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Transcription factor SOX-8

 SOX8_MOUSE              Reviewed;         464 AA.
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
13-FEB-2019, entry version 143.
RecName: Full=Transcription factor SOX-8;
Name=Sox8; Synonyms=Sox-8;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
PubMed=10684944; DOI=10.1093/nar/28.6.1473;
Schepers G.E., Bullejos M., Hosking B.M., Koopman P.;
"Cloning and characterisation of the Sry-related transcription factor
gene Sox8.";
Nucleic Acids Res. 28:1473-1480(2000).
TISSUE=Olfactory epithelium;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
PubMed=8441686; DOI=10.1093/nar/21.3.744;
Wright E.M., Snopek B., Koopman P.;
"Seven new members of the Sox gene family expressed during mouse
Nucleic Acids Res. 21:744-744(1993).
-!- FUNCTION: May play a role in central nervous system, limb and
facial development. May be involved in male sex determination.
Binds the consensus motif 5'-[AT][AT]CAA[AT]G-3'.
-!- TISSUE SPECIFICITY: Brain, gut, limb, and testes. Slightly in
liver, ovaries, spinal cord, lung and heart.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF191325; AAF35837.1; -; Genomic_DNA.
EMBL; BC085619; AAH85619.1; -; mRNA.
EMBL; Z18957; CAA79482.1; -; mRNA.
CCDS; CCDS28521.1; -.
PIR; S30246; S30246.
RefSeq; NP_035577.1; NM_011447.3.
UniGene; Mm.258220; -.
ProteinModelPortal; Q04886; -.
SMR; Q04886; -.
BioGrid; 203412; 15.
IntAct; Q04886; 1.
STRING; 10090.ENSMUSP00000025003; -.
iPTMnet; Q04886; -.
PhosphoSitePlus; Q04886; -.
PaxDb; Q04886; -.
PRIDE; Q04886; -.
Ensembl; ENSMUST00000025003; ENSMUSP00000025003; ENSMUSG00000024176.
GeneID; 20681; -.
KEGG; mmu:20681; -.
UCSC; uc008bay.1; mouse.
CTD; 30812; -.
MGI; MGI:98370; Sox8.
eggNOG; ENOG410IPZ6; Eukaryota.
eggNOG; ENOG4111U1K; LUCA.
GeneTree; ENSGT00940000159920; -.
HOGENOM; HOG000108876; -.
HOVERGEN; HBG002061; -.
InParanoid; Q04886; -.
KO; K09270; -.
OrthoDB; 782373at2759; -.
PhylomeDB; Q04886; -.
TreeFam; TF351735; -.
ChiTaRS; Sox8; mouse.
PRO; PR:Q04886; -.
Proteomes; UP000000589; Chromosome 17.
Bgee; ENSMUSG00000024176; Expressed in 143 organ(s), highest expression level in lumbar subsegment of spinal cord.
ExpressionAtlas; Q04886; baseline and differential.
Genevisible; Q04886; MM.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0044798; C:nuclear transcription factor complex; IDA:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IDA:MGI.
GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IDA:UniProtKB.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0008134; F:transcription factor binding; IPI:UniProtKB.
GO; GO:0060612; P:adipose tissue development; IMP:MGI.
GO; GO:0060018; P:astrocyte fate commitment; IGI:MGI.
GO; GO:0045165; P:cell fate commitment; IGI:MGI.
GO; GO:0048469; P:cell maturation; IMP:MGI.
GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
GO; GO:0048484; P:enteric nervous system development; IMP:UniProtKB.
GO; GO:0045444; P:fat cell differentiation; IMP:MGI.
GO; GO:0001701; P:in utero embryonic development; IGI:MGI.
GO; GO:0008584; P:male gonad development; IGI:MGI.
GO; GO:0072289; P:metanephric nephron tubule formation; IGI:MGI.
GO; GO:0061138; P:morphogenesis of a branching epithelium; IGI:MGI.
GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IDA:MGI.
GO; GO:0046533; P:negative regulation of photoreceptor cell differentiation; IGI:MGI.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:MGI.
GO; GO:0001755; P:neural crest cell migration; IMP:UniProtKB.
GO; GO:0048709; P:oligodendrocyte differentiation; IMP:MGI.
GO; GO:0001649; P:osteoblast differentiation; IMP:MGI.
GO; GO:0007422; P:peripheral nervous system development; IGI:MGI.
GO; GO:0090190; P:positive regulation of branching involved in ureteric bud morphogenesis; IMP:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; IGI:MGI.
GO; GO:0014015; P:positive regulation of gliogenesis; IMP:UniProtKB.
GO; GO:0090184; P:positive regulation of kidney development; IGI:UniProtKB.
GO; GO:0033690; P:positive regulation of osteoblast proliferation; IMP:MGI.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0010817; P:regulation of hormone levels; IMP:MGI.
GO; GO:0072034; P:renal vesicle induction; IMP:UniProtKB.
GO; GO:0060041; P:retina development in camera-type eye; IGI:MGI.
GO; GO:0060221; P:retinal rod cell differentiation; IGI:MGI.
GO; GO:0060009; P:Sertoli cell development; IGI:MGI.
GO; GO:0007165; P:signal transduction; IMP:UniProtKB.
GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
GO; GO:0072197; P:ureter morphogenesis; IGI:MGI.
Gene3D;; -; 1.
InterPro; IPR009071; HMG_box_dom.
InterPro; IPR036910; HMG_box_dom_sf.
InterPro; IPR031265; SOX-8.
InterPro; IPR022151; Sox_N.
PANTHER; PTHR10270:SF20; PTHR10270:SF20; 1.
Pfam; PF00505; HMG_box; 1.
Pfam; PF12444; Sox_N; 1.
SMART; SM00398; HMG; 1.
SUPFAM; SSF47095; SSF47095; 1.
PROSITE; PS50118; HMG_BOX_2; 1.
2: Evidence at transcript level;
Complete proteome; DNA-binding; Nucleus; Reference proteome;
Transcription; Transcription regulation.
CHAIN 1 464 Transcription factor SOX-8.
DNA_BIND 99 167 HMG box. {ECO:0000255|PROSITE-
SEQUENCE 464 AA; 49879 MW; 3C080629F58F5AB5 CRC64;

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Kits Elisa; taq POLYMERASE

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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1541: Energy Metabolism
WP177: Eukaryotic Transcription Initiation
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1983: Splicing factor NOVA regulated synpatic proteins
WP2148: Brain derived neurotrophic factor
WP272: Blood Clotting Cascade
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP344: Eukaryotic Transcription Initiation
WP405: Eukaryotic Transcription Initiation
WP425: Eukaryotic Transcription Initiation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP491: Eukaryotic Transcription Initiation

Related Genes :
[Sox8 Sox-8] Transcription factor SOX-8
[Sox10 Sox-10 Sox21] Transcription factor SOX-10 (Protein SOX-21) (Transcription factor SOX-M)
[SOX8] Transcription factor SOX-8
[sox17b.1 sox17b] Transcription factor Sox-17-beta.1 (SRY (sex determining region Y)-box 17-beta.1) (Transcription factor Sox-17-beta) (XSox17beta)
[Sox2 Sox-2] Transcription factor SOX-2
[Sox17 Sox-17] Transcription factor SOX-17
[sox9-a sox9] Transcription factor Sox-9-A
[Sox7 Sox-7] Transcription factor SOX-7 (mSOX7)
[Sox11 Sox-11] Transcription factor SOX-11
[Sox6 Sox-6] Transcription factor SOX-6 (SOX-LZ)
[SOX10] Transcription factor SOX-10
[sox17a-a sox17a sox17a1] Transcription factor Sox-17-alpha-A (Xsox17alpha) (xSox17alpha1)
[Sox9 Sox-9] Transcription factor SOX-9
[Sox18 Sox-18] Transcription factor SOX-18
[SOX18] Transcription factor SOX-18
[SOX7] Transcription factor SOX-7
[Sox5 Sox-5] Transcription factor SOX-5
[Sox3 Sox-3] Transcription factor SOX-3
[SOX17] Transcription factor SOX-17
[Sox4 Sox-4] Transcription factor SOX-4
[SOX5] Transcription factor SOX-5
[Sox1 Sox-1] Transcription factor SOX-1
[sox3-a sox3] Transcription factor Sox-3-A (xSox3) (xSox-B1)
[sox10] Transcription factor Sox-10 (SRY (sex determining region Y)-box 10)
[SOX9] Transcription factor SOX-9
[SOX11] Transcription factor SOX-11
[SOX2] Transcription factor SOX-2
[SOX3] Transcription factor SOX-3
[SOX9] Transcription factor SOX-9
[SOX4] Transcription factor SOX-4

Bibliography :
[30845377] Overexpression of HIF-2α-Dependent NEAT1 Promotes the Progression of Non-Small Cell Lung Cancer through miR-101-3p/SOX9/Wnt/β-Catenin Signal Pathway.
[30813126] The genetic relationship of SOX9 polymorphisms with osteoarthritis risk in Chinese population: A case-control study.
[30683138] Multiple-gene targeting and mismatch tolerance can confound analysis of genome-wide pooled CRISPR screens.
[30599193] The UV filter benzophenone 3, alters early follicular assembly in rat whole ovary cultures.
[30552336] Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9.
[30522176] [Gangliocytic paragangliomas: a clinicopathologic study].
[30483697] [Effect of cyclic tensile stress on expression of type Ⅱ collagen and Sox9 in rat cranial base synchondrosis].
[30466085] CDK6 and miR-320c Co-Regulate Chondrocyte Catabolism Through NF-κB Signaling Pathways.
[30415011] Dmrt1 directly regulates the transcription of the testis-biased Sox9b gene in Nile tilapia (Oreochromis niloticus).
[30392226] [Relationship between expression level of sex-determining region Y box 9 and metastasis of oral squamous cell carcinoma].