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Toll-like receptor 4 (Toll4) (CD antigen CD284)

 TLR4_RAT                Reviewed;         835 AA.
Q9QX05;
11-FEB-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-APR-2020, entry version 150.
RecName: Full=Toll-like receptor 4;
Short=Toll4;
EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};
AltName: CD_antigen=CD284;
Flags: Precursor;
Name=Tlr4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Heart;
PubMed=10430608; DOI=10.1172/jci6709;
Frantz S., Kobzik L., Kim Y.-D., Fukazawa R., Medzhitov R., Lee R.T.,
Kelly R.A.;
"Toll4 (TLR4) expression in cardiac myocytes in normal and failing
myocardium.";
J. Clin. Invest. 104:271-280(1999).
-!- FUNCTION: Cooperates with LY96 and CD14 to mediate the innate immune
response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP
and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the
inflammatory response. Also involved in LPS-independent inflammatory
responses triggered by free fatty acids, such as palmitate. In complex
with TLR6, promotes sterile inflammation in monocytes/macrophages in
response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta
42. In this context, the initial signal is provided by oxLDL- or
amyloid-beta 42-binding to CD36. This event induces the formation of a
heterodimer of TLR4 and TLR6, which is rapidly internalized and
triggers inflammatory response, leading to the NF-kappa-B-dependent
production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling
pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as
IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the
cytokine release induced by LDL(-) (By similarity).
{ECO:0000250|UniProtKB:O00206}.
-!- CATALYTIC ACTIVITY:
Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
Evidence={ECO:0000255|PROSITE-ProRule:PRU00204};
-!- SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-
protein complex containing at least CD14, LY96 and TLR4. Binding to
bacterial LPS leads to homodimerization. Interacts with LY96 via the
extracellular domain. Interacts with MYD88 and TIRAP via their
respective TIR domains. Interacts with TICAM2. Interacts with NOX4.
Interacts with CNPY3 and HSP90B1; this interaction is required for
proper folding in the endoplasmic reticulum. Interacts with MAP3K21;
this interaction leads to negative regulation of TLR4 signaling.
Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-
beta 42, and forms a heterodimer with TLR6. The trimeric complex is
internalized and triggers inflammatory response. LYN kinase activity
facilitates TLR4-TLR6 heterodimerization and signal initiation.
Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner.
Interacts with WDFY1 in response to LPS. Interacts with SMPDL3B.
Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a
complex including TLR4 and the phosphorylated form of SYK and CEACAM1,
which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the
production of reactive oxygen species (ROS) and lysosome disruption,
which in turn, reduces the activity of the inflammasome. Interacts with
RFTN1; the interaction occurs in response to lipopolysaccharide
stimulation. Interacts with SCIMP; the interaction occurs in response
to lipopolysaccharide stimulation and is enhanced by phosphorylation of
SCIMP by LYN (By similarity). This interaction facilitates the
phosphorylation of TLR4 by LYN which elicits a selective cytokine
response in macrophages (By similarity). {ECO:0000250|UniProtKB:O00206,
ECO:0000250|UniProtKB:Q9QUK6}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00206};
Single-pass type I membrane protein {ECO:0000250|UniProtKB:O00206}.
Early endosome {ECO:0000250|UniProtKB:O00206}. Cell projection, ruffle
{ECO:0000250|UniProtKB:Q9QUK6}. Note=Upon complex formation with CD36
and TLR6, internalized through dynamin-dependent endocytosis.
Colocalizes with RFTN1 at cell membrane and then together with RFTN1
moves to endosomes, upon lipopolysaccharide stimulation.
{ECO:0000250|UniProtKB:O00206}.
-!- DOMAIN: The TIR domain mediates interaction with NOX4.
{ECO:0000250|UniProtKB:O00206}.
-!- DOMAIN: The TIR domain mediates NAD(+) hydrolase (NADase) activity.
Self-association of TIR domains is required for NADase activity.
{ECO:0000255|PROSITE-ProRule:PRU00204}.
-!- PTM: Phosphorylated on tyrosine residues by LYN after binding
lipopolysaccharide. {ECO:0000250|UniProtKB:Q9QUK6}.
-!- SIMILARITY: Belongs to the Toll-like receptor family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; AF057025; AAC13313.1; -; mRNA.
RefSeq; NP_062051.1; NM_019178.1.
SMR; Q9QX05; -.
STRING; 10116.ENSRNOP00000014020; -.
PaxDb; Q9QX05; -.
PRIDE; Q9QX05; -.
GeneID; 29260; -.
KEGG; rno:29260; -.
UCSC; RGD:3870; rat.
CTD; 7099; -.
RGD; 3870; Tlr4.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
InParanoid; Q9QX05; -.
KO; K10160; -.
OrthoDB; 282372at2759; -.
PhylomeDB; Q9QX05; -.
Reactome; R-RNO-5686938; Regulation of TLR by endogenous ligand.
Reactome; R-RNO-936964; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon.
Reactome; R-RNO-937072; TRAF6-mediated induction of TAK1 complex within TLR4 complex.
PRO; PR:Q9QX05; -.
Proteomes; UP000002494; Unplaced.
GO; GO:0009986; C:cell surface; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; ISO:RGD.
GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
GO; GO:0031226; C:intrinsic component of plasma membrane; ISO:RGD.
GO; GO:0046696; C:lipopolysaccharide receptor complex; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
GO; GO:0001891; C:phagocytic cup; ISO:RGD.
GO; GO:0005886; C:plasma membrane; ISO:RGD.
GO; GO:0043235; C:receptor complex; ISO:RGD.
GO; GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO; GO:0042802; F:identical protein binding; ISO:RGD.
GO; GO:0001530; F:lipopolysaccharide binding; IDA:RGD.
GO; GO:0001875; F:lipopolysaccharide immune receptor activity; ISS:UniProtKB.
GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
GO; GO:0043548; F:phosphatidylinositol 3-kinase binding; IPI:RGD.
GO; GO:0046982; F:protein heterodimerization activity; ISO:RGD.
GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
GO; GO:0002218; P:activation of innate immune response; ISO:RGD.
GO; GO:0000187; P:activation of MAPK activity; ISO:RGD.
GO; GO:0014002; P:astrocyte development; ISO:RGD.
GO; GO:0002322; P:B cell proliferation involved in immune response; ISO:RGD.
GO; GO:1904646; P:cellular response to amyloid-beta; ISO:RGD.
GO; GO:0071346; P:cellular response to interferon-gamma; ISO:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0071223; P:cellular response to lipoteichoic acid; ISO:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
GO; GO:0140052; P:cellular response to oxidised low-density lipoprotein particle stimulus; ISO:RGD.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
GO; GO:0042742; P:defense response to bacterium; ISO:RGD.
GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:RGD.
GO; GO:0032497; P:detection of lipopolysaccharide; ISS:UniProtKB.
GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:RGD.
GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:RGD.
GO; GO:0007252; P:I-kappaB phosphorylation; ISO:RGD.
GO; GO:0016064; P:immunoglobulin mediated immune response; IEP:RGD.
GO; GO:0006954; P:inflammatory response; IEP:RGD.
GO; GO:0002758; P:innate immune response-activating signal transduction; IMP:RGD.
GO; GO:0032609; P:interferon-gamma production; ISO:RGD.
GO; GO:0050702; P:interleukin-1 beta secretion; ISS:UniProtKB.
GO; GO:0060729; P:intestinal epithelial structure maintenance; ISO:RGD.
GO; GO:0006691; P:leukotriene metabolic process; IDA:RGD.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISO:RGD.
GO; GO:0042116; P:macrophage activation; ISO:RGD.
GO; GO:0001774; P:microglial cell activation; IDA:RGD.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; ISO:RGD.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:RGD.
GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:RGD.
GO; GO:0032707; P:negative regulation of interleukin-23 production; ISO:RGD.
GO; GO:0032715; P:negative regulation of interleukin-6 production; ISO:RGD.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:RGD.
GO; GO:0002537; P:nitric oxide production involved in inflammatory response; ISO:RGD.
GO; GO:0006909; P:phagocytosis; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0030890; P:positive regulation of B cell proliferation; ISO:RGD.
GO; GO:1903974; P:positive regulation of cellular response to macrophage colony-stimulating factor stimulus; ISO:RGD.
GO; GO:1904209; P:positive regulation of chemokine (C-C motif) ligand 2 secretion; ISO:RGD.
GO; GO:0032722; P:positive regulation of chemokine production; ISO:RGD.
GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; ISO:RGD.
GO; GO:0043388; P:positive regulation of DNA binding; IMP:RGD.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IMP:RGD.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
GO; GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
GO; GO:0032727; P:positive regulation of interferon-alpha production; ISO:RGD.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; ISO:RGD.
GO; GO:0032728; P:positive regulation of interferon-beta production; ISO:RGD.
GO; GO:0032729; P:positive regulation of interferon-gamma production; ISO:RGD.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; ISO:RGD.
GO; GO:0032732; P:positive regulation of interleukin-1 production; ISO:RGD.
GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:RGD.
GO; GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; ISO:RGD.
GO; GO:0032735; P:positive regulation of interleukin-12 production; ISO:RGD.
GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:RGD.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; ISO:RGD.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; ISO:RGD.
GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:RGD.
GO; GO:2000484; P:positive regulation of interleukin-8 secretion; ISO:RGD.
GO; GO:0046330; P:positive regulation of JNK cascade; ISO:RGD.
GO; GO:0010838; P:positive regulation of keratinocyte proliferation; ISO:RGD.
GO; GO:0050671; P:positive regulation of lymphocyte proliferation; ISO:RGD.
GO; GO:0043032; P:positive regulation of macrophage activation; ISO:RGD.
GO; GO:0060907; P:positive regulation of macrophage cytokine production; ISO:RGD.
GO; GO:1904466; P:positive regulation of matrix metallopeptidase secretion; ISO:RGD.
GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; ISO:RGD.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:RGD.
GO; GO:1901224; P:positive regulation of NIK/NF-kappaB signaling; ISO:RGD.
GO; GO:0045429; P:positive regulation of nitric oxide biosynthetic process; ISO:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; ISO:RGD.
GO; GO:1900227; P:positive regulation of NLRP3 inflammasome complex assembly; ISS:UniProtKB.
GO; GO:0070430; P:positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway; ISO:RGD.
GO; GO:0070434; P:positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway; ISO:RGD.
GO; GO:1903223; P:positive regulation of oxidative stress-induced neuron death; ISO:RGD.
GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:RGD.
GO; GO:0010572; P:positive regulation of platelet activation; ISO:RGD.
GO; GO:1903428; P:positive regulation of reactive oxygen species biosynthetic process; ISO:RGD.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISO:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
GO; GO:0042535; P:positive regulation of tumor necrosis factor biosynthetic process; ISO:RGD.
GO; GO:0032760; P:positive regulation of tumor necrosis factor production; ISO:RGD.
GO; GO:0002730; P:regulation of dendritic cell cytokine production; ISO:RGD.
GO; GO:0050727; P:regulation of inflammatory response; ISO:RGD.
GO; GO:0051930; P:regulation of sensory perception of pain; IMP:RGD.
GO; GO:1904467; P:regulation of tumor necrosis factor secretion; IMP:RGD.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0009617; P:response to bacterium; ISO:RGD.
GO; GO:0045471; P:response to ethanol; IMP:RGD.
GO; GO:0070542; P:response to fatty acid; IDA:RGD.
GO; GO:0051384; P:response to glucocorticoid; IEP:RGD.
GO; GO:1990268; P:response to gold nanoparticle; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032868; P:response to insulin; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IDA:RGD.
GO; GO:0043278; P:response to morphine; IEP:RGD.
GO; GO:0006979; P:response to oxidative stress; IMP:RGD.
GO; GO:0032570; P:response to progesterone; IEP:RGD.
GO; GO:0032526; P:response to retinoic acid; IEP:RGD.
GO; GO:0009636; P:response to toxic substance; IEP:RGD.
GO; GO:0003009; P:skeletal muscle contraction; IEP:RGD.
GO; GO:0002224; P:toll-like receptor signaling pathway; IDA:RGD.
GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; ISO:RGD.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
Pfam; PF13855; LRR_8; 3.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 9.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 13.
PROSITE; PS50104; TIR; 1.
2: Evidence at transcript level;
Cell membrane; Cell projection; Disulfide bond; Endosome; Glycoprotein;
Hydrolase; Immunity; Inflammatory response; Innate immunity;
Leucine-rich repeat; Membrane; NAD; Receptor; Reference proteome; Repeat;
Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..25
/evidence="ECO:0000255"
CHAIN 26..835
/note="Toll-like receptor 4"
/id="PRO_0000034728"
TOPO_DOM 26..638
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 639..659
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 660..835
/note="Cytoplasmic"
/evidence="ECO:0000255"
REPEAT 54..75
/note="LRR 1"
REPEAT 78..99
/note="LRR 2"
REPEAT 102..123
/note="LRR 3"
REPEAT 126..147
/note="LRR 4"
REPEAT 150..171
/note="LRR 5"
REPEAT 175..198
/note="LRR 6"
REPEAT 204..224
/note="LRR 7"
REPEAT 226..247
/note="LRR 8"
REPEAT 372..381
/note="LRR 9"
REPEAT 398..420
/note="LRR 10"
REPEAT 421..442
/note="LRR 11"
REPEAT 446..467
/note="LRR 12"
REPEAT 470..491
/note="LRR 13"
REPEAT 495..516
/note="LRR 14"
REPEAT 519..540
/note="LRR 15"
REPEAT 543..564
/note="LRR 16"
DOMAIN 576..627
/note="LRRCT"
DOMAIN 670..813
/note="TIR"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
ACT_SITE 748
/evidence="ECO:0000255|PROSITE-ProRule:PRU00204"
CARBOHYD 34
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 43
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 75
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 172
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 204
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 237
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 248
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 281
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 307
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 492
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 495
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 524
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 572
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 575
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 622
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 28..39
/evidence="ECO:0000250|UniProtKB:O00206"
DISULFID 280..304
/evidence="ECO:0000250|UniProtKB:O00206"
DISULFID 388..389
/evidence="ECO:0000250|UniProtKB:O00206"
DISULFID 580..606
/evidence="ECO:0000250|UniProtKB:O00206"
DISULFID 582..625
/evidence="ECO:0000250|UniProtKB:O00206"
SEQUENCE 835 AA; 96072 MW; DF5E16A30851E3A0 CRC64;
MMPLLHLAGT LIMALFLSCL RPGSLNPCIE VLPNITYQCM DQNLSKIPHD IPYSTKNLDL
SFNPLKILRS YSFTNFSQLQ WLDLSRCEIE TIEDKAWHGL NQLSTLVLTG NPIKSFSPGS
FSGLTNLENL VAVETKMTSL EGFHIGQLIS LKKLNVAHNL IHSFKLPEYF SNLTNLEHVD
LSYNYIQTIS VKDLQFLREN PQVNLSLDLS LNPIDSIQAQ AFQGIRLHEL TLRSNFNSSN
VLKMCLQNMT GLHVHRLILG EFKNERNLES FDRSVMEGLC NVSIDEFRLT YINHFSDDIY
NLNCLANISA MSFTGVHIKH IADVPRHFKW QSLSIIRCHL KPFPKLSLPF LKSWTLTTNR
EDISFGQLAL PSLRYLDLSR NAMSFRGCCS YSDFGTNNLK YLDLSFNGVI LMSANFMGLE
ELEYLDFQHS TLKKVTEFSV FLSLEKLLYL DISYTNTKID FDGIFLGLIS LNTLKMAGNS
FKDNTLSNVF TNTTNLTFLD LSKCQLEQIS RGVFDTLYRL QLLNMSHNNL LFLDPSHYKQ
LYSLRTLDCS FNRIETSKGI LQHFPKSLAV FNLTNNSVAC ICEYQNFLQW VKDQKMFLVN
VEQMKCASPI DMKASLVLDF TNSTCYIYKT IISVSVVSVL VVATVAFLIY HFYFHLILIA
GCKKYSRGES IYDAFVIYSS QNEDWVRNEL VKNLEEGVPR FQLCLHYRDF IPGVAIAANI
IQEGFHKSRK VIVVVSRHFI QSRWCIFEYE IAQTWQFLSS RSGIIFIVLE KVEKSLLRQQ
VELYRLLSRN TYLEWEDNAL GRHIFWRRLK KALLDGKALN PDETSEEEQE ATTLT


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GWB-63F59B TOLL-LIKE RECEPTOR 4 (TLR4. CD284), Antibody
GWB-175B53 TOLL-LIKE RECEPTOR 4 (TLR4. CD284) _MD-2, Antibody
20-321-175147 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - FITC CONJUGATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.1 mg
20-321-175144 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - FITC CONJUGATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.1 mg
20-321-175164 TOLL-LIKE RECEPTOR 1 (TLR1. CD281) - FITC CONJUGATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 1 (TLR1. CD281); Toll_interleukin-1 receptor-like protein; TIL; CD281 antigen Monoclonal 0.1 mg
20-321-175148 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.05 mg
20-321-175145 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.05 mg
20-321-175165 TOLL-LIKE RECEPTOR 1 (TLR1. CD281) - BIOTINYLATED MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 1 (TLR1. CD281); Toll_interleukin-1 receptor-like protein; TIL; CD281 antigen Monoclonal 0.05 mg
20-321-175143 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.1 mg
20-321-175163 TOLL-LIKE RECEPTOR 1 (TLR1. CD281) - MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 1 (TLR1. CD281); Toll_interleukin-1 receptor-like protein; TIL; CD281 antigen Monoclonal 0.1 mg
20-321-175146 TOLL-LIKE RECEPTOR 2 (TLR2. CD282) - MONOCLONAL ANTIBODY TO HUMAN TOLL-LIKE RECEPTOR 2 (TLR2. CD282); Toll_interleukin 1 receptor-like protein 4; CD282 antigen Monoclonal 0.1 mg
Pathways :
WP1067: Toll-like receptor signaling pathway
WP1384: Toll-like receptor signaling pathway
WP88: Toll Like Receptor signaling
WP1271: Toll-like receptor signaling pathway
WP75: Toll-like receptor signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP1449: Regulation of toll-like receptor signaling pathway
WP1183: Toll-like receptor signaling pathway
WP2328: Allograft rejection
WP1309: Toll-like receptor signaling pathway
WP949: Toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP1004: Kit Receptor Signaling Pathway
WP1781: Advanced glycosylation endproduct receptor signaling
WP590: Cardiovascular Signaling
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP252: Androgen Receptor Signaling Pathway
WP886: Kit Receptor Signaling Pathway
WP1284: EPO Receptor Signaling
WP274: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1918: Signaling by Robo receptor
WP733: Serotonin Receptor 2 and STAT3 Signaling
WP1965: VEGF-receptor Signal Transduction

Related Genes :
[Tlr4] Toll-like receptor 4 (Toll4) (EC 3.2.2.6) (CD antigen CD284)
[Tlr4 Lps] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (hToll) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (EC 3.2.2.6) (CD antigen CD284)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[TLR2 TIL4] Toll-like receptor 2 (EC 3.2.2.6) (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
[CD36 GP3B GP4] Platelet glycoprotein 4 (Fatty acid translocase) (FAT) (Glycoprotein IIIb) (GPIIIB) (Leukocyte differentiation antigen CD36) (PAS IV) (PAS-4) (Platelet collagen receptor) (Platelet glycoprotein IV) (GPIV) (Thrombospondin receptor) (CD antigen CD36)
[Tlr1] Toll-like receptor 1 (EC 3.2.2.6) (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[Tlr2] Toll-like receptor 2 (EC 3.2.2.6) (CD antigen CD282)
[TLR6] Toll-like receptor 6 (EC 3.2.2.6) (CD antigen CD286)
[LILRA4 ILT7] Leukocyte immunoglobulin-like receptor subfamily A member 4 (CD85 antigen-like family member G) (Immunoglobulin-like transcript 7) (ILT-7) (CD antigen CD85g)
[TLR2] Toll-like receptor 2 (EC 3.2.2.6) (CD antigen CD282)
[TLR1 KIAA0012] Toll-like receptor 1 (EC 3.2.2.6) (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[CD44 LHR MDU2 MDU3 MIC4] CD44 antigen (CDw44) (Epican) (Extracellular matrix receptor III) (ECMR-III) (GP90 lymphocyte homing/adhesion receptor) (HUTCH-I) (Heparan sulfate proteoglycan) (Hermes antigen) (Hyaluronate receptor) (Phagocytic glycoprotein 1) (PGP-1) (Phagocytic glycoprotein I) (PGP-I) (CD antigen CD44)
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[CD86 CD28LG2] T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86)
[TLR6] Toll-like receptor 6 (EC 3.2.2.6) (CD antigen CD286)
[Tlr6] Toll-like receptor 6 (EC 3.2.2.6) (CD antigen CD286)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[Tlr9] Toll-like receptor 9 (CD antigen CD289)
[TLR9 UNQ5798/PRO19605] Toll-like receptor 9 (CD antigen CD289)

Bibliography :
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