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Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)

 SHPS1_RAT               Reviewed;         509 AA.
P97710; O08951; O70426; Q9QWI5;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-1997, sequence version 1.
07-APR-2021, entry version 160.
RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1;
Short=SHP substrate 1;
Short=SHPS-1;
AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs;
Short=Bit;
AltName: Full=CD172 antigen-like family member A;
AltName: Full=Inhibitory receptor SHPS-1;
AltName: Full=Macrophage fusion receptor;
AltName: Full=Macrophage membrane protein MFP150;
AltName: Full=Signal-regulatory protein alpha-1;
Short=Sirp-alpha-1;
AltName: CD_antigen=CD172a;
Flags: Precursor;
Name=Sirpa; Synonyms=Bit, Mfr, Ptpns1, Shps1, Sirp;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 42-60; 68-91; 128-137;
150-158; 174-189; 192-202; 204-212; 218-237; 259-270; 279-282; 405-415 AND
446-453, GLYCOSYLATION, PHOSPHORYLATION AT TYROSINE RESIDUES, AND
INTERACTION WITH PTPN6 AND PTPN11.
TISSUE=Fetal fibroblast;
PubMed=8943344; DOI=10.1128/mcb.16.12.6887;
Fujioka Y., Matozaki T., Noguchi T., Iwamatsu A., Yamao T., Takahashi N.,
Tsuda M., Takada T., Kasuga M.;
"A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-
containing protein tyrosine phosphatase SHP-2 in response to mitogens and
cell adhesion.";
Mol. Cell. Biol. 16:6887-6899(1996).
[2]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 32-48 AND 446-453,
FUNCTION, AND PHOSPHORYLATION AT TYROSINE RESIDUES.
STRAIN=Sprague-Dawley; TISSUE=Brain;
PubMed=9271230; DOI=10.1016/s0014-5793(97)00724-2;
Sano S., Ohnishi H., Omori A., Hasegawa J., Kubota M.;
"BIT, an immune antigen receptor-like molecule in the brain.";
FEBS Lett. 411:327-334(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 99-107; 128-149; 192-217;
405-417; 419-429; 446-467 AND 496-506, GLYCOSYLATION, AND TISSUE
SPECIFICITY.
STRAIN=Fischer 344; TISSUE=Macrophage;
PubMed=9774638; DOI=10.1128/mcb.18.11.6213;
Saginario C., Sterling H., Beckers C., Kobayashi R., Solimena M., Ullu E.,
Vignery A.;
"MFR, a putative receptor mediating the fusion of macrophages.";
Mol. Cell. Biol. 18:6213-6223(1998).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-419, AND TISSUE SPECIFICITY.
STRAIN=WAG/Rij; TISSUE=Alveolar macrophage;
PubMed=9712053;
Adams S., van der Laan L.J.W., Vernon-Wilson E., Renardel de Lavalette C.,
Doepp E.A., Dijkstra C.D., Simmons D.L., van den Berg T.K.;
"Signal-regulatory protein is selectively expressed by myeloid and neuronal
cells.";
J. Immunol. 161:1853-1859(1998).
[5]
PROTEIN SEQUENCE OF 192-203; 218-226 AND 297-307, AND IDENTIFICATION BY
MASS SPECTROMETRY.
STRAIN=Sprague-Dawley; TISSUE=Brain;
Lubec G., Kang S.U., Lubec S.;
Submitted (SEP-2007) to UniProtKB.
[6]
PHOSPHORYLATION IN RESPONSE TO EGF, AND INTERACTION WITH PTPN11.
PubMed=9344856; DOI=10.1006/bbrc.1997.7489;
Ochi F., Matozaki T., Noguchi T., Fujioka Y., Yamao T., Takada T.,
Tsuda M., Takeda H., Fukunaga K., Okabayashi Y., Kasuga M.;
"Epidermal growth factor stimulates the tyrosine phosphorylation of SHPS-1
and association of SHPS-1 with SHP-2, a SH2 domain-containing protein
tyrosine phosphatase.";
Biochem. Biophys. Res. Commun. 239:483-487(1997).
[7]
PHOSPHORYLATION AT TYR-477 AND TYR-501, AND MUTAGENESIS OF TYR-436;
TYR-460; TYR-477 AND TYR-501.
PubMed=9535915; DOI=10.1074/jbc.273.15.9234;
Takada T., Matozaki T., Takeda H., Fukunaga K., Noguchi T., Fujioka Y.,
Okazaki I., Tsuda M., Yamao T., Ochi F., Kasuga M.;
"Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated
mitogen-activated protein kinase activation.";
J. Biol. Chem. 273:9234-9242(1998).
[8]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-93; ASN-169 AND ASN-312, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=24090084; DOI=10.1021/pr400783j;
Parker B.L., Thaysen-Andersen M., Solis N., Scott N.E., Larsen M.R.,
Graham M.E., Packer N.H., Cordwell S.J.;
"Site-specific glycan-peptide analysis for determination of N-glycoproteome
heterogeneity.";
J. Proteome Res. 12:5791-5800(2013).
-!- FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as
docking protein and induces translocation of PTPN6, PTPN11 and other
binding partners from the cytosol to the plasma membrane. Supports
adhesion of cerebellar neurons, neurite outgrowth and glial cell
attachment. May play a key role in intracellular signaling during
synaptogenesis and in synaptic function. Involved in the negative
regulation of receptor tyrosine kinase-coupled cellular responses
induced by cell adhesion, growth factors or insulin. Mediates negative
regulation of phagocytosis, mast cell activation and dendritic cell
activation. CD47 binding prevents maturation of immature dendritic
cells and inhibits cytokine production by mature dendritic cells. May
play a role in the release of nitric oxide by macrophages (By
similarity). {ECO:0000250, ECO:0000269|PubMed:9271230}.
-!- SUBUNIT: Binds PTPN11 when tyrosine-phosphorylated, except in
macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds
FGR. Binds JAK2 irrespective of its phosphorylation status and forms a
stable complex. Binds SCAP1 and/or SCAP2. The resulting complex
recruits FYB1. Binds PTK2B (By similarity). {ECO:0000250}.
-!- INTERACTION:
P97710; Q9R044: Nphs1; NbExp=2; IntAct=EBI-7945080, EBI-7945021;
P97710; P41499: Ptpn11; NbExp=3; IntAct=EBI-7945080, EBI-7180604;
P97710; Q06124: PTPN11; Xeno; NbExp=3; IntAct=EBI-7945080, EBI-297779;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- TISSUE SPECIFICITY: Highly expressed in brain, spleen, lung, liver and
kidney. Detected at lower levels in heart. Highly expressed in alveolar
and peritoneal macrophages, and at lower levels in dendritic cells.
{ECO:0000269|PubMed:9712053, ECO:0000269|PubMed:9774638}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:8943344,
ECO:0000269|PubMed:9774638}.
-!- PTM: Phosphorylated on tyrosine residues in response to insulin, cell
adhesion or epidermal growth factors. Dephosphorylated by PTPN11.
{ECO:0000269|PubMed:8943344, ECO:0000269|PubMed:9271230,
ECO:0000269|PubMed:9344856, ECO:0000269|PubMed:9535915}.
---------------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; D85183; BAA12734.1; -; mRNA.
EMBL; D38468; BAA20368.1; -; mRNA.
EMBL; U62328; AAC68478.1; -; mRNA.
EMBL; AF055065; AAC18089.1; -; mRNA.
RefSeq; NP_037148.2; NM_013016.2.
RefSeq; XP_017446986.1; XM_017591497.1.
SMR; P97710; -.
BioGRID; 247560; 4.
IntAct; P97710; 4.
MINT; P97710; -.
STRING; 10116.ENSRNOP00000006408; -.
CarbonylDB; P97710; -.
GlyGen; P97710; 13 sites, 25 N-linked glycans (3 sites).
iPTMnet; P97710; -.
PhosphoSitePlus; P97710; -.
jPOST; P97710; -.
PaxDb; P97710; -.
PeptideAtlas; P97710; -.
PRIDE; P97710; -.
Ensembl; ENSRNOT00000006408; ENSRNOP00000006408; ENSRNOG00000004763.
GeneID; 25528; -.
KEGG; rno:25528; -.
UCSC; RGD:3449; rat.
CTD; 140885; -.
RGD; 3449; Sirpa.
eggNOG; ENOG502S1XD; Eukaryota.
GeneTree; ENSGT00960000186656; -.
InParanoid; P97710; -.
Reactome; R-RNO-202733; Cell surface interactions at the vascular wall.
Reactome; R-RNO-2172127; DAP12 interactions.
Reactome; R-RNO-391160; Signal regulatory protein family interactions.
Reactome; R-RNO-6798695; Neutrophil degranulation.
PRO; PR:P97710; -.
Proteomes; UP000002494; Chromosome 3.
Bgee; ENSRNOG00000004763; Expressed in frontal cortex and 21 other tissues.
ExpressionAtlas; P97710; baseline and differential.
Genevisible; P97710; RN.
GO; GO:0009986; C:cell surface; IDA:ARUK-UCL.
GO; GO:0005887; C:integral component of plasma membrane; ISO:RGD.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0098632; F:cell-cell adhesion mediator activity; ISO:RGD.
GO; GO:0030695; F:GTPase regulator activity; IMP:ARUK-UCL.
GO; GO:1990405; F:protein antigen binding; ISO:RGD.
GO; GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; IPI:ARUK-UCL.
GO; GO:0019903; F:protein phosphatase binding; IPI:ARUK-UCL.
GO; GO:0045309; F:protein phosphorylated amino acid binding; ISO:RGD.
GO; GO:1990782; F:protein tyrosine kinase binding; IPI:ARUK-UCL.
GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO; GO:0007015; P:actin filament organization; ISO:RGD.
GO; GO:0016477; P:cell migration; IDA:RGD.
GO; GO:0007160; P:cell-matrix adhesion; ISO:RGD.
GO; GO:0070301; P:cellular response to hydrogen peroxide; IMP:ARUK-UCL.
GO; GO:0071346; P:cellular response to interferon-gamma; IMP:ARUK-UCL.
GO; GO:0071347; P:cellular response to interleukin-1; IMP:ARUK-UCL.
GO; GO:0071349; P:cellular response to interleukin-12; ISO:RGD.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISO:RGD.
GO; GO:0007010; P:cytoskeleton organization; ISO:RGD.
GO; GO:0097530; P:granulocyte migration; ISO:RGD.
GO; GO:0002244; P:hematopoietic progenitor cell differentiation; ISO:RGD.
GO; GO:0035696; P:monocyte extravasation; IMP:ARUK-UCL.
GO; GO:0071650; P:negative regulation of chemokine (C-C motif) ligand 5 production; ISO:RGD.
GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; ISO:RGD.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:1903720; P:negative regulation of I-kappaB phosphorylation; ISO:RGD.
GO; GO:0050728; P:negative regulation of inflammatory response; ISO:RGD.
GO; GO:0032688; P:negative regulation of interferon-beta production; ISO:RGD.
GO; GO:0032715; P:negative regulation of interleukin-6 production; ISO:RGD.
GO; GO:0046329; P:negative regulation of JNK cascade; ISO:RGD.
GO; GO:0071641; P:negative regulation of macrophage inflammatory protein 1 alpha production; ISO:RGD.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISO:RGD.
GO; GO:0050765; P:negative regulation of phagocytosis; IMP:ARUK-UCL.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:RGD.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISO:RGD.
GO; GO:0006911; P:phagocytosis, engulfment; ISO:RGD.
GO; GO:0006910; P:phagocytosis, recognition; ISO:RGD.
GO; GO:0050766; P:positive regulation of phagocytosis; ISO:RGD.
GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
GO; GO:0010468; P:regulation of gene expression; ISO:RGD.
GO; GO:0032649; P:regulation of interferon-gamma production; ISO:RGD.
GO; GO:0032651; P:regulation of interleukin-1 beta production; IMP:ARUK-UCL.
GO; GO:0032675; P:regulation of interleukin-6 production; IMP:ARUK-UCL.
GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; IMP:ARUK-UCL.
GO; GO:0032680; P:regulation of tumor necrosis factor production; IMP:ARUK-UCL.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003006; Ig/MHC_CS.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07654; C1-set; 2.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 2.
SMART; SM00407; IGc1; 2.
SUPFAM; SSF48726; SSF48726; 3.
PROSITE; PS50835; IG_LIKE; 3.
PROSITE; PS00290; IG_MHC; 1.
1: Evidence at protein level;
Direct protein sequencing; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome;
Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..31
/evidence="ECO:0000269|PubMed:9271230"
CHAIN 32..509
/note="Tyrosine-protein phosphatase non-receptor type
substrate 1"
/id="PRO_0000014943"
TOPO_DOM 32..373
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 374..394
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 395..509
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 32..138
/note="Ig-like V-type"
DOMAIN 150..248
/note="Ig-like C1-type 1"
DOMAIN 255..349
/note="Ig-like C1-type 2"
MOTIF 436..439
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 446..451
/note="SH3-binding"
/evidence="ECO:0000255"
MOTIF 460..463
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 477..480
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 501..504
/note="SH2-binding"
/evidence="ECO:0000255"
MOD_RES 436
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 460
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 477
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000269|PubMed:9535915"
MOD_RES 501
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000269|PubMed:9535915"
CARBOHYD 54
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 93
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0007744|PubMed:24090084"
CARBOHYD 169
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0007744|PubMed:24090084"
CARBOHYD 181
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 205
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 209
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 242
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 246
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 271
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 293
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 312
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0007744|PubMed:24090084"
CARBOHYD 320
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 345
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 55..122
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 172..229
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 274..332
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
MUTAGEN 436
/note="Y->F: Abolishes tyrosine phosphorylation and PTPN11
binding; when associated with F-460; F-477 and F-501."
/evidence="ECO:0000269|PubMed:9535915"
MUTAGEN 460
/note="Y->F: Abolishes tyrosine phosphorylation and PTPN11
binding; when associated with F-436; F-477 and F-501."
/evidence="ECO:0000269|PubMed:9535915"
MUTAGEN 477
/note="Y->F: Strongly reduces insulin-induced tyrosine
phosphorylation and PTPN11 binding. Abolishes tyrosine
phosphorylation and PTPN11 binding; when associated with F-
436; F-460 and F-501."
/evidence="ECO:0000269|PubMed:9535915"
MUTAGEN 501
/note="Y->F: Strongly reduces insulin-induced tyrosine
phosphorylation and PTPN11 binding. Abolishes tyrosine
phosphorylation and PTPN11 binding; when associated with F-
436; F-460 and F-477."
/evidence="ECO:0000269|PubMed:9535915"
CONFLICT 8
/note="P -> L (in Ref. 4)"
/evidence="ECO:0000305"
CONFLICT 10
/note="Missing (in Ref. 4)"
/evidence="ECO:0000305"
CONFLICT 25
/note="F -> I (in Ref. 3; AAC68478)"
/evidence="ECO:0000305"
CONFLICT 58
/note="S -> C (in Ref. 4; AAC18089)"
/evidence="ECO:0000305"
CONFLICT 99..100
/note="KR -> MP (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 162
/note="G -> A (in Ref. 2; BAA20368)"
/evidence="ECO:0000305"
CONFLICT 189
/note="D -> N (in Ref. 3; AAC68478)"
/evidence="ECO:0000305"
CONFLICT 205
/note="N -> L (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 209
/note="N -> G (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 405
/note="G -> F (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 416
/note="E -> P (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 418..421
/note="NARE -> EGQN (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 450
/note="R -> E (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
CONFLICT 499
/note="Missing (in Ref. 3; AA sequence)"
/evidence="ECO:0000305"
SEQUENCE 509 AA; 55691 MW; 5BE1FE0A4DD429F4 CRC64;
MEPAGPAPGR LGPLLFCLLL SASCFCAGAS GKELKVTQAD KSVSVAAGDS ATLNCTVSSL
TPVGPIKWFK GEGQNRSPIY SFIGGEHFPR ITNVSDATKR NNMDFSICIS NVTPEDAGTY
YCVKFQKGIV EPDTEIKSGG GTTLYVLAKP SSPEVSGPDS RGSPGQTVNF TCKSYGFSPR
NITLKWLKDG KELSHLETTI SSKSNVSYNI SSTVSVKLSP EDIHSRVICE VAHVTLEGRP
LNGTANFSNI IRVSPTLKIT QQPLTPASQV NLTCQVQKFY PKALQLNWLE NGNLSRTDKP
EHFTDNRDGT YNYTSLFLVN SSAHREDVVF TCQVEHDSQP AITENHTVRA FAHSSSGGSM
ETIPDNNAYY NWNVFIGVGV ACALLVVLLM AALYLLRIKQ KKAKGSTSST RLHEPEKNAR
EITQIQDTND INDITYADLN LPKEKKPAPR VPEPNNHTEY ASIETGKLPR PEDTLTYADL
DMVHLNRAQP TPKPEPSFSE YASVQVQRK


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U0954h CLIA Homo sapiens,Human,Protein-tyrosine phosphatase alpha,PTPA,PTPRA,PTPRL2,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
E0954h ELISA Homo sapiens,Human,Protein-tyrosine phosphatase alpha,PTPA,PTPRA,PTPRL2,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
E0954h ELISA kit Homo sapiens,Human,Protein-tyrosine phosphatase alpha,PTPA,PTPRA,PTPRL2,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
EIAAB38499 CD172 antigen-like family member B,Homo sapiens,Human,Signal-regulatory protein beta-1,SIRPB1,SIRP-beta-1
E0954r ELISA Lrp,Protein-tyrosine phosphatase alpha,Ptpra,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
E0954r ELISA kit Lrp,Protein-tyrosine phosphatase alpha,Ptpra,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
U0954r CLIA Lrp,Protein-tyrosine phosphatase alpha,Ptpra,Rat,Rattus norvegicus,Receptor-type tyrosine-protein phosphatase alpha,R-PTP-alpha 96T
EIAAB33092 Density-enhanced phosphatase 1,DEP1,DEP-1,Homo sapiens,HPTP eta,Human,Protein-tyrosine phosphatase eta,Protein-tyrosine phosphatase receptor type J,PTPRJ,Receptor-type tyrosine-protein phosphatase eta
15-288-21045 C-C chemokine receptor type 1 - C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; HM145; LD78 receptor; CD191 antigen Polyclonal 0.05 mg
15-288-21045 C-C chemokine receptor type 1 - C-C CKR-1; CC-CKR-1; CCR-1; CCR1; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; HM145; LD78 receptor; CD191 antigen Polyclonal 0.1 mg
Pathways :
WP2272: Pathogenic Escherichia coli infection
WP1909: Signal regulatory protein (SIRP) family interactions
WP2199: Seed Development
WP2292: Chemokine signaling pathway
WP1714: Tyrosine metabolism
WP566: canonical wnt - zebrafish
WP1566: Citrate cycle (TCA cycle)
WP1963: The effect of Glucocorticoids on target gene expression
WP2328: Allograft rejection
WP1531: Vitamin D synthesis
WP210: Cytoplasmic Ribosomal Proteins
WP1502: Mitochondrial biogenesis
WP1692: Protein export
WP1713: Two-component system
WP1493: Carbon assimilation C4 pathway
WP26: Signal Transduction of S1P Receptor
WP57: Signal Transduction of S1P Receptor
WP1689: Porphyrin and chlorophyll metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1965: VEGF-receptor Signal Transduction
WP731: Sterol regulatory element binding protein related
WP1665: Limonene and pinene degradation
WP1624: Bacterial secretion system
WP1121: Kit Receptor Signaling Pathway
WP1644: DNA replication

Related Genes :
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[SIRPA MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[Ptpn6 Hcp Hcph Ptp1C] Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
[PTPN11 PTP2C SHPTP2] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[Cd300lf Clm1 Lmir3] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Leukocyte mono-Ig-like receptor 3) (Myeloid-associated immunoglobulin-like receptor 5) (MAIR-5) (MAIR-V) (CD antigen CD300f)
[Mst1r Ron Stk] Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (Stem cell-derived tyrosine kinase) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
[Ptpn11] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[MST1R PTK8 RON] Macrophage-stimulating protein receptor (MSP receptor) (EC 2.7.10.1) (CDw136) (Protein-tyrosine kinase 8) (p185-Ron) (CD antigen CD136) [Cleaved into: Macrophage-stimulating protein receptor alpha chain; Macrophage-stimulating protein receptor beta chain]
[Cd244 2b4 Nmrk] Natural killer cell receptor 2B4 (NK cell type I receptor protein 2B4) (NKR2B4) (Non-MHC restricted killing associated) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[PTPRJ DEP1] Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
[Ptprj Byp Scc1] Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (HPTP beta-like tyrosine phosphatase) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (Susceptibility to colon cancer 1) (CD antigen CD148)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[Ptprc Ly-5] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[CD244 2B4] Natural killer cell receptor 2B4 (NK cell activation-inducing ligand) (NAIL) (NK cell type I receptor protein 2B4) (NKR2B4) (h2B4) (SLAM family member 4) (SLAMF4) (Signaling lymphocytic activation molecule 4) (CD antigen CD244)
[DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE] Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
[CD80 CD28LG CD28LG1 LAB7] T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) (BB1) (CTLA-4 counter-receptor B7.1) (B7) (CD antigen CD80)
[Ptprs] Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
[LILRB2 ILT4 LIR2 MIR10] Leukocyte immunoglobulin-like receptor subfamily B member 2 (LIR-2) (Leukocyte immunoglobulin-like receptor 2) (CD85 antigen-like family member D) (Immunoglobulin-like transcript 4) (ILT-4) (Monocyte/macrophage immunoglobulin-like receptor 10) (MIR-10) (CD antigen CD85d)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)

Bibliography :