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Toll like receptor 8

 G3WLZ9_SARHA            Unreviewed;      1039 AA.
G3WLZ9;
16-NOV-2011, integrated into UniProtKB/TrEMBL.
16-NOV-2011, sequence version 1.
08-MAY-2019, entry version 55.
SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSSHAP00000016454};
Name=TLR8 {ECO:0000313|Ensembl:ENSSHAP00000016454};
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016454, ECO:0000313|Proteomes:UP000007648};
[1] {ECO:0000313|Ensembl:ENSSHAP00000016454}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=21709235; DOI=10.1073/pnas.1102838108;
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
"Genetic diversity and population structure of the endangered
marsupial Sarcophilus harrisii (Tasmanian devil).";
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
[2] {ECO:0000313|Ensembl:ENSSHAP00000016454}
IDENTIFICATION.
Ensembl;
Submitted (SEP-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AEFK01126332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9305.ENSSHAP00000016454; -.
Ensembl; ENSSHAT00000016591; ENSSHAP00000016454; ENSSHAG00000013998.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
InParanoid; G3WLZ9; -.
OMA; RWMDENL; -.
TreeFam; TF351113; -.
Proteomes; UP000007648; Unassembled WGS sequence.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR026906; LRR_5.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR47410:SF1; PTHR47410:SF1; 1.
Pfam; PF13306; LRR_5; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 16.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000007648};
Immunity {ECO:0000256|SAAS:SAAS00179614};
Innate immunity {ECO:0000256|SAAS:SAAS00179614};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00179597};
Reference proteome {ECO:0000313|Proteomes:UP000007648};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 20 {ECO:0000256|SAM:SignalP}.
CHAIN 21 1039 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003459088.
TRANSMEM 826 848 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 878 1025 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1039 AA; 119941 MW; F18DE26850B68794 CRC64;
QVTMILQSLN FICLCFLVIC SPELLDQKVN LRDYPCSIKR QNSSVIANCL ACRLHSVPKS
LDHNVTEIDL SFNFIKNITS ESFVGLNNLT KINLNSNTNS QVEDRNFMKI SDGAFFNLTN
LKELLLEDNH LQKIPIHLPP SLTTISLVLN NIYHITKNCT SGLIQLKSLY LGWNCFYGNE
CKKNVLIDDG AFEDLANLTV LSLSFNNLSH VPTKLPPSLN ELYLSNNKIK NISQDDFKNL
GNLRVLDLSG NCPRCFNNPY PCTPCENSAS IQIHPDAFQN LGQLTHLNLS STSLKSLPAS
WFSNMTNLEV LLLEFNYLVK EIATGDFFTK LPKLEILDFS YNYLKNSYPQ YIVISGNFSK
LVSLKTLHLK GYVFQELRKE DFQPLTKLQN LQSINLGINF INHIDFTLFE EFNNLSLIYL
SENRISPQVT NSLGEKSNSL SFTNHVIHQR SIDSDNEPLG HYEIDPHRNF YHHTYPLMKP
ECTSYGKALD LSLNSIFFVN HNLFEGLHDI VCLNLSSNGN AQVLNGSEFS SINRTKYLDL
SHNRLDFDDD GAFQELRELE VLDLSNNEHY FRIAGVTHRL GFIQNLPQLK VLNLSQNGIF
TLTENQLISK SLKELVFKGN RLDILWKKED KRYLAIFKEL SNLTLLDLSI NRLHRIPNEA
FLNLPHSLEE LRLNNNHLSI FNWTSLQYFH SLRVLDLQSN SLSTINFDLS NSSLKILLLG
KNRISHLPDD LLSKAKGLYQ LDLSYNHIKM INKSTFQMKA SNHLKILELR GNPFDCTCEI
RDFRKWMDEN LNVTIPKLVE VTCSTPGDQM GKSIMELELN TCISDVIAAI FFFFSFIITV
SSMVIATFHH LFYWDIWYIY HLCSAKIKGY KSVSTSKTFY DAFIAYDTKD TCVTDWVINE
LRFQLEENEE KKVLLCLEER DWDPGIAIID NLMQSINQSK KTIFVLTKKY AKNWNFKTAF
YLALQRLMDD NMDVIIFILL EPVLQHSQYL RLRRRICKSS VLKWPDNPKA EELFWQSLKN
VVLTDNDTRY NNLYVKFIK


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LF-PA41167 anti-Toll-like Receptor 5 (TLR5) , Rabbit polyclonal to Toll-like Receptor 5 (TLR5), Isotype IgG, Host Rabbit 50 ug
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Pathways :
WP1271: Toll-like receptor signaling pathway
WP1183: Toll-like receptor signaling pathway
WP88: Toll Like Receptor signaling
WP1309: Toll-like receptor signaling pathway
WP75: Toll-like receptor signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP1449: Regulation of toll-like receptor signaling pathway
WP949: Toll-like receptor signaling pathway
WP1067: Toll-like receptor signaling pathway
WP1384: Toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP252: Androgen Receptor Signaling Pathway
WP886: Kit Receptor Signaling Pathway
WP1781: Advanced glycosylation endproduct receptor signaling
WP590: Cardiovascular Signaling
WP1014: Androgen receptor signaling pathway
WP1918: Signaling by Robo receptor
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP274: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1336: EPO Receptor Signaling
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[Tollo Tl-8 Toll-8 CG6890] Toll-like receptor Tollo (Toll-like receptor 8)
[SIGIRR UNQ301/PRO342] Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
[TLR8 UNQ249/PRO286] Toll-like receptor 8 (CD antigen CD288)
[Tlr8] Toll-like receptor 8 (CD antigen CD288)
[Sigirr Tir8] Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
[TLR2 TIL4] Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
[TLR5 TIL3] Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
[TLR1 KIAA0012] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[Tlr1] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[TICAM2 TIRAP3 TIRP TRAM] TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
[Toll-7 CG8595] Toll-like receptor 7
[Tlr4] Toll-like receptor 4 (Toll4) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (Toll-like receptor 4 isoform 1) (Toll-like receptor 4 isoform A)
[TLR4] Toll-like receptor 4 (hToll) (CD antigen CD284)
[Tlr9] Toll-like receptor 9 (CD antigen CD289)
[TLR9 UNQ5798/PRO19605] Toll-like receptor 9 (CD antigen CD289)
[Tlr2] Toll-like receptor 2 (CD antigen CD282)
[TLR3] Toll-like receptor 3 (CD antigen CD283)
[Tlr4 Lps] Toll-like receptor 4 (CD antigen CD284)
[TLR7 UNQ248/PRO285] Toll-like receptor 7
[TLR6] Toll-like receptor 6 (CD antigen CD286)
[Tlr7] Toll-like receptor 7
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[Tlr6] Toll-like receptor 6 (CD antigen CD286)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[Tlr3] Toll-like receptor 3 (CD antigen CD283)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
[TLR2] Toll-like receptor 2 (CD antigen CD282)

Bibliography :
[31293023] Subtle Differences in Chemical Pattern between Human Toll-Like Receptor 8 Agonists and Antagonists: Emerging Chemical Patterns Analysis.
[31284084] Identification and characterization of a novel chemotype for human TLR8 inhibitors.
[31269085] Red Queen revisited: Immune gene diversity and parasite load in the asexual Poecilia formosa versus its sexual host species P. mexicana.
[31244825] Structural Modification of the Antidepressant Mianserin Suggests That Its Anti-inflammatory Activity May Be Independent of 5-Hydroxytryptamine Receptors.
[31214180] Human Toll-like Receptor 8 (TLR8) Is an Important Sensor of Pyogenic Bacteria, and Is Attenuated by Cell Surface TLR Signaling.
[30972055] Human TLR8 Senses RNA From -Infected Red Blood Cells Which Is Uniquely Required for the IFN-γ Response in NK Cells.
[30935923] Evaluation of Toll-like receptor expression profile in patients with psoriasis vulgaris.
[30763883] In vitro metabolic profiles of motolimod by using liquid chromatography tandem mass spectrometry: Metabolic stability, metabolite characterization and species comparison.
[30579933] Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells.
[30568763] The emerging chemical patterns applied in predicting human toll-like receptor 8 agonists.