GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Transcription factor SOX-8

 SOX8_MOUSE              Reviewed;         464 AA.
Q04886;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
13-FEB-2019, entry version 143.
RecName: Full=Transcription factor SOX-8;
Name=Sox8; Synonyms=Sox-8;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=129/Sv;
PubMed=10684944; DOI=10.1093/nar/28.6.1473;
Schepers G.E., Bullejos M., Hosking B.M., Koopman P.;
"Cloning and characterisation of the Sry-related transcription factor
gene Sox8.";
Nucleic Acids Res. 28:1473-1480(2000).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 107-162.
PubMed=8441686; DOI=10.1093/nar/21.3.744;
Wright E.M., Snopek B., Koopman P.;
"Seven new members of the Sox gene family expressed during mouse
development.";
Nucleic Acids Res. 21:744-744(1993).
-!- FUNCTION: May play a role in central nervous system, limb and
facial development. May be involved in male sex determination.
Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00267}.
-!- TISSUE SPECIFICITY: Brain, gut, limb, and testes. Slightly in
liver, ovaries, spinal cord, lung and heart.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF191325; AAF35837.1; -; Genomic_DNA.
EMBL; BC085619; AAH85619.1; -; mRNA.
EMBL; Z18957; CAA79482.1; -; mRNA.
CCDS; CCDS28521.1; -.
PIR; S30246; S30246.
RefSeq; NP_035577.1; NM_011447.3.
UniGene; Mm.258220; -.
ProteinModelPortal; Q04886; -.
SMR; Q04886; -.
BioGrid; 203412; 15.
IntAct; Q04886; 1.
STRING; 10090.ENSMUSP00000025003; -.
iPTMnet; Q04886; -.
PhosphoSitePlus; Q04886; -.
PaxDb; Q04886; -.
PRIDE; Q04886; -.
Ensembl; ENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
GeneID; 20681; -.
KEGG; mmu:20681; -.
UCSC; uc008bay.1; mouse.
CTD; 30812; -.
MGI; MGI:98370; Sox8.
eggNOG; ENOG410IPZ6; Eukaryota.
eggNOG; ENOG4111U1K; LUCA.
GeneTree; ENSGT00940000159920; -.
HOGENOM; HOG000108876; -.
HOVERGEN; HBG002061; -.
InParanoid; Q04886; -.
KO; K09270; -.
OMA; NWDQPVY; -.
OrthoDB; 782373at2759; -.
PhylomeDB; Q04886; -.
TreeFam; TF351735; -.
ChiTaRS; Sox8; mouse.
PRO; PR:Q04886; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000024176; Expressed in 143 organ(s), highest expression level in lumbar subsegment of spinal cord.
ExpressionAtlas; Q04886; baseline and differential.
Genevisible; Q04886; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0044798; C:nuclear transcription factor complex; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0060612; P:adipose tissue development; IMP:MGI.
GO; GO:0060018; P:astrocyte fate commitment; IGI:MGI.
GO; GO:0045165; P:cell fate commitment; IGI:MGI.
GO; GO:0048469; P:cell maturation; IMP:MGI.
GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
GO; GO:0048484; P:enteric nervous system development; IMP:UniProtKB.
GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
GO; GO:0008584; P:male gonad development; IGI:MGI.
GO; GO:0072289; P:metanephric nephron tubule formation; IGI:MGI.
GO; GO:0061138; P:morphogenesis of a branching epithelium; IGI:MGI.
GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0001755; P:neural crest cell migration; IMP:UniProtKB.
GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
GO; GO:0007422; P:peripheral nervous system development; IGI:MGI.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IGI:MGI.
GO; GO:0014015; P:positive regulation of gliogenesis; IMP:UniProtKB.
GO; GO:0090184; P:positive regulation of kidney development; IGI:UniProtKB.
GO; GO:0033690; P:positive regulation of osteoblast proliferation; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0010817; P:regulation of hormone levels; IMP:MGI.
GO; GO:0072034; P:renal vesicle induction; IMP:UniProtKB.
GO; GO:0060041; P:retina development in camera-type eye; IGI:MGI.
GO; GO:0060221; P:retinal rod cell differentiation; IGI:MGI.
GO; GO:0060009; P:Sertoli cell development; IGI:MGI.
GO; GO:0007165; P:signal transduction; IMP:UniProtKB.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
GO; GO:0072197; P:ureter morphogenesis; IGI:MGI.
Gene3D; 1.10.30.10; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR031265; SOX-8.
InterPro; IPR022151; Sox_N.
PANTHER; PTHR10270:SF20; PTHR10270:SF20; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12444; Sox_N; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Nucleus; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 464 Transcription factor SOX-8.
/FTId=PRO_0000048734.
DNA_BIND 99 167 HMG box. {ECO:0000255|PROSITE-
ProRule:PRU00267}.
SEQUENCE 464 AA; 49879 MW; 3C080629F58F5AB5 CRC64;
MLDMSEARAQ PPCSPSGTAS SMSHVEDSDS DAPPSPAGSE GLGRAGGGGR GDTAEAADER
FPACIRDAVS QVLKGYDWSL VPMPVRGGGG GTLKAKPHVK RPMNAFMVWA QAARRKLADQ
YPHLHNAELS KTLGKLWRLL SESEKRPFVE EAERLRVQHK KDHPDYKYQP RRRKSVKTGR
SDSDSGTELG HHPGGPMYKA DAVLGEAHHH SDHHTGQTHG PPTPPTTPKT DLHQASNGSK
QELRLEGRRL VDSGRQNIDF SNVDISELSS EVISNMDTFD VHEFDQYLPL NGHSALPTEP
SQATASGSYG GASYSHSGAT GIGASPVWAH KGAPSASASP TEAGPLRPQI KTEQLSPSHY
NDQSHGSPGR ADYGSYSAQA SVTTAASATA ASSFASAQCD YTDLQASNYY SPYPGYPPSL
YQYPYFHSSR RPYASPLLNG LSMPPAHSPS SNWDQPVYTT LTRP


Related products :

Catalog number Product name Quantity
EIAAB42084 Homo sapiens,Human,Mitochondrial transcription factor 1,MtTF1,mtTFA,TCF6,TCF-6,TCF6L2,TFAM,Transcription factor 6,Transcription factor 6-like 2,Transcription factor A, mitochondrial
18-003-42098 Ets domain transcription factor - ESE3 transcription factor; EHF protein; DJ875K15.1.2 (Ets homologous factor (Ets-domain transcription factor. ESE-3B (Isoform 2))); ETS-family transcription factor EH 0.1 mg Protein A
EIAAB42103 Immunoglobulin enhancer-binding factor E12_E47,Pan,Pancreas specific transcription factor 1c,Ptf1c,Rat,Rattus norvegicus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor E2-alpha,Transcri
EIAAB42104 Alf2,Immunoglobulin enhancer-binding factor E12_E47,Me2,Mouse,Mus musculus,Tcf3,TCF-3,Tcfe2a,Transcription factor 3,Transcription factor A1,Transcription factor E2-alpha
31-248 Transcription initiation factor IIA . and . chains (GTranscription Factor Antibodies2A1, Transcription Factor AntibodiesIIA p35 and p19 subunits, Transcription Factor AntibodiesIIAL) binding ability o 0.05 mg
EIAAB12290 E4F transcription factor 1,E4f1,Mouse,Mus musculus,p120E4F,Putative E3 ubiquitin-protein ligase E4F1,Transcription factor E4F,Transcription factor E4F1,Transcription factor phi AP3
18-003-44075 Transcription factor E2-alpha - Immunoglobulin enhancer-binding factor E12_E47; Transcription factor 3; TCF-3; Immunoglobulin transcription factor 1; Transcription factor ITF-1; Kappa-E2-binding facto 0.1 mg Protein A
EIAAB25650 Homo sapiens,Human,Metal regulatory transcription factor 1,MRE-binding transcription factor,MTF1,Transcription factor MTF-1
EIAAB42045 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,GTF2H3,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42050 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,GTF2H4,Homo sapiens,Human,TFIIH basal transcription facto
EIAAB42049 Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,General transcription factor IIH subunit 4,Gtf2h4,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42048 Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,General transcription factor IIH subunit 3,Gtf2h3,Mouse,Mus musculus,TFIIH basal transcription facto
EIAAB42039 Basic transcription factor 2 62 kDa subunit,BTF2 p62,General transcription factor IIH polypeptide 1,General transcription factor IIH subunit 1,Gtf2h1,Mouse,Mus musculus,TFIIH basal transcription facto
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-42234 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB25651 Metal regulatory transcription factor 1,Mouse,MRE-binding transcription factor,Mtf1,Mtf-1,Mus musculus,Transcription factor MTF-1
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.05 mg Aff Pur
18-003-43070 T-box transcription factor TBX21 - T-box protein 21; Transcription factor TBLYM; T-cell-specific T-box transcription factor T-bet Polyclonal 0.1 mg Protein A
18-003-42235 POU domain. class 2. transcription factor 3 - Octamer-binding transcription factor 11; Oct-11; Transcription factor Skn-1; PLA-1 protein Polyclonal 0.1 mg Protein A
EIAAB42078 HMG box transcription factor 4,Homo sapiens,hTCF-4,Human,T-cell factor 4,T-cell-specific transcription factor 4,TCF4,TCF-4,TCF7L2,Transcription factor 7-like 2
EIAAB42042 Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,General transcription factor IIH subunit 2,Gtf2h2,Rat,Rattus norvegicus,TFIIH basal transcription fa
EIAAB32964 bHLH transcription factor p48,Mouse,Mus musculus,p48 DNA-binding subunit of transcription factor PTF1,Pancreas transcription factor 1 subunit alpha,Pancreas-specific transcription factor 1a,Ptf1a,Ptf1
18-003-42999 Cyclic AMP-dependent transcription factor ATF-5 - Activating transcription factor 5; Transcription factor ATFx Polyclonal 0.05 mg Aff Pur
EIAAB42079 HMG box transcription factor 4,Mouse,mTCF-4,Mus musculus,T-cell factor 4,T-cell-specific transcription factor 4,Tcf4,TCF-4,Tcf7l2,Transcription factor 7-like 2
EIAAB47163 CREB_ATF bZIP transcription factor,Crebzf,HCF-binding transcription factor Zhangfei,Host cell factor-binding transcription factor Zhangfei,Mouse,Mus musculus,Tyrosine kinase-associated leucine zipper

Kits Elisa; taq POLYMERASE

Search in Google:

google

Share this page:
share on twitter rss feedsfacebookgoogle gentaur



Quick order!
Enter catalog number :


Gentaur; yes we can

Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1541: Energy Metabolism
WP177: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP344: Eukaryotic Transcription Initiation
WP405: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP491: Eukaryotic Transcription Initiation

Related Genes :
[Sox8 Sox-8] Transcription factor SOX-8
[Sox10 Sox-10 Sox21] Transcription factor SOX-10 (Protein SOX-21) (Transcription factor SOX-M)
[SOX8] Transcription factor SOX-8
[sox17b.1 sox17b] Transcription factor Sox-17-beta.1 (SRY (sex determining region Y)-box 17-beta.1) (Transcription factor Sox-17-beta) (XSox17beta)
[Sox2 Sox-2] Transcription factor SOX-2
[Sox17 Sox-17] Transcription factor SOX-17
[sox9-a sox9] Transcription factor Sox-9-A
[Sox7 Sox-7] Transcription factor SOX-7 (mSOX7)
[Sox11 Sox-11] Transcription factor SOX-11
[Sox6 Sox-6] Transcription factor SOX-6 (SOX-LZ)
[SOX10] Transcription factor SOX-10
[sox17a-a sox17a sox17a1] Transcription factor Sox-17-alpha-A (Xsox17alpha) (xSox17alpha1)
[Sox9 Sox-9] Transcription factor SOX-9
[Sox18 Sox-18] Transcription factor SOX-18
[SOX18] Transcription factor SOX-18
[SOX7] Transcription factor SOX-7
[Sox5 Sox-5] Transcription factor SOX-5
[Sox3 Sox-3] Transcription factor SOX-3
[SOX17] Transcription factor SOX-17
[Sox4 Sox-4] Transcription factor SOX-4
[SOX5] Transcription factor SOX-5
[Sox1 Sox-1] Transcription factor SOX-1
[sox3-a sox3] Transcription factor Sox-3-A (xSox3) (xSox-B1)
[sox10] Transcription factor Sox-10 (SRY (sex determining region Y)-box 10)
[SOX9] Transcription factor SOX-9
[SOX11] Transcription factor SOX-11
[SOX2] Transcription factor SOX-2
[SOX3] Transcription factor SOX-3
[SOX9] Transcription factor SOX-9
[SOX4] Transcription factor SOX-4

Bibliography :
[30845377] Overexpression of HIF-2α-Dependent NEAT1 Promotes the Progression of Non-Small Cell Lung Cancer through miR-101-3p/SOX9/Wnt/β-Catenin Signal Pathway.
[30813126] The genetic relationship of SOX9 polymorphisms with osteoarthritis risk in Chinese population: A case-control study.
[30683138] Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens.
[30599193] The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures.
[30552336] Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.
[30522176] [Gangliocytic paragangliomas: a clinicopathologic study].
[30483697] [Effect of cyclic tensile stress on expression of type Ⅱ collagen and Sox9 in rat cranial base synchondrosis].
[30466085] CDK6 and miR-320c Co-Regulate Chondrocyte Catabolism Through NF-κB Signaling Pathways.
[30415011] Dmrt1 directly regulates the transcription of the testis-biased Sox9b gene in Nile tilapia (Oreochromis niloticus).
[30392226] [Relationship between expression level of sex-determining region Y box 9 and metastasis of oral squamous cell carcinoma].
?>