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Transcription factor bHLH63 (Basic helix-loop-helix protein 63) (AtbHLH63) (bHLH 63) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1) (Transcription factor EN 84) (bHLH transcription factor bHLH063)

 BH063_ARATH             Reviewed;         335 AA.
Q8GY61; O65678; Q8L851; Q8S3D9;
16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
31-JUL-2019, entry version 113.
RecName: Full=Transcription factor bHLH63;
AltName: Full=Basic helix-loop-helix protein 63;
Short=AtbHLH63;
Short=bHLH 63;
AltName: Full=Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1;
AltName: Full=Transcription factor EN 84;
AltName: Full=bHLH transcription factor bHLH063;
Name=BHLH63; Synonyms=CIB1, EN84; OrderedLocusNames=At4g34530;
ORFNames=T4L20.110;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GENE FAMILY, AND
NOMENCLATURE.
STRAIN=cv. Columbia;
PubMed=12679534; DOI=10.1093/molbev/msg088;
Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
"The basic helix-loop-helix transcription factor family in plants: a
genome-wide study of protein structure and functional diversity.";
Mol. Biol. Evol. 20:735-747(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617198; DOI=10.1038/47134;
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
Langham S.-A., McCullagh B., Bilham L., Robben J.,
van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
Chen E., Marra M.A., Martienssen R., McCombie W.R.;
"Sequence and analysis of chromosome 4 of the plant Arabidopsis
thaliana.";
Nature 402:769-777(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=11910074; DOI=10.1126/science.1071006;
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
Shibata K., Shinagawa A., Shinozaki K.;
"Functional annotation of a full-length Arabidopsis cDNA collection.";
Science 296:141-145(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[6]
GENE FAMILY.
PubMed=12897250; DOI=10.1105/tpc.013839;
Toledo-Ortiz G., Huq E., Quail P.H.;
"The Arabidopsis basic/helix-loop-helix transcription factor family.";
Plant Cell 15:1749-1770(2003).
[7]
GENE FAMILY, AND NOMENCLATURE.
PubMed=14600211; DOI=10.1105/tpc.151140;
Bailey P.C., Martin C., Toledo-Ortiz G., Quail P.H., Huq E.,
Heim M.A., Jakoby M., Werber M., Weisshaar B.;
"Update on the basic helix-loop-helix transcription factor gene family
in Arabidopsis thaliana.";
Plant Cell 15:2497-2502(2003).
[8]
FUNCTION, INTERACTION WITH CRY2, AND SUBCELLULAR LOCATION.
PubMed=18988809; DOI=10.1126/science.1163927;
Liu H., Yu X., Li K., Klejnot J., Yang H., Lisiero D., Lin C.;
"Photoexcited CRY2 interacts with CIB1 to regulate transcription and
floral initiation in Arabidopsis.";
Science 322:1535-1539(2008).
[9]
INTERACTION WITH IBH1.
PubMed=23161888; DOI=10.1105/tpc.112.105023;
Ikeda M., Fujiwara S., Mitsuda N., Ohme-Takagi M.;
"A triantagonistic basic helix-loop-helix system regulates cell
elongation in Arabidopsis.";
Plant Cell 24:4483-4497(2012).
[10]
BIOTECHNOLOGY.
PubMed=22847441; DOI=10.1073/pnas.1211305109;
Idevall-Hagren O., Dickson E.J., Hille B., Toomre D.K., De Camilli P.;
"Optogenetic control of phosphoinositide metabolism.";
Proc. Natl. Acad. Sci. U.S.A. 109:E2316-E2323(2012).
[11]
FUNCTION, AND INTERACTION WITH CRY2.
PubMed=24130508; DOI=10.1371/journal.pgen.1003861;
Liu Y., Li X., Li K., Liu H., Lin C.;
"Multiple bHLH proteins form heterodimers to mediate CRY2-dependent
regulation of flowering-time in Arabidopsis.";
PLoS Genet. 9:E1003861-E1003861(2013).
[12]
INDUCTION BY BLUE LIGHT.
STRAIN=cv. Columbia;
PubMed=24101505; DOI=10.1073/pnas.1308987110;
Liu H., Wang Q., Liu Y., Zhao X., Imaizumi T., Somers D.E.,
Tobin E.M., Lin C.;
"Arabidopsis CRY2 and ZTL mediate blue-light regulation of the
transcription factor CIB1 by distinct mechanisms.";
Proc. Natl. Acad. Sci. U.S.A. 110:17582-17587(2013).
[13]
INTERACTION WITH CRY2.
PubMed=24780222; DOI=10.1016/j.ab.2014.04.023;
Cui Y., Choudhury S.R., Irudayaraj J.;
"Quantitative real-time kinetics of optogenetic proteins CRY2 and
CIB1/N using single-molecule tools.";
Anal. Biochem. 458:58-60(2014).
[14]
BIOTECHNOLOGY.
PubMed=24718798; DOI=10.1007/978-1-4939-0470-9_8;
Idevall-Hagren O., Decamilli P.;
"Manipulation of plasma membrane phosphoinositides using photoinduced
protein-protein interactions.";
Methods Mol. Biol. 1148:109-128(2014).
[15]
BIOTECHNOLOGY.
PubMed=25963241; DOI=10.1016/j.chembiol.2015.04.014;
Duan L., Che D., Zhang K., Ong Q., Guo S., Cui B.;
"Optogenetic control of molecular motors and organelle distributions
in cells.";
Chem. Biol. 22:671-682(2015).
-!- FUNCTION: Transcription factor that binds DNA to G box 5'-CACGTG-
3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds
to chromatin DNA of the FT gene and promotes its expression, and
thus triggers flowering in response to blue light.
{ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
-!- SUBUNIT: Homodimer (Probable). Interacts with IBH1
(PubMed:23161888). Binds reversibly to CRY2 after blue light
illumination (PubMed:18988809, PubMed:24780222, PubMed:24130508).
{ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:23161888,
ECO:0000269|PubMed:24130508, ECO:0000269|PubMed:24780222,
ECO:0000305}.
-!- INTERACTION:
Q9C8Z9:BHLH148; NbExp=3; IntAct=EBI-4469930, EBI-4434374;
Q96524:CRY2; NbExp=3; IntAct=EBI-4469930, EBI-531555;
Q9SKX1:IBH1; NbExp=3; IntAct=EBI-4469930, EBI-4433589;
Q9LXU1:PIM1; NbExp=3; IntAct=EBI-4469930, EBI-15193025;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00981, ECO:0000269|PubMed:18988809}.
-!- TISSUE SPECIFICITY: Expressed constitutively in roots, leaves, and
stems. {ECO:0000269|PubMed:12679534}.
-!- INDUCTION: Accumulates strongly in response to blue light due to
reduced preventing 26S proteasome-mediated degradation in an
ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in
the absence of blue light via 26S proteasome degradation (at
protein level). {ECO:0000269|PubMed:24101505}.
-!- BIOTECHNOLOGY: The blue light-mediated interaction between CRY2
and BHLH63/CIB1 is used to design an optogenetic control of target
proteins or organelles. {ECO:0000269|PubMed:22847441,
ECO:0000269|PubMed:24718798, ECO:0000269|PubMed:25963241}.
-!- SEQUENCE CAUTION:
Sequence=CAA18832.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAB80170.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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EMBL; AF488596; AAM10952.1; -; mRNA.
EMBL; AL023094; CAA18832.1; ALT_SEQ; Genomic_DNA.
EMBL; AL161585; CAB80170.1; ALT_SEQ; Genomic_DNA.
EMBL; CP002687; AEE86389.1; -; Genomic_DNA.
EMBL; AK117846; BAC42487.1; -; mRNA.
EMBL; AY120741; AAM53299.1; -; mRNA.
EMBL; BT005313; AAO63377.1; -; mRNA.
PIR; T05273; T05273.
RefSeq; NP_195179.2; NM_119618.3.
SMR; Q8GY61; -.
BioGrid; 14886; 40.
DIP; DIP-59356N; -.
IntAct; Q8GY61; 37.
STRING; 3702.AT4G34530.1; -.
PaxDb; Q8GY61; -.
EnsemblPlants; AT4G34530.1; AT4G34530.1; AT4G34530.
GeneID; 829604; -.
Gramene; AT4G34530.1; AT4G34530.1; AT4G34530.
KEGG; ath:AT4G34530; -.
Araport; AT4G34530; -.
TAIR; locus:2139484; AT4G34530.
eggNOG; ENOG410IGTK; Eukaryota.
eggNOG; ENOG410YGAM; LUCA.
HOGENOM; HOG000238007; -.
InParanoid; Q8GY61; -.
OMA; GYSHEMV; -.
OrthoDB; 1022319at2759; -.
PhylomeDB; Q8GY61; -.
PRO; PR:Q8GY61; -.
Proteomes; UP000006548; Chromosome 4.
GO; GO:0005634; C:nucleus; IDA:TAIR.
GO; GO:0003677; F:DNA binding; IDA:TAIR.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
GO; GO:0009911; P:positive regulation of flower development; IMP:TAIR.
GO; GO:0009637; P:response to blue light; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IDA:TAIR.
CDD; cd00083; HLH; 1.
Gene3D; 4.10.280.10; -; 1.
InterPro; IPR011598; bHLH_dom.
InterPro; IPR024097; bHLH_ZIP_TF.
InterPro; IPR036638; HLH_DNA-bd_sf.
PANTHER; PTHR12565; PTHR12565; 1.
Pfam; PF00010; HLH; 1.
SMART; SM00353; HLH; 1.
SUPFAM; SSF47459; SSF47459; 1.
PROSITE; PS50888; BHLH; 1.
1: Evidence at protein level;
Activator; Complete proteome; DNA-binding; Flowering; Nucleus;
Reference proteome; Transcription; Transcription regulation.
CHAIN 1 335 Transcription factor bHLH63.
/FTId=PRO_0000358758.
DOMAIN 178 228 bHLH. {ECO:0000255|PROSITE-
ProRule:PRU00981}.
CONFLICT 86 86 L -> F (in Ref. 5; AAM53299).
{ECO:0000305}.
CONFLICT 110 110 M -> V (in Ref. 1; AAM10952).
{ECO:0000305}.
SEQUENCE 335 AA; 37540 MW; 05F0CA14FC2B3C7A CRC64;
MNGAIGGDLL LNFPDMSVLE RQRAHLKYLN PTFDSPLAGF FADSSMITGG EMDSYLSTAG
LNLPMMYGET TVEGDSRLSI SPETTLGTGN FKKRKFDTET KDCNEKKKKM TMNRDDLVEE
GEEEKSKITE QNNGSTKSIK KMKHKAKKEE NNFSNDSSKV TKELEKTDYI HVRARRGQAT
DSHSIAERVR REKISERMKF LQDLVPGCDK ITGKAGMLDE IINYVQSLQR QIEFLSMKLA
IVNPRPDFDM DDIFAKEVAS TPMTVVPSPE MVLSGYSHEM VHSGYSSEMV NSGYLHVNPM
QQVNTSSDPL SCFNNGEAPS MWDSHVQNLY GNLGV


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WP272: Blood Clotting Cascade
WP1235: Signaling of Hepatocyte Growth Factor Receptor
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WP1822: Generic Transcription Pathway
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Related Genes :
[BHLH63 CIB1 EN84 At4g34530 T4L20.110] Transcription factor bHLH63 (Basic helix-loop-helix protein 63) (AtbHLH63) (bHLH 63) (Protein CRYPTOCHROME INTERACTING BASIC-HELIX-LOOP-HELIX 1) (Transcription factor EN 84) (bHLH transcription factor bHLH063)
[PIF3 BHLH8 EN100 PAP3 At1g09530 F14J9.19] Transcription factor PIF3 (Basic helix-loop-helix protein 8) (AtbHLH8) (bHLH 8) (Phytochrome-associated protein 3) (Phytochrome-interacting factor 3) (Transcription factor EN 100) (bHLH transcription factor bHLH008)
[PIF1 BHLH15 EN101 PIL5 At2g20180 T2G17.2] Transcription factor PIF1 (Basic helix-loop-helix protein 15) (AtbHLH15) (bHLH 15) (Protein PHY-INTERACTING FACTOR 1) (Protein PHYTOCHROME INTERACTING FACTOR 3-LIKE 5) (Transcription factor EN 101) (bHLH transcription factor bHLH015)
[TT8 BHLH42 EN32 At4g09820 F17A8.170] Transcription factor TT8 (Basic helix-loop-helix protein 42) (AtbHLH42) (bHLH 42) (Protein TRANSPARENT TESTA 8) (Transcription factor EN 32) (bHLH transcription factor bHLH042)
[MYC2 BHLH6 EN38 JAI1 JIN1 RAP1 RD22BP1 ZBF1 At1g32640 F6N18.4] Transcription factor MYC2 (AtMYC2) (Basic helix-loop-helix protein 6) (AtbHLH6) (bHLH 6) (Protein JASMONATE INSENSITIVE 1) (R-homologous Arabidopsis protein 1) (RAP-1) (Transcription factor EN 38) (Z-box binding factor 1 protein) (bHLH transcription factor bHLH006) (rd22BP1)
[PIF4 BHLH9 EN102 SRL2 At2g43010 MFL8.13] Transcription factor PIF4 (Basic helix-loop-helix protein 9) (AtbHLH9) (bHLH 9) (Phytochrome-interacting factor 4) (Short under red-light 2) (Transcription factor EN 102) (bHLH transcription factor bHLH009)
[HFR1 BHLH26 EN68 FBI1 REP1 RSF1 At1g02340 T6A9.4 T6A9_13] Transcription factor HFR1 (Basic helix-loop-helix protein 26) (AtbHLH26) (bHLH 26) (Protein LONG HYPOCOTYL IN FAR-RED 1) (Protein REDUCED PHYTOCHROME SIGNALING) (Reduced sensitivity to far-red light) (Transcription factor EN 68) (bHLH transcription factor bHLH026)
[SPCH BHLH98 EN19 At5g53210 MFH8.15] Transcription factor SPEECHLESS (Basic helix-loop-helix protein 98) (AtbHLH98) (bHLH 98) (Transcription factor EN 19) (bHLH transcription factor bHLH098)
[GL3 BHLH1 EN31 MYC6 SST At5g41315 MYC6.2] Transcription factor GLABRA 3 (Basic helix-loop-helix protein 1) (AtMYC6) (AtbHLH1) (bHLH 1) (Protein SHAPESHIFTER) (Transcription factor EN 31) (bHLH transcription factor bHLH001)
[BHLH2 EGL1 EGL3 EN30 MYC146 At1g63650 F24D7.16] Transcription factor EGL1 (Basic helix-loop-helix protein 2) (AtMYC146) (AtbHLH2) (bHLH 2) (Protein ENHANCER OF GLABRA 3) (Transcription factor EN 30) (bHLH transcription factor bHLH002)
[BHLH95 EN21 RGE1 ZOU At1g49770 F14J22.2] Transcription factor bHLH95 (Basic helix-loop-helix protein 95) (AtbHLH95) (bHLH 95) (Protein RETARDED GROWTH OF EMBRYO 1) (Protein ZHOUPI) (Transcription factor EN 21) (bHLH transcription factor bHLH095)
[BIM1 BHLH46 EN126 At5g08130 T22D6.70] Transcription factor BIM1 (BES1-interacting Myc-like protein 1) (Basic helix-loop-helix protein 46) (AtbHLH46) (bHLH 46) (Transcription factor EN 126) (bHLH transcription factor bHLH046)
[PTF1A BHLHA29 PTF1P48] Pancreas transcription factor 1 subunit alpha (Class A basic helix-loop-helix protein 29) (bHLHa29) (Pancreas-specific transcription factor 1a) (bHLH transcription factor p48) (p48 DNA-binding subunit of transcription factor PTF1) (PTF1-p48)
[PIL1 BHLH124 EN110 At2g46970 F14M4.20] Transcription factor PIL1 (Basic helix-loop-helix protein 124) (AtbHLH124) (bHLH 124) (Protein PHYTOCHROME INTERACTING FACTOR 3-LIKE 1) (Transcription factor EN 110) (bHLH transcription factor bHLH124)
[TCF3 BHLHB21 E2A ITF1] Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
[HEY1 BHLHB31 CHF2 HERP2 HESR1 HRT1] Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)
[TCF12 BHLHB20 HEB HTF4] Transcription factor 12 (TCF-12) (Class B basic helix-loop-helix protein 20) (bHLHb20) (DNA-binding protein HTF4) (E-box-binding protein) (Transcription factor HTF-4)
[PIL13 BHLH152 PIL1 Os03g0782500 LOC_Os03g56950] Transcription factor PHYTOCHROME INTERACTING FACTOR-LIKE 13 (OsPIL13) (PIF-like protein 13) (Basic helix-loop-helix protein 152) (OsbHLH152) (OsPIL1)
[USF2 BHLHB12] Upstream stimulatory factor 2 (Class B basic helix-loop-helix protein 12) (bHLHb12) (FOS-interacting protein) (FIP) (Major late transcription factor 2) (Upstream transcription factor 2)
[TCF4 BHLHB19 ITF2 SEF2] Transcription factor 4 (TCF-4) (Class B basic helix-loop-helix protein 19) (bHLHb19) (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2)
[HIF1A BHLHE78 MOP1 PASD8] Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
[ARNTL BHLHE5 BMAL1 MOP3 PASD3] Aryl hydrocarbon receptor nuclear translocator-like protein 1 (Basic-helix-loop-helix-PAS protein MOP3) (Brain and muscle ARNT-like 1) (Class E basic helix-loop-helix protein 5) (bHLHe5) (Member of PAS protein 3) (PAS domain-containing protein 3) (bHLH-PAS protein JAP3)
[LAX1 BHLH123 LAX Os01g0831000 LOC_Os01g61480 P0446G04.27] Transcription factor LAX PANICLE 1 (Basic helix-loop-helix protein 123) (OsbHLH123) (Protein LAX PANICLE)
[TCF21 BHLHA23 POD1] Transcription factor 21 (TCF-21) (Capsulin) (Class A basic helix-loop-helix protein 23) (bHLHa23) (Epicardin) (Podocyte-expressed 1) (Pod-1)
[NPAS4 BHLHE79 NXF PASD10] Neuronal PAS domain-containing protein 4 (Neuronal PAS4) (Class E basic helix-loop-helix protein 79) (bHLHe79) (HLH-PAS transcription factor NXF) (PAS domain-containing protein 10)
[USF1 BHLHB11 USF] Upstream stimulatory factor 1 (Class B basic helix-loop-helix protein 11) (bHLHb11) (Major late transcription factor 1)
[MYC BHLHE39] Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39) (bHLHe39) (Proto-oncogene c-Myc) (Transcription factor p64)
[TFEB BHLHE35] Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)
[BHLH100 EN7 At2g41240 F13H10.21] Transcription factor bHLH100 (Basic helix-loop-helix protein 100) (AtbHLH100) (bHLH 100) (Transcription factor EN 7) (bHLH transcription factor bHLH100)
[EPAS1 BHLHE73 HIF2A MOP2 PASD2] Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)

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