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Troponin I, cardiac muscle (Cardiac troponin I)

 TNNI3_RAT               Reviewed;         211 AA.
P23693; Q4PP23;
01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
16-JAN-2019, entry version 124.
RecName: Full=Troponin I, cardiac muscle;
AltName: Full=Cardiac troponin I;
Name=Tnni3; Synonyms=Ctni, Tni;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1988058; DOI=10.1021/bi00217a018;
Murphy A.M., Jones L. II, Sims H.F., Strauss A.W.;
"Molecular cloning of rat cardiac troponin I and analysis of troponin
I isoform expression in developing rat heart.";
Biochemistry 30:707-712(1991).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1935696;
Ausoni S., de Nardi C., Moretti P., Gorza L., Schiaffino S.;
"Developmental expression of rat cardiac troponin I mRNA.";
Development 112:1041-1051(1991).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1886137; DOI=10.1016/0022-2828(91)90050-V;
Martin A.F., Orlowski J.;
"Molecular cloning and developmental expression of the rat cardiac-
specific isoform of troponin I.";
J. Mol. Cell. Cardiol. 23:583-588(1991).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9065755; DOI=10.1042/bj3220393;
Murphy A.M., Thompson W.R., Peng L.F., Jones L. II;
"Regulation of the rat cardiac troponin I gene by the transcription
factor GATA-4.";
Biochem. J. 322:393-401(1997).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Sprague-Dawley; TISSUE=Heart muscle;
Chandra M., Tschirgi M.L.;
"Troponin T regulates low-frequency cardiac muscle mechano-dynamics.";
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[6]
INTERACTION WITH TRIM63.
PubMed=15601779; DOI=10.1073/pnas.0404341102;
Kedar V., McDonough H., Arya R., Li H.-H., Rockman H.A., Patterson C.;
"Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that
degrades cardiac troponin I.";
Proc. Natl. Acad. Sci. U.S.A. 101:18135-18140(2004).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6 AND SER-200, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the
thin filament regulatory complex which confers calcium-sensitivity
to striated muscle actomyosin ATPase activity.
-!- SUBUNIT: Interacts with TRIM63 (By similarity). Binds to actin and
tropomyosin. Interacts with STK4/MST1 (By similarity).
{ECO:0000250}.
-!- INTERACTION:
Q5VU43-11:PDE4DIP (xeno); NbExp=2; IntAct=EBI-10817583, EBI-10769071;
-!- PTM: Phosphorylated at Ser-23 and Ser-24 by PRKD1; phosphorylation
reduces myofilament calcium sensitivity. Phosphorylated
preferentially at Thr-32. Phosphorylation by STK4/MST1 alters its
binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T).
Phosphorylated at Ser-43 and Ser-45 by PRKCE; phosphorylation
increases myocardium contractile dysfunction (By similarity).
{ECO:0000250}.
-!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; M57679; AAA63504.1; -; mRNA.
EMBL; X58499; CAA41402.1; -; mRNA.
EMBL; M92074; AAA42294.1; -; mRNA.
EMBL; U77354; AAB52234.1; -; Genomic_DNA.
EMBL; DQ062462; AAY63993.1; -; mRNA.
PIR; A60124; A60124.
PIR; I56441; I56441.
RefSeq; NP_058840.1; NM_017144.2.
UniGene; Rn.64141; -.
ProteinModelPortal; P23693; -.
SMR; P23693; -.
BioGrid; 247923; 2.
IntAct; P23693; 1.
STRING; 10116.ENSRNOP00000024640; -.
iPTMnet; P23693; -.
PhosphoSitePlus; P23693; -.
PaxDb; P23693; -.
PRIDE; P23693; -.
Ensembl; ENSRNOT00000024640; ENSRNOP00000024640; ENSRNOG00000018250.
GeneID; 29248; -.
KEGG; rno:29248; -.
UCSC; RGD:62052; rat.
CTD; 7137; -.
RGD; 62052; Tnni3.
eggNOG; KOG3977; Eukaryota.
eggNOG; ENOG410Y9IX; LUCA.
GeneTree; ENSGT00940000158518; -.
HOGENOM; HOG000293300; -.
HOVERGEN; HBG052737; -.
InParanoid; P23693; -.
KO; K12044; -.
OMA; HTRVDKV; -.
OrthoDB; 1566919at2759; -.
PhylomeDB; P23693; -.
TreeFam; TF313374; -.
Reactome; R-RNO-390522; Striated Muscle Contraction.
Reactome; R-RNO-5578775; Ion homeostasis.
PRO; PR:P23693; -.
Proteomes; UP000002494; Chromosome 1.
Bgee; ENSRNOG00000018250; Expressed in 8 organ(s), highest expression level in heart.
Genevisible; P23693; RN.
GO; GO:0097512; C:cardiac myofibril; IEA:Ensembl.
GO; GO:1990584; C:cardiac Troponin complex; IEA:Ensembl.
GO; GO:0043292; C:contractile fiber; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0030016; C:myofibril; IDA:RGD.
GO; GO:0030017; C:sarcomere; IDA:MGI.
GO; GO:0005861; C:troponin complex; IBA:GO_Central.
GO; GO:0051015; F:actin filament binding; IEA:Ensembl.
GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
GO; GO:0048306; F:calcium-dependent protein binding; IEA:Ensembl.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
GO; GO:0030172; F:troponin C binding; IEA:Ensembl.
GO; GO:0031014; F:troponin T binding; IEA:Ensembl.
GO; GO:0060048; P:cardiac muscle contraction; IDA:RGD.
GO; GO:0006874; P:cellular calcium ion homeostasis; IEA:Ensembl.
GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
GO; GO:0032780; P:negative regulation of ATPase activity; IEA:Ensembl.
GO; GO:0010882; P:regulation of cardiac muscle contraction by calcium ion signaling; IEA:Ensembl.
GO; GO:0006937; P:regulation of muscle contraction; TAS:RGD.
GO; GO:0006940; P:regulation of smooth muscle contraction; IMP:RGD.
GO; GO:0001980; P:regulation of systemic arterial blood pressure by ischemic conditions; IEA:Ensembl.
GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
GO; GO:0001570; P:vasculogenesis; IEA:Ensembl.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
Gene3D; 1.20.5.350; -; 1.
InterPro; IPR001978; Troponin.
InterPro; IPR021666; Troponin-I_N.
InterPro; IPR038077; Troponin_sf.
Pfam; PF00992; Troponin; 1.
Pfam; PF11636; Troponin-I_N; 1.
1: Evidence at protein level;
Acetylation; Actin-binding; Calcium; Complete proteome; Metal-binding;
Muscle protein; Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P08057}.
CHAIN 2 211 Troponin I, cardiac muscle.
/FTId=PRO_0000186155.
CA_BIND 138 149 {ECO:0000250}.
REGION 33 80 Involved in binding TNC.
REGION 130 151 Involved in binding TNC and actin.
SITE 81 81 Involved in TNI-TNT interactions.
SITE 98 98 Involved in TNI-TNT interactions.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P08057}.
MOD_RES 5 5 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 6 6 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 23 23 Phosphoserine; by PKA and PKD/PRKD1.
{ECO:0000250|UniProtKB:P02646}.
MOD_RES 24 24 Phosphoserine; by PKA and PKD/PRKD1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 27 27 Phosphotyrosine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 32 32 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 43 43 Phosphoserine; by PKC/PRKCE.
{ECO:0000250|UniProtKB:P48787}.
MOD_RES 45 45 Phosphoserine; by PKC/PRKCE.
{ECO:0000250|UniProtKB:P48787}.
MOD_RES 52 52 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 78 78 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 79 79 Phosphothreonine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 130 130 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 144 144 Phosphothreonine; by STK4/MST1.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 151 151 Phosphoserine; by PAK3.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 167 167 Phosphoserine.
{ECO:0000250|UniProtKB:P19429}.
MOD_RES 200 200 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
CONFLICT 8 8 A -> S (in Ref. 3; AAA42294).
{ECO:0000305}.
CONFLICT 182 182 I -> T (in Ref. 3; AAA42294).
{ECO:0000305}.
SEQUENCE 211 AA; 24160 MW; 17586B0FDB682B4C CRC64;
MADESSDAAG EPQPAPAPVR RRSSANYRAY ATEPHAKKKS KISASRKLQL KTLMLQIAKQ
EMEREAEERR GEKGRVLSTR CQPLVLDGLG FEELQDLCRQ LHARVDKVDE ERYDVEAKVT
KNITEIADLT QKIYDLRGKF KRPTLRRVRI SADAMMQALL GTRAKESLDL RAHLKQVKKE
DIEKENREVG DWRKNIDALS GMEGRKKKFE G


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Pathways :
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP1043: Calcium Regulation in the Cardiac Cell
WP1159: Calcium Regulation in the Cardiac Cell
WP1365: Calcium Regulation in the Cardiac Cell
WP2406: Cardiac Progenitor Differentiation
WP326: Calcium Regulation in the Cardiac Cell
WP536: Calcium Regulation in the Cardiac Cell
WP553: Calcium Regulation in the Cardiac Cell
WP608: miR-1 in cardiac development
WP808: Calcium Regulation in the Cardiac Cell
WP923: Calcium Regulation in the Cardiac Cell
WP1403: AMPK signaling
WP1526: Cardiac Hypertrophy: miR-208
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP1946: Cori Cycle
WP2005: Muscle cell TarBase
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP10: IL-9 Signaling Pathway
WP100: Glutathione metabolism
WP1001: Peptide GPCRs
WP1003: Ovarian Infertility Genes
WP1004: Kit Receptor Signaling Pathway
WP1006: metapathway biotransformation
WP1011: T Cell Receptor Signaling Pathway
WP1012: IL-7 Signaling Pathway

Related Genes :
[TNNI3 TNNC1] Troponin I, cardiac muscle (Cardiac troponin I)
[TNNT2] Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
[TNNI3K CARK] Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)
[TNNT1 TNT] Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT)
[TNNI2] Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
[Actc1 Actc] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[TNNT3] Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)
[ACTC1 ACTC] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[Actc1 Actc] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[MYBPC3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[RYR2] Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
[Ryr2] Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
[MYL2 MLC2] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Smooth muscle calcium channel blocker receptor) (CACB-receptor) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Mybpc3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[MYBPC3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[Tnnt3] Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT)
[Mybpc3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[actc1 acta1 actc] Actin, alpha cardiac muscle 1 (Actin alpha 1) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
[wupA HDP TnI CG7178] Troponin I (Tn I) (Protein heldup) (Protein wings apart-A)
[SCN5A] Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (MELC-CC) (Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[CSRP3 CLP MLP] Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Scn5a] Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (mH1)
[Scn5a] Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
[MYL3] Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)
[Myl2 Mylpc] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v)
[MYH6 MYHCA] Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)

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