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Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)

 TNNT2_MOUSE             Reviewed;         301 AA.
P50752; Q64360; Q64377;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
13-FEB-2019, entry version 129.
RecName: Full=Troponin T, cardiac muscle;
Short=TnTc;
AltName: Full=Cardiac muscle troponin T;
Short=cTnT;
Name=Tnnt2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE (ISOFORMS A1; A2; A3B AND EMBRYONIC).
TISSUE=Heart;
Jin J.-P., Wang J., Zhang J.;
"Expression of mouse cardiac troponin T isoforms: characterization of
a large sample of independent cDNA clones.";
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[2]
PHOSPHORYLATION AT THR-207; SER-211; THR-216 AND THR-297.
PubMed=12832403; DOI=10.1074/jbc.M306325200;
Sumandea M.P., Pyle W.G., Kobayashi T., de Tombe P.P., Solaro R.J.;
"Identification of a functionally critical protein kinase C
phosphorylation residue of cardiac troponin T.";
J. Biol. Chem. 278:35135-35144(2003).
[3]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Heart;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Troponin T is the tropomyosin-binding subunit of
troponin, the thin filament regulatory complex which confers
calcium-sensitivity to striated muscle actomyosin ATPase activity.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=Embryonic; Synonyms=EA;
IsoId=P50752-1; Sequence=Displayed;
Name=A1;
IsoId=P50752-4; Sequence=VSP_007913;
Name=A2;
IsoId=P50752-3; Sequence=VSP_006649;
Name=A3B;
IsoId=P50752-2; Sequence=VSP_006649, VSP_006650;
-!- PTM: Phosphorylation at Thr-216 by PRKCA induces significant
reduction in myofilament calcium sensitivity and actomyosin ATPase
activity. {ECO:0000269|PubMed:12832403}.
-!- SIMILARITY: Belongs to the troponin T family. {ECO:0000305}.
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EMBL; L47549; AAA85345.1; -; mRNA.
EMBL; L47550; AAA85346.1; -; mRNA.
EMBL; L47551; AAA85347.1; -; mRNA.
EMBL; L47552; AAA85348.1; -; mRNA.
EMBL; L47553; AAA85349.1; -; mRNA.
EMBL; L47570; AAA85350.1; -; Genomic_DNA.
EMBL; L47599; AAA85351.1; -; mRNA.
EMBL; L47600; AAA85352.1; -; mRNA.
CCDS; CCDS48376.1; -. [P50752-4]
CCDS; CCDS48377.1; -. [P50752-1]
CCDS; CCDS48378.1; -. [P50752-3]
RefSeq; NP_001123648.1; NM_001130176.1. [P50752-1]
RefSeq; NP_001123650.1; NM_001130178.2. [P50752-4]
RefSeq; NP_001123651.4; NM_001130179.2.
RefSeq; NP_001123652.1; NM_001130180.2. [P50752-3]
RefSeq; NP_001123653.4; NM_001130181.2.
RefSeq; NP_035749.1; NM_011619.3. [P50752-2]
RefSeq; XP_006529456.1; XM_006529393.3. [P50752-1]
RefSeq; XP_006529457.1; XM_006529394.3. [P50752-1]
RefSeq; XP_006529458.1; XM_006529395.3. [P50752-3]
UniGene; Mm.247470; -.
ProteinModelPortal; P50752; -.
SMR; P50752; -.
ComplexPortal; CPX-16; Cardiac Troponin complex.
IntAct; P50752; 4.
MINT; P50752; -.
STRING; 10090.ENSMUSP00000137093; -.
iPTMnet; P50752; -.
PhosphoSitePlus; P50752; -.
PaxDb; P50752; -.
PRIDE; P50752; -.
Ensembl; ENSMUST00000027671; ENSMUSP00000027671; ENSMUSG00000026414. [P50752-3]
Ensembl; ENSMUST00000112087; ENSMUSP00000107717; ENSMUSG00000026414. [P50752-1]
Ensembl; ENSMUST00000178854; ENSMUSP00000136265; ENSMUSG00000026414. [P50752-4]
Ensembl; ENSMUST00000189355; ENSMUSP00000139919; ENSMUSG00000026414. [P50752-3]
Ensembl; ENSMUST00000189732; ENSMUSP00000139669; ENSMUSG00000026414. [P50752-4]
GeneID; 21956; -.
KEGG; mmu:21956; -.
UCSC; uc007ctu.3; mouse. [P50752-4]
UCSC; uc007ctw.3; mouse. [P50752-3]
UCSC; uc007ctx.3; mouse. [P50752-2]
UCSC; uc011wso.2; mouse. [P50752-1]
CTD; 7139; -.
MGI; MGI:104597; Tnnt2.
eggNOG; KOG3634; Eukaryota.
eggNOG; ENOG410XS6A; LUCA.
GeneTree; ENSGT00940000154709; -.
HOGENOM; HOG000231049; -.
HOVERGEN; HBG052790; -.
InParanoid; P50752; -.
KO; K12045; -.
OrthoDB; 1480247at2759; -.
Reactome; R-MMU-390522; Striated Muscle Contraction.
ChiTaRS; Tnnt2; mouse.
PMAP-CutDB; P50752; -.
PRO; PR:P50752; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026414; Expressed in 221 organ(s), highest expression level in cardiac ventricle.
ExpressionAtlas; P50752; baseline and differential.
Genevisible; P50752; MM.
GO; GO:0097512; C:cardiac myofibril; ISO:MGI.
GO; GO:1990584; C:cardiac Troponin complex; ISO:MGI.
GO; GO:0005737; C:cytoplasm; IDA:MGI.
GO; GO:0030016; C:myofibril; IDA:MGI.
GO; GO:0030017; C:sarcomere; IDA:MGI.
GO; GO:0005865; C:striated muscle thin filament; ISS:UniProtKB.
GO; GO:0005861; C:troponin complex; IDA:MGI.
GO; GO:0003779; F:actin binding; ISS:UniProtKB.
GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
GO; GO:0030674; F:protein binding, bridging; ISO:MGI.
GO; GO:0005200; F:structural constituent of cytoskeleton; IDA:MGI.
GO; GO:0005523; F:tropomyosin binding; ISS:UniProtKB.
GO; GO:0030172; F:troponin C binding; ISS:UniProtKB.
GO; GO:0031013; F:troponin I binding; ISS:UniProtKB.
GO; GO:0051764; P:actin crosslink formation; ISO:MGI.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IMP:MGI.
GO; GO:0060048; P:cardiac muscle contraction; ISO:MGI.
GO; GO:0007507; P:heart development; IMP:MGI.
GO; GO:0006936; P:muscle contraction; IDA:MGI.
GO; GO:0030049; P:muscle filament sliding; ISS:UniProtKB.
GO; GO:0032780; P:negative regulation of ATPase activity; ISS:UniProtKB.
GO; GO:0032781; P:positive regulation of ATPase activity; ISS:UniProtKB.
GO; GO:0051291; P:protein heterooligomerization; ISO:MGI.
GO; GO:0008016; P:regulation of heart contraction; IMP:MGI.
GO; GO:0006937; P:regulation of muscle contraction; ISO:MGI.
GO; GO:0032972; P:regulation of muscle filament sliding speed; ISO:MGI.
GO; GO:0009617; P:response to bacterium; IEP:MGI.
GO; GO:0051592; P:response to calcium ion; ISS:UniProtKB.
GO; GO:0045214; P:sarcomere organization; IMP:MGI.
GO; GO:0003009; P:skeletal muscle contraction; IBA:GO_Central.
GO; GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IMP:MGI.
Gene3D; 1.20.5.350; -; 1.
InterPro; IPR027707; TNNT.
InterPro; IPR001978; Troponin.
InterPro; IPR038077; Troponin_sf.
PANTHER; PTHR11521; PTHR11521; 1.
Pfam; PF00992; Troponin; 2.
1: Evidence at protein level;
Acetylation; Alternative splicing; Complete proteome; Muscle protein;
Phosphoprotein; Reference proteome.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P09741}.
CHAIN 2 301 Troponin T, cardiac muscle.
/FTId=PRO_0000186174.
MOD_RES 2 2 N-acetylserine.
{ECO:0000250|UniProtKB:P09741}.
MOD_RES 2 2 Phosphoserine; by CK2.
{ECO:0000250|UniProtKB:P13789}.
MOD_RES 207 207 Phosphothreonine; by PKC/PRKCA.
{ECO:0000269|PubMed:12832403}.
MOD_RES 211 211 Phosphoserine; by PKC/PRKCA.
{ECO:0000269|PubMed:12832403}.
MOD_RES 216 216 Phosphothreonine; by PKC/PRKCA and RAF1.
{ECO:0000305|PubMed:12832403}.
MOD_RES 297 297 Phosphothreonine; by PKC/PRKCA.
{ECO:0000269|PubMed:12832403}.
VAR_SEQ 18 27 Missing (in isoform A2 and isoform A3B).
{ECO:0000305}.
/FTId=VSP_006649.
VAR_SEQ 18 26 EDWSEEEED -> AVE (in isoform A1).
{ECO:0000305}.
/FTId=VSP_007913.
VAR_SEQ 204 206 Missing (in isoform A3B). {ECO:0000305}.
/FTId=VSP_006650.
SEQUENCE 301 AA; 35825 MW; 60B2185A140AF2D5 CRC64;
MSDAEEVVEE YEEEQEEEDW SEEEEDEQEE AVEEEEAGGA EPEPEGEAET EEANVEEVGP
DEEAKDAEEG PVEDTKPKPS RLFMPNLVPP KIPDGERVDF DDIHRKRVEK DLNELQTLIE
AHFENRKKEE EELISLKDRI EKRRAERAEQ QRIRNEREKE RQNRLAEERA RREEEENRRK
AEDEARKKKA LSNMMHFGGY IQKQAQTERK SGKRQTEREK KKKILAERRK ALAIDHLNED
QLREKAKELW QSIHNLEAEK FDLQEKFKQQ KYEINVLRNR INDNQKVSKT RGKAKVTGRW
K


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Kits Elisa; taq POLYMERASE

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Pathways :
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP1088: Striated Muscle Contraction
WP1316: Striated Muscle Contraction
WP1403: AMPK signaling
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP2005: Muscle cell TarBase
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP216: Striated Muscle Contraction
WP2406: Cardiac Progenitor Differentiation
WP316: Striated Muscle Contraction
WP383: Striated Muscle Contraction
WP745: Striated Muscle Contraction
WP850: Striated Muscle Contraction
WP969: Striated Muscle Contraction
WP1043: Calcium Regulation in the Cardiac Cell
WP1159: Calcium Regulation in the Cardiac Cell
WP1365: Calcium Regulation in the Cardiac Cell
WP1526: Cardiac Hypertrophy: miR-208
WP1864: Muscle contraction
WP1946: Cori Cycle
WP1991: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP2012: miRs in Muscle Cell Differentiation
WP2076: miRs in Muscle Cell Differentiation
WP2081: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP326: Calcium Regulation in the Cardiac Cell

Related Genes :
[TNNT2] Troponin T, cardiac muscle (TnTc) (Cardiac muscle troponin T) (cTnT)
[TNNI3 TNNC1] Troponin I, cardiac muscle (Cardiac troponin I)
[TNNT1 TNT] Troponin T, slow skeletal muscle (TnTs) (Slow skeletal muscle troponin T) (sTnT)
[TNNT3] Troponin T, fast skeletal muscle (TnTf) (Beta-TnTF) (Fast skeletal muscle troponin T) (fTnT)
[TNNI3K CARK] Serine/threonine-protein kinase TNNI3K (EC 2.7.11.1) (Cardiac ankyrin repeat kinase) (Cardiac troponin I-interacting kinase) (TNNI3-interacting kinase)
[Tnnt3] Troponin T, fast skeletal muscle (TnTf) (Fast skeletal muscle troponin T) (fTnT)
[TNNI2] Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform)
[ACTC1 ACTC] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[Actc1 Actc] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[RYR2] Ryanodine receptor 2 (RYR-2) (RyR2) (hRYR-2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
[Ryr2] Ryanodine receptor 2 (RYR-2) (RyR2) (Cardiac muscle ryanodine receptor) (Cardiac muscle ryanodine receptor-calcium release channel) (Type 2 ryanodine receptor)
[Actc1 Actc] Actin, alpha cardiac muscle 1 (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[MYL2 MLC2] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
[MYBPC3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[Mybpc3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[MYBPC3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[Mybpc3] Myosin-binding protein C, cardiac-type (Cardiac MyBP-C) (C-protein, cardiac muscle isoform)
[CSRP3 CLP MLP] Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
[Myl2 Mylpc] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v)
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Smooth muscle calcium channel blocker receptor) (CACB-receptor) (Voltage-gated calcium channel subunit alpha Cav1.2)
[SCN5A] Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
[actc1 acta1 actc] Actin, alpha cardiac muscle 1 (Actin alpha 1) (Alpha-cardiac actin) [Cleaved into: Actin, alpha cardiac muscle 1, intermediate form]
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
[MYH6 MYHCA] Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)
[Scn5a] Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (mH1)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (MELC-CC) (Mouse brain class C) (MBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[CASQ2] Calsequestrin-2 (Calsequestrin, cardiac muscle isoform)
[Scn5a] Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[MYL3] Myosin light chain 3 (Cardiac myosin light chain 1) (CMLC1) (Myosin light chain 1, slow-twitch muscle B/ventricular isoform) (MLC1SB) (Ventricular myosin alkali light chain) (Ventricular myosin light chain 1) (VLCl) (Ventricular/slow twitch myosin alkali light chain) (MLC-lV/sb)

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