GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

 TNFL6_CERAT             Reviewed;         280 AA.
Q9BDN1;
06-JUN-2002, integrated into UniProtKB/Swiss-Prot.
01-JUN-2001, sequence version 1.
02-JUN-2021, entry version 113.
RecName: Full=Tumor necrosis factor ligand superfamily member 6;
AltName: Full=CD95 ligand;
Short=CD95-L;
AltName: Full=Fas antigen ligand;
Short=Fas ligand;
Short=FasL;
AltName: CD_antigen=CD178;
Contains:
RecName: Full=Tumor necrosis factor ligand superfamily member 6, membrane form;
Contains:
RecName: Full=Tumor necrosis factor ligand superfamily member 6, soluble form;
AltName: Full=Receptor-binding FasL ectodomain;
AltName: Full=Soluble Fas ligand;
Short=sFasL;
Contains:
RecName: Full=ADAM10-processed FasL form;
Short=APL;
Contains:
RecName: Full=FasL intracellular domain;
Short=FasL ICD;
AltName: Full=SPPL2A-processed FasL form;
Short=SPA;
Name=FASLG; Synonyms=CD95L, FASL, TNFSF6;
Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Cercopithecinae; Cercocebus.
NCBI_TaxID=9531;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lymphocyte;
PubMed=11491535; DOI=10.1007/s002510100322;
Villinger F.J., Bostik P., Mayne A.E., King C.L., Genain C.P., Weiss W.R.,
Ansari A.A.;
"Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-
ligand and co-stimulatory molecules.";
Immunogenetics 53:315-328(2001).
-!- FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that
transduces the apoptotic signal into cells. Involved in cytotoxic T-
cell-mediated apoptosis, natural killer cell-mediated apoptosis and in
T-cell development. Initiates fratricidal/suicidal activation-induced
cell death (AICD) in antigen-activated T-cells contributing to the
termination of immune responses. TNFRSF6/FAS-mediated apoptosis has
also a role in the induction of peripheral tolerance. Binds to
TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis.
{ECO:0000250|UniProtKB:P41047, ECO:0000250|UniProtKB:P48023}.
-!- FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble
form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-
apoptotic signaling pathways. Can induce apoptosis but does not appear
to be essential for this process. {ECO:0000250|UniProtKB:P41047}.
-!- FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene
transcription inhibition. {ECO:0000250|UniProtKB:P48023}.
-!- SUBUNIT: Homotrimer. Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3,
CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK,
ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD,
OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A,
SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3,
TEC, TJP3 and YES1. {ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48023};
Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic vesicle
lumen {ECO:0000250|UniProtKB:P48023}. Lysosome lumen
{ECO:0000250|UniProtKB:P48023}. Note=Colocalizes with the SPPL2A
protease at the cell membrane. Is internalized into multivesicular
bodies of secretory lysosomes after phosphorylation by FGR and
monoubiquitination. {ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member
6, soluble form]: Secreted {ECO:0000250|UniProtKB:P48023}. Note=May be
released into the extracellular fluid by cleavage from the cell
surface. {ECO:0000250|UniProtKB:P48023}.
-!- SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus
{ECO:0000250|UniProtKB:P48023}. Note=The FasL ICD cytoplasmic form is
translocated into the nucleus. {ECO:0000250|UniProtKB:P48023}.
-!- PTM: The soluble form derives from the membrane form by proteolytic
processing. The membrane-bound form undergoes two successive
intramembrane proteolytic cleavages. The first one is processed by
ADAM10 producing an N-terminal fragment, which lacks the receptor-
binding extracellular domain. This ADAM10-processed FasL (FasL APL)
remnant form is still membrane anchored and further processed by SPPL2A
that liberates the FasL intracellular domain (FasL ICD). FasL shedding
by ADAM10 is a prerequisite for subsequent intramembrane cleavage by
SPPL2A in T-cells. {ECO:0000250|UniProtKB:P48023}.
-!- PTM: Phosphorylated by FGR on tyrosine residues; this is required for
ubiquitination and subsequent internalization.
{ECO:0000250|UniProtKB:P48023}.
-!- PTM: N-glycosylated. Glycosylation enhances apoptotic activity.
{ECO:0000250|UniProtKB:P48023}.
-!- PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:P48023}.
-!- SIMILARITY: Belongs to the tumor necrosis factor family. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; AF344847; AAK37606.1; -; mRNA.
RefSeq; NP_001292889.1; NM_001305960.1.
SMR; Q9BDN1; -.
Ensembl; ENSCATT00000045516; ENSCATP00000021314; ENSCATG00000034389.
GeneID; 105597557; -.
CTD; 356; -.
GeneTree; ENSGT01030000234737; -.
OMA; PQIFWVD; -.
OrthoDB; 1029363at2759; -.
Proteomes; UP000233060; Unplaced.
GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043202; C:lysosomal lumen; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; ISS:AgBase.
GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
GO; GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
GO; GO:0006955; P:immune response; IEA:InterPro.
GO; GO:0097527; P:necroptotic signaling pathway; IEA:Ensembl.
GO; GO:0016525; P:negative regulation of angiogenesis; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:2000353; P:positive regulation of endothelial cell apoptotic process; IEA:Ensembl.
GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
GO; GO:1905782; P:positive regulation of phosphatidylserine exposure on apoptotic cell surface; IEA:Ensembl.
GO; GO:1903514; P:release of sequestered calcium ion into cytosol by endoplasmic reticulum; IEA:Ensembl.
GO; GO:0046666; P:retinal cell programmed cell death; IEA:Ensembl.
GO; GO:0070231; P:T cell apoptotic process; IEA:Ensembl.
CDD; cd00184; TNF; 1.
Gene3D; 2.60.120.40; -; 1.
InterPro; IPR028326; FASL.
InterPro; IPR006053; TNF.
InterPro; IPR021184; TNF_CS.
InterPro; IPR006052; TNF_dom.
InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
Pfam; PF00229; TNF; 1.
PRINTS; PR01681; FASLIGAND.
PRINTS; PR01234; TNECROSISFCT.
SMART; SM00207; TNF; 1.
SUPFAM; SSF49842; SSF49842; 1.
PROSITE; PS00251; TNF_1; 1.
PROSITE; PS50049; TNF_2; 1.
2: Evidence at transcript level;
Apoptosis; Cell membrane; Cytokine; Cytoplasmic vesicle; Disulfide bond;
Glycoprotein; Lysosome; Membrane; Nucleus; Reference proteome; Repressor;
Secreted; Signal-anchor; Transcription; Transcription regulation;
Transmembrane; Transmembrane helix; Ubl conjugation.
CHAIN 1..280
/note="Tumor necrosis factor ligand superfamily member 6,
membrane form"
/id="PRO_0000034498"
CHAIN 1..128
/note="ADAM10-processed FasL form"
/evidence="ECO:0000250"
/id="PRO_0000417148"
CHAIN 1..81
/note="FasL intracellular domain"
/evidence="ECO:0000250"
/id="PRO_0000417149"
CHAIN 129..280
/note="Tumor necrosis factor ligand superfamily member 6,
soluble form"
/evidence="ECO:0000250"
/id="PRO_0000034499"
TOPO_DOM 1..80
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 81..101
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 102..280
/note="Extracellular"
/evidence="ECO:0000255"
REGION 20..70
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 117..155
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 26..70
/note="Pro residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 133..148
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SITE 80..81
/note="Cleavage; by SPPL2A"
/evidence="ECO:0000250"
SITE 128..129
/note="Cleavage; by ADAM10"
/evidence="ECO:0000250"
CARBOHYD 183
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 249
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 259
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 201..232
/evidence="ECO:0000250|UniProtKB:P48023"
SEQUENCE 280 AA; 31408 MW; 729EA60067B7D398 CRC64;
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP PPPLPPPPPP
PLPPLPLPPL KKRGNHSTGL CLLVMFFMVL VALVGLGLGM FQLFHLQKEL AELRESTSQK
HTASSLEKQI GHPSPPPEKK EQRKVAHLTG KPNSRSMPLE WEDTYGIVLL SGVKYKKGGL
VINETGLYFV YSKVYFRGQS CTNLPLSHKV YMRNSKYPQD LVMMEGKMMS YCTTGQMWAH
SSYLGAVFNL TSTDHLYVNV SELSLVNFEE SQTFFGLYKL


Related products :

Catalog number Product name Quantity
E0031p ELISA CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Pig,Sus scrofa,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
U0031p CLIA CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Pig,Sus scrofa,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
E0031p ELISA kit CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Pig,Sus scrofa,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
E0031h ELISA kit Apoptosis antigen ligand,APT1LG1,APTL,CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Homo sapiens,Human,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
U0031h CLIA Apoptosis antigen ligand,APT1LG1,APTL,CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Homo sapiens,Human,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
E0031h ELISA Apoptosis antigen ligand,APT1LG1,APTL,CD95 ligand,CD95L,CD95-L,Fas antigen ligand,Fas ligand,FASL,FASLG,Homo sapiens,Human,TNFSF6,Tumor necrosis factor ligand superfamily member 6 96T
E0031r ELISA Apt1Lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,Rat,Rattus norvegicus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
E0031r ELISA kit Apt1Lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,Rat,Rattus norvegicus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
U0031m CLIA Apt1lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,gld,Mouse,Mus musculus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
U0031r CLIA Apt1Lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,Rat,Rattus norvegicus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
E0031m ELISA kit Apt1lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,gld,Mouse,Mus musculus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
E0031m ELISA Apt1lg1,CD95 ligand,Cd95l,CD95-L,Fas antigen ligand,Fas ligand,Fasl,Faslg,gld,Mouse,Mus musculus,Tnfsf6,Tumor necrosis factor ligand superfamily member 6 96T
18-003-42883 Tumor necrosis factor ligand superfamily member 6 - Fas antigen ligand; Fas ligand; CD178 antigen; CD95L protein; Apoptosis antigen ligand; APTL Polyclonal 0.1 mg Protein A
RF0038-10 Recombinant Human sRANK Ligand (Receptor activator of nuclear factor kappa-B ligand); Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activatio 10ug
RF0038-100 Recombinant Human sRANK Ligand (Receptor activator of nuclear factor kappa-B ligand); Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activatio 100ug
RF0038-50 Recombinant Human sRANK Ligand (Receptor activator of nuclear factor kappa-B ligand); Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activatio 50ug
18-003-42879 Tumor necrosis factor ligand superfamily member 10 - TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Polyclonal 0.05 mg Aff Pur
15-288-21166 Tumor necrosis factor ligand superfamily member 10 - TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Polyclonal 0.05 mg
15-288-21166 Tumor necrosis factor ligand superfamily member 10 - TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Polyclonal 0.1 mg
18-661-15007 Tumor necrosis factor ligand superfamily member 10 - TNF-related apoptosis-inducing ligand; Protein TRAIL; Apo-2 ligand; Apo-2L; CD253 antigen Polyclonal 0.1 mg
188-01473 RANK Ligand Soluble, Human, recombinant  (RANKL) Receptor activator of nuclear factor kappa_B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF_related ac 1 mg
RF0038 Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activation-induced cytokine (TRANCE), Recombinant Human sRANK Ligand (Receptor activator of nuc 100ug
RF0038 Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activation-induced cytokine (TRANCE), Recombinant Human sRANK Ligand (Receptor activator of nuc 50ug
RF0038 Tumor necrosis factor ligand superfamily member 11 (TNFSF11), Osteoprotegerin ligand (OPGL), TNF-related activation-induced cytokine (TRANCE), Recombinant Human sRANK Ligand (Receptor activator of nuc 10ug
18-661-15142 TNF superfamily ligand TL1A - Tumor necrosis factor (Ligand) superfamily. member 15 Polyclonal 0.1 mg
Pathways :
WP1825: GPCR ligand binding
WP2355: Corticotropin-releasing hormone
WP353: Small Ligand GPCRs
WP746: Small Ligand GPCRs
WP161: Small Ligand GPCRs
WP971: Small Ligand GPCRs
WP853: Small Ligand GPCRs
WP1089: Small Ligand GPCRs
WP247: Small Ligand GPCRs
WP1317: Small Ligand GPCRs
WP1834: Interactions of the immunoglobulin superfamily (IgSF) member proteins
WP1254: Apoptosis
WP1772: Apoptosis Modulation and Signaling
WP493: MAPK signaling pathway
WP571: FAS pathway and Stress induction of HSP regulation
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP927: Signaling of Hepatocyte Growth Factor Receptor

Related Genes :
[Faslg Apt1Lg1 Cd95l Fasl Tnfsf6] Tumor necrosis factor ligand superfamily member 6 (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form; Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL); ADAM10-processed FasL form (APL); FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Fas Apt1 Tnfrsf6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[FAS APT1 FAS1 TNFRSF6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnfsf11 Opgl Rankl Trance] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[Fas Apt1 Tnfrsf6] Tumor necrosis factor receptor superfamily member 6 (Apo-1 antigen) (Apoptosis-mediating surface antigen FAS) (FASLG receptor) (CD antigen CD95)
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[Tnf Tnfa Tnfsf2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF11 OPGL RANKL TRANCE] Tumor necrosis factor ligand superfamily member 11 (Osteoclast differentiation factor) (ODF) (Osteoprotegerin ligand) (OPGL) (Receptor activator of nuclear factor kappa-B ligand) (RANKL) (TNF-related activation-induced cytokine) (TRANCE) (CD antigen CD254) [Cleaved into: Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form]
[CD40LG CD40L TNFSF5 TRAP] CD40 ligand (CD40-L) (T-cell antigen Gp39) (TNF-related activation protein) (TRAP) (Tumor necrosis factor ligand superfamily member 5) (CD antigen CD154) [Cleaved into: CD40 ligand, membrane form; CD40 ligand, soluble form (sCD40L)]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF14 HVEML LIGHT UNQ391/PRO726] Tumor necrosis factor ligand superfamily member 14 (Herpes virus entry mediator ligand) (HVEM-L) (Herpesvirus entry mediator ligand) (CD antigen CD258) [Cleaved into: Tumor necrosis factor ligand superfamily member 14, membrane form; Tumor necrosis factor ligand superfamily member 14, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNFSF13B BAFF BLYS TALL1 TNFSF20 ZTNF4 UNQ401/PRO738] Tumor necrosis factor ligand superfamily member 13B (B lymphocyte stimulator) (BLyS) (B-cell-activating factor) (BAFF) (Dendritic cell-derived TNF-like molecule) (TNF- and APOL-related leukocyte expressed ligand 1) (TALL-1) (CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]
[TNF TNFA TNFSF2] Tumor necrosis factor (Cachectin) (TNF-alpha) (Tumor necrosis factor ligand superfamily member 2) (TNF-a) [Cleaved into: Tumor necrosis factor, membrane form (N-terminal fragment) (NTF); Intracellular domain 1 (ICD1); Intracellular domain 2 (ICD2); C-domain 1; C-domain 2; Tumor necrosis factor, soluble form]

Bibliography :