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Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]

 TGFB2_MOUSE             Reviewed;         414 AA.
P27090; Q91VP5;
01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
16-OCT-2019, entry version 172.
RecName: Full=Transforming growth factor beta-2 proprotein;
Contains:
RecName: Full=Latency-associated peptide;
Short=LAP;
Contains:
RecName: Full=Transforming growth factor beta-2;
Short=TGF-beta-2;
Flags: Precursor;
Name=Tgfb2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=2797004; DOI=10.1210/mend-3-7-1108;
Miller D.A., Lee A., Pelton R.W., Chen E.Y., Moses H.L., Derynck R.;
"Murine transforming growth factor-beta 2 cDNA sequence and expression
in adult tissues and embryos.";
Mol. Endocrinol. 3:1108-1114(1989).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
INTERACTION WITH NREP.
PubMed=14985127; DOI=10.1016/j.bbrc.2004.01.171;
Paliwal S., Shi J., Dhru U., Zhou Y., Schuger L.;
"P311 binds to the latency associated protein and downregulates the
expression of TGF-beta1 and TGF-beta2.";
Biochem. Biophys. Res. Commun. 315:1104-1109(2004).
[4]
INTERACTION WITH HTRA3.
PubMed=15206957; DOI=10.1111/j.1440-169x.2004.00743.x;
Tocharus J., Tsuchiya A., Kajikawa M., Ueta Y., Oka C., Kawaichi M.;
"Developmentally regulated expression of mouse HtrA3 and its role as
an inhibitor of TGF-beta signaling.";
Dev. Growth Differ. 46:257-274(2004).
[5]
INTERACTION WITH HTRA1.
PubMed=14973287; DOI=10.1242/dev.00999;
Oka C., Tsujimoto R., Kajikawa M., Koshiba-Takeuchi K., Ina J.,
Yano M., Tsuchiya A., Ueta Y., Soma A., Kanda H., Matsumoto M.,
Kawaichi M.;
"HtrA1 serine protease inhibits signaling mediated by Tgfbeta family
proteins.";
Development 131:1041-1053(2004).
[6]
INTERACTION WITH MFAP5.
PubMed=23963447; DOI=10.1074/jbc.m113.497727;
Combs M.D., Knutsen R.H., Broekelmann T.J., Toennies H.M., Brett T.J.,
Miller C.A., Kober D.L., Craft C.S., Atkinson J.J., Shipley J.M.,
Trask B.C., Mecham R.P.;
"Microfibril-associated glycoprotein 2 (MAGP2) loss of function has
pleiotropic effects in vivo.";
J. Biol. Chem. 288:28869-28880(2013).
-!- FUNCTION: Transforming growth factor beta-2 proprotein: Precursor
of the Latency-associated peptide (LAP) and Transforming growth
factor beta-2 (TGF-beta-2) chains, which constitute the regulatory
and active subunit of TGF-beta-2, respectively.
{ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.
-!- FUNCTION: Latency-associated peptide: Required to maintain the
Transforming growth factor beta-2 (TGF-beta-2) chain in a latent
state during storage in extracellular matrix. Associates non-
covalently with TGF-beta-2 and regulates its activation via
interaction with 'milieu molecules', such as LTBP1 and
LRRC32/GARP, that control activation of TGF-beta-2.
{ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.
-!- FUNCTION: Transforming growth factor beta-2: Multifunctional
protein that regulates various processes such as angiogenesis and
heart development (By similarity). Activation into mature form
follows different steps: following cleavage of the proprotein in
the Golgi apparatus, Latency-associated peptide (LAP) and
Transforming growth factor beta-2 (TGF-beta-2) chains remain non-
covalently linked rendering TGF-beta-2 inactive during storage in
extracellular matrix (By similarity). At the same time, LAP chain
interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP,
that control activation of TGF-beta-2 and maintain it in a latent
state during storage in extracellular milieus (By similarity).
Once activated following release of LAP, TGF-beta-2 acts by
binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce
signal (By similarity). {ECO:0000250|UniProtKB:P01137,
ECO:0000250|UniProtKB:P04202, ECO:0000250|UniProtKB:P61812}.
-!- SUBUNIT: Interacts with the serine proteases, HTRA1 and HTRA3
(PubMed:15206957, PubMed:14973287). Interacts with ASPN (By
similarity). Interacts with MFAP5 (PubMed:23963447). Latency-
associated peptide: Interacts with Transforming growth factor
beta-2 (TGF-beta-2) chain; interaction is non-covalent and
maintains (TGF-beta-2) in a latent state (By similarity). Latency-
associated peptide: Interacts with LRRC32/GARP; leading to
regulate activation of TGF-beta-2 (By similarity). Latency-
associated peptide: Interacts with NREP; the interaction results
in a decrease in TGFB2 autoinduction (PubMed:14985127).
Transforming growth factor beta-2: Homodimer; disulfide-linked (By
similarity). Transforming growth factor beta-2: Interacts with
TGF-beta receptors (TGFBR1 and TGFBR2), leading to signal
transduction (By similarity). {ECO:0000250|UniProtKB:P01137,
ECO:0000250|UniProtKB:P61812, ECO:0000269|PubMed:14973287,
ECO:0000269|PubMed:14985127, ECO:0000269|PubMed:15206957,
ECO:0000269|PubMed:23963447}.
-!- SUBCELLULAR LOCATION: Latency-associated peptide: Secreted,
extracellular space, extracellular matrix
{ECO:0000250|UniProtKB:P01137}.
-!- SUBCELLULAR LOCATION: Transforming growth factor beta-2: Secreted
{ECO:0000250|UniProtKB:P01137}.
-!- PTM: Transforming growth factor beta-2 proprotein: The precursor
proprotein is cleaved in the Golgi apparatus to form Transforming
growth factor beta-2 (TGF-beta-2) and Latency-associated peptide
(LAP) chains, which remain non-covalently linked, rendering TGF-
beta-2 inactive. {ECO:0000250|UniProtKB:P01137}.
-!- SIMILARITY: Belongs to the TGF-beta family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; X57413; CAA40672.1; -; mRNA.
EMBL; BC011170; AAH11170.1; -; mRNA.
CCDS; CCDS15601.1; -.
PIR; A40148; WFMSB2.
RefSeq; NP_033393.2; NM_009367.4.
PDB; 5TX2; X-ray; 1.82 A; A/B=303-414.
PDB; 5TX6; X-ray; 2.75 A; A/B/C=303-414.
PDBsum; 5TX2; -.
PDBsum; 5TX6; -.
SMR; P27090; -.
BioGrid; 204160; 2.
ComplexPortal; CPX-827; TGF-beta-2 complex.
ComplexPortal; CPX-836; TGF-beta-2-TGFR complex.
IntAct; P27090; 1.
MINT; P27090; -.
STRING; 10090.ENSMUSP00000043849; -.
GlyConnect; 2777; -.
iPTMnet; P27090; -.
PhosphoSitePlus; P27090; -.
MaxQB; P27090; -.
PaxDb; P27090; -.
PeptideAtlas; P27090; -.
PRIDE; P27090; -.
Ensembl; ENSMUST00000045288; ENSMUSP00000043849; ENSMUSG00000039239.
GeneID; 21808; -.
KEGG; mmu:21808; -.
UCSC; uc007dzo.2; mouse.
CTD; 7042; -.
MGI; MGI:98726; Tgfb2.
eggNOG; KOG3900; Eukaryota.
eggNOG; ENOG410XT8Z; LUCA.
GeneTree; ENSGT00940000157390; -.
HOGENOM; HOG000290198; -.
InParanoid; P27090; -.
KO; K13376; -.
OMA; NAIPPPF; -.
OrthoDB; 643840at2759; -.
TreeFam; TF318514; -.
Reactome; R-MMU-114608; Platelet degranulation.
Reactome; R-MMU-2129379; Molecules associated with elastic fibres.
ChiTaRS; Tgfb2; mouse.
PRO; PR:P27090; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000039239; Expressed in 378 organ(s), highest expression level in uterus.
ExpressionAtlas; P27090; baseline and differential.
Genevisible; P27090; MM.
GO; GO:0030424; C:axon; IDA:UniProtKB.
GO; GO:0005604; C:basement membrane; ISO:MGI.
GO; GO:0009986; C:cell surface; ISO:MGI.
GO; GO:0062023; C:collagen-containing extracellular matrix; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005768; C:endosome; IDA:UniProtKB.
GO; GO:0031012; C:extracellular matrix; ISS:UniProtKB.
GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
GO; GO:0005615; C:extracellular space; IDA:MGI.
GO; GO:0043025; C:neuronal cell body; IDA:UniProtKB.
GO; GO:0030141; C:secretory granule; ISO:MGI.
GO; GO:0005802; C:trans-Golgi network; ISO:MGI.
GO; GO:0001540; F:amyloid-beta binding; ISS:UniProtKB.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0008083; F:growth factor activity; TAS:UniProtKB.
GO; GO:0046982; F:protein heterodimerization activity; ISO:MGI.
GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
GO; GO:0047485; F:protein N-terminus binding; ISO:MGI.
GO; GO:0005102; F:signaling receptor binding; ISS:UniProtKB.
GO; GO:0005160; F:transforming growth factor beta receptor binding; ISS:UniProtKB.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; ISS:UniProtKB.
GO; GO:0034714; F:type III transforming growth factor beta receptor binding; ISS:AgBase.
GO; GO:0032147; P:activation of protein kinase activity; ISS:UniProtKB.
GO; GO:0035910; P:ascending aorta morphogenesis; IMP:BHF-UCL.
GO; GO:0060413; P:atrial septum morphogenesis; IMP:BHF-UCL.
GO; GO:0003289; P:atrial septum primum morphogenesis; IMP:BHF-UCL.
GO; GO:0003181; P:atrioventricular valve morphogenesis; IMP:BHF-UCL.
GO; GO:0007411; P:axon guidance; IMP:MGI.
GO; GO:0001568; P:blood vessel development; IMP:MGI.
GO; GO:0001974; P:blood vessel remodeling; IMP:MGI.
GO; GO:0030509; P:BMP signaling pathway; IBA:GO_Central.
GO; GO:0060317; P:cardiac epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0003214; P:cardiac left ventricle morphogenesis; TAS:DFLAT.
GO; GO:0060038; P:cardiac muscle cell proliferation; ISS:UniProtKB.
GO; GO:0003215; P:cardiac right ventricle morphogenesis; IMP:BHF-UCL.
GO; GO:0010002; P:cardioblast differentiation; ISS:UniProtKB.
GO; GO:0001502; P:cartilage condensation; IGI:MGI.
GO; GO:0007050; P:cell cycle arrest; ISS:UniProtKB.
GO; GO:0008219; P:cell death; ISS:UniProtKB.
GO; GO:0048468; P:cell development; IBA:GO_Central.
GO; GO:0016477; P:cell migration; ISS:UniProtKB.
GO; GO:0000902; P:cell morphogenesis; ISS:UniProtKB.
GO; GO:0045216; P:cell-cell junction organization; ISS:UniProtKB.
GO; GO:0030199; P:collagen fibril organization; ISS:UniProtKB.
GO; GO:1904888; P:cranial skeletal system development; IMP:BHF-UCL.
GO; GO:0042416; P:dopamine biosynthetic process; IMP:UniProtKB.
GO; GO:0048566; P:embryonic digestive tract development; ISS:AgBase.
GO; GO:0030326; P:embryonic limb morphogenesis; IMP:BHF-UCL.
GO; GO:0048702; P:embryonic neurocranium morphogenesis; ISO:MGI.
GO; GO:0003274; P:endocardial cushion fusion; IMP:BHF-UCL.
GO; GO:0003203; P:endocardial cushion morphogenesis; IMP:BHF-UCL.
GO; GO:0001837; P:epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:0030198; P:extracellular matrix organization; IMP:MGI.
GO; GO:0097191; P:extrinsic apoptotic signaling pathway; ISS:BHF-UCL.
GO; GO:0001654; P:eye development; ISS:UniProtKB.
GO; GO:0060325; P:face morphogenesis; IEP:UniProtKB.
GO; GO:0008347; P:glial cell migration; ISS:UniProtKB.
GO; GO:0001942; P:hair follicle development; IMP:UniProtKB.
GO; GO:0031069; P:hair follicle morphogenesis; IMP:UniProtKB.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0003007; P:heart morphogenesis; ISS:UniProtKB.
GO; GO:0003179; P:heart valve morphogenesis; IMP:BHF-UCL.
GO; GO:0030097; P:hemopoiesis; IMP:UniProtKB.
GO; GO:0048839; P:inner ear development; IMP:BHF-UCL.
GO; GO:0001822; P:kidney development; IMP:BHF-UCL.
GO; GO:0008584; P:male gonad development; IMP:BHF-UCL.
GO; GO:0003149; P:membranous septum morphogenesis; IMP:BHF-UCL.
GO; GO:0010693; P:negative regulation of alkaline phosphatase activity; ISS:UniProtKB.
GO; GO:0016525; P:negative regulation of angiogenesis; ISO:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0061037; P:negative regulation of cartilage development; IMP:MGI.
GO; GO:0030308; P:negative regulation of cell growth; ISS:AgBase.
GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISS:UniProtKB.
GO; GO:1905006; P:negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0010629; P:negative regulation of gene expression; IDA:UniProtKB.
GO; GO:0050777; P:negative regulation of immune response; ISO:MGI.
GO; GO:0045617; P:negative regulation of keratinocyte differentiation; NAS:UniProtKB.
GO; GO:0010936; P:negative regulation of macrophage cytokine production; ISS:UniProtKB.
GO; GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:BHF-UCL.
GO; GO:0051280; P:negative regulation of release of sequestered calcium ion into cytosol; ISO:MGI.
GO; GO:0003407; P:neural retina development; IMP:BHF-UCL.
GO; GO:0001843; P:neural tube closure; IMP:BHF-UCL.
GO; GO:0048666; P:neuron development; IMP:UniProtKB.
GO; GO:0048663; P:neuron fate commitment; IDA:MGI.
GO; GO:0030593; P:neutrophil chemotaxis; ISS:UniProtKB.
GO; GO:0003151; P:outflow tract morphogenesis; TAS:DFLAT.
GO; GO:0003148; P:outflow tract septum morphogenesis; IMP:BHF-UCL.
GO; GO:0060389; P:pathway-restricted SMAD protein phosphorylation; IDA:BHF-UCL.
GO; GO:0061626; P:pharyngeal arch artery morphogenesis; IMP:BHF-UCL.
GO; GO:0070237; P:positive regulation of activation-induced cell death of T cells; IDA:MGI.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0051891; P:positive regulation of cardioblast differentiation; ISS:UniProtKB.
GO; GO:0033630; P:positive regulation of cell adhesion mediated by integrin; ISS:UniProtKB.
GO; GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
GO; GO:0030335; P:positive regulation of cell migration; ISO:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IMP:BHF-UCL.
GO; GO:0090091; P:positive regulation of extracellular matrix disassembly; IDA:UniProtKB.
GO; GO:2001241; P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; IDA:MGI.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:1904426; P:positive regulation of GTP binding; IDA:UniProtKB.
GO; GO:0045823; P:positive regulation of heart contraction; ISS:UniProtKB.
GO; GO:0050778; P:positive regulation of immune response; ISS:UniProtKB.
GO; GO:0045726; P:positive regulation of integrin biosynthetic process; ISS:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0045747; P:positive regulation of Notch signaling pathway; ISO:MGI.
GO; GO:0045778; P:positive regulation of ossification; ISS:AgBase.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IBA:GO_Central.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; ISS:UniProtKB.
GO; GO:1902895; P:positive regulation of pri-miRNA transcription by RNA polymerase II; ISO:MGI.
GO; GO:1900182; P:positive regulation of protein localization to nucleus; IDA:UniProtKB.
GO; GO:0050714; P:positive regulation of protein secretion; ISS:UniProtKB.
GO; GO:0032874; P:positive regulation of stress-activated MAPK cascade; ISS:UniProtKB.
GO; GO:0051795; P:positive regulation of timing of catagen; ISS:UniProtKB.
GO; GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
GO; GO:0003184; P:pulmonary valve morphogenesis; IMP:BHF-UCL.
GO; GO:0032956; P:regulation of actin cytoskeleton organization; IDA:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; IMP:MGI.
GO; GO:1902256; P:regulation of apoptotic process involved in outflow tract morphogenesis; IMP:BHF-UCL.
GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
GO; GO:1903053; P:regulation of extracellular matrix organization; IMP:MGI.
GO; GO:0043408; P:regulation of MAPK cascade; IBA:GO_Central.
GO; GO:0051794; P:regulation of timing of catagen; ISS:UniProtKB.
GO; GO:0032909; P:regulation of transforming growth factor beta2 production; ISS:UniProtKB.
GO; GO:0042493; P:response to drug; ISS:UniProtKB.
GO; GO:0043627; P:response to estrogen; ISO:MGI.
GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
GO; GO:0032570; P:response to progesterone; ISS:UniProtKB.
GO; GO:0009611; P:response to wounding; ISS:AgBase.
GO; GO:0007435; P:salivary gland morphogenesis; ISS:AgBase.
GO; GO:0062009; P:secondary palate development; IMP:BHF-UCL.
GO; GO:0001501; P:skeletal system development; IMP:BHF-UCL.
GO; GO:0060395; P:SMAD protein signal transduction; ISS:BHF-UCL.
GO; GO:0048103; P:somatic stem cell division; IDA:UniProtKB.
GO; GO:1903701; P:substantia propria of cornea development; IMP:BHF-UCL.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
GO; GO:0060065; P:uterus development; IMP:BHF-UCL.
GO; GO:0060412; P:ventricular septum morphogenesis; IMP:BHF-UCL.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IMP:BHF-UCL.
GO; GO:0042060; P:wound healing; ISS:UniProtKB.
Gene3D; 2.10.90.10; -; 1.
InterPro; IPR029034; Cystine-knot_cytokine.
InterPro; IPR001839; TGF-b_C.
InterPro; IPR001111; TGF-b_propeptide.
InterPro; IPR016319; TGF-beta.
InterPro; IPR015615; TGF-beta-rel.
InterPro; IPR003940; TGFb2.
InterPro; IPR017948; TGFb_CS.
PANTHER; PTHR11848; PTHR11848; 1.
Pfam; PF00019; TGF_beta; 1.
Pfam; PF00688; TGFb_propeptide; 1.
PIRSF; PIRSF001787; TGF-beta; 1.
PRINTS; PR01423; TGFBETA.
PRINTS; PR01425; TGFBETA2.
SMART; SM00204; TGFB; 1.
SUPFAM; SSF57501; SSF57501; 1.
PROSITE; PS00250; TGF_BETA_1; 1.
PROSITE; PS51362; TGF_BETA_2; 1.
1: Evidence at protein level;
3D-structure; Cleavage on pair of basic residues; Complete proteome;
Disulfide bond; Extracellular matrix; Glycoprotein; Growth factor;
Mitogen; Reference proteome; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 302 Latency-associated peptide.
{ECO:0000250|UniProtKB:P61812}.
/FTId=PRO_0000033786.
CHAIN 303 414 Transforming growth factor beta-2.
{ECO:0000250|UniProtKB:P61812}.
/FTId=PRO_0000033787.
CARBOHYD 72 72 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 140 140 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 241 241 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 309 318 {ECO:0000250|UniProtKB:P61812}.
DISULFID 317 380 {ECO:0000250|UniProtKB:P61812}.
DISULFID 346 411 {ECO:0000250|UniProtKB:P61812}.
DISULFID 350 413 {ECO:0000250|UniProtKB:P61812}.
DISULFID 379 379 Interchain.
{ECO:0000250|UniProtKB:P61812}.
CONFLICT 95 96 DE -> EQ (in Ref. 1; CAA40672).
{ECO:0000305}.
HELIX 306 311 {ECO:0000244|PDB:5TX2}.
STRAND 315 320 {ECO:0000244|PDB:5TX2}.
STRAND 323 325 {ECO:0000244|PDB:5TX2}.
HELIX 326 330 {ECO:0000244|PDB:5TX2}.
STRAND 334 337 {ECO:0000244|PDB:5TX2}.
STRAND 339 342 {ECO:0000244|PDB:5TX2}.
STRAND 345 347 {ECO:0000244|PDB:5TX2}.
STRAND 374 376 {ECO:0000244|PDB:5TX2}.
STRAND 379 382 {ECO:0000244|PDB:5TX2}.
STRAND 385 394 {ECO:0000244|PDB:5TX2}.
STRAND 397 408 {ECO:0000244|PDB:5TX2}.
STRAND 410 414 {ECO:0000244|PDB:5TX2}.
SEQUENCE 414 AA; 47589 MW; DB37A7C38881F286 CRC64;
MHYCVLSTFL LLHLVPVALS LSTCSTLDMD QFMRKRIEAI RGQILSKLKL TSPPEDYPEP
DEVPPEVISI YNSTRDLLQE KASRRAAACE RERSDEEYYA KEVYKIDMPS HLPSENAIPP
TFYRPYFRIV RFDVSTMEKN ASNLVKAEFR VFRLQNPKAR VAEQRIELYQ ILKSKDLTSP
TQRYIDSKVV KTRAEGEWLS FDVTDAVQEW LHHKDRNLGF KISLHCPCCT FVPSNNYIIP
NKSEELEARF AGIDGTSTYA SGDQKTIKST RKKTSGKTPH LLLMLLPSYR LESQQSSRRK
KRALDAAYCF RNVQDNCCLR PLYIDFKRDL GWKWIHEPKG YNANFCAGAC PYLWSSDTQH
TKVLSLYNTI NPEASASPCC VSQDLEPLTI LYYIGNTPKI EQLSNMIVKS CKCS


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EIAAB42139 Betaglycan,Homo sapiens,Human,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
LF-MA42051 Anti-Transforming Growth Factor Beta (TGFB) (TB21), Mouse Monoclonal to Transforming Growth Factor Beta (TGFB), Isotype IgG1, Host Mouse 50
EIAAB42137 Betaglycan,Mouse,Mus musculus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42140 Betaglycan,Rat,Rattus norvegicus,TGF-beta receptor type 3,TGF-beta receptor type III,Tgfbr3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
EIAAB42138 Betaglycan,Pig,Sus scrofa,TGF-beta receptor type 3,TGF-beta receptor type III,TGFBR3,TGFR-3,Transforming growth factor beta receptor III,Transforming growth factor beta receptor type 3
U0218b CLIA Bos taurus,Bovine,MGF,Milk growth factor,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
E0218b ELISA Bos taurus,Bovine,MGF,Milk growth factor,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
E0218b ELISA kit Bos taurus,Bovine,MGF,Milk growth factor,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
U0218h CLIA BSC-1 cell growth inhibitor,Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,Homo sapiens,Human,Polyergin,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
E0218h ELISA kit BSC-1 cell growth inhibitor,Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,Homo sapiens,Human,Polyergin,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
E0218h ELISA BSC-1 cell growth inhibitor,Cetermin,Glioblastoma-derived T-cell suppressor factor,G-TSF,Homo sapiens,Human,Polyergin,TGFB2,TGF-beta-2,Transforming growth factor beta-2 96T
RF003-5 rHuman TGF beta-2 Active; Transforming growth factor beta-2; TGF-beta-2 5ug
RF004-5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 Active 5ug
RF003-2.5 Transforming growth factor beta-2; TGF-beta-2 , rHuman TGF beta-2 Active 2.5ug
RF004-2.5 Transforming growth factor beta-3; TGF-beta-3 , rHuman TGF beta-3 Active 2.5ug
RF003-5 Transforming growth factor beta-2; TGF-beta-2 , rHuman TGF beta-2 Active 5ug
RF004-2.5 rHuman TGF beta-3 Active; Transforming growth factor beta-3; TGF-beta-3 2.5ug
RF004-5 rHuman TGF beta-3 Active; Transforming growth factor beta-3; TGF-beta-3 5ug
RF003-2.5 rHuman TGF beta-2 Active; Transforming growth factor beta-2; TGF-beta-2 2.5ug
AS10 1397 Antibody: TGF-beta | transforming growth factor beta , Host: chicken, polyclonal, Comfirmed reactivity: human, mouse, rat, swine TGF (beta) 100
32-224 TGF beta(transforming growth factor beta), with 390-amino acid protein (about 43 kDa), is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types 0.1 mL
Pathways :
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1897: Regulation of beta-cell development
WP368: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP871: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1370: TGF Beta Signaling Pathway
WP505: TGF Beta Signaling Pathway
WP1048: TGF Beta Signaling Pathway
WP1434: Osteopontin Signaling
WP542: Electron Transport Chain
WP1224: EBV LMP1 signaling
WP401: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1982: SREBP signalling
WP419: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP943: Fatty Acid Beta Oxidation

Related Genes :
[TGFB2] Transforming growth factor beta-2 proprotein (Cetermin) (Glioblastoma-derived T-cell suppressor factor) (G-TSF) [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB2] Transforming growth factor beta-2 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-2 (TGF-beta-2)]
[TGFB1 TGFB] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[Tgfb1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFB3] Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
[TGFB1] Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-1 (TGF-beta-1)]
[TGFBR2] TGF-beta receptor type-2 (TGFR-2) (EC 2.7.11.30) (TGF-beta type II receptor) (Transforming growth factor-beta receptor type II) (TGF-beta receptor type II) (TbetaR-II)
[TGFBR1 ALK5 SKR4] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr3] Transforming growth factor beta receptor type 3 (TGF-beta receptor type 3) (TGFR-3) (Betaglycan) (Transforming growth factor beta receptor III) (TGF-beta receptor type III)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (ESK2) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[Tgfbr1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[TGFBR1] TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
[LEFTY2 EBAF LEFTA LEFTYA TGFB4 PSEC0024] Left-right determination factor 2 (Endometrial bleeding-associated factor) (Left-right determination factor A) (Protein lefty-2) (Protein lefty-A) (Transforming growth factor beta-4) (TGF-beta-4)
[Nrros Lrrc33] Transforming growth factor beta activator LRRC33 (Leucine-rich repeat-containing protein 33) (Negative regulator of reactive oxygen species)
[MAP3K7 TAK1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Map3k7 Tak1] Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
[Lefty1 Ebaf Lefty Stra3 Tgfb4] Left-right determination factor 1 (Protein lefty-1) (Lefty protein) (Stimulated by retinoic acid gene 3 protein) (Transforming growth factor beta-4) (TGF-beta-4)
[LTBP4] Latent-transforming growth factor beta-binding protein 4 (LTBP-4)
[KLF11 FKLF TIEG2] Krueppel-like factor 11 (Transforming growth factor-beta-inducible early growth response protein 2) (TGFB-inducible early growth response protein 2) (TIEG-2)
[LTBP2 C14orf141 LTBP3] Latent-transforming growth factor beta-binding protein 2 (LTBP-2)

Bibliography :
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