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Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

 TNFA_RAT                Reviewed;         235 AA.
P16599; Q6EE11; Q9JI26; Q9JI27;
01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
01-AUG-1990, sequence version 1.
16-OCT-2019, entry version 179.
RecName: Full=Tumor necrosis factor;
AltName: Full=Cachectin;
AltName: Full=TNF-alpha;
AltName: Full=Tumor necrosis factor ligand superfamily member 2;
Short=TNF-a;
Contains:
RecName: Full=Tumor necrosis factor, membrane form;
AltName: Full=N-terminal fragment;
Short=NTF;
Contains:
RecName: Full=Intracellular domain 1;
Short=ICD1;
Contains:
RecName: Full=Intracellular domain 2;
Short=ICD2;
Contains:
RecName: Full=C-domain 1;
Contains:
RecName: Full=C-domain 2;
Contains:
RecName: Full=Tumor necrosis factor, soluble form;
Flags: Precursor;
Name=Tnf; Synonyms=Tnfa, Tnfsf2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Shirai T., Shimizu N., Horiguchi S., Ito H.;
"Cloning and expression in Escherichia coli of the gene for rat tumor
necrosis factor.";
Agric. Biol. Chem. 53:1733-1736(1989).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=1627266;
Estler H.C., Grewe M., Gaussling R., Pavlovic M., Decker K.F.;
"Rat tumor necrosis factor-alpha. Transcription in rat Kupffer cells
and in vitro posttranslational processing based on a PCR-derived
cDNA.";
Biol. Chem. Hoppe-Seyler 373:271-281(1992).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=Sprague-Dawley; TISSUE=Testis;
PubMed=8224868; DOI=10.1016/0378-1119(93)90200-m;
Kwon J., Chung I.Y., Benveniste E.N.;
"Cloning and sequence analysis of the rat tumor necrosis factor-
encoding genes.";
Gene 132:227-236(1993).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ACI/SegHsd, BB(DR)/Wor, Brown Norway/SsNHsd, DA/Bkl, F344/NHsd,
and LEW/NHsd;
PubMed=11477479; DOI=10.1038/sj.gene.6363761;
Furuya T., Joe B., Salstrom J.L., Hashiramoto A., Dobbins D.E.,
Wilder R.L., Remmers E.F.;
"Polymorphisms of the tumor necrosis factor alpha locus among
autoimmune disease susceptible and resistant inbred rat strains.";
Genes Immun. 2:229-232(2001).
[5]
NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS PRO-122 AND GLU-190.
STRAIN=Dark agouti;
Seidel M.F., Junier M.-P., Vetter H.;
"TNF-alpha polymorphism in rats with collagen-induced arthritis.";
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=AUG/OlaHsd, PVG/OlaHsd, and WF/HanHsd;
PubMed=15935297; DOI=10.1016/j.trim.2005.04.002;
Warle M.C., van der Laan L.J., Kusters J.G., Pot R.G., Hop W.C.,
Segeren K.C., Ijzermans J.N., Metselaar H.J., Tilanus H.W.;
"No association between tumor necrosis factor-alpha production and
gene polymorphisms among inbred rat strains.";
Transpl. Immunol. 14:77-82(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Brown Norway;
PubMed=15060004; DOI=10.1101/gr.1987704;
Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T.,
Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
"The genomic sequence and comparative analysis of the rat major
histocompatibility complex.";
Genome Res. 14:631-639(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Prostate;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-231.
TISSUE=Tail;
Kirisits M.J., Vardimon D., Kunz H.W., Gill T.J. III;
"Mapping of the TNF-alpha locus in the rat.";
Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and
TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
induce cell death of certain tumor cell lines. It is potent
pyrogen causing fever by direct action or by stimulation of
interleukin-1 secretion and is implicated in the induction of
cachexia, Under certain conditions it can stimulate cell
proliferation and induce cell differentiation (By similarity).
Induces insulin resistance in adipocytes via inhibition of
insulin-induced IRS1 tyrosine phosphorylation and insulin-induced
glucose uptake. Induces GKAP42 protein degradation in adipocytes
which is partially responsible for TNF-induced insulin resistance
(By similarity). {ECO:0000250|UniProtKB:P01375,
ECO:0000250|UniProtKB:P06804}.
-!- FUNCTION: The TNF intracellular domain (ICD) form induces IL12
production in dendritic cells. {ECO:0000250|UniProtKB:P01375}.
-!- SUBUNIT: Homotrimer. Interacts with SPPL2B (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
type II membrane protein {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Tumor necrosis factor, membrane form:
Membrane {ECO:0000250}; Single-pass type II membrane protein
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Tumor necrosis factor, soluble form:
Secreted {ECO:0000250}.
-!- SUBCELLULAR LOCATION: C-domain 1: Secreted {ECO:0000250}.
-!- SUBCELLULAR LOCATION: C-domain 2: Secreted {ECO:0000250}.
-!- PTM: The soluble form derives from the membrane form by
proteolytic processing. The membrane-bound form is further
proteolytically processed by SPPL2A or SPPL2B through regulated
intramembrane proteolysis producing TNF intracellular domains
(ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-
domain 2 secreted into the extracellular space (By similarity).
{ECO:0000250}.
-!- PTM: The membrane form, but not the soluble form, is
phosphorylated on serine residues. Dephosphorylation of the
membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By
similarity). {ECO:0000250}.
-!- PTM: O-glycosylated; glycans contain galactose, N-
acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000250}.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; D00475; BAA00367.1; -; Genomic_DNA.
EMBL; X66539; CAA47146.1; -; mRNA.
EMBL; AJ002278; CAA05290.1; -; mRNA.
EMBL; L00981; AAA16275.1; -; Genomic_DNA.
EMBL; AF329982; AAK53568.1; -; Genomic_DNA.
EMBL; AF329983; AAK53569.1; -; Genomic_DNA.
EMBL; AF329984; AAK53570.1; -; Genomic_DNA.
EMBL; AF329985; AAK53571.1; -; Genomic_DNA.
EMBL; AF329986; AAK53572.1; -; Genomic_DNA.
EMBL; AF329987; AAK53573.1; -; Genomic_DNA.
EMBL; AF269159; AAF82567.1; -; mRNA.
EMBL; AF269160; AAF82568.1; -; mRNA.
EMBL; AY427673; AAR91624.1; -; Genomic_DNA.
EMBL; AY427674; AAR91625.1; -; Genomic_DNA.
EMBL; AY427675; AAR91626.1; -; Genomic_DNA.
EMBL; BX883046; CAE84003.1; -; Genomic_DNA.
EMBL; BC107671; AAI07672.1; -; mRNA.
EMBL; L19123; AAA42255.1; -; Genomic_DNA.
PIR; JU0029; JU0029.
RefSeq; NP_036807.1; NM_012675.3.
RefSeq; XP_008770997.1; XM_008772775.2.
SMR; P16599; -.
DIP; DIP-39461N; -.
IntAct; P16599; 74.
STRING; 10116.ENSRNOP00000001110; -.
BindingDB; P16599; -.
PhosphoSitePlus; P16599; -.
PaxDb; P16599; -.
PRIDE; P16599; -.
Ensembl; ENSRNOT00000001110; ENSRNOP00000001110; ENSRNOG00000000837.
Ensembl; ENSRNOT00000079677; ENSRNOP00000074520; ENSRNOG00000055156.
GeneID; 103694380; -.
GeneID; 24835; -.
KEGG; rno:103694380; -.
KEGG; rno:24835; -.
UCSC; RGD:3876; rat.
CTD; 7124; -.
RGD; 3876; Tnf.
eggNOG; ENOG410ISAN; Eukaryota.
eggNOG; ENOG410YQC4; LUCA.
GeneTree; ENSGT00970000193380; -.
HOGENOM; HOG000048729; -.
InParanoid; P16599; -.
KO; K03156; -.
OMA; SPCHRET; -.
OrthoDB; 1124938at2759; -.
PhylomeDB; P16599; -.
TreeFam; TF332169; -.
Reactome; R-RNO-5357786; TNFR1-induced proapoptotic signaling.
Reactome; R-RNO-5357905; Regulation of TNFR1 signaling.
Reactome; R-RNO-5357956; TNFR1-induced NFkappaB signaling pathway.
Reactome; R-RNO-5626978; TNFR1-mediated ceramide production.
Reactome; R-RNO-5668541; TNFR2 non-canonical NF-kB pathway.
Reactome; R-RNO-75893; TNF signaling.
PRO; PR:P16599; -.
Proteomes; UP000002494; Chromosome 20.
Bgee; ENSRNOG00000000837; Expressed in 2 organ(s), highest expression level in spleen.
Genevisible; P16599; RN.
GO; GO:0009986; C:cell surface; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IDA:RGD.
GO; GO:0009897; C:external side of plasma membrane; IDA:RGD.
GO; GO:0005615; C:extracellular space; IDA:RGD.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043025; C:neuronal cell body; IDA:RGD.
GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IDA:RGD.
GO; GO:0002526; P:acute inflammatory response; IEP:RGD.
GO; GO:0006915; P:apoptotic process; IDA:RGD.
GO; GO:0019722; P:calcium-mediated signaling; IDA:RGD.
GO; GO:0001775; P:cell activation; IDA:RGD.
GO; GO:1904646; P:cellular response to amyloid-beta; IEP:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
GO; GO:0071300; P:cellular response to retinoic acid; IEP:RGD.
GO; GO:0007623; P:circadian rhythm; IEP:RGD.
GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:RGD.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IBA:GO_Central.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0006954; P:inflammatory response; TAS:RGD.
GO; GO:0097527; P:necroptotic signaling pathway; ISS:UniProtKB.
GO; GO:0008285; P:negative regulation of cell population proliferation; IDA:RGD.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IDA:RGD.
GO; GO:0046325; P:negative regulation of glucose import; IDA:RGD.
GO; GO:0002037; P:negative regulation of L-glutamate import across plasma membrane; IDA:RGD.
GO; GO:0031642; P:negative regulation of myelination; IMP:RGD.
GO; GO:0045760; P:positive regulation of action potential; IDA:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0090197; P:positive regulation of chemokine secretion; IDA:ARUK-UCL.
GO; GO:0050754; P:positive regulation of fractalkine biosynthetic process; IDA:ARUK-UCL.
GO; GO:0010628; P:positive regulation of gene expression; IDA:UniProtKB.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IDA:ARUK-UCL.
GO; GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
GO; GO:0032741; P:positive regulation of interleukin-18 production; IMP:RGD.
GO; GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IDA:ARUK-UCL.
GO; GO:2000778; P:positive regulation of interleukin-6 secretion; IDA:ARUK-UCL.
GO; GO:0045840; P:positive regulation of mitotic nuclear division; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:ARUK-UCL.
GO; GO:0051000; P:positive regulation of nitric-oxide synthase activity; IC:ARUK-UCL.
GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IDA:ARUK-UCL.
GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IMP:ARUK-UCL.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IMP:ARUK-UCL.
GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IMP:ARUK-UCL.
GO; GO:0051222; P:positive regulation of protein transport; IDA:RGD.
GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IDA:ARUK-UCL.
GO; GO:0050806; P:positive regulation of synaptic transmission; IMP:RGD.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IDA:ARUK-UCL.
GO; GO:0042127; P:regulation of cell population proliferation; IDA:RGD.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:ARUK-UCL.
GO; GO:0014823; P:response to activity; IEP:RGD.
GO; GO:0042493; P:response to drug; IEP:RGD.
GO; GO:1990268; P:response to gold nanoparticle; IEP:RGD.
GO; GO:0001666; P:response to hypoxia; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IMP:UniProtKB.
GO; GO:0009612; P:response to mechanical stimulus; IEP:RGD.
GO; GO:0009314; P:response to radiation; IEP:RGD.
GO; GO:0007165; P:signal transduction; IDA:RGD.
GO; GO:0003009; P:skeletal muscle contraction; IEP:RGD.
GO; GO:0034138; P:toll-like receptor 3 signaling pathway; IMP:UniProtKB.
GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IBA:GO_Central.
GO; GO:0042311; P:vasodilation; IMP:RGD.
CDD; cd00184; TNF; 1.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR006053; TNF.
InterPro; IPR002959; TNF_alpha.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
PANTHER; PTHR11471:SF23; PTHR11471:SF23; 1.
Pfam; PF00229; TNF; 1.
PRINTS; PR01234; TNECROSISFCT.
PRINTS; PR01235; TNFALPHA.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Cytokine; Disulfide bond;
Glycoprotein; Lipoprotein; Membrane; Myristate; Phosphoprotein;
Reference proteome; Secreted; Signal-anchor; Transmembrane;
Transmembrane helix.
CHAIN 1 235 Tumor necrosis factor, membrane form.
/FTId=PRO_0000034451.
CHAIN 1 39 Intracellular domain 1. {ECO:0000250}.
/FTId=PRO_0000417287.
CHAIN 1 35 Intracellular domain 2. {ECO:0000250}.
/FTId=PRO_0000417288.
CHAIN 50 ? C-domain 1. {ECO:0000250}.
/FTId=PRO_0000417289.
CHAIN 52 ? C-domain 2. {ECO:0000250}.
/FTId=PRO_0000417290.
CHAIN 80 235 Tumor necrosis factor, soluble form.
/FTId=PRO_0000034452.
TOPO_DOM 1 35 Cytoplasmic. {ECO:0000255}.
TRANSMEM 36 56 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 57 235 Extracellular. {ECO:0000255}.
SITE 34 35 Cleavage; by SPPL2A or SPPL2B.
{ECO:0000250}.
SITE 39 40 Cleavage; by SPPL2A or SPPL2B.
{ECO:0000250}.
SITE 49 50 Cleavage; by SPPL2A or SPPL2B.
{ECO:0000250}.
SITE 51 52 Cleavage; by SPPL2A or SPPL2B.
{ECO:0000250}.
SITE 79 80 Cleavage; by ADAM17. {ECO:0000250}.
MOD_RES 2 2 Phosphoserine; by CK1. {ECO:0000250}.
LIPID 19 19 N6-myristoyl lysine. {ECO:0000250}.
LIPID 20 20 N6-myristoyl lysine. {ECO:0000250}.
CARBOHYD 83 83 O-linked (GalNAc...) serine; in soluble
form. {ECO:0000250}.
CARBOHYD 86 86 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 148 179 {ECO:0000250}.
VARIANT 122 122 L -> P. {ECO:0000269|Ref.5}.
VARIANT 190 190 K -> E. {ECO:0000269|Ref.5}.
CONFLICT 39 39 L -> P (in Ref. 2; CAA05290/CAA47146).
{ECO:0000305}.
CONFLICT 163 163 I -> T (in Ref. 2; CAA05290/CAA47146).
{ECO:0000305}.
CONFLICT 202 202 F -> S (in Ref. 2; CAA05290/CAA47146).
{ECO:0000305}.
SEQUENCE 235 AA; 25806 MW; B808EC6D049C2F3B CRC64;
MSTESMIRDV ELAEEALPKK MGGLQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPNK
EEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ AEEQLEWLSQ RANALLANGM
DLKDNQLVVP ADGLYLIYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVS LLSAIKSPCP
KDTPEGAELK PWYEPMYLGG VFQLEKGDLL SAEVNLPKYL DITESGQVYF GVIAL


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WP1689: Porphyrin and chlorophyll metabolism
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WP927: Signaling of Hepatocyte Growth Factor Receptor
WP2249: Metastatic brain tumor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1983: Splicing factor NOVA regulated synpatic proteins
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP272: Blood Clotting Cascade
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP313: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP537: Translation Factors
WP32: Translation Factors
WP1566: Citrate cycle (TCA cycle)
WP149: Translation Factors
WP1486: Intracellular trafficking of CFTR
WP2256: Integrated Pancreatic Cancer Pathway
WP1948: Citrate cycle (TCA cycle)
WP307: Translation Factors

Related Genes :
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form] (Fragment)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

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