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Transcription factor RelB (I-Rel)

 RELB_HUMAN              Reviewed;         579 AA.
Q01201; Q6GTX7; Q9UEI7;
01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
04-APR-2006, sequence version 2.
13-FEB-2019, entry version 186.
RecName: Full=Transcription factor RelB;
AltName: Full=I-Rel;
Name=RELB;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=T-cell;
PubMed=1577270; DOI=10.1101/gad.6.5.745;
Ruben S.M., Klement J.F., Maher M., Coleman T.A., Chen C.H.,
Rosen C.A.;
"I-Rel: a novel rel-related protein that inhibits NF-kappa B
transcriptional activity.";
Genes Dev. 6:745-760(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Yoshiura K., Murray J.C.;
"A transcriptional map in the region of 19q13 derived using direct
sequencing and exon trapping.";
Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NHLBI resequencing and genotyping service (RS&G);
Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Blood;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
FUNCTION, AND IDENTIFICATION IN THE NF-KAPPA-B RELB-P50 COMPLEX.
PubMed=1732739; DOI=10.1128/MCB.12.2.674;
Ryseck R.P., Bull P., Takamiya M., Bours V., Siebenlist U.,
Dobrzanski P., Bravo R.;
"RelB, a new Rel family transcription activator that can interact with
p50-NF-kappa B.";
Mol. Cell. Biol. 12:674-684(1992).
[6]
FUNCTION.
PubMed=8441398; DOI=10.1128/MCB.13.3.1572;
Dobrzanski P., Ryseck R.P., Bravo R.;
"Both N- and C-terminal domains of RelB are required for full
transactivation: role of the N-terminal leucine zipper-like motif.";
Mol. Cell. Biol. 13:1572-1582(1993).
[7]
FUNCTION, IDENTIFICATION IN THE NF-KAPPA-B RELB-P50 COMPLEX, AND
IDENTIFICATION IN THE NF-KAPPA-B RELB-P52 COMPLEX.
PubMed=7925301;
Dobrzanski P., Ryseck R.P., Bravo R.;
"Differential interactions of Rel-NF-kappa B complexes with I kappa B
alpha determine pools of constitutive and inducible NF-kappa B
activity.";
EMBO J. 13:4608-4616(1994).
[8]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37 AND SER-573, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-573, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[10]
SUBCELLULAR LOCATION.
PubMed=20873783; DOI=10.1021/pr100562w;
Vaz Meirelles G., Ferreira Lanza D.C., da Silva J.C.,
Santana Bernachi J., Paes Leme A.F., Kobarg J.;
"Characterization of hNek6 interactome reveals an important role for
its short N-terminal domain and colocalization with proteins at the
centrosome.";
J. Proteome Res. 9:6298-6316(2010).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[12]
FUNCTION, AND INDUCTION BY NUPR1.
PubMed=22565310; DOI=10.1172/JCI60144;
Hamidi T., Algul H., Cano C.E., Sandi M.J., Molejon M.I., Riemann M.,
Calvo E.L., Lomberk G., Dagorn J.C., Weih F., Urrutia R., Schmid R.M.,
Iovanna J.L.;
"Nuclear protein 1 promotes pancreatic cancer development and protects
cells from stress by inhibiting apoptosis.";
J. Clin. Invest. 122:2092-2103(2012).
[13]
METHYLATION [LARGE SCALE ANALYSIS] AT ARG-16, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Colon carcinoma;
PubMed=24129315; DOI=10.1074/mcp.O113.027870;
Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V.,
Aguiar M., Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C.,
Vemulapalli V., Bedford M.T., Comb M.J.;
"Immunoaffinity enrichment and mass spectrometry analysis of protein
methylation.";
Mol. Cell. Proteomics 13:372-387(2014).
[14]
FUNCTION, INVOLVEMENT IN IMD53, AND VARIANT IMD53 397-TYR--THR-579
DEL.
PubMed=26385063; DOI=10.1016/j.jaut.2015.09.001;
Sharfe N., Merico D., Karanxha A., Macdonald C., Dadi H., Ngan B.,
Herbrick J.A., Roifman C.M.;
"The effects of RelB deficiency on lymphocyte development and
function.";
J. Autoimmun. 65:90-100(2015).
-!- FUNCTION: NF-kappa-B is a pleiotropic transcription factor which
is present in almost all cell types and is involved in many
biological processed such as inflammation, immunity,
differentiation, cell growth, tumorigenesis and apoptosis. NF-
kappa-B is a homo- or heterodimeric complex formed by the Rel-like
domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50,
REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of
their target genes and the individual dimers have distinct
preferences for different kappa-B sites that they can bind with
distinguishable affinity and specificity. Different dimer
combinations act as transcriptional activators or repressors,
respectively. NF-kappa-B is controlled by various mechanisms of
post-translational modification and subcellular
compartmentalization as well as by interactions with other
cofactors or corepressors. NF-kappa-B complexes are held in the
cytoplasm in an inactive state complexed with members of the NF-
kappa-B inhibitor (I-kappa-B) family. In a conventional activation
pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs)
in response to different activators, subsequently degraded thus
liberating the active NF-kappa-B complex which translocates to the
nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes
are transcriptional activators. RELB neither associates with DNA
nor with RELA/p65 or REL. Stimulates promoter activity in the
presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival
pathway, may provide pancreatic ductal adenocarcinoma with
remarkable resistance to cell stress, such as starvation or
gemcitabine treatment. Regulates the circadian clock by repressing
the transcriptional activator activity of the CLOCK-ARNTL/BMAL1
heterodimer in a CRY1/CRY2 independent manner. Increased
repression of the heterodimer is seen in the presence of
NFKB2/p52. Is required for both T and B lymphocyte maturation and
function (PubMed:26385063). {ECO:0000269|PubMed:1732739,
ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:26385063,
ECO:0000269|PubMed:7925301, ECO:0000269|PubMed:8441398}.
-!- SUBUNIT: Component of the NF-kappa-B RelB-p50 complex. Component
of the NF-kappa-B RelB-p52 complex. Self-associates; the
interaction seems to be transient and may prevent degradation
allowing for heterodimer formation with p50 or p52. Interacts with
NFKB1/p50, NFKB2/p52 and NFKB2/p100. Interacts with NFKBID.
Interacts with ARNTL/BMAL1 and the interaction is enhanced in the
presence of CLOCK (By similarity). {ECO:0000250}.
-!- INTERACTION:
Q8N668:COMMD1; NbExp=2; IntAct=EBI-357837, EBI-1550112;
P49841:GSK3B; NbExp=4; IntAct=EBI-357837, EBI-373586;
P19838:NFKB1; NbExp=3; IntAct=EBI-357837, EBI-300010;
Q04206:RELA; NbExp=2; IntAct=EBI-357837, EBI-73886;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20873783}.
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
{ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the
centrosome.
-!- INDUCTION: Up-regulated by mitogens and NUPR1.
{ECO:0000269|PubMed:22565310}.
-!- DOMAIN: Both N- and C-terminal domains are required for
transcriptional activation.
-!- PTM: Phosphorylation at 'Thr-103' and 'Ser-573' is followed by
proteasomal degradation. {ECO:0000250}.
-!- DISEASE: Immunodeficiency 53 (IMD53) [MIM:617585]: An autosomal
recessive primary immunodeficiency apparent from early infancy and
resulting in recurrent infections, severe autoimmune skin disease
rheumatoid arthritis, and failure to thrive. Immunologic workup
shows increased CD4+/CD8+ ratio, impaired T-cell proliferative
response to multiple antigen, T-cell developmental and functional
defects, and impaired ability to produce specific immunoglobulins.
{ECO:0000269|PubMed:26385063}. Note=The disease is caused by
mutations affecting the gene represented in this entry.
-!- CAUTION: Was originally thought to inhibit the transcriptional
activity of nuclear factor NF-kappa-B.
{ECO:0000305|PubMed:1577270}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/RELBID324.html";
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; M83221; AAA36127.1; -; mRNA.
EMBL; AF043463; AAC82346.1; -; Genomic_DNA.
EMBL; AF043454; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043455; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043456; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043457; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043458; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043459; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043460; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043461; AAC82346.1; JOINED; Genomic_DNA.
EMBL; AF043462; AAC82346.1; JOINED; Genomic_DNA.
EMBL; DQ314887; ABC40746.1; -; Genomic_DNA.
EMBL; BC028013; AAH28013.1; -; mRNA.
CCDS; CCDS46110.1; -.
PIR; A42617; A42617.
RefSeq; NP_006500.2; NM_006509.3.
UniGene; Hs.654402; -.
ProteinModelPortal; Q01201; -.
SMR; Q01201; -.
BioGrid; 111903; 61.
CORUM; Q01201; -.
DIP; DIP-27531N; -.
IntAct; Q01201; 32.
MINT; Q01201; -.
STRING; 9606.ENSP00000221452; -.
iPTMnet; Q01201; -.
PhosphoSitePlus; Q01201; -.
BioMuta; RELB; -.
DMDM; 92090634; -.
EPD; Q01201; -.
jPOST; Q01201; -.
MaxQB; Q01201; -.
PaxDb; Q01201; -.
PeptideAtlas; Q01201; -.
PRIDE; Q01201; -.
ProteomicsDB; 57938; -.
DNASU; 5971; -.
Ensembl; ENST00000221452; ENSP00000221452; ENSG00000104856.
Ensembl; ENST00000625761; ENSP00000485826; ENSG00000104856.
GeneID; 5971; -.
KEGG; hsa:5971; -.
UCSC; uc060zvi.1; human.
CTD; 5971; -.
DisGeNET; 5971; -.
EuPathDB; HostDB:ENSG00000104856.13; -.
GeneCards; RELB; -.
HGNC; HGNC:9956; RELB.
HPA; CAB007753; -.
HPA; HPA040506; -.
MalaCards; RELB; -.
MIM; 604758; gene.
MIM; 617585; phenotype.
neXtProt; NX_Q01201; -.
OpenTargets; ENSG00000104856; -.
PharmGKB; PA34322; -.
eggNOG; ENOG410IFBK; Eukaryota.
eggNOG; ENOG410ZMME; LUCA.
GeneTree; ENSGT00940000160230; -.
HOGENOM; HOG000148598; -.
HOVERGEN; HBG017021; -.
InParanoid; Q01201; -.
KO; K09253; -.
OMA; TMLDMLP; -.
OrthoDB; 916931at2759; -.
PhylomeDB; Q01201; -.
TreeFam; TF325632; -.
Reactome; R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
Reactome; R-HSA-5621575; CD209 (DC-SIGN) signaling.
Reactome; R-HSA-5676590; NIK-->noncanonical NF-kB signaling.
SIGNOR; Q01201; -.
ChiTaRS; RELB; human.
GeneWiki; RELB; -.
GenomeRNAi; 5971; -.
PRO; PR:Q01201; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000104856; Expressed in 120 organ(s), highest expression level in adrenal gland.
ExpressionAtlas; Q01201; baseline and differential.
Genevisible; Q01201; HS.
GO; GO:0005829; C:cytosol; IDA:HPA.
GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:CACAO.
GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
GO; GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:ProtInc.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0000977; F:RNA polymerase II regulatory region sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
GO; GO:0019882; P:antigen processing and presentation; IEA:Ensembl.
GO; GO:0071470; P:cellular response to osmotic stress; IEA:Ensembl.
GO; GO:0032922; P:circadian regulation of gene expression; ISS:UniProtKB.
GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
GO; GO:0030098; P:lymphocyte differentiation; IMP:UniProtKB.
GO; GO:0043011; P:myeloid dendritic cell differentiation; IEA:Ensembl.
GO; GO:0032688; P:negative regulation of interferon-beta production; IMP:CACAO.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0038061; P:NIK/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
GO; GO:0034097; P:response to cytokine; IBA:GO_Central.
GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
CDD; cd01177; IPT_NFkappaB; 1.
Gene3D; 2.60.40.10; -; 1.
Gene3D; 2.60.40.340; -; 1.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR014756; Ig_E-set.
InterPro; IPR002909; IPT_dom.
InterPro; IPR033926; IPT_NFkappaB.
InterPro; IPR000451; NFkB/Dor.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR030496; RelB.
InterPro; IPR032399; RelB_leu_zip.
InterPro; IPR032400; RelB_transact.
InterPro; IPR030492; RHD_CS.
InterPro; IPR032397; RHD_dimer.
InterPro; IPR011539; RHD_DNA_bind_dom.
InterPro; IPR037059; RHD_DNA_bind_dom_sf.
PANTHER; PTHR24169; PTHR24169; 1.
PANTHER; PTHR24169:SF18; PTHR24169:SF18; 1.
Pfam; PF16180; RelB_leu_zip; 1.
Pfam; PF16181; RelB_transactiv; 1.
Pfam; PF16179; RHD_dimer; 1.
Pfam; PF00554; RHD_DNA_bind; 1.
PRINTS; PR00057; NFKBTNSCPFCT.
SMART; SM00429; IPT; 1.
SUPFAM; SSF49417; SSF49417; 1.
SUPFAM; SSF81296; SSF81296; 1.
PROSITE; PS01204; REL_1; 1.
PROSITE; PS50254; REL_2; 1.
1: Evidence at protein level;
Activator; Biological rhythms; Complete proteome; Cytoplasm;
Cytoskeleton; Disease mutation; DNA-binding; Methylation; Nucleus;
Phosphoprotein; Polymorphism; Reference proteome; Repressor;
Transcription; Transcription regulation.
CHAIN 1 579 Transcription factor RelB.
/FTId=PRO_0000205173.
DOMAIN 125 440 RHD. {ECO:0000255|PROSITE-
ProRule:PRU00265}.
REGION 40 68 Leucine-zipper.
MOTIF 433 438 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 16 16 Omega-N-methylarginine.
{ECO:0000244|PubMed:24129315}.
MOD_RES 37 37 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231}.
MOD_RES 573 573 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:19690332}.
VARIANT 396 396 T -> M (in dbSNP:rs2230682).
/FTId=VAR_051782.
VARIANT 397 579 Missing (in IMD53).
{ECO:0000269|PubMed:26385063}.
/FTId=VAR_079201.
CONFLICT 139 139 R -> P (in Ref. 1; AAA36127).
{ECO:0000305}.
CONFLICT 411 411 R -> A (in Ref. 1; AAA36127).
{ECO:0000305}.
SEQUENCE 579 AA; 62134 MW; C2C61C2C8640513E CRC64;
MLRSGPASGP SVPTGRAMPS RRVARPPAAP ELGALGSPDL SSLSLAVSRS TDELEIIDEY
IKENGFGLDG GQPGPGEGLP RLVSRGAASL STVTLGPVAP PATPPPWGCP LGRLVSPAPG
PGPQPHLVIT EQPKQRGMRF RYECEGRSAG SILGESSTEA SKTLPAIELR DCGGLREVEV
TACLVWKDWP HRVHPHSLVG KDCTDGICRV RLRPHVSPRH SFNNLGIQCV RKKEIEAAIE
RKIQLGIDPY NAGSLKNHQE VDMNVVRICF QASYRDQQGQ MRRMDPVLSE PVYDKKSTNT
SELRICRINK ESGPCTGGEE LYLLCDKVQK EDISVVFSRA SWEGRADFSQ ADVHRQIAIV
FKTPPYEDLE IVEPVTVNVF LQRLTDGVCS EPLPFTYLPR DHDSYGVDKK RKRGMPDVLG
ELNSSDPHGI ESKRRKKKPA ILDHFLPNHG SGPFLPPSAL LPDPDFFSGT VSLPGLEPPG
GPDLLDDGFA YDPTAPTLFT MLDLLPPAPP HASAVVCSGG AGAVVGETPG PEPLTLDSYQ
APGPGDGGTA SLVGSNMFPN HYREAAFGGG LLSPGPEAT


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1369: TNF-alpha NF-kB Signaling Pathway
WP1541: Energy Metabolism
WP177: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP246: TNF-alpha NF-kB Signaling Pathway
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP344: Eukaryotic Transcription Initiation

Related Genes :
[RELB] Transcription factor RelB (I-Rel)
[Relb] Transcription factor RelB
[Rel CG11992] Nuclear factor NF-kappa-B p110 subunit (Rel-p110) (Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit (Rel-p68); Nuclear factor NF-kappa-B p49 subunit (Rel-p49)]
[REL] Proto-oncogene c-Rel
[Rel] Proto-oncogene c-Rel
[RELA NFKB3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[Rela Nfkb3] Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[NFKB2 LYT10] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (H2TF1) (Lymphocyte translocation chromosome 10 protein) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) (Oncogene Lyt-10) (Lyt10) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[CHUK IKKA TCF16] Inhibitor of nuclear factor kappa-B kinase subunit alpha (I-kappa-B kinase alpha) (IKK-A) (IKK-alpha) (IkBKA) (IkappaB kinase) (EC 2.7.11.10) (Conserved helix-loop-helix ubiquitous kinase) (I-kappa-B kinase 1) (IKK1) (Nuclear factor NF-kappa-B inhibitor kinase alpha) (NFKBIKA) (Transcription factor 16) (TCF-16)
[RUNX2 AML3 CBFA1 OSF2 PEBP2A] Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
[REL] Proto-oncogene c-Rel (p68)
[PIF3 BHLH8 EN100 PAP3 At1g09530 F14J9.19] Transcription factor PIF3 (Basic helix-loop-helix protein 8) (AtbHLH8) (bHLH 8) (Phytochrome-associated protein 3) (Phytochrome-interacting factor 3) (Transcription factor EN 100) (bHLH transcription factor bHLH008)
[TCF3 BHLHB21 E2A ITF1] Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit] (Fragment)
[Atf5 Atfx Nap1] Cyclic AMP-dependent transcription factor ATF-5 (cAMP-dependent transcription factor ATF-5) (Activating transcription factor 5-alpha/beta) (BZIP protein ATF7) (NAP1) (NRIF3-associated protein) (Transcription factor ATFx) (Transcription factor-like protein ODA-10)
[Ebf2 Coe2 Mmot1] Transcription factor COE2 (Early B-cell factor 2) (EBF-2) (Metencephalon-mesencephalon-olfactory transcription factor 1) (MET-mesencephalon-olfactory TF1) (MET-mesencephalon-olfactory transcription factor 1) (Olf-1/EBF-like 3) (O/E-3) (OE-3)
[NFE2L1 HBZ17 NRF1 TCF11] Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
[Taf1 Ccg1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[Nfkb2] Nuclear factor NF-kappa-B p100 subunit (DNA-binding factor KBF2) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2) [Cleaved into: Nuclear factor NF-kappa-B p52 subunit]
[SMARCA4 BAF190A BRG1 SNF2B SNF2L4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
[PTF1A BHLHA29 PTF1P48] Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
[Ptf1a Ptf1p48] Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
[RUNX1 AML1 CBFA2] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[ATF2 CREB2 CREBP1] Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (EC 2.3.1.48) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (Histone acetyltransferase ATF2) (cAMP response element-binding protein CRE-BP1)
[TAF14 ANC1 CST10 SWP29 TAF30 TFG3 YPL129W] Transcription initiation factor TFIID subunit 14 (Actin non-complementing mutant 1) (Chromosome stability protein 10) (SWI/SNF chromatin-remodeling complex subunit TAF14) (SWI/SNF complex 29 kDa subunit) (SWI/SNF complex subunit TAF14) (TBP-associated factor 14) (TBP-associated factor 30 kDa) (Transcription factor G 30 kDa subunit) (Transcription initiation factor TFIIF 30 kDa subunit)
[MYC2 BHLH6 EN38 JAI1 JIN1 RAP1 RD22BP1 ZBF1 At1g32640 F6N18.4] Transcription factor MYC2 (AtMYC2) (Basic helix-loop-helix protein 6) (AtbHLH6) (bHLH 6) (Protein JASMONATE INSENSITIVE 1) (R-homologous Arabidopsis protein 1) (RAP-1) (Transcription factor EN 38) (Z-box binding factor 1 protein) (bHLH transcription factor bHLH006) (rd22BP1)
[HNF1A TCF1] Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
[Ptf1a Ptf1p48] Pancreas transcription factor 1 subunit alpha (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)

Bibliography :
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[26739459] Human T-cell leukemia virus type 1 (HTLV-1) Tax1 oncoprotein but not HTLV-2 Tax2 induces the expression of OX40 ligand by interacting with p52/p100 and RelB.
[26377645] The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3' Immunoglobulin Heavy Chain Regulatory Region.
[25633199] NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival.
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[24908319] Analysis of TGFβ1 and IL-10 transcriptional regulation in CTCL cells by chromatin immunoprecipitation.
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