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Toll-like receptor 8

 B2BE52_FELCA            Unreviewed;      1039 AA.
B2BE52; M3WT64;
20-MAY-2008, integrated into UniProtKB/TrEMBL.
20-MAY-2008, sequence version 1.
16-JAN-2019, entry version 78.
SubName: Full=Toll-like receptor 8 {ECO:0000313|EMBL:ABS28967.1, ECO:0000313|Ensembl:ENSFCAP00000017550};
Name=TLR8 {ECO:0000313|EMBL:ABS28967.1,
ECO:0000313|Ensembl:ENSFCAP00000017550};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|EMBL:ABS28967.1};
[1] {ECO:0000313|Ensembl:ENSFCAP00000017550, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|EMBL:ABS28967.1}
NUCLEOTIDE SEQUENCE.
PubMed=19568743; DOI=10.1007/s00251-009-0381-z;
Astakhova N.M., Perelygin A.A., Zharkikh A.A., Lear T.L.,
Coleman S.J., Macleod J.N., Brinton M.A.;
"Characterization of equine and other vertebrate TLR3, TLR7, and TLR8
genes.";
Immunogenetics 61:529-539(2009).
[3] {ECO:0000313|Ensembl:ENSFCAP00000017550}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|Ensembl:ENSFCAP00000017550}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000017550};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- SIMILARITY: Belongs to the Toll-like receptor family.
{ECO:0000256|SAAS:SAAS00596625}.
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EMBL; AANG04001271; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; EF484949; ABS28967.1; -; Genomic_DNA.
RefSeq; XP_019679113.1; XM_019823554.1.
RefSeq; XP_019679114.1; XM_019823555.1.
RefSeq; XP_019679115.1; XM_019823556.1.
ProteinModelPortal; B2BE52; -.
STRING; 9685.ENSFCAP00000017550; -.
Ensembl; ENSFCAT00000022218; ENSFCAP00000017550; ENSFCAG00000027513.
GeneID; 101091762; -.
KEGG; fca:101091762; -.
eggNOG; KOG4641; Eukaryota.
eggNOG; COG4886; LUCA.
GeneTree; ENSGT00940000160879; -.
HOVERGEN; HBG018601; -.
KO; K10170; -.
OrthoDB; 96378at2759; -.
Proteomes; UP000011712; Chromosome X.
Bgee; ENSFCAG00000027513; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:0006954; P:inflammatory response; IEA:InterPro.
GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
GO; GO:2001183; P:negative regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0045356; P:positive regulation of interferon-alpha biosynthetic process; IEA:Ensembl.
GO; GO:0045359; P:positive regulation of interferon-beta biosynthetic process; IEA:Ensembl.
GO; GO:0045078; P:positive regulation of interferon-gamma biosynthetic process; IEA:Ensembl.
GO; GO:0050718; P:positive regulation of interleukin-1 beta secretion; IEA:Ensembl.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IEA:Ensembl.
GO; GO:0045416; P:positive regulation of interleukin-8 biosynthetic process; IEA:Ensembl.
GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
Gene3D; 3.40.50.10140; -; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR000483; Cys-rich_flank_reg_C.
InterPro; IPR001611; Leu-rich_rpt.
InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
InterPro; IPR032675; LRR_dom_sf.
InterPro; IPR000157; TIR_dom.
InterPro; IPR027175; TLR8.
InterPro; IPR035897; Toll_tir_struct_dom_sf.
PANTHER; PTHR44312:SF2; PTHR44312:SF2; 1.
Pfam; PF13855; LRR_8; 5.
Pfam; PF01582; TIR; 1.
SMART; SM00369; LRR_TYP; 18.
SMART; SM00082; LRRCT; 1.
SMART; SM00255; TIR; 1.
SUPFAM; SSF52200; SSF52200; 1.
PROSITE; PS51450; LRR; 20.
PROSITE; PS50104; TIR; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000011712};
Immunity {ECO:0000256|SAAS:SAAS00472892};
Innate immunity {ECO:0000256|SAAS:SAAS00472892};
Leucine-rich repeat {ECO:0000256|SAAS:SAAS00488662};
Membrane {ECO:0000256|SAAS:SAAS00598878, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00473103, ECO:0000313|EMBL:ABS28967.1};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Repeat {ECO:0000256|SAAS:SAAS00597472};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00598878,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 18 {ECO:0000256|SAM:SignalP}.
CHAIN 19 1039 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5014084809.
TRANSMEM 825 845 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 876 1023 TIR. {ECO:0000259|PROSITE:PS50104}.
SEQUENCE 1039 AA; 119530 MW; 20A5D0A2979498A2 CRC64;
MTLQSLLLTC LFLLISDSRE FFTEANYSRS YPCDEKRQNG SIIAQCNDRR LREVPQTVSK
YVTALDLSYN FITHITNESF QGLQNLTRIN LNHNANQQHL NENPDINRSG MNITDGAFLN
LQNLNQLLLE DNQLDQIPAG LPGSLRELSL IQNNIIWVAK KNTSGLTNLQ RLYLSWNCYF
GNNCNNKTFD IEDGTFESLT NLQVLSLSFN KLVHVPPKLP NSLTELYLSN AKIKVISQED
FKGLTNLRVL DLSGNCPRCF NAPFPCTPCE GGSSIQIHPL AFQTLTELRY LNLSSTSLQK
IPAMWFQSMH NLKVLHLEFN YLVDEIASGE FLTKLPSLEI LDLSYNYVKA KYPRYINISQ
NFSHLKLLQT LHLRGYVFQE LRAEDFQPLM NLSNLKTINL GINFIKQINF TLFQNFSNLS
IIYLSENRIS PLVNDIKQND MSGSSFQSHI RRLRSADTEF DPHSNFYHNT NPLIKPQCTV
YGKALDLSLN SIFFIGREQF KAFHDIACLN LSSNGNGQVL HGTEFSAVPH IKYLDLTNNR
LDFDDDNALS DLPELEVLDL SYNAHYFRIA GVTHRLGFIQ NLTQLKVLNL SHNSIYTLTE
QDLRSMSLKE LVFSGNRLDI LWNAEGDKYW KIFTNLGNLT WLDLSSNNLR HIPNEAFLNL
PQSLTKLYIR DNVLNSFNWT LLQLFPHLQL LDLSGNRLSS LTNSLSKFTP SLRTLLLRRN
RISHLPSNFL SEASSLIHLD LSSNLLKMIN KSTLQTKTAT NLTILELGRN PFDCTCDIGD
FRRWMDENLD VTIPRLADVI CSSPGDQRGK SIVSLELTTC VSDTIAAILC FFTFFITITV
MLAALGHHWF YWDVWFIYHV CLAKIKGYRS LSTSQTFYDA YVSYDTKDAS VTDWVINELR
FHLEESEEKN VLLCLEERDW DPGLAIIDNL IQSINQSKKT IFVLTKKYAK NWNFKTAFYL
ALQRLMDENM DVIIFILLEP VLQNSQYLRL RQRICKSSIL QWPDNPKAEG LFWQSLKNVV
LTENDSRYNN LYVDSIKQY


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Pathways :
WP1067: Toll-like receptor signaling pathway
WP1183: Toll-like receptor signaling pathway
WP1271: Toll-like receptor signaling pathway
WP1309: Toll-like receptor signaling pathway
WP1384: Toll-like receptor signaling pathway
WP1449: Regulation of toll-like receptor signaling pathway
WP2272: Pathogenic Escherichia coli infection
WP75: Toll-like receptor signaling pathway
WP829: Toll-like receptor signaling pathway
WP88: Toll Like Receptor signaling
WP949: Toll-like receptor signaling pathway
WP1004: Kit Receptor Signaling Pathway
WP1011: T Cell Receptor Signaling Pathway
WP1014: Androgen receptor signaling pathway
WP1025: B Cell Receptor Signaling Pathway
WP1045: TGF-beta Receptor Signaling Pathway
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1112: EPO Receptor Signaling
WP1121: Kit Receptor Signaling Pathway
WP1130: T Cell Receptor Signaling Pathway
WP1133: Androgen receptor signaling pathway
WP1144: B Cell Receptor Signaling Pathway
WP1161: TGF-beta Receptor Signaling Pathway
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[Tollo Tl-8 Toll-8 CG6890] Toll-like receptor Tollo (Toll-like receptor 8)
[TLR2 TIL4] Toll-like receptor 2 (Toll/interleukin-1 receptor-like protein 4) (CD antigen CD282)
[TLR8 UNQ249/PRO286] Toll-like receptor 8 (CD antigen CD288)
[SIGIRR UNQ301/PRO342] Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
[TLR5 TIL3] Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)
[TLR1 KIAA0012] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[Tlr8] Toll-like receptor 8 (CD antigen CD288)
[Tlr1] Toll-like receptor 1 (Toll/interleukin-1 receptor-like protein) (TIL) (CD antigen CD281)
[TICAM2 TIRAP3 TIRP TRAM] TIR domain-containing adapter molecule 2 (TICAM-2) (Putative NF-kappa-B-activating protein 502) (TRIF-related adapter molecule) (Toll-like receptor adaptor protein 3) (Toll/interleukin-1 receptor domain-containing protein) (MyD88-4)
[Sigirr Tir8] Single Ig IL-1-related receptor (Single Ig IL-1R-related molecule) (Single immunoglobulin domain-containing IL1R-related protein) (Toll/interleukin-1 receptor 8) (TIR8)
[Toll-7 CG8595] Toll-like receptor 7
[Tlr4] Toll-like receptor 4 (Toll4) (CD antigen CD284)
[TLR4] Toll-like receptor 4 (hToll) (CD antigen CD284)
[Tlr9] Toll-like receptor 9 (CD antigen CD289)
[TLR9 UNQ5798/PRO19605] Toll-like receptor 9 (CD antigen CD289)
[TLR3] Toll-like receptor 3 (CD antigen CD283)
[Tlr2] Toll-like receptor 2 (CD antigen CD282)
[Tlr2 rCG_62480] RCG62480 (Toll-like receptor 2 variant 1) (Toll-like receptor 2 variant 2)
[Tlr4 Lps] Toll-like receptor 4 (CD antigen CD284)
[TLR6] Toll-like receptor 6 (CD antigen CD286)
[TLR7 UNQ248/PRO285] Toll-like receptor 7
[Tlr6] Toll-like receptor 6 (CD antigen CD286)
[Tlr7] Toll-like receptor 7
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[Tlr3] Toll-like receptor 3 (CD antigen CD283)
[TICAM1 PRVTIRB TRIF] TIR domain-containing adapter molecule 1 (TICAM-1) (Proline-rich, vinculin and TIR domain-containing protein B) (Putative NF-kappa-B-activating protein 502H) (Toll-interleukin-1 receptor domain-containing adapter protein inducing interferon beta) (MyD88-3) (TIR domain-containing adapter protein inducing IFN-beta)
[TLR9] Toll-like receptor 9 (CD antigen CD289)
[TLR2] Toll-like receptor 2 (CD antigen CD282)

Bibliography :
[30763883] In vitro metabolic profiles of motolimod by using liquid chromatography tandem mass spectrometry: Metabolic stability, metabolite characterization and species comparison.
[30579933] Icariside II induces cell cycle arrest and differentiation via TLR8/MyD88/p38 pathway in acute myeloid leukemia cells.
[30568763] The emerging chemical patterns applied in predicting human toll-like receptor 8 agonists.
[30535046] Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs.
[30521597] Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set.
[30424735] Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.
[30403212] Acidic pH-responsive polymer nanoparticles as a TLR7/8 agonist delivery platform for cancer immunotherapy.
[30390423] In vivo cancer vaccination: Which dendritic cells to target and how?
[30382118] Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches.
[30366275] Dead or alive: how the immune system detects microbial viability.
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