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Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

 TNFL6_RAT               Reviewed;         278 AA.
P36940;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
18-SEP-2019, entry version 158.
RecName: Full=Tumor necrosis factor ligand superfamily member 6;
AltName: Full=CD95 ligand;
Short=CD95-L;
AltName: Full=Fas antigen ligand;
Short=Fas ligand;
Short=FasL;
AltName: CD_antigen=CD178;
Contains:
RecName: Full=Tumor necrosis factor ligand superfamily member 6, membrane form;
Contains:
RecName: Full=Tumor necrosis factor ligand superfamily member 6, soluble form;
AltName: Full=Receptor-binding FasL ectodomain;
AltName: Full=Soluble Fas ligand;
Short=sFasL;
Contains:
RecName: Full=ADAM10-processed FasL form;
Short=APL;
Contains:
RecName: Full=FasL intracellular domain;
Short=FasL ICD;
AltName: Full=SPPL2A-processed FasL form;
Short=SPA;
Name=Faslg; Synonyms=Apt1Lg1, Cd95l, Fasl, Tnfsf6;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, AND INDUCTION.
PubMed=7505205; DOI=10.1016/0092-8674(93)90326-l;
Suda T., Takahashi T., Golstein P., Nagata S.;
"Molecular cloning and expression of the Fas ligand, a novel member of
the tumor necrosis factor family.";
Cell 75:1169-1178(1993).
-!- FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that
transduces the apoptotic signal into cells (PubMed:7505205).
Involved in cytotoxic T-cell-mediated apoptosis, natural killer
cell-mediated apoptosis and in T-cell development
(PubMed:7505205). Initiates fratricidal/suicidal activation-
induced cell death (AICD) in antigen-activated T-cells
contributing to the termination of immune responses (By
similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the
induction of peripheral tolerance (By similarity). Binds to
TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By
similarity). {ECO:0000250|UniProtKB:P41047,
ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:7505205}.
-!- FUNCTION: Tumor necrosis factor ligand superfamily member 6,
soluble form: Induces FAS-mediated activation of NF-kappa-B,
initiating non-apoptotic signaling pathways. Can induce apoptosis
but does not appear to be essential for this process.
{ECO:0000250|UniProtKB:P41047}.
-!- FUNCTION: FasL intracellular domain: Cytoplasmic form induces gene
transcription inhibition. {ECO:0000250|UniProtKB:P48023}.
-!- SUBUNIT: Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK,
CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN,
HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1,
NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3,
SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1,
SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.
{ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7505205};
Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic
vesicle lumen {ECO:0000250|UniProtKB:P48023}. Lysosome lumen
{ECO:0000250|UniProtKB:P48023}. Note=Colocalizes with the SPPL2A
protease at the cell membrane. Is internalized into multivesicular
bodies of secretory lysosomes after phosphorylation by FGR and
monoubiquitination. {ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: Tumor necrosis factor ligand superfamily
member 6, soluble form: Secreted {ECO:0000250|UniProtKB:P48023}.
Note=May be released into the extracellular fluid by cleavage from
the cell surface. {ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: FasL intracellular domain: Nucleus
{ECO:0000250|UniProtKB:P48023}. Note=The FasL ICD cytoplasmic form
is translocated into the nucleus. {ECO:0000250|UniProtKB:P48023}.
-!- TISSUE SPECIFICITY: Expressed in activated splenocytes and
thymocytes. Moderate or weak expression found in small intestines,
kidney and lung. {ECO:0000269|PubMed:7505205}.
-!- INDUCTION: By PMA/ionomycin and concanavalin/interleukin-2.
{ECO:0000269|PubMed:7505205}.
-!- PTM: The soluble form derives from the membrane form by
proteolytic processing. The membrane-bound form undergoes two
successive intramembrane proteolytic cleavages. The first one is
processed by ADAM10 producing an N-terminal fragment, which lacks
the receptor-binding extracellular domain. This ADAM10-processed
FasL (FasL APL) remnant form is still membrane anchored and
further processed by SPPL2A that liberates the FasL intracellular
domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for
subsequent intramembrane cleavage by SPPL2A in T-cells.
{ECO:0000250|UniProtKB:P48023}.
-!- PTM: Phosphorylated by FGR on tyrosine residues; this is required
for ubiquitination and subsequent internalization.
{ECO:0000250|UniProtKB:P48023}.
-!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:P48023}.
-!- PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:P48023}.
-!- SIMILARITY: Belongs to the tumor necrosis factor family.
{ECO:0000305}.
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EMBL; U03470; AAC52129.1; -; mRNA.
PIR; A49266; A49266.
RefSeq; NP_037040.1; NM_012908.1.
RefSeq; XP_006250210.1; XM_006250148.3.
RefSeq; XP_008767829.1; XM_008769607.2.
RefSeq; XP_017454164.1; XM_017598675.1.
SMR; P36940; -.
STRING; 10116.ENSRNOP00000003998; -.
PhosphoSitePlus; P36940; -.
PaxDb; P36940; -.
PRIDE; P36940; -.
Ensembl; ENSRNOT00000003998; ENSRNOP00000003998; ENSRNOG00000002978.
GeneID; 25385; -.
KEGG; rno:25385; -.
UCSC; RGD:3880; rat.
CTD; 356; -.
RGD; 3880; Faslg.
eggNOG; ENOG410IHZF; Eukaryota.
eggNOG; ENOG4112D9R; LUCA.
GeneTree; ENSGT00970000193380; -.
HOGENOM; HOG000290680; -.
InParanoid; P36940; -.
KO; K04389; -.
OMA; PLNHKVY; -.
OrthoDB; 1029363at2759; -.
PhylomeDB; P36940; -.
TreeFam; TF332169; -.
Reactome; R-RNO-3371378; Regulation by c-FLIP.
Reactome; R-RNO-5213460; RIPK1-mediated regulated necrosis.
Reactome; R-RNO-5218900; CASP8 activity is inhibited.
Reactome; R-RNO-69416; Dimerization of procaspase-8.
Reactome; R-RNO-75157; FasL/ CD95L signaling.
PRO; PR:P36940; -.
Proteomes; UP000002494; Chromosome 13.
Bgee; ENSRNOG00000002978; Expressed in 8 organ(s), highest expression level in spleen.
ExpressionAtlas; P36940; baseline and differential.
Genevisible; P36940; RN.
GO; GO:0005901; C:caveola; IDA:RGD.
GO; GO:0031410; C:cytoplasmic vesicle; IDA:RGD.
GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO; GO:0045121; C:membrane raft; IDA:RGD.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005123; F:death receptor binding; IPI:RGD.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IMP:RGD.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0030644; P:cellular chloride ion homeostasis; IDA:RGD.
GO; GO:0048388; P:endosomal lumen acidification; IDA:RGD.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IMP:RGD.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0006925; P:inflammatory cell apoptotic process; IGI:RGD.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:RGD.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0045742; P:positive regulation of epidermal growth factor receptor signaling pathway; IMP:RGD.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IBA:GO_Central.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:1903514; P:release of sequestered calcium ion into cytosol by endoplasmic reticulum; IEA:Ensembl.
GO; GO:0070848; P:response to growth factor; IEP:RGD.
GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
GO; GO:0046666; P:retinal cell programmed cell death; IEA:Ensembl.
GO; GO:0070231; P:T cell apoptotic process; IEA:Ensembl.
CDD; cd00184; TNF; 1.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR028326; FASL.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
PRINTS; PR01681; FASLIGAND.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Apoptosis; Cell membrane; Complete proteome; Cytokine;
Cytoplasmic vesicle; Disulfide bond; Glycoprotein; Lysosome; Membrane;
Nucleus; Reference proteome; Repressor; Secreted; Signal-anchor;
Transcription; Transcription regulation; Transmembrane;
Transmembrane helix; Ubl conjugation.
CHAIN 1 278 Tumor necrosis factor ligand superfamily
member 6, membrane form.
/FTId=PRO_0000034512.
CHAIN 1 126 ADAM10-processed FasL form.
{ECO:0000250}.
/FTId=PRO_0000417163.
CHAIN 1 79 FasL intracellular domain. {ECO:0000250}.
/FTId=PRO_0000417164.
CHAIN 127 278 Tumor necrosis factor ligand superfamily
member 6, soluble form. {ECO:0000250}.
/FTId=PRO_0000034513.
TOPO_DOM 1 77 Cytoplasmic. {ECO:0000255}.
TRANSMEM 78 99 Helical; Signal-anchor for type II
membrane protein. {ECO:0000255}.
TOPO_DOM 100 278 Extracellular. {ECO:0000255}.
COMPBIAS 4 69 Pro-rich.
COMPBIAS 45 58 Poly-Pro.
SITE 78 79 Cleavage; by SPPL2A. {ECO:0000250}.
SITE 126 127 Cleavage; by ADAM10. {ECO:0000250}.
CARBOHYD 116 116 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 247 247 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 257 257 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 199 230 {ECO:0000250|UniProtKB:P48023}.
SEQUENCE 278 AA; 31140 MW; 2898E18A862CEAC6 CRC64;
MQQPVNYPCP QIYWVDSSAT SPWAPPGSVF SCPSSGPRGP GQRRPPPPPP PPSPLPPPSQ
PPPLPPLSPL KKKDNIELWL PVIFFMVLVA LVGMGLGMYQ LFHLQKELAE LREFTNHSLR
VSSFEKQIAN PSTPSETKKP RSVAHLTGNP RSRSIPLEWE DTYGTALISG VKYKKGGLVI
NEAGLYFVYS KVYFRGQSCN SQPLSHKVYM RNFKYPGDLV LMEEKKLNYC TTGQIWAHSS
YLGAVFNLTV ADHLYVNISQ LSLINFEESK TFFGLYKL


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Pathways :
WP1825: GPCR ligand binding
WP2355: Corticotropin-releasing hormone
WP353: Small Ligand GPCRs
WP746: Small Ligand GPCRs
WP161: Small Ligand GPCRs
WP971: Small Ligand GPCRs
WP853: Small Ligand GPCRs
WP1089: Small Ligand GPCRs
WP247: Small Ligand GPCRs
WP1317: Small Ligand GPCRs
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP1254: Apoptosis
WP1772: Apoptosis Modulation and Signaling
WP493: MAPK signaling pathway
WP571: FAS pathway and Stress induction of HSP regulation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
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WP94: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
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WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
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Related Genes :
[Faslg Apt1Lg1 Cd95l Fasl Tnfsf6] Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Fas Apt1 Tnfrsf6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[FAS APT1 FAS1 TNFRSF6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnfsf11 Opgl Rankl Trance] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Fas Apt1 Tnfrsf6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF11 OPGL RANKL TRANCE] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form]
[TNFSF14 HVEML LIGHT UNQ391/PRO726] Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

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