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Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)

 TNNI2_RABIT             Reviewed;         182 AA.
P02643;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
28-MAR-2018, entry version 113.
RecName: Full=Troponin I, fast skeletal muscle;
AltName: Full=Troponin I, fast-twitch isoform;
Name=TNNI2;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Skeletal muscle;
PubMed=1339446;
Sheng Z., Pan B.S., Miller T., Potter J.D.;
"Isolation, expression, and mutation of a rabbit skeletal muscle cDNA
clone for troponin I. The role of the NH2 terminus of fast skeletal
muscle troponin I in its biological activity.";
J. Biol. Chem. 267:25407-25413(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
PubMed=8173075; DOI=10.3109/10425179309020150;
Wu Q.L., Raychowdhury M.K., Du Y., Jha P.K., Leavis P.C., Sarkar S.;
"Characterization of a rabbit fast skeletal troponin I cDNA: a
comparative sequence analysis of vertebrate isoforms and tissue-
specific expression of a single copy gene.";
DNA Seq. 4:113-121(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8495752; DOI=10.1016/0014-5793(93)81453-7;
Kluwe L., Maeda K., Maeda Y.;
"E. coli expression and characterization of a mutant troponin I with
the three cysteine residues substituted.";
FEBS Lett. 323:83-88(1993).
[4]
PROTEIN SEQUENCE OF 2-182, AND ACETYLATION AT GLY-2.
TISSUE=Skeletal muscle;
PubMed=1180911; DOI=10.1042/bj1490493;
Wilkinson J.M., Grand R.J.A.;
"The amino acid sequence of troponin I from rabbit skeletal muscle.";
Biochem. J. 149:493-496(1975).
[5]
SEQUENCE REVISION.
PubMed=146828; DOI=10.1038/271031a0;
Wilkinson J.M., Grand R.J.A.;
"Comparison of amino acid sequence of troponin I from different
striated muscles.";
Nature 271:31-35(1978).
[6]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-25 AND 166-178.
PubMed=6687628; DOI=10.1038/302718a0;
Putney S.D., Herlihy W.C., Schimmel P.R.;
"A new troponin T and cDNA clones for 13 different muscle proteins,
found by shotgun sequencing.";
Nature 302:718-721(1983).
[7]
PHOSPHORYLATION AT THR-12 AND SER-118.
TISSUE=Skeletal muscle;
PubMed=4369337; DOI=10.1016/0014-5793(74)80739-8;
Moir A.J.G., Wilkinson J.M., Perry S.V.;
"The phosphorylation sites of troponin I from white skeletal muscle of
the rabbit.";
FEBS Lett. 42:253-256(1974).
[8]
PHOSPHORYLATION AT THR-12 AND SER-118.
TISSUE=Skeletal muscle;
PubMed=4369265; DOI=10.1016/0014-5793(74)80738-6;
Huang T.S., Bylund D.B., Stull J.T., Krebs E.G.;
"The amino acid sequences of the phosphorylated sites in troponin-I
from rabbit skeletal muscle.";
FEBS Lett. 42:249-252(1974).
[9]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1-48 IN COMPLEX WITH TNC.
PubMed=9560191; DOI=10.1073/pnas.95.9.4847;
Vassylyev D.G., Takeda S., Wakatsuki S., Maeda K., Maeda Y.;
"Crystal structure of troponin C in complex with troponin I fragment
at 2.3-A resolution.";
Proc. Natl. Acad. Sci. U.S.A. 95:4847-4852(1998).
-!- FUNCTION: Troponin I is the inhibitory subunit of troponin, the
thin filament regulatory complex which confers calcium-sensitivity
to striated muscle actomyosin ATPase activity.
-!- SUBUNIT: Binds to actin and tropomyosin.
{ECO:0000269|PubMed:9560191}.
-!- SIMILARITY: Belongs to the troponin I family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; L04347; AAA31490.1; -; mRNA.
EMBL; X14190; CAA32392.1; -; mRNA.
EMBL; S61403; AAB26824.1; -; mRNA.
EMBL; V00897; CAA24262.1; -; mRNA.
EMBL; V00898; CAA24263.1; -; mRNA.
PIR; A45060; TPRBIS.
PIR; I46513; I46513.
RefSeq; NP_001076252.1; NM_001082783.1.
UniGene; Ocu.6670; -.
PDB; 1A2X; X-ray; 2.30 A; B=2-48.
PDB; 1EW7; Model; -; I=4-137.
PDB; 1NPQ; NMR; -; B=116-132.
PDBsum; 1A2X; -.
PDBsum; 1EW7; -.
PDBsum; 1NPQ; -.
ProteinModelPortal; P02643; -.
SMR; P02643; -.
BioGrid; 1172600; 5.
CORUM; P02643; -.
IntAct; P02643; 1.
iPTMnet; P02643; -.
GeneID; 100009581; -.
KEGG; ocu:100009581; -.
CTD; 7136; -.
HOVERGEN; HBG052737; -.
InParanoid; P02643; -.
KO; K12043; -.
EvolutionaryTrace; P02643; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005861; C:troponin complex; IEA:InterPro.
GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0031014; F:troponin T binding; IPI:UniProtKB.
Gene3D; 1.20.5.350; -; 1.
InterPro; IPR001978; Troponin.
InterPro; IPR038077; Troponin_sf.
Pfam; PF00992; Troponin; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Actin-binding; Calcium; Complete proteome;
Direct protein sequencing; Metal-binding; Muscle protein;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000269|PubMed:1180911}.
CHAIN 2 182 Troponin I, fast skeletal muscle.
/FTId=PRO_0000186145.
CA_BIND 105 116 {ECO:0000250}.
REGION 2 48 Involved in binding TNC.
REGION 97 117 Involved in binding TNC and actin.
MOD_RES 2 2 N-acetylglycine.
{ECO:0000269|PubMed:1180911}.
MOD_RES 12 12 Phosphothreonine; by PHK.
{ECO:0000269|PubMed:4369265,
ECO:0000269|PubMed:4369337}.
MOD_RES 118 118 Phosphoserine; by PKA.
{ECO:0000269|PubMed:4369265,
ECO:0000269|PubMed:4369337}.
CONFLICT 154 156 Missing (in Ref. 4; AA sequence).
{ECO:0000305}.
HELIX 6 32 {ECO:0000244|PDB:1A2X}.
HELIX 120 126 {ECO:0000244|PDB:1NPQ}.
SEQUENCE 182 AA; 21214 MW; 5BE12DBB6C90FFCF CRC64;
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEEGRREAE KQNYLAEHCP PLSLPGSMAE
VQELCKQLHA KIDAAEEEKY DMEIKVQKSS KELEDMNQKL FDLRGKFKRP PLRRVRMSAD
AMLKALLGSK HKVCMDLRAN LKQVKKEDTE KERDLRDVGD WRKNIEEKSG MEGRKKMFES
ES


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1403: AMPK signaling
WP1946: Cori Cycle
WP2005: Muscle cell TarBase
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP10: IL-9 Signaling Pathway
WP100: Glutathione metabolism
WP1001: Peptide GPCRs
WP1003: Ovarian Infertility Genes
WP1004: Kit Receptor Signaling Pathway
WP1006: metapathway biotransformation
WP1011: T Cell Receptor Signaling Pathway
WP1012: IL-7 Signaling Pathway
WP1017: Type II interferon signaling (IFNG)
WP1018: Apoptosis
WP1019: FAS pathway and Stress induction of HSP regulation
WP1021: Phase I, non P450
WP1022: Hedgehog Signaling Pathway
WP1025: B Cell Receptor Signaling Pathway
WP1029: Notch Signaling Pathway
WP103: Cholesterol Biosynthesis
WP1031: IL-3 Signaling Pathway
WP1032: NLR proteins
WP1033: ACE Inhibitor Pathway
WP1035: Mismatch repair
WP1036: Homologous recombination

Related Genes :
[TNNI2] Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
[TNNT3] Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)
[Tnnt3] Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT)
[TNNT1 TNT] Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT)
[ATP2A1] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
[ATP2A2 ATP2B] Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
[TNNT2] Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
[MYBPC2 MYBPCF] Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
[TNNI3 TNNC1] Troponin I, cardiac muscle (Cardiac troponin I)
[RYR1] Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
[ACTA1 ACTA] Actin, alpha skeletal muscle (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
[Eno3 Eno-3] Beta-enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (Enolase 3) (Muscle-specific enolase) (MSE) (Skeletal muscle enolase)
[CASQ1 CASQ] Calsequestrin-1 (Calmitine) (Calsequestrin, skeletal muscle isoform)
[wupA HDP TnI CG7178] Troponin I (Tn I) (Protein heldup) (Protein wings apart-A)
[GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12] General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein)
[MYH3] Myosin-3 (Muscle embryonic myosin heavy chain) (Myosin heavy chain 3) (Myosin heavy chain, fast skeletal muscle, embryonic) (SMHCE)
[MYBPC2] Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
[Foxh1 Fast1 Fast2] Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (Forkhead activin signal transducer 2) (Fast-2)
[MYL3] Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)
[PHKA1] Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)
[TPM1] Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
[MYBPC1 MYBPCS] Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)
[RYR1 RYDR] Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
[Myl2 Mylpc] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v)
[PHKA1 PHKA] Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)
[Mybpc2] Myosin-binding protein C, fast-type (Fast MyBP-C) (C-protein, skeletal muscle fast isoform)
[FOXH1 FAST1 FAST2] Forkhead box protein H1 (Forkhead activin signal transducer 1) (Fast-1) (hFAST-1) (Forkhead activin signal transducer 2) (Fast-2)
[SCN4A] Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4)
[Cacna1s Cach1 Cacn1 Cacnl1a3 Cchl1a3] Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (ROB1) (Voltage-gated calcium channel subunit alpha Cav1.1)
[Six4 Arec3] Homeobox protein SIX4 (Sine oculis homeobox homolog 4) (Skeletal muscle-specific ARE-binding protein AREC3)

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