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Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)

 SHPS1_HUMAN             Reviewed;         504 AA.
P78324; A2A2E1; A8K411; B2R6C3; O00683; O43799; Q8N517; Q8TAL8; Q9H0Z2;
Q9UDX2; Q9UIJ6; Q9Y4U9;
28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
05-APR-2011, sequence version 2.
07-APR-2021, entry version 211.
RecName: Full=Tyrosine-protein phosphatase non-receptor type substrate 1;
Short=SHP substrate 1;
Short=SHPS-1;
AltName: Full=Brain Ig-like molecule with tyrosine-based activation motifs;
Short=Bit;
AltName: Full=CD172 antigen-like family member A;
AltName: Full=Inhibitory receptor SHPS-1;
AltName: Full=Macrophage fusion receptor;
AltName: Full=MyD-1 antigen;
AltName: Full=Signal-regulatory protein alpha-1;
Short=Sirp-alpha-1;
AltName: Full=Signal-regulatory protein alpha-2;
Short=Sirp-alpha-2;
AltName: Full=Signal-regulatory protein alpha-3;
Short=Sirp-alpha-3;
AltName: Full=p84;
AltName: CD_antigen=CD172a;
Flags: Precursor;
Name=SIRPA; Synonyms=BIT, MFR, MYD1, PTPNS1, SHPS1, SIRP;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANTS SER-44; SER-50;
ILE-52; HIS-54; VAL-57; ALA-75; GLU-95; SER-96; GLU-100; SER-107; SER-109
AND THR-132.
TISSUE=Brain;
PubMed=9070220; DOI=10.1006/bbrc.1996.6047;
Yamao T., Matozaki T., Amano K., Matsuda Y., Takahashi N., Ochi F.,
Fujioka Y., Kasuga M.;
"Mouse and human SHPS-1: molecular cloning of cDNAs and chromosomal
localization of genes.";
Biochem. Biophys. Res. Commun. 231:61-67(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), POLYMORPHISM, PHOSPHORYLATION,
GLYCOSYLATION, INTERACTION WITH PTPN11; PTPN6 AND GRB2, AND VARIANTS
SER-44; SER-50; ILE-52; HIS-54; VAL-57; ALA-75; GLU-95; SER-96; GLU-100;
SER-107; SER-109 AND THR-132.
TISSUE=Placenta;
PubMed=9062191; DOI=10.1038/386181a0;
Kharitonenkov A., Chen Z., Sures I., Wang H., Schilling J., Ullrich A.;
"A family of proteins that inhibit signalling through tyrosine kinase
receptors.";
Nature 386:181-186(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=10585853; DOI=10.1042/bj3440667;
Sano S., Ohnishi H., Kubota M.;
"Gene structure of mouse BIT/SHPS-1.";
Biochem. J. 344:667-675(1999).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS SER-44;
SER-50; ILE-52; HIS-54; VAL-57; ALA-75; GLU-95; SER-96; GLU-100; SER-107;
SER-109 AND THR-132.
TISSUE=Thalamus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=11780052; DOI=10.1038/414865a;
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANTS
SER-44; SER-50; ILE-52; HIS-54; VAL-57; ALA-75; GLU-95; SER-96; GLU-100;
SER-107; SER-109 AND THR-132.
TISSUE=Brain, Kidney, and Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 76-504.
TISSUE=Monocyte;
PubMed=9485180;
DOI=10.1002/(sici)1521-4141(199801)28:01<1::aid-immu1>3.0.co;2-v;
Brooke G.P., Parsons K.R., Howard C.J.;
"Cloning of two members of the SIRP alpha family of protein tyrosine
phosphatase binding proteins in cattle that are expressed on monocytes and
a subpopulation of dendritic cells and which mediate binding to CD4 T
cells.";
Eur. J. Immunol. 28:1-11(1998).
[8]
FUNCTION, AND INTERACTION WITH FYB1; SCAP2 AND PTK2B.
PubMed=10469599; DOI=10.1016/s0960-9822(99)80401-1;
Timms J.F., Swanson K.D., Marie-Cardine A., Raab M., Rudd C.E.,
Schraven B., Neel B.G.;
"SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-
protein complexes in macrophages.";
Curr. Biol. 9:927-930(1999).
[9]
PHOSPHORYLATION BY JAK2, AND INTERACTION WITH PTPN11 AND JAK2.
PubMed=10842184; DOI=10.1074/jbc.m004238200;
Stofega M.R., Argetsinger L.S., Wang H., Ullrich A., Carter-Su C.;
"Negative regulation of growth hormone receptor/JAK2 signaling by signal
regulatory protein alpha.";
J. Biol. Chem. 275:28222-28229(2000).
[10]
FUNCTION, AND INTERACTION WITH CD47.
PubMed=11509594; DOI=10.4049/jimmunol.167.5.2547;
Latour S., Tanaka H., Demeure C., Mateo V., Rubio M., Brown E.J.,
Maliszewski C., Lindberg F.P., Oldenborg A., Ullrich A., Delespesse G.,
Sarfati M.;
"Bidirectional negative regulation of human T and dendritic cells by CD47
and its cognate receptor signal-regulator protein-alpha: down-regulation of
IL-12 responsiveness and inhibition of dendritic cell activation.";
J. Immunol. 167:2547-2554(2001).
[11]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-245.
TISSUE=Plasma;
PubMed=16335952; DOI=10.1021/pr0502065;
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J.,
Smith R.D.;
"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,
hydrazide chemistry, and mass spectrometry.";
J. Proteome Res. 4:2070-2080(2005).
[12]
GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-270 AND ASN-292.
TISSUE=Liver;
PubMed=19159218; DOI=10.1021/pr8008012;
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
"Glycoproteomics analysis of human liver tissue by combination of multiple
enzyme digestion and hydrazide chemistry.";
J. Proteome Res. 8:651-661(2009).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-496, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
phosphoproteome.";
J. Proteomics 96:253-262(2014).
[14]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=25944712; DOI=10.1002/pmic.201400617;
Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
"N-terminome analysis of the human mitochondrial proteome.";
Proteomics 15:2519-2524(2015).
[15]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 31-149, AND DISULFIDE BOND.
PubMed=17369261; DOI=10.1074/jbc.m611511200;
Hatherley D., Harlos K., Dunlop D.C., Stuart D.I., Barclay A.N.;
"The structure of the macrophage signal regulatory protein alpha
(SIRPalpha) inhibitory receptor reveals a binding face reminiscent of that
used by T cell receptors.";
J. Biol. Chem. 282:14567-14575(2007).
[16]
X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 31-149 IN COMPLEX WITH CD47, AND
DISULFIDE BOND.
PubMed=18657508; DOI=10.1016/j.molcel.2008.05.026;
Hatherley D., Graham S.C., Turner J., Harlos K., Stuart D.I., Barclay A.N.;
"Paired receptor specificity explained by structures of signal regulatory
proteins alone and complexed with CD47.";
Mol. Cell 31:266-277(2008).
-!- FUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as
docking protein and induces translocation of PTPN6, PTPN11 and other
binding partners from the cytosol to the plasma membrane. Supports
adhesion of cerebellar neurons, neurite outgrowth and glial cell
attachment. May play a key role in intracellular signaling during
synaptogenesis and in synaptic function (By similarity). Involved in
the negative regulation of receptor tyrosine kinase-coupled cellular
responses induced by cell adhesion, growth factors or insulin. Mediates
negative regulation of phagocytosis, mast cell activation and dendritic
cell activation. CD47 binding prevents maturation of immature dendritic
cells and inhibits cytokine production by mature dendritic cells.
{ECO:0000250, ECO:0000269|PubMed:10469599,
ECO:0000269|PubMed:11509594}.
-!- SUBUNIT: Binds PTPN11 when tyrosine-phosphorylated, except in
macrophages, where it primarily binds PTPN6. Binds GRB2 in vitro. Binds
FGR (By similarity). Binds JAK2 irrespective of its phosphorylation
status and forms a stable complex. Binds SCAP1 and/or SCAP2. The
resulting complex recruits FYB1. Binds PTK2B. {ECO:0000250,
ECO:0000269|PubMed:18657508}.
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=P78324-1; Sequence=Displayed;
Name=2;
IsoId=P78324-2; Sequence=VSP_007030;
Name=4;
IsoId=P78324-4; Sequence=VSP_040799;
-!- TISSUE SPECIFICITY: Ubiquitous. Highly expressed in brain. Detected on
myeloid cells, but not T-cells. Detected at lower levels in heart,
placenta, lung, testis, ovary, colon, liver, small intestine, prostate,
spleen, kidney, skeletal muscle and pancreas.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:16335952,
ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:9062191}.
-!- PTM: Phosphorylated on tyrosine residues in response to stimulation
with EGF, growth hormone, insulin and PDGF. Dephosphorylated by PTPN11.
{ECO:0000269|PubMed:10842184, ECO:0000269|PubMed:9062191}.
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EMBL; D86043; BAA12974.1; -; mRNA.
EMBL; Y10375; CAA71403.1; -; mRNA.
EMBL; AB023430; BAA87929.1; -; mRNA.
EMBL; AK290776; BAF83465.1; -; mRNA.
EMBL; AK312521; BAG35420.1; -; mRNA.
EMBL; AL034562; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL117335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC026692; AAH26692.1; -; mRNA.
EMBL; BC033092; AAH33092.1; -; mRNA.
EMBL; BC038510; AAH38510.1; -; mRNA.
EMBL; BC075849; AAH75849.1; -; mRNA.
EMBL; Y11047; CAA71944.1; -; mRNA.
CCDS; CCDS13022.1; -. [P78324-1]
CCDS; CCDS82593.1; -. [P78324-2]
PIR; JC5287; JC5287.
RefSeq; NP_001035111.1; NM_001040022.1. [P78324-1]
RefSeq; NP_001035112.1; NM_001040023.1. [P78324-1]
RefSeq; NP_001317657.1; NM_001330728.1. [P78324-2]
RefSeq; NP_542970.1; NM_080792.2. [P78324-1]
RefSeq; XP_005260727.1; XM_005260670.3. [P78324-2]
PDB; 2JJS; X-ray; 1.85 A; A/B=31-149.
PDB; 2JJT; X-ray; 2.30 A; A/B=31-149.
PDB; 2UV3; X-ray; 1.80 A; A/B=31-149.
PDB; 2WNG; X-ray; 2.49 A; A=31-350.
PDB; 4CMM; X-ray; 1.92 A; A=31-149.
PDB; 6BIT; X-ray; 2.19 A; G/H=31-147.
PDB; 6NMR; X-ray; 2.42 A; E/I/M/S=31-149.
PDB; 6NMS; X-ray; 2.11 A; C/S=31-149.
PDB; 6NMT; X-ray; 1.83 A; C=31-149.
PDB; 6NMU; X-ray; 2.55 A; C/S=31-149.
PDB; 6NMV; X-ray; 2.61 A; S=31-149.
PDB; 7KPG; X-ray; 2.27 A; S=33-147.
PDBsum; 2JJS; -.
PDBsum; 2JJT; -.
PDBsum; 2UV3; -.
PDBsum; 2WNG; -.
PDBsum; 4CMM; -.
PDBsum; 6BIT; -.
PDBsum; 6NMR; -.
PDBsum; 6NMS; -.
PDBsum; 6NMT; -.
PDBsum; 6NMU; -.
PDBsum; 6NMV; -.
PDBsum; 7KPG; -.
SMR; P78324; -.
BioGRID; 126752; 79.
IntAct; P78324; 10.
STRING; 9606.ENSP00000382941; -.
GlyConnect; 650; 13 N-Linked glycans (4 sites).
GlyGen; P78324; 7 sites, 2 N-linked glycans (1 site).
iPTMnet; P78324; -.
PhosphoSitePlus; P78324; -.
BioMuta; SIRPA; -.
DMDM; 327478534; -.
EPD; P78324; -.
jPOST; P78324; -.
MassIVE; P78324; -.
MaxQB; P78324; -.
PaxDb; P78324; -.
PeptideAtlas; P78324; -.
PRIDE; P78324; -.
ProteomicsDB; 57564; -. [P78324-1]
ProteomicsDB; 57565; -. [P78324-2]
ProteomicsDB; 57566; -. [P78324-4]
ABCD; P78324; 101 sequenced antibodies.
Antibodypedia; 3458; 969 antibodies.
DNASU; 140885; -.
Ensembl; ENST00000356025; ENSP00000348307; ENSG00000198053. [P78324-1]
Ensembl; ENST00000358771; ENSP00000351621; ENSG00000198053. [P78324-1]
Ensembl; ENST00000400068; ENSP00000382941; ENSG00000198053. [P78324-1]
Ensembl; ENST00000622179; ENSP00000478763; ENSG00000198053. [P78324-2]
GeneID; 140885; -.
KEGG; hsa:140885; -.
UCSC; uc002wfq.3; human. [P78324-1]
CTD; 140885; -.
DisGeNET; 140885; -.
GeneCards; SIRPA; -.
HGNC; HGNC:9662; SIRPA.
HPA; ENSG00000198053; Tissue enhanced (brain).
MIM; 602461; gene.
neXtProt; NX_P78324; -.
OpenTargets; ENSG00000198053; -.
PharmGKB; PA34006; -.
VEuPathDB; HostDB:ENSG00000198053.11; -.
eggNOG; ENOG502S1XD; Eukaryota.
GeneTree; ENSGT00960000186656; -.
HOGENOM; CLU_044430_2_0_1; -.
InParanoid; P78324; -.
OMA; QESDPNN; -.
OrthoDB; 904196at2759; -.
PhylomeDB; P78324; -.
TreeFam; TF341862; -.
PathwayCommons; P78324; -.
Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
Reactome; R-HSA-391160; Signal regulatory protein family interactions.
Reactome; R-HSA-6798695; Neutrophil degranulation.
SignaLink; P78324; -.
SIGNOR; P78324; -.
BioGRID-ORCS; 140885; 8 hits in 989 CRISPR screens.
ChiTaRS; SIRPA; human.
EvolutionaryTrace; P78324; -.
GeneWiki; Signal-regulatory_protein_alpha; -.
GenomeRNAi; 140885; -.
Pharos; P78324; Tbio.
PRO; PR:P78324; -.
Proteomes; UP000005640; Chromosome 20.
RNAct; P78324; protein.
Bgee; ENSG00000198053; Expressed in anterior cingulate cortex and 229 other tissues.
Genevisible; P78324; HS.
GO; GO:0009986; C:cell surface; IDA:ARUK-UCL.
GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
GO; GO:0101003; C:ficolin-1-rich granule membrane; TAS:Reactome.
GO; GO:0005887; C:integral component of plasma membrane; IDA:ARUK-UCL.
GO; GO:0016020; C:membrane; TAS:ProtInc.
GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
GO; GO:0070821; C:tertiary granule membrane; TAS:Reactome.
GO; GO:0098632; F:cell-cell adhesion mediator activity; IPI:ARUK-UCL.
GO; GO:0030695; F:GTPase regulator activity; ISS:ARUK-UCL.
GO; GO:1990405; F:protein antigen binding; IPI:ARUK-UCL.
GO; GO:0086080; F:protein binding involved in heterotypic cell-cell adhesion; ISS:ARUK-UCL.
GO; GO:0019903; F:protein phosphatase binding; ISS:ARUK-UCL.
GO; GO:1990782; F:protein tyrosine kinase binding; ISS:ARUK-UCL.
GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
GO; GO:0016477; P:cell migration; ISS:ARUK-UCL.
GO; GO:0070301; P:cellular response to hydrogen peroxide; ISS:ARUK-UCL.
GO; GO:0071346; P:cellular response to interferon-gamma; ISS:ARUK-UCL.
GO; GO:0071347; P:cellular response to interleukin-1; ISS:ARUK-UCL.
GO; GO:0071349; P:cellular response to interleukin-12; IMP:ARUK-UCL.
GO; GO:0071222; P:cellular response to lipopolysaccharide; ISS:ARUK-UCL.
GO; GO:0050900; P:leukocyte migration; TAS:Reactome.
GO; GO:0035696; P:monocyte extravasation; ISS:ARUK-UCL.
GO; GO:0071650; P:negative regulation of chemokine (C-C motif) ligand 5 production; ISS:ARUK-UCL.
GO; GO:1900016; P:negative regulation of cytokine production involved in inflammatory response; ISS:ARUK-UCL.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:ARUK-UCL.
GO; GO:1903720; P:negative regulation of I-kappaB phosphorylation; ISS:ARUK-UCL.
GO; GO:0050728; P:negative regulation of inflammatory response; IMP:ARUK-UCL.
GO; GO:0032688; P:negative regulation of interferon-beta production; ISS:ARUK-UCL.
GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:ARUK-UCL.
GO; GO:0046329; P:negative regulation of JNK cascade; ISS:ARUK-UCL.
GO; GO:0071641; P:negative regulation of macrophage inflammatory protein 1 alpha production; ISS:ARUK-UCL.
GO; GO:0045019; P:negative regulation of nitric oxide biosynthetic process; ISS:ARUK-UCL.
GO; GO:0050765; P:negative regulation of phagocytosis; ISS:ARUK-UCL.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISS:ARUK-UCL.
GO; GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:ARUK-UCL.
GO; GO:0043312; P:neutrophil degranulation; TAS:Reactome.
GO; GO:0050766; P:positive regulation of phagocytosis; IBA:GO_Central.
GO; GO:0050870; P:positive regulation of T cell activation; IBA:GO_Central.
GO; GO:0010468; P:regulation of gene expression; IMP:ARUK-UCL.
GO; GO:0032649; P:regulation of interferon-gamma production; IMP:ARUK-UCL.
GO; GO:0032651; P:regulation of interleukin-1 beta production; ISS:ARUK-UCL.
GO; GO:0032675; P:regulation of interleukin-6 production; ISS:ARUK-UCL.
GO; GO:0045428; P:regulation of nitric oxide biosynthetic process; ISS:ARUK-UCL.
GO; GO:0032680; P:regulation of tumor necrosis factor production; IGI:ARUK-UCL.
Gene3D; 2.60.40.10; -; 3.
InterPro; IPR007110; Ig-like_dom.
InterPro; IPR036179; Ig-like_dom_sf.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR003597; Ig_C1-set.
InterPro; IPR003599; Ig_sub.
InterPro; IPR013106; Ig_V-set.
Pfam; PF07654; C1-set; 2.
Pfam; PF07686; V-set; 1.
SMART; SM00409; IG; 2.
SMART; SM00407; IGc1; 2.
SMART; SM00406; IGv; 1.
SUPFAM; SSF48726; SSF48726; 3.
PROSITE; PS50835; IG_LIKE; 3.
1: Evidence at protein level;
3D-structure; Alternative splicing; Disulfide bond; Glycoprotein;
Immunoglobulin domain; Membrane; Phosphoprotein; Reference proteome;
Repeat; SH3-binding; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..30
/evidence="ECO:0000255"
CHAIN 31..504
/note="Tyrosine-protein phosphatase non-receptor type
substrate 1"
/id="PRO_0000014941"
TOPO_DOM 31..373
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 374..394
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 395..504
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 32..137
/note="Ig-like V-type"
DOMAIN 148..247
/note="Ig-like C1-type 1"
DOMAIN 254..348
/note="Ig-like C1-type 2"
MOTIF 429..432
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 439..444
/note="SH3-binding"
/evidence="ECO:0000255"
MOTIF 453..456
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 470..473
/note="SH2-binding"
/evidence="ECO:0000255"
MOTIF 496..499
/note="SH2-binding"
/evidence="ECO:0000255"
MOD_RES 429
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 453
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000255"
MOD_RES 470
/note="Phosphotyrosine; by Tyr-kinases"
/evidence="ECO:0000250|UniProtKB:P97710"
MOD_RES 496
/note="Phosphotyrosine"
/evidence="ECO:0007744|PubMed:24275569"
CARBOHYD 245
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16335952"
CARBOHYD 270
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:19159218"
CARBOHYD 292
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:19159218"
CARBOHYD 319
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 55..121
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114,
ECO:0000269|PubMed:17369261, ECO:0000269|PubMed:18657508"
DISULFID 170..228
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
DISULFID 273..331
/evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
VAR_SEQ 130
/note="Missing (in isoform 4)"
/evidence="ECO:0000305"
/id="VSP_040799"
VAR_SEQ 422
/note="Q -> QVQSL (in isoform 2)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_007030"
VARIANT 6..7
/note="PA -> RS"
/id="VAR_015462"
VARIANT 20
/note="A -> P"
/id="VAR_015463"
VARIANT 40
/note="D -> E (in dbSNP:rs1349896458)"
/id="VAR_015464"
VARIANT 44
/note="L -> S (in dbSNP:rs143735290)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015465"
VARIANT 50
/note="T -> S (in dbSNP:rs17855609)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015466"
VARIANT 52
/note="T -> I (in dbSNP:rs17855610)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015468"
VARIANT 54
/note="R -> H (in dbSNP:rs17855611)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015470"
VARIANT 57
/note="A -> V (in dbSNP:rs17855612)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015471"
VARIANT 61
/note="I -> N (in dbSNP:rs1371837011)"
/id="VAR_015472"
VARIANT 68
/note="W -> R"
/id="VAR_015473"
VARIANT 75
/note="G -> A (in dbSNP:rs1057114)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015474"
VARIANT 77
/note="E -> K (in dbSNP:rs1182420620)"
/id="VAR_015475"
VARIANT 81
/note="N -> H"
/id="VAR_015477"
VARIANT 95
/note="D -> E (in dbSNP:rs138283486)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015478"
VARIANT 96
/note="L -> S"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015479"
VARIANT 100
/note="N -> E (requires 2 nucleotide substitutions;
dbSNP:rs386811662)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015480"
VARIANT 107
/note="R -> S (in dbSNP:rs17855615)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015483"
VARIANT 109
/note="G -> S (in dbSNP:rs17855616)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015484"
VARIANT 125
/note="R -> Q (in dbSNP:rs767136065)"
/id="VAR_015485"
VARIANT 132
/note="V -> T (requires 2 nucleotide substitutions;
dbSNP:rs386811663)"
/evidence="ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9062191,
ECO:0000269|PubMed:9070220"
/id="VAR_015486"
VARIANT 134
/note="F -> L"
/id="VAR_015487"
VARIANT 163
/note="Q -> D (requires 2 nucleotide substitutions)"
/id="VAR_015488"
VARIANT 181
/note="T -> S"
/id="VAR_015489"
VARIANT 190
/note="E -> Q"
/id="VAR_015490"
VARIANT 201..202
/note="VG -> AR"
/id="VAR_015491"
VARIANT 214
/note="K -> N"
/id="VAR_015492"
VARIANT 220
/note="E -> G"
/id="VAR_015493"
VARIANT 222
/note="V -> I (in dbSNP:rs143385810)"
/id="VAR_015494"
VARIANT 236
/note="Q -> R"
/id="VAR_015495"
VARIANT 239..240
/note="PL -> SF"
/id="VAR_015496"
VARIANT 251
/note="R -> Q (in dbSNP:rs377448893)"
/id="VAR_015497"
VARIANT 261
/note="Q -> L"
/id="VAR_015498"
VARIANT 263
/note="V -> M (in dbSNP:rs754806675)"
/id="VAR_015499"
VARIANT 271
/note="V -> I"
/id="VAR_015500"
VARIANT 276
/note="R -> T"
/id="VAR_015501"
VARIANT 302
/note="V -> L (in dbSNP:rs2422666)"
/id="VAR_015502"
VARIANT 339
/note="P -> S"
/id="VAR_015503"
VARIANT 353
/note="P -> L (in dbSNP:rs138876160)"
/id="VAR_015504"
VARIANT 357
/note="G -> S (in dbSNP:rs1200233096)"
/id="VAR_015505"
VARIANT 367
/note="S -> P"
/id="VAR_015506"
VARIANT 370
/note="R -> Q (in dbSNP:rs778218860)"
/id="VAR_015507"
VARIANT 389
/note="A -> E"
/id="VAR_015508"
VARIANT 443
/note="Q -> R"
/id="VAR_015509"
VARIANT 460
/note="P -> L (in dbSNP:rs1168490568)"
/id="VAR_015510"
VARIANT 486
/note="A -> L (requires 2 nucleotide substitutions)"
/id="VAR_015511"
VARIANT 491
/note="P -> L (in dbSNP:rs367629199)"
/id="VAR_015512"
CONFLICT 259
/note="T -> I (in Ref. 7; CAA71944)"
/evidence="ECO:0000305"
CONFLICT 503
/note="R -> K (in Ref. 7; CAA71944)"
/evidence="ECO:0000305"
STRAND 41..46
/evidence="ECO:0007744|PDB:2UV3"
STRAND 51..53
/evidence="ECO:0007744|PDB:2UV3"
STRAND 56..58
/evidence="ECO:0007744|PDB:2UV3"
STRAND 66..70
/evidence="ECO:0007744|PDB:2UV3"
STRAND 77..85
/evidence="ECO:0007744|PDB:2UV3"
STRAND 90..94
/evidence="ECO:0007744|PDB:2UV3"
STRAND 96..98
/evidence="ECO:0007744|PDB:6NMU"
STRAND 106..110
/evidence="ECO:0007744|PDB:2UV3"
HELIX 113..115
/evidence="ECO:0007744|PDB:2UV3"
STRAND 117..125
/evidence="ECO:0007744|PDB:2UV3"
STRAND 127..129
/evidence="ECO:0007744|PDB:2UV3"
STRAND 132..136
/evidence="ECO:0007744|PDB:2UV3"
STRAND 140..145
/evidence="ECO:0007744|PDB:2UV3"
STRAND 152..154
/evidence="ECO:0007744|PDB:2WNG"
STRAND 165..178
/evidence="ECO:0007744|PDB:2WNG"
STRAND 181..186
/evidence="ECO:0007744|PDB:2WNG"
STRAND 194..199
/evidence="ECO:0007744|PDB:2WNG"
STRAND 207..216
/evidence="ECO:0007744|PDB:2WNG"
HELIX 221..223
/evidence="ECO:0007744|PDB:2WNG"
STRAND 225..231
/evidence="ECO:0007744|PDB:2WNG"
STRAND 240..245
/evidence="ECO:0007744|PDB:2WNG"
HELIX 246..248
/evidence="ECO:0007744|PDB:2WNG"
STRAND 255..261
/evidence="ECO:0007744|PDB:2WNG"
STRAND 269..281
/evidence="ECO:0007744|PDB:2WNG"
STRAND 283..289
/evidence="ECO:0007744|PDB:2WNG"
STRAND 292..298
/evidence="ECO:0007744|PDB:2WNG"
STRAND 310..318
/evidence="ECO:0007744|PDB:2WNG"
STRAND 328..335
/evidence="ECO:0007744|PDB:2WNG"
STRAND 341..346
/evidence="ECO:0007744|PDB:2WNG"
SEQUENCE 504 AA; 54967 MW; 18D2FD04F6182AD0 CRC64;
MEPAGPAPGR LGPLLCLLLA ASCAWSGVAG EEELQVIQPD KSVLVAAGET ATLRCTATSL
IPVGPIQWFR GAGPGRELIY NQKEGHFPRV TTVSDLTKRN NMDFSIRIGN ITPADAGTYY
CVKFRKGSPD DVEFKSGAGT ELSVRAKPSA PVVSGPAARA TPQHTVSFTC ESHGFSPRDI
TLKWFKNGNE LSDFQTNVDP VGESVSYSIH STAKVVLTRE DVHSQVICEV AHVTLQGDPL
RGTANLSETI RVPPTLEVTQ QPVRAENQVN VTCQVRKFYP QRLQLTWLEN GNVSRTETAS
TVTENKDGTY NWMSWLLVNV SAHRDDVKLT CQVEHDGQPA VSKSHDLKVS AHPKEQGSNT
AAENTGSNER NIYIVVGVVC TLLVALLMAA LYLVRIRQKK AQGSTSSTRL HEPEKNAREI
TQDTNDITYA DLNLPKGKKP APQAAEPNNH TEYASIQTSP QPASEDTLTY ADLDMVHLNR
TPKQPAPKPE PSFSEYASVQ VPRK


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Related Genes :
[SIRPA BIT MFR MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
[Sirpa Bit Myd1 Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (mSIRP-alpha1) (p84) (CD antigen CD172a)
[Sirpa Bit Mfr Ptpns1 Shps1 Sirp] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (Macrophage membrane protein MFP150) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[SIRPA MYD1 PTPNS1 SHPS1 SIRP] Tyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (CD antigen CD172a)
[PDGFRA PDGFR2 RHEPDGFRA] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (CD140a antigen) (Platelet-derived growth factor alpha receptor) (Platelet-derived growth factor receptor 2) (PDGFR-2) (CD antigen CD140a)
[Cd79a Iga Mb-1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[Ptpn6 Hcp Hcph Ptp1C] Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (70Z-SHP) (Hematopoietic cell protein-tyrosine phosphatase) (PTPTY-42) (Protein-tyrosine phosphatase 1C) (PTP-1C) (SH-PTP1) (SHP-1)
[PTPN11 PTP2C SHPTP2] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[PPP2R1A] Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[LILRB1 ILT2 LIR1 MIR7] Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD antigen CD85j)
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Pdgfra] Platelet-derived growth factor receptor alpha (PDGF-R-alpha) (PDGFR-alpha) (EC 2.7.10.1) (Alpha platelet-derived growth factor receptor) (Alpha-type platelet-derived growth factor receptor) (CD140 antigen-like family member A) (Platelet-derived growth factor alpha receptor) (CD antigen CD140a)
[CD300A CMRF35H IGSF12 HSPC083] CMRF35-like molecule 8 (CLM-8) (CD300 antigen-like family member A) (CMRF-35-H9) (CMRF35-H9) (CMRF35-H) (IRC1/IRC2) (Immunoglobulin superfamily member 12) (IgSF12) (Inhibitory receptor protein 60) (IRp60) (NK inhibitory receptor) (CD antigen CD300a)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[CD79A IGA MB1] B-cell antigen receptor complex-associated protein alpha chain (Ig-alpha) (MB-1 membrane glycoprotein) (Membrane-bound immunoglobulin-associated protein) (Surface IgM-associated protein) (CD antigen CD79a)
[STAT1] Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84)
[] Genome polyprotein [Cleaved into: Capsid protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[CD300LF CD300F CLM1 IGSF13 IREM1 NKIR UNQ3105/PRO10111] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Immune receptor expressed on myeloid cells 1) (IREM-1) (Immunoglobulin superfamily member 13) (IgSF13) (NK inhibitory receptor) (CD antigen CD300f)
[Il1rl1 Ly84 St2 Ste2] Interleukin-1 receptor-like 1 (EC 3.2.2.6) (Interleukin-33 receptor alpha chain) (Lymphocyte antigen 84) (Protein ST2) (Protein T1)
[Tek Hyk Tie-2 Tie2] Angiopoietin-1 receptor (EC 2.7.10.1) (Endothelial tyrosine kinase) (HYK) (STK1) (Tunica interna endothelial cell kinase) (Tyrosine kinase with Ig and EGF homology domains-2) (Tyrosine-protein kinase receptor TEK) (Tyrosine-protein kinase receptor TIE-2) (mTIE2) (p140 TEK) (CD antigen CD202b)
[Ptprc Ly-5] Receptor-type tyrosine-protein phosphatase C (EC 3.1.3.48) (Leukocyte common antigen) (L-CA) (Lymphocyte antigen 5) (Ly-5) (T200) (CD antigen CD45)
[Cd300lf Clm1 Lmir3] CMRF35-like molecule 1 (CLM-1) (CD300 antigen-like family member F) (Leukocyte mono-Ig-like receptor 3) (Myeloid-associated immunoglobulin-like receptor 5) (MAIR-5) (MAIR-V) (CD antigen CD300f)
[Ptpn11] Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase SYP) (SH-PTP2) (SHP-2) (Shp2)
[Igf1r] Insulin-like growth factor 1 receptor (EC 2.7.10.1) (Insulin-like growth factor I receptor) (IGF-I receptor) (CD antigen CD221) [Cleaved into: Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain]
[] Genome polyprotein [Cleaved into: Protein C (Core protein); Protein prM; Peptide pr; Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Non-structural protein 2A-alpha (NS2A-alpha); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[Ptprs] Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)

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