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Tyrosine-protein kinase (EC 2 7 10 2)

 H0VJS5_CAVPO            Unreviewed;       512 AA.
H0VJS5;
22-FEB-2012, integrated into UniProtKB/TrEMBL.
22-FEB-2012, sequence version 1.
11-DEC-2019, entry version 59.
RecName: Full=Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096};
EC=2.7.10.2 {ECO:0000256|RuleBase:RU362096};
Name=LYN {ECO:0000313|Ensembl:ENSCPOP00000010517};
Cavia porcellus (Guinea pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
Cavia.
NCBI_TaxID=10141 {ECO:0000313|Ensembl:ENSCPOP00000010517};
[1] {ECO:0000313|Ensembl:ENSCPOP00000010517}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010517};
PubMed=21993624; DOI=10.1038/nature10530;
Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
"A high-resolution map of human evolutionary constraint using 29 mammals.";
Nature 478:476-482(2011).
[2] {ECO:0000313|Ensembl:ENSCPOP00000010517}
IDENTIFICATION.
STRAIN=2N {ECO:0000313|Ensembl:ENSCPOP00000010517};
Ensembl;
Submitted (JAN-2012) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
Evidence={ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS01115681};
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00941529}.
---------------------------------------------------------------------------
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EMBL; AAKN02044914; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AAKN02044915; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003466034.1; XM_003465986.3.
STRING; 10141.ENSCPOP00000010517; -.
Ensembl; ENSCPOT00000011806; ENSCPOP00000010517; ENSCPOG00000011693.
GeneID; 100714653; -.
CTD; 4067; -.
eggNOG; KOG0197; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000158011; -.
InParanoid; H0VJS5; -.
OMA; MAYYNNT; -.
OrthoDB; 539311at2759; -.
TreeFam; TF351634; -.
Proteomes; UP000005447; Unassembled WGS sequence.
Bgee; ENSCPOG00000011693; Expressed in 3 organ(s), highest expression level in liver.
GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
GO; GO:0045121; C:membrane raft; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0046875; F:ephrin receptor binding; IEA:Ensembl.
GO; GO:0044325; F:ion channel binding; IEA:Ensembl.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
GO; GO:0140031; F:phosphorylation-dependent protein binding; IEA:Ensembl.
GO; GO:0044877; F:protein-containing complex binding; IEA:Ensembl.
GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
GO; GO:0001782; P:B cell homeostasis; IEA:Ensembl.
GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:Ensembl.
GO; GO:0071300; P:cellular response to retinoic acid; IEA:Ensembl.
GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
GO; GO:0030218; P:erythrocyte differentiation; IEA:Ensembl.
GO; GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; IEA:Ensembl.
GO; GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0030889; P:negative regulation of B cell proliferation; IEA:Ensembl.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0043407; P:negative regulation of MAP kinase activity; IEA:Ensembl.
GO; GO:0070667; P:negative regulation of mast cell proliferation; IEA:Ensembl.
GO; GO:0002762; P:negative regulation of myeloid leukocyte differentiation; IEA:Ensembl.
GO; GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; IEA:Ensembl.
GO; GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
GO; GO:0002576; P:platelet degranulation; IEA:Ensembl.
GO; GO:1902961; P:positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process; IEA:Ensembl.
GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
GO; GO:2000670; P:positive regulation of dendritic cell apoptotic process; IEA:Ensembl.
GO; GO:0070668; P:positive regulation of mast cell proliferation; IEA:Ensembl.
GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
GO; GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IEA:Ensembl.
GO; GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; IEA:Ensembl.
GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
GO; GO:0046777; P:protein autophosphorylation; IEA:Ensembl.
GO; GO:0002902; P:regulation of B cell apoptotic process; IEA:Ensembl.
GO; GO:0050855; P:regulation of B cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0050707; P:regulation of cytokine secretion; IEA:Ensembl.
GO; GO:0045646; P:regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0050727; P:regulation of inflammatory response; IEA:Ensembl.
GO; GO:0043304; P:regulation of mast cell degranulation; IEA:Ensembl.
GO; GO:0090025; P:regulation of monocyte chemotaxis; IEA:Ensembl.
GO; GO:0090330; P:regulation of platelet aggregation; IEA:Ensembl.
GO; GO:0051279; P:regulation of release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0009725; P:response to hormone; IEA:Ensembl.
GO; GO:0002513; P:tolerance induction to self antigen; IEA:Ensembl.
GO; GO:0034142; P:toll-like receptor 4 signaling pathway; IEA:Ensembl.
GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:Ensembl.
CDD; cd10364; SH2_Src_Lyn; 1.
CDD; cd12004; SH3_Lyn; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR035852; Lyn_SH2.
InterPro; IPR035748; Lyn_SH3.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
Pfam; PF07714; Pkinase_Tyr; 1.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
PRINTS; PR00109; TYRKINASE.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 1.
SMART; SM00219; TyrKc; 1.
SUPFAM; SSF50044; SSF50044; 1.
SUPFAM; SSF55550; SSF55550; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00990534};
Kinase {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00897698};
Nucleotide-binding {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00990534};
Reference proteome {ECO:0000313|Proteomes:UP000005447};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
ECO:0000256|SAAS:SAAS01042643};
Transferase {ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00897698};
Tyrosine-protein kinase {ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897698}.
DOMAIN 63..123
/note="SH3"
/evidence="ECO:0000259|PROSITE:PS50002"
DOMAIN 129..226
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 247..501
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..49
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 24..45
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 512 AA; 58617 MW; 1ECA93449364EAE0 CRC64;
MGCIKSKGKS NLNGDEIDLK TQPVRNTDRT IYVRDPTSNK QPRPVPESQL LPGQRFQAKD
PEEQGDIVVA LYPYDGIHPD DLSFKKGEKM RVLEEHGEWW KAKSLSTKRE GFIPSNYVAK
VNTLETEEWF FKDITRKDAE RQLLAPGNSP GAFLIRESET LKGSFSLSVR DFDPMHGDVI
KHYKIRSLDN GGYYISPRIT FPCISDMIKH YQKQADGLCR RLEKACISPK PQKPWDKDAW
EIPRESIKLV KKLGAGQFGE VWMGYYNNST KVAVKTLKPG TMSVQAFLEE ANLMKTLQHD
KLVRLYAVVT KEEPIYIITE YMAKGSLLDF LKSDEGGKVL LPKLIDFSAQ IAEGMAYIER
KNYIHRDLRA ANVLVSESLM CKIADFGLAR VIEDNEYTAR EGAKFPIKWT APEAINFGCF
TIKSDVWSFG ILLYEIVTYG KIPYPGRTNA DVMTALSQGY RMPRMENCPE ELYDIMKMCW
KEKAEERPTF DYLQSVLDDF YTATEGQYQQ QP


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[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Ptk2b Fak2 Pyk2] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
[ABL2 ABLL ARG] Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)
[Flt3 Flk-2 Flt-3] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase 2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Tyrosine-protein kinase receptor flk-2) (CD antigen CD135)

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