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Toxin aagardi

 3S1A_HYDTO              Reviewed;          60 AA.
P0CG02;
15-JUN-2010, integrated into UniProtKB/Swiss-Prot.
15-JUN-2010, sequence version 1.
31-JUL-2019, entry version 33.
RecName: Full=Toxin aagardi;
Hydrophis torquatus (West Coast black-headed sea snake) (Chitulia
torquata).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Hydrophiidae; Hydrophis.
NCBI_TaxID=747462;
[1]
PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND LETHAL
DOSE.
STRAIN=Subsp. aagaardi; TISSUE=Venom;
DOI=10.3390/toxins1020162;
Nagamizu M., Komori Y., Uchiya K.-I., Nikai T., Tu A.T.;
"Isolation and chemical characterization of a toxin isolated from the
venom of the sea snake, Hydrophis torquatus aagardi.";
Toxins 1:162-172(2009).
-!- FUNCTION: Binds to muscle nicotinic acetylcholine receptor (nAChR)
and inhibit acetylcholine from binding to the receptor, thereby
impairing neuromuscular transmission.
{ECO:0000250|UniProtKB:P60775}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- MASS SPECTROMETRY: Mass=6591.1; Method=MALDI; Range=1-60;
Evidence={ECO:0000269|Ref.1};
-!- TOXIC DOSE: LD(50) is 36 ng/kg by intravenous injection into mice.
{ECO:0000269|Ref.1}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type I alpha-neurotoxin sub-subfamily.
{ECO:0000305}.
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SMR; P0CG02; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
Disulfide bond; Ion channel impairing toxin; Neurotoxin;
Postsynaptic neurotoxin; Secreted; Toxin.
CHAIN 1 60 Toxin aagardi. {ECO:0000269|Ref.1}.
/FTId=PRO_0000394533.
DISULFID 3 22 {ECO:0000250|UniProtKB:P0C1Z0}.
DISULFID 17 39 {ECO:0000250|UniProtKB:P0C1Z0}.
DISULFID 41 52 {ECO:0000250|UniProtKB:P0C1Z0}.
DISULFID 53 58 {ECO:0000250|UniProtKB:P0C1Z0}.
SEQUENCE 60 AA; 6599 MW; DE41989F9056E59A CRC64;
MTCCNQQSSQ PKTTTNCAGN SCYKKTWSDH RGTIIERGCG CPQVKSGIKL ECCHTNECNN


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Pathways :
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Related Genes :
[] Toxin aagardi
[rtxA rtx VC_1451] Multifunctional-autoprocessing repeats-in-toxin (MARTX) (EC 3.4.22.-) [Cleaved into: Actin cross-linking toxin F1 (EC 6.3.2.-); Actin cross-linking toxin F4 (EC 6.3.2.-); Rho inactivation domain-containing toxin F2; ABH effector region toxin F5; Cysteine protease domain-containing toxin F3 (EC 3.4.22.-)]
[tetX CTC_p60] Tetanus toxin (EC 3.4.24.68) (Tentoxylysin) [Cleaved into: Tetanus toxin light chain (Tetanus toxin chain L); Tetanus toxin heavy chain (Tetanus toxin chain H)]
[] Beta-mammal/insect toxin Ts1 (PT-Mice-Ins-beta NaTx6.1) (Tityustoxin VII) (Ts VII) (Ts7) (TsTX-VII) (Toxin II-11) (Toxin III-10) (Toxin T2-IV) (Toxin gamma) (TsTX-I)
[] Diphtheria toxin (DT) (NAD(+)--diphthamide ADP-ribosyltransferase) (EC 2.4.2.36) [Cleaved into: Diphtheria toxin fragment A; Diphtheria toxin fragment B]
[] Omega-ctenitoxin-Cs1a (Omega-CNTX-Cs1a) (Toxin CSTX-1) [Cleaved into: Toxin CSTX-2a; Toxin CSTX-2b]
[relE b1563 JW1555] mRNA interferase toxin RelE (EC 3.1.-.-) (Endoribonuclease RelE) (Toxin RelE)
[] Alpha-mammal toxin AaH2 (AaH II) (AaHII) (Neurotoxin II) (Toxin II)
[mqsR ygiU b3022 JW2990] mRNA interferase toxin MqsR (EC 3.1.-.-) (Endoribonuclease MqsR) (Motility quorum-sensing regulator MqsR) (Toxin MqsR)
[mazF chpA chpAK b2782 JW2753] Endoribonuclease toxin MazF (EC 3.1.27.-) (Toxin MazF) (mRNA interferase MazF)
[yafQ b0225 JW0215] mRNA interferase toxin YafQ (EC 3.1.-.-) (Endoribonuclease YafQ) (Toxin YafQ)
[relK relE3 yoeB Rv3358 MTV004.15] Toxin RelK (EC 3.1.-.-) (Endoribonuclease YoeB) (Putative mRNA interferase RelE3) (Putative mRNA interferase YoeB) (Toxin YoeB)
[] Beta-insect depressant toxin LqhIT2 (Insect toxin 2) (Lqh IT2) (LqhIT2-44)
[] Toxin GTx1-15 (Beta/omega-theraphotoxin-Gr2a) (Beta/omega-TRTX-Gr2a) (Toxin GpTx-1)
[hipA b1507 JW1500] Serine/threonine-protein kinase toxin HipA (Ser/Thr-protein kinase HipA) (EC 2.7.11.1) (Toxin HipA)
[cdiA2 BP1026B_II2207] tRNA nuclease CdiA-2 (tRNase CdiA-2) (EC 3.1.-.-) (CdiA-Bp1026b) (Toxin CdiA-2) (Toxin CdiA-II)
[] Fasciculin-2 (Fas-2) (Fas2) (Acetylcholinesterase toxin F-VII) (Fasciculin-II) (FAS-II) (Toxin TA1)
[PAU_02230] Toxin PAU_02230 (Photorhabdus asymbiotica toxin) (PaTox) [Includes: Protein N-acetylglucosaminyltransferase (Protein O-GlcNAc transferase) (EC 2.4.1.-) (PaToxG) (Tyrosine glycosyltransferase); Protein-glutamine amidohydrolase (EC 3.5.1.44) (Glutamine deamidase) (PaToxD) (Protein-glutamine glutaminase)]
[] Mu-scoloptoxin(15)-Ssm1a (Mu-SLPTX(15)-Ssm1a) (Potassium channel toxin SsTx) (Ssm spooky toxin)
[cpnT Rv3903c] Outer membrane channel protein CpnT (Channel protein with necrosis-inducing toxin) [Cleaved into: N-terminal channel domain; Tuberculosis necrotizing toxin (TNT) (NAD(+) glycohydrolase) (EC 3.2.2.5)]
[bre-5 T12G3.8] Beta-1,3-galactosyltransferase bre-5 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 5) (Bt toxin-resistant protein 5)
[bre-1 gmd-1 C53B4.7] GDP-mannose 4,6 dehydratase 1 (EC 4.2.1.47) (Bacillus thuringiensis toxin-resistant protein 1) (Bt toxin-resistant protein 1) (GDP-D-mannose dehydratase) (GMD)
[bre-4 Y73E7A.7] Beta-1,4-N-acetylgalactosaminyltransferase bre-4 (EC 2.4.1.-) (Bacillus thuringiensis toxin-resistant protein 4) (Bt toxin-resistant protein 4) (Beta-4-GalNAcT)
[hipA SO_0706] Serine/threonine-protein kinase toxin HipA (Ser/Thr-protein kinase HipA) (EC 2.7.11.1) (Toxin HipA)
[pezT SP_1051] Toxin PezT (UDP-N-acetylglucosamine kinase) (UNAG kinase) (EC 2.7.1.176) (Zeta toxin)
[ttm-1 Y39E4A.2] Zinc transporter ttm-1 (Toxin-regulated target of MAPK 1) (Toxin-regulated target of p38MAPK)
[ptxA BP3783] Pertussis toxin subunit 1 (PTX S1) (Islet-activating protein S1) (IAP S1) (NAD-dependent ADP-ribosyltransferase) (EC 2.4.2.-)
[] Potassium channel toxin gamma-KTx 2.1 (Neurotoxin BeKm-1) (BeKm1)
[] Alpha-like toxin BmK M1 (BmK-M1) (BmKM1) (BmK-I) (BmK I) (BmKI) (BmK1)
[yoeB b4539 JW5331] Toxin YoeB (EC 3.1.-.-) (Putative endoribonuclease YoeB) (Putative mRNA interferase Yoeb)

Bibliography :
[22069538] Isolation and chemical characterization of a toxin isolated from the venom of the sea snake, Hydrophis torquatus aagardi.