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme LMR-47 (SVTLE LM-47) (SVTLE LMR-47) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Gyroxin analog) (Snake venom serine protease) (SVSP) (Venombin A) (Fragment)
[] Thrombin-like enzyme BpirSP41 (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme ancrod (SVTLE) (EC 3.4.21.74) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Venombin A)
[] Thrombin-like enzyme elegaxobin-1 (SVTLE) (EC 3.4.21.-) (Elegaxobin I) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme BpSP-1 (SVTLE BpSP-1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Thrombin-like enzyme BpSP-I) (SVTLE BpSP-I) (Fragment)
[] Thrombin-like enzyme Cdc SI (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme Cdc SII (SVTLE) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP) (Fragment)
[] Thrombin-like enzyme gyroxin B1.4 (SVTLE gyroxin B1.4) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.3 (SVTLE gyroxin B1.3) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B1.7 (SVTLE gyroxin B1.7) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Factor V activator (FVA) (VLFVA) (EC 3.4.21.95) (Lebetina viper venom FV activator) (LVV-V) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme halystase (SVTLE) (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Thrombin-like enzyme gyroxin B2.1 (SVTLE gyroxin B2.1) (EC 3.4.21.-) (Fibrinogen-clotting enzyme) (Snake venom serine protease) (SVSP)
[] Venom plasminogen activator LV-PA (EC 3.4.21.-) (LMUT0402S) (Plasminogen activating proteinase) (Snake venom serine protease) (SVSP)
[] Chymotrypsin-like protease VLCTLP (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Vipera Lebetina with chymotrypsin-like proteolytic activity)
[] Venom plasminogen activator TSV-PA (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Snake venom serine protease 2 (SP2) (SVSP) (EC 3.4.21.-) (Jerdonobin-II)
[] Protein C activator (EC 3.4.21.-) (ACC-C) (Snake venom serine protease) (SVSP)
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[] Alpha- and beta-fibrinogenase OhS1 (EC 3.4.21.-) (Snake venom serine protease) (SVSP)
[] Snake venom serine protease LmrSP-4 (SVSP) (EC 3.4.21.-) (Fragment)
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[ADAM17 CSVP TACE] Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
[] Beta-fibrinogenase mucrofibrase-5 (EC 3.4.21.-) (Snake venom serine protease) (SVSP) (Tm-5) (Tm-IIG)

Bibliography :