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Thrombospondin 1

 A0A2I3RP89_PANTR        Unreviewed;      1173 AA.
A0A2I3RP89;
28-FEB-2018, integrated into UniProtKB/TrEMBL.
28-FEB-2018, sequence version 1.
11-DEC-2019, entry version 14.
SubName: Full=Thrombospondin 1 {ECO:0000313|Ensembl:ENSPTRP00000066460};
Name=THBS1 {ECO:0000313|Ensembl:ENSPTRP00000066460,
ECO:0000313|VGNC:VGNC:1597};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000066460, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000066460, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the human
genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000066460}
IDENTIFICATION.
Ensembl;
Submitted (JAN-2018) to UniProtKB.
-!- CAUTION: Lacks conserved residue(s) required for the propagation of
feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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EMBL; AACZ04038091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSPTRT00000092195; ENSPTRP00000066460; ENSPTRG00000006907.
VGNC; VGNC:1597; THBS1.
GeneTree; ENSGT00940000155832; -.
Proteomes; UP000002277; Chromosome 15.
GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0005577; C:fibrinogen complex; IEA:Ensembl.
GO; GO:0031091; C:platelet alpha granule; IEA:Ensembl.
GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
GO; GO:0070052; F:collagen V binding; IEA:Ensembl.
GO; GO:0070051; F:fibrinogen binding; IEA:Ensembl.
GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
GO; GO:0001968; F:fibronectin binding; IEA:Ensembl.
GO; GO:0008201; F:heparin binding; IEA:Ensembl.
GO; GO:0005178; F:integrin binding; IEA:Ensembl.
GO; GO:0043236; F:laminin binding; IEA:Ensembl.
GO; GO:0030169; F:low-density lipoprotein particle binding; IEA:Ensembl.
GO; GO:0001786; F:phosphatidylserine binding; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0007155; P:cell adhesion; IEA:InterPro.
GO; GO:0007050; P:cell cycle arrest; IEA:Ensembl.
GO; GO:0016477; P:cell migration; IEA:Ensembl.
GO; GO:0002544; P:chronic inflammatory response; IEA:Ensembl.
GO; GO:0043652; P:engulfment of apoptotic cell; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; IBA:GO_Central.
GO; GO:0002581; P:negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:Ensembl.
GO; GO:1903588; P:negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
GO; GO:0001953; P:negative regulation of cell-matrix adhesion; IEA:Ensembl.
GO; GO:0010754; P:negative regulation of cGMP-mediated signaling; IEA:Ensembl.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0002605; P:negative regulation of dendritic cell antigen processing and presentation; IEA:Ensembl.
GO; GO:2001027; P:negative regulation of endothelial cell chemotaxis; IEA:Ensembl.
GO; GO:0051918; P:negative regulation of fibrinolysis; IEA:Ensembl.
GO; GO:0040037; P:negative regulation of fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
GO; GO:0010748; P:negative regulation of long-chain fatty acid import across plasma membrane; IEA:Ensembl.
GO; GO:0010751; P:negative regulation of nitric oxide mediated signal transduction; IEA:Ensembl.
GO; GO:0010757; P:negative regulation of plasminogen activation; IEA:Ensembl.
GO; GO:0018149; P:peptide cross-linking; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IEA:Ensembl.
GO; GO:0050921; P:positive regulation of chemotaxis; IEA:Ensembl.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:1902043; P:positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0010763; P:positive regulation of fibroblast migration; IEA:Ensembl.
GO; GO:0043032; P:positive regulation of macrophage activation; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Ensembl.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; IEA:Ensembl.
GO; GO:0051592; P:response to calcium ion; IEA:Ensembl.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0009749; P:response to glucose; IEA:Ensembl.
GO; GO:0032026; P:response to magnesium ion; IEA:Ensembl.
GO; GO:0002040; P:sprouting angiogenesis; IEA:Ensembl.
Gene3D; 2.20.100.10; -; 3.
Gene3D; 4.10.1080.10; -; 2.
InterPro; IPR013320; ConA-like_dom_sf.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR001791; Laminin_G.
InterPro; IPR028499; Thrombospondin-1.
InterPro; IPR003367; Thrombospondin_3-like_rpt.
InterPro; IPR017897; Thrombospondin_3_rpt.
InterPro; IPR008859; Thrombospondin_C.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR036383; TSP1_rpt_sf.
InterPro; IPR028974; TSP_type-3_rpt.
InterPro; IPR001007; VWF_dom.
PANTHER; PTHR10199:SF78; PTHR10199:SF78; 1.
Pfam; PF00090; TSP_1; 3.
Pfam; PF02412; TSP_3; 7.
Pfam; PF05735; TSP_C; 1.
Pfam; PF00093; VWC; 1.
SMART; SM00181; EGF; 3.
SMART; SM00179; EGF_CA; 2.
SMART; SM00209; TSP1; 3.
SMART; SM00210; TSPN; 1.
SMART; SM00214; VWC; 1.
SUPFAM; SSF103647; SSF103647; 3.
SUPFAM; SSF49899; SSF49899; 2.
SUPFAM; SSF82895; SSF82895; 3.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS50092; TSP1; 3.
PROSITE; PS51234; TSP3; 8.
PROSITE; PS51236; TSP_CTER; 1.
PROSITE; PS01208; VWFC_1; 1.
PROSITE; PS50184; VWFC_2; 1.
4: Predicted;
Calcium {ECO:0000256|PROSITE-ProRule:PRU00634};
Coiled coil {ECO:0000256|SAM:Coils};
Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Repeat {ECO:0000256|SAAS:SAAS00814929}; Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1..18
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 19..1173
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5014178335"
DOMAIN 316..373
/note="VWFC"
/evidence="ECO:0000259|PROSITE:PS50184"
DOMAIN 547..587
/note="EGF-like"
/evidence="ECO:0000259|PROSITE:PS50026"
DOMAIN 646..690
/note="EGF-like"
/evidence="ECO:0000259|PROSITE:PS50026"
REPEAT 691..726
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 727..762
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 763..785
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 786..821
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 822..844
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 845..882
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 883..918
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
REPEAT 919..954
/note="TSP type-3"
/evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
DOMAIN 958..1172
/note="TSP C-terminal"
/evidence="ECO:0000259|PROSITE:PS51236"
REGION 839..934
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COILED 291..311
/evidence="ECO:0000256|SAM:Coils"
COMPBIAS 841..868
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 883..897
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 903..934
/note="Polyampholyte"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 1173 AA; 129741 MW; 35761311F45BEE8E CRC64;
MGLAWGLGVL FLMHVCGTNR IPESGGDNSV FDIFELTGAA RKGSGRRLVK GPDPSSPAFR
IEDANLIPPV PDDKFQDLVD AVRAEKGFLL LASLRQMKKT RGTLLALERK DHSGQVFSVV
SNGKAGTLDL SLTVQGKQHV VSVEEALLAT GQWKSITLFV QEDRAQLYID CEKMENAELD
VPIQSVFTRD LASIARLRIA KGGVNDNFQG VLQNVRFVFG TTPEDILRNK GCSSSTSVLL
TLDNNVVNGS SPAIRTNYIG HKTKDLQAIC GISCDELSSM VLELRGLRTI VTTLQDSIRK
VTEENKELAN ELRRPPLCYH NGVQYRNNEE WTVDSCTECH CQNSVTICKK VSCPIMPCSN
ATVPDGECCP RCWPSDSADD GWSPWSEWTS CSTSCGNGIQ QRGRSCDSLN NRCEGSSVQT
RTCHIQECDK RFKQDGGWSH WSPWSSCSVT CGDGVITRIR LCNSPSPQMN GKPCEGEARE
TKACKKDACP INGGWGPWSP WDICSVTCGG GVQKRSRLCN NPTPQFGGKD CVGDVTENQI
CNKQDCPIDG CLSNPCFAGV KCTSYPDGSW KCGACPPGYS GNGIQCTDVD ECKEVPDACF
NHNGEHRCEN TDPGYNCLPC PPRFTGSQPF GQGVEYATAN KQVCKPRNPC TDGTHDCNKN
AKCNYLGHYS DPMFRCECKP GYAGNGIICG EDTDLDGWPN ENLVCVANAT YHCKKDNCPN
LPNSGQEDYD KDGIGDACDD DDDNDKIPDD RDNCPFHYNP AQYDYDRDDV GDRCDNCPYN
HNPDQADTDN NGEGDACAAD IDGDGILNER DNCQYVYNVD QRDTDMDGVG DQCDNCPLEH
NPDQLDSDSD RIGDTCDNNQ DIDEDGHQNN LDNCPYVPNA NQADHDKDGK GDACDHDDDN
DGIPDDRDNC RLVPNPDQKD SDGDGRGDAC KDDFDHDSVP DIDDICPENV DISETDFRRF
QMIPLDPKGT SQNDPNWVVR HQGKELVQTV NCDPGLAVGY DEFNAVDFSG TFFINTERDD
DYAGFVFGYQ SSSRFYVVMW KQVTQSYWDT NPTRAQGYSG LSVKVVNSTT GPGEHLRNAL
WHTGNTPGQV RTLWHDPRHI GWKDFTAYRW RLSHRPKTGF IRVVMYEGKK IMADSGPIYD
KTYAGGRLGL FVFSQEMVFF SDLKYECRDS LNC


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528-75 Thrombospondin (TSP) 100 ug
528-75 Thrombospondin (TSP) 10 ug
528-75 Thrombospondin (TSP) 25 ug
528-75 Thrombospondin (TSP) 50 ug
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BMMS-420-MX Thrombospondin (TSP) MTO
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BMMS-421-MX Thrombospondin (TSP) MTO
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Pathways :
WP1333: Hypothetical Network for Drug Addiction
WP564: Wnt Signaling Pathway
WP1355: One Carbon Metabolism
WP497: Urea cycle and metabolism of amino groups
WP1537: E2F/MIRHG1 feedback-loop
WP295: Electron Transport Chain
WP1371: G Protein Signaling Pathways
WP164: Glutathione metabolism
WP2075: Alzheimers Disease
WP899: Wnt Signaling Pathway
WP2085: miRNAs involved in DDR
WP1313: Insulin Signaling
WP558: Complement and Coagulation Cascades
WP1354: B Cell Receptor Signaling Pathway
WP1318: Eicosanoid Synthesis
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP2353: vitamin B9 (folate) biosynthesis pathway
WP1372: Oxidative Stress
WP17: daf-2 or insulin signaling pathway
WP2287: Male mating
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1982: SREBP signalling
WP1126: Tryptophan metabolism
WP1337: MAPK signaling pathway
WP1135: Wnt Signaling Pathway

Related Genes :
[THSD7A KIAA0960] Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]
[Adamts2] A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)
[THBS1] Thrombospondin 1
[THBS1 TSP TSP1] Thrombospondin-1 (Glycoprotein G)
[Thbs1 Tsp1] Thrombospondin-1 (Glycoprotein G)
[Adamts1] A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-)
[Adamts1] A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-)
[Thsd7a Gm837 Kiaa0960] Thrombospondin type-1 domain-containing protein 7A [Cleaved into: Thrombospondin type-1 domain-containing protein 7A, soluble form]
[ADAMTS4 KIAA0688 UNQ769/PRO1563] A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAM-TS 4) (ADAM-TS4) (ADAMTS-4) (EC 3.4.24.82) (ADMP-1) (Aggrecanase-1)
[thsd7aa thsd7a si:dkey-12h3.1] Thrombospondin type-1 domain-containing protein 7A
[ADAMTS1 KIAA1346 METH1] A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAM-TS 1) (ADAM-TS1) (ADAMTS-1) (EC 3.4.24.-) (METH-1)
[gon-1 F25H8.3] A disintegrin and metalloproteinase with thrombospondin motifs gon-1 (ADAMTS gon-1) (EC 3.4.24.-) (Abnormal gonad development protein 1)
[ADAMTS5 ADAMTS11 ADMP2] A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAM-TS 5) (ADAM-TS5) (ADAMTS-5) (EC 3.4.24.-) (A disintegrin and metalloproteinase with thrombospondin motifs 11) (ADAM-TS 11) (ADAMTS-11) (ADMP-2) (Aggrecanase-2)
[Rspo1] R-spondin-1 (Cysteine-rich and single thrombospondin domain-containing protein 3) (Cristin-3) (mCristin-3) (Roof plate-specific spondin-1)
[ADAMTSL4 TSRC1 PP1396 UNQ2803/PRO34012] ADAMTS-like protein 4 (ADAMTSL-4) (Thrombospondin repeat-containing protein 1)
[ADAMTS2 PCINP PCPNI] A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)
[ADAMTS2 NPI] A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS 2) (ADAM-TS2) (ADAMTS-2) (EC 3.4.24.14) (Procollagen I N-proteinase) (PC I-NP) (Procollagen I/II amino propeptide-processing enzyme) (Procollagen N-endopeptidase) (pNPI)
[RSPO3 PWTSR THSD2] R-spondin-3 (Protein with TSP type-1 repeat) (hPWTSR) (Roof plate-specific spondin-3) (hRspo3) (Thrombospondin type-1 domain-containing protein 2)
[Rspo3] R-spondin-3 (Cabriolet) (Cysteine-rich and single thrombospondin domain-containing protein 1) (Cristin-1) (Nucleopondin) (Roof plate-specific spondin-3)
[ADAMTSL5 THSD6] ADAMTS-like protein 5 (ADAMTSL-5) (Thrombospondin type-1 domain-containing protein 6)
[Thbs1 Tsp1] Thrombospondin 1
[Thbs1] thrombospondin-1 isoform X1
[Thbs1] Thrombospondin-1
[Thbs1] Thrombospondin 1
[THBS1] Thrombospondin 1
[THBS1] Thrombospondin 1
[Thbs1] Thrombospondin 1
[THBS1] Thrombospondin 1
[THBS1] Thrombospondin 1
[THBS1] Thrombospondin 1

Bibliography :
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