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Tyrosine-protein kinase (EC 2 7 10 2)

 X1WHN6_DANRE            Unreviewed;      1103 AA.
X1WHN6;
14-MAY-2014, integrated into UniProtKB/TrEMBL.
20-JUN-2018, sequence version 3.
26-FEB-2020, entry version 43.
RecName: Full=Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
EC=2.7.10.2 {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096};
Name=jak3 {ECO:0000313|Ensembl:ENSDARP00000129749,
ECO:0000313|ZFIN:ZDB-GENE-070725-4};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000129749, ECO:0000313|Proteomes:UP000000437};
[1] {ECO:0000313|Ensembl:ENSDARP00000129749, ECO:0000313|Proteomes:UP000000437}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129749,
ECO:0000313|Proteomes:UP000000437};
PubMed=23594743; DOI=10.1038/nature12111;
Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
"The zebrafish reference genome sequence and its relationship to the human
genome.";
Nature 496:498-503(2013).
[2] {ECO:0000313|Ensembl:ENSDARP00000129749}
IDENTIFICATION.
STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000129749};
Ensembl;
Submitted (MAR-2014) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2;
Evidence={ECO:0000256|PIRNR:PIRNR000636,
ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS01115681};
-!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
kinase family. JAK subfamily. {ECO:0000256|PIRNR:PIRNR000636}.
---------------------------------------------------------------------------
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EMBL; CR936448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSDART00000154266; ENSDARP00000129749; ENSDARG00000010252.
ZFIN; ZDB-GENE-070725-4; jak3.
eggNOG; KOG0197; Eukaryota.
eggNOG; COG0515; LUCA.
GeneTree; ENSGT00940000166579; -.
HOGENOM; CLU_008155_0_0_1; -.
Proteomes; UP000000437; Chromosome 8.
Bgee; ENSDARG00000010252; Expressed in multi-cellular organism and 14 other tissues.
ExpressionAtlas; X1WHN6; baseline.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-UniRule.
GO; GO:0016020; C:membrane; IEA:InterPro.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-UniRule.
GO; GO:0030218; P:erythrocyte differentiation; IBA:GO_Central.
GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
GO; GO:0030098; P:lymphocyte differentiation; IMP:ZFIN.
GO; GO:0001779; P:natural killer cell differentiation; IMP:ZFIN.
GO; GO:0030217; P:T cell differentiation; IMP:ZFIN.
GO; GO:0033077; P:T cell differentiation in thymus; IMP:ZFIN.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR019749; Band_41_domain.
InterPro; IPR000299; FERM_domain.
InterPro; IPR041155; FERM_F1.
InterPro; IPR041046; FERM_F2.
InterPro; IPR041381; Jak1_PHL_dom.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR008266; Tyr_kinase_AS.
InterPro; IPR020635; Tyr_kinase_cat_dom.
InterPro; IPR016251; Tyr_kinase_non-rcpt_Jak/Tyk2.
Pfam; PF18379; FERM_F1; 1.
Pfam; PF18377; FERM_F2; 1.
Pfam; PF17887; Jak1_Phl; 1.
Pfam; PF07714; Pkinase_Tyr; 2.
Pfam; PF00017; SH2; 1.
PIRSF; PIRSF000636; TyrPK_Jak; 1.
PRINTS; PR01823; JANUSKINASE.
PRINTS; PR00109; TYRKINASE.
SMART; SM00295; B41; 1.
SMART; SM00252; SH2; 1.
SMART; SM00219; TyrKc; 2.
SUPFAM; SSF55550; SSF55550; 1.
SUPFAM; SSF56112; SSF56112; 2.
PROSITE; PS50057; FERM_3; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 2.
PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PROSITE; PS50001; SH2; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|PIRSR:PIRSR000636-
2, ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00990534};
Kinase {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897698};
Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000636,
ECO:0000256|PIRSR:PIRSR000636-2, ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00990534};
Reference proteome {ECO:0000313|Proteomes:UP000000437};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
Transferase {ECO:0000256|PIRNR:PIRNR000636, ECO:0000256|RuleBase:RU362096,
ECO:0000256|SAAS:SAAS00897698};
Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000636,
ECO:0000256|RuleBase:RU362096, ECO:0000256|SAAS:SAAS00897698}.
DOMAIN 24..359
/note="FERM"
/evidence="ECO:0000259|PROSITE:PS50057"
DOMAIN 378..459
/note="SH2"
/evidence="ECO:0000259|PROSITE:PS50001"
DOMAIN 521..777
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
DOMAIN 816..1095
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
NP_BIND 822..830
/note="ATP"
/evidence="ECO:0000256|PIRSR:PIRSR000636-2"
REGION 1..20
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
ACT_SITE 943
/note="Proton acceptor"
/evidence="ECO:0000256|PIRSR:PIRSR000636-1"
BINDING 849
/note="ATP"
/evidence="ECO:0000256|PIRSR:PIRSR000636-2"
SEQUENCE 1103 AA; 126057 MW; F40B52A6109289F4 CRC64;
MSEEEEVPLM KSERAGSQRS SCDSALQVHL YYSPSLNSET TFSIPTGHVT AESVCVLAAK
ASGILPVYHN LFALASEDLS YWYPPNHLFK SEEPVKVYYR VRFFFSSWFG QESRASYRFS
LSKGRIFAVL DYAVIDYVFA QSRSDFVTGC GGISPALSLQ QECLGLAVLD LWRLAKERNQ
SLAEICNTTS YKSCLPETHR QDIQRMNRLA RYQIRKTLKR FLKKLGKCSA GERSLKLKYL
MKLSELEPDY GSESFPLHHS GWLEQSEQQR VLAVKVSGEG GIQIQKTDRQ EWQTFCDFPQ
IIDISIKRLC QEQMPLEGRV VTLTRQDDQC MEAEFQTLTD ALSFVSLVDG YFRLTTDSTH
YFCAEVAPPS LLEDIQNYCH GPITSEFAVH KLKKAGGKNG MFLLRHSPKE FDKYFLTVCI
QTPLGMDYKD CLIEKNEKFS LAGIHNSFIN LKQLIDFYQL STLYVSDIPV TLGKCCPPRA
KELTNMIIIR NSSMTEIPSS PTLQRHKPSH MQFHMIKHED LIWSESLGQG SFTHIFRGSK
IDQRDGGTHS TEVLLKVLDA NHKNCWESLF EAASLMSQIS HRHLLLVYGI SVHKSKNIMV
QEFVKHGALD LYLKRSMCVS VSWKLDVAKQ LACALNFLEE KNIAHGNICA KNLLLVREGD
SPFIKLSDPG VSMSLLGKDV VLDRIPWVAP EVLDTLEIEL ECDKWSFGTT LWEIFNGGEA
PLQGLDLMQK LQFYENFSNL PTLEWTELAE LISHCMQYQP ELRPSCRSII RQLNSLITSD
YEILHATDTL PESNGFWKKL NIFKKQQEDV FEERYLRFIS VLGKGNFGSV ELCRYDPWGD
NTGELVAVKE LQSNKQATMA DFQREIQTIS SLHCDYIVKY KGICYSTGRL STKLVMEYLP
YGSLIGYMEK HRHNVGNRKL LLFASQICKG MEYLQSMRYV HRDLAARNIL VASDNLVKIA
DFGLTKIIPV DKEYYRVTQP GESPVFWYAP ESISELKFSH KSDVWSFGIV LHELFSYCDI
SQNPKKVRES SMSLYVHSPS MAIHLLTLLK NNWRLPAPAQ CPLKVHSIMM QCWEFNSENR
PSFSSLKDLI ENSLLDEREG CKG


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Related Genes :
[Eif2ak2 Pkr Prkr Tik] Interferon-induced, double-stranded RNA-activated protein kinase (EC 2.7.11.1) (Eukaryotic translation initiation factor 2-alpha kinase 2) (eIF-2A protein kinase 2) (Interferon-inducible RNA-dependent protein kinase) (P1/eIF-2A protein kinase) (Protein kinase RNA-activated) (PKR) (Protein kinase R) (Serine/threonine-protein kinase TIK) (Tyrosine-protein kinase EIF2AK2) (EC 2.7.10.2) (p68 kinase)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQE83_22775 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Ptk2 Fadk Fak Fak1 Kiaa4203] Focal adhesion kinase 1 (FADK 1) (EC 2.7.10.2) (Focal adhesion kinase-related nonkinase) (FRNK) (Protein-tyrosine kinase 2) (p125FAK) (pp125FAK)
[ark-1 C01C7.1] Ack-related non-receptor tyrosine kinase (EC 2.7.10.2) (EC 2.7.11.1) (Ras-regulating kinase ark-1)
[Melk Kiaa0175 Pk38] Maternal embryonic leucine zipper kinase (EC 2.7.11.1) (Protein kinase PK38) (mPK38) (Tyrosine-protein kinase MELK) (EC 2.7.10.2)
[let-23 kin-7 ZK1067.1] Receptor tyrosine-protein kinase let-23 (EC 2.7.10.1) (Lethal protein 23)
[csk-1 Y48G1C.2] Tyrosine-protein kinase csk-1 (EC 2.7.10.2) (C-terminal src kinase)
[EPHB1 ELK EPHT2 HEK6 NET] Ephrin type-B receptor 1 (EC 2.7.10.1) (ELK) (EPH tyrosine kinase 2) (EPH-like kinase 6) (EK6) (hEK6) (Neuronally-expressed EPH-related tyrosine kinase) (NET) (Tyrosine-protein kinase receptor EPH-2)
[Lyn] Tyrosine-protein kinase Lyn (EC 2.7.10.2) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn)
[ABL1 ABL JTK7] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[vab-1 M03A1.1] Ephrin receptor 1 (EC 2.7.10.1) (Tyrosine-protein kinase Eph receptor) (Variable abnormal protein 1)
[Fgr] Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Proto-oncogene c-Fgr) (p55-Fgr)
[FLT1 FLT FRT VEGFR1] Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
[Abl1 Abl] Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
[cam-1 kin-8 C01G6.8] Tyrosine-protein kinase receptor cam-1 (EC 2.7.10.1)
[scd-2 T10H9.2] ALK tyrosine kinase receptor homolog scd-2 (EC 2.7.10.1) (Suppressor of constitutive dauer formation protein 2)
[EPHA2 ECK] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[src-1 Y92H12A.1] Tyrosine protein-kinase src-1 (EC 2.7.10.2) (SRC oncogene related protein 1)
[SRC] Proto-oncogene tyrosine-protein kinase Src (EC 2.7.10.2) (Proto-oncogene c-Src) (pp60c-src) (p60-Src)
[TEK TIE2 VMCM VMCM1] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (hTIE2) (p140 TEK) (CD antigen CD202b)
[PTK2B FAK2 PYK2 RAFTK] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[Ptk2b Fak2 Pyk2 Raftk] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
[EPHB2 DRT EPHT3 EPTH3 ERK HEK5 TYRO5] Ephrin type-B receptor 2 (EC 2.7.10.1) (Developmentally-regulated Eph-related tyrosine kinase) (ELK-related tyrosine kinase) (EPH tyrosine kinase 3) (EPH-like kinase 5) (EK5) (hEK5) (Renal carcinoma antigen NY-REN-47) (Tyrosine-protein kinase TYRO5) (Tyrosine-protein kinase receptor EPH-3) [Cleaved into: EphB2/CTF1; EphB2/CTF2]
[Epha2 Eck Myk2 Sek2] Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK) (Tyrosine-protein kinase receptor MPK-5) (Tyrosine-protein kinase receptor SEK-2)
[KIT SCFR] Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
[Ptk2b Fak2 Pyk2] Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2)
[FLT3 CD135 FLK2 STK1] Receptor-type tyrosine-protein kinase FLT3 (EC 2.7.10.1) (FL cytokine receptor) (Fetal liver kinase-2) (FLK-2) (Fms-like tyrosine kinase 3) (FLT-3) (Stem cell tyrosine kinase 1) (STK-1) (CD antigen CD135)
[ABL2 ABLL ARG] Tyrosine-protein kinase ABL2 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 2) (Abelson tyrosine-protein kinase 2) (Abelson-related gene protein) (Tyrosine-protein kinase ARG)

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[32565533] Plasticity of High-Density Neutrophils in Multiple Myeloma is Associated with Increased Autophagy Via STAT3.
[32528040] Holding CoVID in check through JAK? The MPN-approved compound ruxolitinib as a potential strategy to treat SARS-CoV-2 induced systemic hyperinflammation.
[32513989] The inhibition of IL-2/IL-2R gives rise to CD8 T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia.
[32503877] Inhibition of Bruton tyrosine kinase in patients with severe COVID-19.
[32441195] miR-136 improves renal fibrosis in diabetic rats by targeting down-regulation of tyrosine kinase SYK and inhibition of TGF-β1/Smad3 signaling pathway.
[32397031] [A case report of BCR-ABL negative chronic basophilic cell leukemia].
[32392562] JAK Inhibition as a New Treatment Strategy for Patients with COVID-19.
[32385146] The Society for Immunotherapy of Cancer perspective on regulation of interleukin-6 signaling in COVID-19-related systemic inflammatory response.
[32384445] Occurrence of lymphoplasmacytic lymphoma in a chronic myeloid leukemia patient following long-term treatment with tyrosine kinase inhibitors: A case report.
[32376394] Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review.