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Translationally-controlled tumor protein (TCTP)

 TCTP_BOVIN              Reviewed;         172 AA.
Q5E984; Q3SX12; Q862G3; Q862H4; Q862N1; Q862X2; Q862Y4;
26-APR-2005, integrated into UniProtKB/Swiss-Prot.
15-MAR-2005, sequence version 1.
13-FEB-2019, entry version 97.
RecName: Full=Translationally-controlled tumor protein;
Short=TCTP;
Name=TPT1;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=16305752; DOI=10.1186/1471-2164-6-166;
Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
"Characterization of 954 bovine full-CDS cDNA sequences.";
BMC Genomics 6:166-166(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus; TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-155.
PubMed=12658628; DOI=10.1002/mrd.10292;
Ishiwata H., Katsuma S., Kizaki K., Patel O.V., Nakano H.,
Takahashi T., Imai K., Hirasawa A., Shiojima S., Ikawa H., Suzuki Y.,
Tsujimoto G., Izaike Y., Todoroki J., Hashizume K.;
"Characterization of gene expression profiles in early bovine
pregnancy using a custom cDNA microarray.";
Mol. Reprod. Dev. 65:9-18(2003).
-!- FUNCTION: Involved in calcium binding and microtubule
stabilization. {ECO:0000250}.
-!- SUBUNIT: Interacts with STEAP3. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- SIMILARITY: Belongs to the TCTP family. {ECO:0000255|PROSITE-
ProRule:PRU01133}.
-!- SEQUENCE CAUTION:
Sequence=BAC56439.1; Type=Frameshift; Positions=24, 117; Evidence={ECO:0000305};
Sequence=BAC56506.1; Type=Frameshift; Positions=118; Evidence={ECO:0000305};
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; BT021036; AAX09053.1; -; mRNA.
EMBL; BC104562; AAI04563.1; -; mRNA.
EMBL; AB098949; BAC56439.1; ALT_FRAME; mRNA.
EMBL; AB099016; BAC56506.1; ALT_FRAME; mRNA.
EMBL; AB099031; BAC56521.1; -; mRNA.
RefSeq; NP_001014410.1; NM_001014388.1.
UniGene; Bt.7776; -.
ProteinModelPortal; Q5E984; -.
SMR; Q5E984; -.
STRING; 9913.ENSBTAP00000053875; -.
PaxDb; Q5E984; -.
PeptideAtlas; Q5E984; -.
PRIDE; Q5E984; -.
Ensembl; ENSBTAT00000013402; ENSBTAP00000013402; ENSBTAG00000010156.
Ensembl; ENSBTAT00000065799; ENSBTAP00000053875; ENSBTAG00000048229.
GeneID; 326599; -.
KEGG; bta:326599; -.
CTD; 7178; -.
eggNOG; KOG1727; Eukaryota.
eggNOG; ENOG4111FVP; LUCA.
GeneTree; ENSGT00390000006051; -.
HOVERGEN; HBG002282; -.
InParanoid; Q5E984; -.
OMA; IVYEADC; -.
OrthoDB; 1439384at2759; -.
TreeFam; TF300238; -.
Proteomes; UP000009136; Chromosome 12.
Proteomes; UP000009136; Chromosome 25.
Bgee; ENSBTAG00000010156; Expressed in 9 organ(s), highest expression level in skeletal muscle tissue.
ExpressionAtlas; Q5E984; baseline.
GO; GO:0005737; C:cytoplasm; ISS:AgBase.
GO; GO:0005881; C:cytoplasmic microtubule; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0005615; C:extracellular space; ISS:AgBase.
GO; GO:0005771; C:multivesicular body; ISS:AgBase.
GO; GO:0000922; C:spindle pole; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; ISS:AgBase.
Gene3D; 2.170.150.10; -; 1.
InterPro; IPR011057; Mss4-like_sf.
InterPro; IPR011323; Mss4/transl-control_tumour.
InterPro; IPR034737; TCTP.
InterPro; IPR018103; Translation_control_tumour_CS.
InterPro; IPR018105; Translational_control_tumour_p.
PANTHER; PTHR11991; PTHR11991; 1.
Pfam; PF00838; TCTP; 1.
PRINTS; PR01653; TCTPROTEIN.
SUPFAM; SSF51316; SSF51316; 1.
PROSITE; PS01002; TCTP_1; 1.
PROSITE; PS01003; TCTP_2; 1.
PROSITE; PS51797; TCTP_3; 1.
2: Evidence at transcript level;
Calcium; Complete proteome; Cytoplasm; Phosphoprotein;
Reference proteome.
CHAIN 1 172 Translationally-controlled tumor protein.
/FTId=PRO_0000211267.
DOMAIN 1 172 TCTP. {ECO:0000255|PROSITE-
ProRule:PRU01133}.
MOD_RES 46 46 Phosphoserine; by PLK1.
{ECO:0000250|UniProtKB:P13693}.
MOD_RES 53 53 Phosphoserine.
{ECO:0000250|UniProtKB:P13693}.
MOD_RES 64 64 Phosphoserine; by PLK1.
{ECO:0000250|UniProtKB:P13693}.
SEQUENCE 172 AA; 19581 MW; ECDE3985802DFFD0 CRC64;
MIIYRDLISH DEMFSDIYKI REVADGLCLE VEGKMVSRTE GNIDDSLIGG NASAEGPEGE
GTESTVITGV DIVMNHHLQE TSFTKEAYKK YIKDYMKSIK GKLEEQRPER VKPFMTGAAE
QIKHILANFK NYQFFIGENM NPDGMVALLD YREDGVTPYM IFFKDGLEME KC


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair

Related Genes :
[TCTP1 TXTP At3g16640 MGL6.10] Translationally-controlled tumor protein 1 (TCTP1)
[TMA19 MMI1 YKL056C YKL312] Translationally-controlled tumor protein homolog (TCTP) (Microtubule and mitochondria-interacting protein 1) (Translation machinery-associated protein 19)
[TCTP2 At3g05540 F18C1.20] Translationally controlled tumor protein 2 (AtTCTP2)
[STEAP3 TSAP6] Metalloreductase STEAP3 (EC 1.16.1.-) (Dudulin-2) (Six-transmembrane epithelial antigen of prostate 3) (Tumor suppressor-activated pathway protein 6) (hTSAP6) (pHyde) (hpHyde)
[gag-pro-pol] Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein-dUTPase (NC-dUTPase) (EC 3.6.1.23); Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pro-pol] Gag-Pro-Pol polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein-dUTPase (NC-dUTPase) (EC 3.6.1.23); Protease (EC 3.4.23.-); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pro] Gag-Pro polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein-dUTPase (NC-dUTPase) (EC 3.6.1.23); Protease (EC 3.4.23.-)]
[gag] Gag polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein p14]
[gag-pro] Gag-Pro polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein-dUTPase (NC-dUTPase) (EC 3.6.1.23); Protease (EC 3.4.23.-)]
[gag] Gag polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein p8; Protein n; Capsid protein p27; Nucleocapsid protein p14]
[TP63 KET P63 P73H P73L TP73L] Tumor protein 63 (p63) (Chronic ulcerative stomatitis protein) (CUSP) (Keratinocyte transcription factor KET) (Transformation-related protein 63) (TP63) (Tumor protein p73-like) (p73L) (p40) (p51)
[env] Envelope glycoprotein gp70 (Env polyprotein) [Cleaved into: Surface protein (SU) (Glycoprotein 52) (gp52); Transmembrane protein (TM) (Glycoprotein 36) (gp36)]
[dct-1 C14F5.1] NIP3 homolog (CeBNIP3) (Daf-16/FOXO controlled germline tumor affecting-1)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

Bibliography :
[30815593] Assessment of the role of translationally controlled tumor protein 1 (TPT1/TCTP) in breast cancer susceptibility and ATM signaling.
[30797749] Solution structure of a unicellular microalgae-derived translationally controlled tumor protein revealed both conserved features and structural diversity.
[30763986] Suppressor of Variegation 3-9 Homolog 2, a Novel Binding Protein of Translationally Controlled Tumor Protein, Regulates Cancer Cell Proliferation.
[30695029] TCTP and CSN4 control cell cycle progression and development by regulating CULLIN1 neddylation in plants and animals.
[30513758] Evaluation of [Ga]Ga-DOTA-TCTP-1 for the Detection of Metalloproteinase 2/9 Expression in Mouse Atherosclerotic Plaques.
[30459552] Growth Cone Tctp Is Dynamically Regulated by Guidance Cues.
[30386790] The translationally controlled tumor protein TCTP is involved in cell cycle progression and heat stress response in the bloodstream form of .
[30381327] Identification of a Specific Translational Machinery via TCTP-EF1A2 Interaction Regulating NF1-associated Tumor Growth by Affinity Purification and Data-independent Mass Spectrometry Acquisition (AP-DIA).
[30066846] Translationally controlled tumor protein affects colorectal cancer metastasis through the high mobility group box 1-dependent pathway.
[30044154] Modified translationally controlled tumor protein-derived protein transduction domain enhances nasal delivery of exendin-4 as shown with insulin.
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