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Thymosin beta-10

 TYB10_HORSE             Reviewed;          44 AA.
P63314; P13472; Q547C6;
11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
16-JAN-2019, entry version 72.
RecName: Full=Thymosin beta-10;
Name=TMSB10; Synonyms=PTMB10, THYB10;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Takafuji V.A., Sharova L.V., Crisman M.V., Howard R.D.;
"Equus caballus thymosin, beta 10 (TMSB10) mRNA.";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[2]
PROTEIN SEQUENCE OF 2-44.
TISSUE=Spleen;
Hoerger S., Gallert B., Kellerman J., Voelter W.;
"Isolation and structural identification of beta-thymosins from equine
tissue: development of a specific ELISA against thymosin beta-10
(TBeta-10).";
(In) Schneider C.H., Eberles A.N. (eds.);
Peptides 1992, pp.749-750, Escom Science Publishers, Leiden (1993).
-!- FUNCTION: Plays an important role in the organization of the
cytoskeleton. Binds to and sequesters actin monomers (G actin) and
therefore inhibits actin polymerization (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
-!- SIMILARITY: Belongs to the thymosin beta family. {ECO:0000305}.
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EMBL; AF506973; AAM34215.1; -; mRNA.
RefSeq; NP_001075334.1; NM_001081865.1.
UniGene; Eca.1228; -.
ProteinModelPortal; P63314; -.
SMR; P63314; -.
PeptideAtlas; P63314; -.
PRIDE; P63314; -.
GeneID; 100033928; -.
KEGG; ecb:100033928; -.
CTD; 9168; -.
HOVERGEN; HBG012534; -.
InParanoid; P63314; -.
KO; K13785; -.
OrthoDB; 1632292at2759; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0003785; F:actin monomer binding; IBA:GO_Central.
GO; GO:0007015; P:actin filament organization; IEA:InterPro.
GO; GO:0030334; P:regulation of cell migration; IBA:GO_Central.
GO; GO:0042989; P:sequestering of actin monomers; IBA:GO_Central.
Gene3D; 1.20.5.520; -; 1.
InterPro; IPR001152; Beta-thymosin.
InterPro; IPR038386; Beta-thymosin_sf.
PANTHER; PTHR12021; PTHR12021; 1.
Pfam; PF01290; Thymosin; 1.
PIRSF; PIRSF001828; Thymosin_beta; 1.
ProDom; PD005116; Thymosin_b4; 1.
SMART; SM00152; THY; 1.
PROSITE; PS00500; THYMOSIN_B4; 1.
1: Evidence at protein level;
Acetylation; Actin-binding; Complete proteome; Cytoplasm;
Cytoskeleton; Direct protein sequencing; Phosphoprotein;
Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P21752,
ECO:0000269|Ref.2}.
CHAIN 2 44 Thymosin beta-10.
/FTId=PRO_0000045930.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P21752}.
MOD_RES 4 4 N6-acetyllysine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 12 12 Phosphoserine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 15 15 N6-acetyllysine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 21 21 Phosphothreonine.
{ECO:0000250|UniProtKB:Q6ZWY8}.
MOD_RES 23 23 Phosphothreonine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 34 34 Phosphothreonine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 39 39 N6-acetyllysine.
{ECO:0000250|UniProtKB:P63313}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P63312}.
SEQUENCE 44 AA; 5026 MW; 5485277C275A1C70 CRC64;
MADKPDMGEI ASFDKAKLKK TETQEKNTLP TKETIEQEKR SEIS


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Pathways :
WP1045: TGF-beta Receptor Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP105: Fatty Acid Beta Oxidation 2
WP1056: Complement and Coagulation Cascades
WP1058: Senescence and Autophagy
WP1061: Fatty Acid Beta Oxidation
WP1106: Keap1-Nrf2
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP113: TGF Beta Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1164: TGF Beta Signaling Pathway
WP1172: Complement and Coagulation Cascades
WP1177: Fatty Acid Beta Oxidation
WP1207: Fatty Acid Beta Oxidation
WP1224: EBV LMP1 signaling
WP1225: estrogen signalling
WP1226: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1237: Fatty Acid Beta Oxidation
WP126: Fatty Acid Beta Oxidation 1
WP1269: Fatty Acid Beta Oxidation
WP1307: Fatty Acid Beta Oxidation
WP1355: One Carbon Metabolism
WP1367: TGF-beta Receptor Signaling Pathway
WP1370: TGF Beta Signaling Pathway
WP143: Fatty Acid Beta Oxidation

Related Genes :
[TMSB4X TB4X THYB4 TMSB4] Thymosin beta-4 (T beta-4) (Fx) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[TMSB4 THYB4] Thymosin beta-4 (T beta-4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[Tmsb4x Ptmb4 Tmsb4] Thymosin beta-4 (T beta 4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[tth-1 F08F1.8] Thymosin beta (Tetrathymosin beta)
[TMSB10] Thymosin beta-10 (Thymosin beta-9) [Cleaved into: Thymosin beta-8]
[TMSB4] Thymosin beta-4 (T beta-4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[TMSB10 PTMB10 THYB10] Thymosin beta-10
[] Thymosin beta (Beta-thymosin)
[TMSB4X] Thymosin beta-4 (T beta-4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[PTMA TMSA] Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]
[TMSB15A TMSL8 TMSNB] Thymosin beta-15A (NB thymosin beta) (Thymosin-like protein 8)
[TMSB4] Thymosin beta-4 (T beta-4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[rep 1a-1b] Replicase polyprotein 1ab (ORF1ab polyprotein) [Cleaved into: Nsp1 (EC 3.4.22.-); Nsp1-alpha papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-alpha); Nsp1-beta papain-like cysteine proteinase (EC 3.4.22.-) (PCP1-beta); Nsp2 cysteine proteinase (EC 3.4.19.12) (EC 3.4.22.-) (CP2) (CP); Non-structural protein 3 (Nsp3); Serine protease nsp4 (3CLSP) (EC 3.4.21.-) (3C-like serine proteinase) (Nsp4); Non-structural protein 5-6-7 (Nsp5-6-7); Non-structural protein 5 (Nsp5); Non-structural protein 6 (Nsp6); Non-structural protein 7-alpha (Nsp7-alpha); Non-structural protein 7-beta (Nsp7-beta); Non-structural protein 8 (Nsp8); RNA-directed RNA polymerase (Pol) (RdRp) (EC 2.7.7.48) (Nsp9); Helicase nsp10 (Hel) (EC 3.6.4.12) (EC 3.6.4.13) (Nsp10); Non-structural protein 11 (Nsp11); Non-structural protein 12 (Nsp12)]
[Tmsb4x Thyb4 Tmsb4] Thymosin beta-4 (T beta 4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[Tmsb10 Ptmb10 Thyb10] Thymosin beta-10
[BCO2 BCDO2] Beta,beta-carotene 9',10'-oxygenase (EC 1.13.11.71) (B-diox-II) (Beta-carotene dioxygenase 2)
[Bco2 Bcdo2] Beta,beta-carotene 9',10'-oxygenase (EC 1.13.11.71) (B-diox-II) (Beta-carotene dioxygenase 2)
[TMSB10] Thymosin beta-10 (Thymosin beta-9)
[HSD17B10 ERAB HADH2 MRPP2 SCHAD SDR5C1 XH98G2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)
[Hsd17b10 Erab Hadh2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)
[tmsb4] Thymosin beta-4 (T beta 4) (Thymosin beta 4Xen)
[CCD7 D17 HTD1 Os04g0550600 LOC_Os04g46470 OsJ_15694 OSJNBb0034G17.9] Carotenoid cleavage dioxygenase 7, chloroplastic (OsCCD7) (Beta,beta-carotene 9',10'-oxygenase) (EC 1.13.11.68) (Protein DWARF-17) (Protein HIGH-TILLERING DWARF 1) (Protein MAX3 homolog)
[CCD7 MAX3 NCED7 At2g44990 T14P1.21] Carotenoid cleavage dioxygenase 7, chloroplastic (AtCCD7) (AtNCED7) (Beta,beta-carotene 9',10'-oxygenase) (EC 1.13.11.68) (Protein MORE AXILLARY BRANCHING 3) (Protein MORE AXILLARY GROWTH 3)
[At5g42100 MJC20.21] Glucan endo-1,3-beta-glucosidase 10 (EC 3.2.1.39) ((1->3)-beta-glucan endohydrolase 10) ((1->3)-beta-glucanase 10) (Beta-1,3-endoglucanase 10) (Beta-1,3-glucanase 10) (Putative plasmodesmal associated protein) (AtBG_ppap)
[TMSB10 PTMB10 THYB10] Thymosin beta-10
[B3galnt1 B3galt3 B3gt3 Mbrn1] UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 (Beta-1,3-GalNAc-T1) (EC 2.4.1.79) (Beta-1,3-galactosyltransferase 3) (Beta-1,3-GalTase 3) (Beta3Gal-T3) (Beta3GalT3) (b3Gal-T3) (Beta-3-Gx-T3) (Brainiac 1) (Galactosylgalactosylglucosylceramide beta-D-acetyl-galactosaminyltransferase) (Globoside synthase) (UDP-N-acetylgalactosamine:globotriaosylceramide beta-1,3-N-acetylgalactosaminyltransferase)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[TMSB4 THYB4] Thymosin beta-4 (T beta-4) [Cleaved into: Hematopoietic system regulatory peptide (Seraspenide)]
[HSD17B10 HADH2] 3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-hydroxysteroid dehydrogenase 10) (17-beta-HSD 10) (EC 1.1.1.51) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Type II HADH)

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